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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF580 Gene

protein-coding   GIFtS: 43
GCID: GC19P056152

Zinc Finger Protein 580

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5801 2
LDL-Induced EC Protein2 3
LDL Induced EC Protein2

External Ids:    HGNC: 294731   Entrez Gene: 511572   Ensembl: ENSG000002130157   UniProtKB: Q9UK333   

Export aliases for ZNF580 gene to outside databases

Previous GC identifers: GC19P060845 GC19P060848 GC19P052462


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF580 Gene: 
ZNF580 (zinc finger protein 580) is a protein-coding gene. Diseases associated with ZNF580 include acute monocytic leukemia, and monocytic leukemia. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF580 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F-2   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF580 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF580

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF580


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

ZNF580 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF580 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056152:  view genomic region     (about GC identifiers)

Start:
56,146,382 bp from pter      End:
56,154,836 bp from pter
Size:
8,455 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33 (See protein sequence)
Recommended Name: Zinc finger protein 580  
Size: 172 amino acids; 18756 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAB94389.1; Type=Erroneous initiation;
Secondary accessions: B2RC05 Q9NPP7

Explore the universe of human proteins at neXtProt for ZNF580: NX_Q9UK33

Explore proteomics data for ZNF580 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK33

  • ZNF580 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF580 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001156895.1  NP_057286.1  NP_996998.1  

    ENSEMBL proteins: 
     ENSP00000468407   ENSP00000320050   ENSP00000465028   ENSP00000467142   ENSP00000443957  
     ENSP00000446126  

    Human Recombinant Protein Products for ZNF580: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ZNF580 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF580 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UK33

    ProtoNet protein and cluster: Q9UK33

    UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33
    Similarity: Contains 3 C2H2-type zinc fingers


    ZNF580 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN580_HUMAN, Q9UK33
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF580 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF580 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZNF580 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF580


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF580

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for ZNF580 (Q9UK332, 3 ENSP000003200504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF6Q150522, 3, ENSP000002506174MINT-8249091 I2D: score=2 STRING: ENSP00000250617
    SH3GL2Q999622, 3MINT-8270638 I2D: score=2 
    TSC22D4Q9Y3Q82, 3, ENSP000003001814MINT-66806 I2D: score=5 STRING: ENSP00000300181
    RAD54BQ9Y6202, 3, ENSP000003366064MINT-66895 I2D: score=5 STRING: ENSP00000336606
    PAX9P557713, ENSP000003552454I2D: score=1 STRING: ENSP00000355245
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF580 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF580 (ZN580)

    Search CenterWatch for drugs/clinical trials and news about ZNF580 / ZN580

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF580 gene (3 alternative transcripts): 
    NM_001163423.1  NM_016202.2  NM_207115.1  

    Unigene Cluster for ZNF580:

    Zinc finger protein 580
    Hs.631551  [show with all ESTs]
    Unigene Representative Sequence: AK123294
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592881 ENST00000325333(uc002qlo.3) ENST00000590190 ENST00000592461
    ENST00000543039(uc002qlp.3) ENST00000545125(uc010ygd.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF580
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF580 (see all 11):
    hsa-miR-3618 hsa-miR-206 hsa-miR-3184 hsa-miR-922 hsa-miR-499-3p hsa-miR-1 hsa-miR-423-5p hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidZNF580 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF580
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): ZNF580 (NM_207115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF580
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF580
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF580 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF580 
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF580
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF580
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF580

    Additional mRNA sequence: 

    AF184939.1 AK123294.1 AK314888.1 AL359054.1 BC017698.1 

    4 DOTS entries:

    DT.211450  DT.97781312  DT.92015887  DT.95371629 

    24/374 AceView cDNA sequences (see all 374):

    BI907663 AI540673 CR609477 NM_207115 BM701120 CB129949 BQ477323 CR608870 
    CR619004 CR608767 CR601401 BM998114 CR609067 BM712801 BI909057 AI864430 
    CB113771 AI679440 CR616291 CF127611 CR622650 BQ673971 CR604697 BC001219 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF580 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCTCTAA
    ZNF580 Expression
    About this image


    See ZNF580 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF580

    SOURCE GeneReport for Unigene cluster: Hs.631551
        SABiosciences Custom PCR Arrays for ZNF580
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF580

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF580 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5801 , 5 zinc finger protein 5801, 5 91.67(n)1
    97.09(a)1
      7 (2.92 cM)5
    689921  NM_026900.11  NP_081176.11 
     50515325 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8656
    --
    --
    8(a)
    16(a)
    many ↔ many
    many ↔ many
    GL343279.1(637229-650798)
    GL343279.1(624270-625394)
    zebrafish
    (Danio rerio)
    Actinopterygii BX323458.16
    Uncharacterized protein
    6(a)
    1 → many
    16(15308342-15311002)


    ENSEMBL Gene Tree for ZNF580 (if available)
    TreeFam Gene Tree for ZNF580 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF580 gene
    ZNF5812  ZNF3622  ZNF5242  ZNF3842  
    18/30 SIMAP similar genes for ZNF580 using alignment to 4 protein entries:     ZN580_HUMAN (see all proteins) (see all similar genes):
    ZNF883    ZNF71    ZNF460    ZNF384    ZNF681    ZNF729
    ZNF84    ZNF99    ZNF251    ZNF75A    ZNF581    ZNF250
    ZNF648    DKFZp686G16228    ZNF320    ZNF572    ZNF677    ZNF461

    ZNF580 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF580
    PGOHUM00000235698


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/38 SNPs in ZNF580 are shown (see all 38)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468226931,2
    C--56150433(+) TATATC/TAGGGA 1 -- us2k10--------
    rs6122111,2
    C,F,H--56150471(-) TACTTG/AGACAA 1 -- us2k124Minor allele frequency- A:0.07NS EA NA WA CSA 2330
    rs1996254381,2
    --56150481(+) AGACC-/AGGGGT 1 -- us2k10--------
    rs1823075491,2
    --56150485(+) CAGGGA/GTTCTC 1 -- us2k10--------
    rs1869209971,2
    --56150562(+) CTTGGA/GGTTGG 1 -- us2k10--------
    rs1444793701,2
    C--56150565(+) GGGTT-/GGGGGG 1 -- us2k10--------
    rs1405791931,2
    --56150758(+) GCAGTC/GAGCCA 1 -- us2k10--------
    rs1434129191,2
    --56150792(+) GTGGGC/TGACAG 1 -- us2k10--------
    rs1467194691,2
    C--56151058(+) GCACAC/GTGCAA 1 -- us2k10--------
    rs1404178591,2
    --56151143(+) ACGGCC/TGGCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF580 (56146382 - 56154836 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF580:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2553CNV Insertion18451855
    nsv912504CNV Loss21882294
    nsv912501CNV Loss21882294
    nsv912500CNV Loss21882294
    nsv828643CNV Loss20364138
    nsv912503CNV Loss21882294
    dgv4025n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for ZNF580:    About MalaCards
    acute monocytic leukemia    monocytic leukemia    endotheliitis    leukemia
    gastric cancer


    ZNF580 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF580

    Export disorders for ZNF580 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF580 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF580)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. ROS-induced ZNF580 expression: a key role for H2O2/NF- kB signaling pathway in vascular endothelial inflammation. (PubMed id 21830064)1 DangLi R....WenCheng Z. (2012)
    4. ZNF580, a novel C2H2 zinc-finger transcription factor , interacts with the TGF-I^ signal molecule Smad2. (PubMed id 21599657)1 Luo Y....Zhang W. (2011)
    5. Suppression of zinc finger protein 580 by high oxLDL/ LDL-ratios is followed by enhanced expression of endothelial IL-8. (PubMed id 21310414)1 Hoffmann C.J....Zakrzewicz A. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Sphingosine-1-phosphate induces human endothelial VEG F and MMP-2 production via transcription factor ZNF580: novel insights into ang iogenesis. (PubMed id 20382120)1 Sun H.Y....Zhang W.C. (2010)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51157 HGNC: 29473 AceView: HSU79303andZNF580andZNF581 Ensembl:ENSG00000213015 euGenes: HUgn51157
    ECgene: ZNF580 H-InvDB: ZNF580

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF580 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF580 gene:
    Search GeneIP for patents involving ZNF580

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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