ZNF580 Gene
protein-coding GIFtS: 40
GCID: GC19P056152
|
|
zinc finger protein 580
| |
Aliases
for ZNF580 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5801 2 | | LDL-Induced EC Protein2 3 | | LDL Induced EC Protein2 |
Export aliases for ZNF580 gene to outside databasesPrevious GC identifers: GC19P060845 GC19P060848 GC19P052462 |
Summaries
for ZNF580 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF580 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF580 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-1 E2F-2 PPAR-gamma2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF580
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF580 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC chromosome: 19ZNF580 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P056152: view genomic region
(about GC identifiers)
Start:
|
56,146,382 bp from pter |
End:
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56,154,836 bp from pter |
Size:
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8,455 bases |
Orientation:
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plus strand |
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Proteins
for ZNF580 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33 (See
protein sequence)Recommended Name: Zinc finger protein 580 Size: 172 amino acids; 18756 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAB94389.1; Type=Erroneous initiation;
Secondary accessions: B2RC05 Q9NPP7Explore the universe of human proteins at neXtProt for ZNF580: NX_Q9UK33
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UK33
ZNF580 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001156895.1 NP_057286.1 NP_996998.1
ENSEMBL proteins: ENSP00000468407 ENSP00000320050 ENSP00000465028 ENSP00000467142 ENSP00000443957 ENSP00000446126
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF580 for ontologies About GeneDecksing
ZNF580 Antibody Products:
Assay Products for ZNF580: |
Protein
Domains /
Families
for ZNF580 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF580 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UK33ProtoNet protein and cluster: Q9UK33 UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33Similarity: Contains 3 C2H2-type zinc fingers |
Function
for ZNF580 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF580 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF580 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF580 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF580 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF580 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF580 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF580
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for ZNF580 (Q9UK332, 3 ENSP000003200504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF580 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF580 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF580
Search CenterWatch for drugs/clinical trials and news about ZNF580 / ZN580
|
Transcripts
for ZNF580 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF580 gene (3 alternative transcripts): NM_001163423.1 NM_016202.2 NM_207115.1 Unigene Cluster for ZNF580: Zinc finger protein 580 Hs.631551 [show with all ESTs]Unigene Representative Sequence: AK1232946 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592881 ENST00000325333(uc002qlo.3) ENST00000590190 ENST00000592461
ENST00000543039(uc002qlp.3) ENST00000545125(uc010ygd.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF580 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF580 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF580 (NM_207115) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF580 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF580 |
Additional cDNA sequence: AF184939.1 AK123294.1 AK314888.1 AL359054.1 BC017698.1 4 DOTS entries: DT.211450 DT.97781312 DT.92015887 DT.95371629 24/374 AceView cDNA sequences (see all 374): CF127611 BM712801 BC001219 CR605840 CR619004 CR608767 CR604697 BC010097 CR601401 AI540673 CB129949 CR609477 BQ477323 BF058512 BM925190 BM998114 BU957315 BM931984 AI074023 CR612899 BM710177 BM712297 BM811442 AJ713243
GeneLoc Exon Structure
|
Expression
for ZNF580 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF580 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTCTCTAA
About this image
See ZNF580 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF580
SOURCE GeneReport for Unigene cluster: Hs.631551
SABiosciences Custom PCR Arrays for ZNF580
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF580
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF580 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF580 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF580 |
Orthologs
for ZNF580 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF580 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
9(a) |
1 → many |
GL343279.1(637229-650798) |
zebrafish
(Danio rerio) |
Actinopterygii |
BX323458.16 |
-- |
6(a) |
1 → many |
16(15308342-15311002) |
ENSEMBL Gene Tree for ZNF580 (if available)
TreeFam Gene Tree for ZNF580 (if available) |
Paralogs
for ZNF580 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF580 gene
- ZNF7682 ZNF5812 ZNF7872 ZNF3582 ZNF5242 ZNF5752 ZNF702
18/31 SIMAP similar genes for ZNF580 using alignment to 4 protein entries: ZN580_HUMAN (see all proteins)
(see all similar genes):ZNF883 ZNF71 ZNF460 ZNF99 ZNF384 ZNF681
ZNF729 ZNF84 ZNF251 ZNF75A ZNF581 ZNF250
ZNF648 DKFZp686G16228 ZNF320 ZNF572 ZNF677 ZNF461
ZNF580 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF580
PGOHUM00000235698
|
Genomic Variants
for ZNF580 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF580 (56146382 - 56154836 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF580: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF580 |
|
Disorders
/ Diseases
for ZNF580 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF580 for disorders About GeneDecksing
3  diseases for ZNF580: About MalaCardsmonocytic leukemia acute monocytic leukemia leukemia
Export disorders for ZNF580 gene to outside databases
|
Publications
for ZNF580 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF580 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with ZNF580) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- ROS-induced ZNF580 expression: a key role for H2O2/NF- kB signaling pathway in vascular endothelial inflammation. (PubMed id 21830064)1 DangLi R....WenCheng Z. (2012)
- ZNF580, a novel C2H2 zinc-finger transcription factor , interacts with the TGF-I^ signal molecule Smad2. (PubMed id 21599657)1 Luo Y....Zhang W. (2011)
- Suppression of zinc finger protein 580 by high oxLDL/ LDL-ratios is followed by enhanced expression of endothelial IL-8. (PubMed id 21310414)1 Hoffmann C.J....Zakrzewicz A. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Sphingosine-1-phosphate induces human endothelial VEG F and MMP-2 production via transcription factor ZNF580: novel insights into ang iogenesis. (PubMed id 20382120)1 Sun H.Y....Zhang W.C. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for ZNF580 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF580 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF580 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF580 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF580 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF580 gene:
Search GeneIP for patents involving ZNF580
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF580 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF580 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF580 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF580 | | | OriGene Protein Over-expression Lysate for ZNF580 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF580 | | OriGene 3'-UTR Clone for ZNF580 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF580 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF580 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZNF580 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF580 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF580 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF580 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF580 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF580 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF580 |
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 | | | ZNF580 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZNF580 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF580 |
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