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Aliases for ZNF580 Gene

Aliases for ZNF580 Gene

  • Zinc Finger Protein 580 2 3
  • LDL-Induced EC Protein 4

External Ids for ZNF580 Gene

Summaries for ZNF580 Gene

GeneCards Summary for ZNF580 Gene

ZNF580 (Zinc Finger Protein 580) is a Protein Coding gene. An important paralog of this gene is ZNF524.

UniProtKB/Swiss-Prot for ZNF580 Gene

  • Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF580 Gene

Genomics for ZNF580 Gene

Genomic Location for ZNF580 Gene

Start:
55,634,995 bp from pter
End:
55,643,470 bp from pter
Size:
8,476 bases
Orientation:
Plus strand

Genomic View for ZNF580 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF580 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF580 Gene

Regulatory Elements for ZNF580 Gene

Proteins for ZNF580 Gene

  • Protein details for ZNF580 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK33-ZN580_HUMAN
    Recommended name:
    Zinc finger protein 580
    Protein Accession:
    Q9UK33
    Secondary Accessions:
    • B2RC05
    • Q9NPP7

    Protein attributes for ZNF580 Gene

    Size:
    172 amino acids
    Molecular mass:
    18756 Da
    Quaternary structure:
    • Interacts with SMAD2.
    SequenceCaution:
    • Sequence=CAB94389.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF580 Gene

Proteomics data for ZNF580 Gene at MOPED

Post-translational modifications for ZNF580 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF580 Gene

No data available for DME Specific Peptides for ZNF580 Gene

Domains for ZNF580 Gene

Gene Families for ZNF580 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF580 Gene

UniProtKB/Swiss-Prot:

ZN580_HUMAN
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q9UK33
genes like me logo Genes that share domains with ZNF580: view

Function for ZNF580 Gene

Molecular function for ZNF580 Gene

UniProtKB/Swiss-Prot Function: Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction: Up-regulated in presence of reactive oxygen species (ROS), like H(2)O(2), through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level).

Gene Ontology (GO) - Molecular Function for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21599657
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF580: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF580 Gene

Localization for ZNF580 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF580 Gene

Nucleus. Note=Colocalized with SMAD2 in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF580 Gene COMPARTMENTS Subcellular localization image for ZNF580 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20382120
genes like me logo Genes that share ontologies with ZNF580: view

Pathways for ZNF580 Gene

SuperPathways for ZNF580 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 20382120
GO:0002690 positive regulation of leukocyte chemotaxis IDA 21830064
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with ZNF580: view

No data available for Pathways by source for ZNF580 Gene

Transcripts for ZNF580 Gene

Unigene Clusters for ZNF580 Gene

Zinc finger protein 580:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF580 Gene

No ASD Table

Relevant External Links for ZNF580 Gene

GeneLoc Exon Structure for
ZNF580
ECgene alternative splicing isoforms for
ZNF580

Expression for ZNF580 Gene

mRNA expression in normal human tissues for ZNF580 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF580 Gene

SOURCE GeneReport for Unigene cluster for ZNF580 Gene Hs.631551

mRNA Expression by UniProt/SwissProt for ZNF580 Gene

Q9UK33-ZN580_HUMAN
Tissue specificity: Expressed in endothelial cells.
genes like me logo Genes that share expressions with ZNF580: view

Orthologs for ZNF580 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF580 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF580 36
  • 100 (n)
  • 100 (a)
ZNF580 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF580 36
  • 91.67 (n)
  • 94.37 (a)
ZNF580 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF580 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp580 36
  • 90.81 (n)
  • 96.79 (a)
Zfp580 16
Zfp580 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF580 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 10 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp580 36
  • 90.81 (n)
  • 96.79 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 13 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF581 37
  • 10 (a)
OneToMany
Species with no ortholog for ZNF580:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF580 Gene

ENSEMBL:
Gene Tree for ZNF580 (if available)
TreeFam:
Gene Tree for ZNF580 (if available)

Paralogs for ZNF580 Gene

Paralogs for ZNF580 Gene

Pseudogenes.org Pseudogenes for ZNF580 Gene

genes like me logo Genes that share paralogs with ZNF580: view

Variants for ZNF580 Gene

Sequence variations from dbSNP and Humsavar for ZNF580 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs575274 -- 55,634,062(-) TCCCA(A/G)ATCAA upstream-variant-2KB
rs579496 -- 55,633,621(-) tgtct(C/T)aaata upstream-variant-2KB
rs596075 -- 55,633,854(-) cgggc(A/G)gatca upstream-variant-2KB
rs8108198 -- 55,635,103(+) CTTAA(A/G)AGTCC utr-variant-5-prime, upstream-variant-2KB
rs8111497 -- 55,635,558(+) TGCCA(C/G)CCTCG utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF580 Gene

Variant ID Type Subtype PubMed ID
dgv4025n71 CNV Loss 21882294
nsv828643 CNV Loss 20364138
nsv912500 CNV Loss 21882294
nsv912501 CNV Loss 21882294
nsv2553 CNV Insertion 18451855
nsv912503 CNV Loss 21882294
nsv912504 CNV Loss 21882294

Relevant External Links for ZNF580 Gene

HapMap Linkage Disequilibrium report
ZNF580

Disorders for ZNF580 Gene

Relevant External Links for ZNF580

Genetic Association Database (GAD)
ZNF580
genes like me logo Genes that share disorders with ZNF580: view

No data available for UniProtKB/Swiss-Prot for ZNF580 Gene

Publications for ZNF580 Gene

  1. ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-I^ signal molecule Smad2. (PMID: 21599657) Luo Y. … Zhang W. (Cell Biol. Int. 2011) 2 3 4
  2. ROS-induced ZNF580 expression: a key role for H2O2/NF-I_B signaling pathway in vascular endothelial inflammation. (PMID: 21830064) DangLi R. … WenCheng Z. (Mol. Cell. Biochem. 2012) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. (PMID: 20382120) Sun H.Y. … Zhang W.C. (Biochem. Biophys. Res. Commun. 2010) 3 4
  5. Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8. (PMID: 21310414) Hoffmann C.J. … Zakrzewicz A. (Atherosclerosis 2011) 3

Products for ZNF580 Gene

Sources for ZNF580 Gene

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