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ZNF580 Gene

protein-coding   GIFtS: 43
GCID: GC19P056152

Zinc Finger Protein 580

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5801 2
LDL-Induced EC Protein2 3
LDL Induced EC Protein2

External Ids:    HGNC: 294731   Entrez Gene: 511572   Ensembl: ENSG000002130157   UniProtKB: Q9UK333   

Export aliases for ZNF580 gene to outside databases

Previous GC identifers: GC19P060845 GC19P060848 GC19P052462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF580 Gene:
ZNF580 (zinc finger protein 580) is a protein-coding gene. Diseases associated with ZNF580 include monocytic leukemia, and acute monocytic leukemia. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33
Function: Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced
leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved
in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF580 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F-2   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF580 promoter sequence
   Search Chromatin IP Primers for ZNF580

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF580


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

ZNF580 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF580 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056152:  view genomic region     (about GC identifiers)

Start:
56,146,382 bp from pter      End:
56,154,836 bp from pter
Size:
8,455 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33 (See protein sequence)
Recommended Name: Zinc finger protein 580  
Size: 172 amino acids; 18756 Da
Subunit: Interacts with SMAD2
Sequence caution: Sequence=CAB94389.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RC05 Q9NPP7

Explore the universe of human proteins at neXtProt for ZNF580: NX_Q9UK33

Explore proteomics data for ZNF580 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF580 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001156895.1  NP_057286.1  NP_996998.1  

    ENSEMBL proteins: 
     ENSP00000468407   ENSP00000320050   ENSP00000465028   ENSP00000467142   ENSP00000443957  
     ENSP00000446126  

    ZNF580 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ZNF580


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UK33

    ProtoNet protein and cluster: Q9UK33

    UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33
    Similarity: Contains 3 C2H2-type zinc fingers


    ZNF580 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN580_HUMAN, Q9UK33
    Function: Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced
    leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved
    in transcriptional regulation
    Induction: Up-regulated in presence of reactive oxygen species (ROS), like H(2)O(2), through the NF-kappaB
    signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at
    protein level)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    ZNF580 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF580
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    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF580 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF580 (see all 11):
    hsa-miR-3618 hsa-miR-206 hsa-miR-3184 hsa-miR-922 hsa-miR-499-3p hsa-miR-1 hsa-miR-423-5p hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidZNF580 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF580


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN580_HUMAN, Q9UK33: Nucleus. Note=Colocalized with SMAD2 in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    ZNF580 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF580
    Interactions:

        Search GeneGlobe Interaction Network for ZNF580

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ZNF580 (Q9UK332, 3 ENSP000003200504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF6Q150522, 3, ENSP000002506174MINT-8249091 I2D: score=2 STRING: ENSP00000250617
    SH3GL2Q999622, 3MINT-8270638 I2D: score=2 
    TSC22D4Q9Y3Q82, 3, ENSP000003001814MINT-66806 I2D: score=5 STRING: ENSP00000300181
    RAD54BQ9Y6202, 3, ENSP000003366064MINT-66895 I2D: score=5 STRING: ENSP00000336606
    PAX9P557713, ENSP000003552454I2D: score=1 STRING: ENSP00000355245
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA--
    GO:0002690positive regulation of leukocyte chemotaxis IDA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006935chemotaxis IEA--

    ZNF580 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF580 (ZN580)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF580 gene (3 alternative transcripts): 
    NM_001163423.1  NM_016202.2  NM_207115.1  

    Unigene Cluster for ZNF580:

    Zinc finger protein 580
    Hs.631551  [show with all ESTs]
    Unigene Representative Sequence: AK123294
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592881 ENST00000325333(uc002qlo.3) ENST00000590190 ENST00000592461
    ENST00000543039(uc002qlp.3) ENST00000545125(uc010ygd.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF580 (see all 11):
    hsa-miR-3618 hsa-miR-206 hsa-miR-3184 hsa-miR-922 hsa-miR-499-3p hsa-miR-1 hsa-miR-423-5p hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidZNF580 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): ZNF580 (NM_207115)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF580
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF580
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF580
      QuantiFast Probe-based Assays in human, mouse, rat ZNF580

    Additional mRNA sequence: 

    AF184939.1 AK123294.1 AK314888.1 AL359054.1 BC017698.1 

    4 DOTS entries:

    DT.211450  DT.97781312  DT.92015887  DT.95371629 

    Selected AceView cDNA sequences (see all 374):

    BC001219 CR604697 CB113771 BM712801 CR619004 AI679948 BQ673971 AK026203 
    CF127611 AI540673 NM_016535 BI907663 AI679440 CR611450 BU947898 BU527605 
    AI282328 CR593563 BC071620 AK123294 BU902332 CD653037 CR610458 BQ774311 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF580 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCTCTAA
    ZNF580 Expression
    About this image

    ZNF580 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF580 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631551

    UniProtKB/Swiss-Prot: ZN580_HUMAN, Q9UK33
    Tissue specificity: Expressed in endothelial cells

        Custom PCR Arrays for ZNF580
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF580 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5801 , 5 zinc finger protein 5801, 5 90.81(n)1
    96.79(a)1
      7 (2.92 cM)5
    689921  NM_026900.11  NP_081176.11 
     50515325 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    13(a)
    1 → many
    GL343279.1(660127-671951)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF5816
    zinc finger protein 581
    10(a)
    1 → many
    21(2735709-2742444) ENSDARG00000093967


    ENSEMBL Gene Tree for ZNF580 (if available)
    TreeFam Gene Tree for ZNF580 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF580 gene
    ZNF5812  ZNF3622  ZNF5242  ZNF3842  
    Selected SIMAP similar genes for ZNF580 using alignment to 4 protein entries:     ZN580_HUMAN (see all proteins) (see all similar genes):
    ZNF883    ZNF71    ZNF460    ZNF384    ZNF681    ZNF729
    ZNF84    ZNF99    ZNF251    ZNF75A    ZNF581    ZNF250
    ZNF648    DKFZp686G16228    ZNF320    ZNF572    ZNF677    ZNF461

    ZNF580 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF580
    PGOHUM00000235698


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF580 (see all 38)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468226931,2
    C--56150433(+) TATATC/TAGGGA 1 -- us2k10--------
    rs6122111,2
    C,F,H--56150471(-) TACTTG/AGACAA 1 -- us2k124Minor allele frequency- A:0.07NS EA NA WA CSA 2330
    rs1996254381,2
    --56150481(+) AGACC-/AGGGGT 1 -- us2k10--------
    rs1823075491,2
    --56150485(+) CAGGGA/GTTCTC 1 -- us2k10--------
    rs1869209971,2
    --56150562(+) CTTGGA/GGTTGG 1 -- us2k10--------
    rs1444793701,2
    C--56150565(+) GGGTT-/GGGGGG 1 -- us2k10--------
    rs1405791931,2
    --56150758(+) GCAGTC/GAGCCA 1 -- us2k10--------
    rs1434129191,2
    --56150792(+) GTGGGC/TGACAG 1 -- us2k10--------
    rs1467194691,2
    C--56151058(+) GCACAC/GTGCAA 1 -- us2k10--------
    rs1404178591,2
    --56151143(+) ACGGCC/TGGCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF580 (56146382 - 56154836 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF580:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2553CNV Insertion18451855
    nsv912504CNV Loss21882294
    nsv912501CNV Loss21882294
    nsv912500CNV Loss21882294
    nsv828643CNV Loss20364138
    nsv912503CNV Loss21882294
    dgv4025n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for ZNF580:    About MalaCards
    monocytic leukemia    acute monocytic leukemia    endotheliitis    leukemia


    ZNF580 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF580

    Export disorders for ZNF580 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF580 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF580)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ROS-induced ZNF580 expression: a key role for H2O2/NF-I_B signaling pathway in vascular endothelial inflammation. (PubMed id 21830064)1, 2 DangLi R....WenCheng Z. (Mol. Cell. Biochem. 2012)
    2. ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-I^ signal molecule Smad2. (PubMed id 21599657)1, 2 Luo Y....Zhang W. (Cell Biol. Int. 2011)
    3. Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. (PubMed id 20382120)1, 2 Sun H.Y....Zhang W.C. (Biochem. Biophys. Res. Commun. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8. (PubMed id 21310414)1 Hoffmann C.J....Zakrzewicz A. (Atherosclerosis 2011)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51157 HGNC: 29473 AceView: HSU79303andZNF580andZNF581 Ensembl:ENSG00000213015 euGenes: HUgn51157
    ECgene: ZNF580 H-InvDB: ZNF580

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF580 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF580 gene:
    Search GeneIP for patents involving ZNF580

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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