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Aliases for ZNF580 Gene

Aliases for ZNF580 Gene

  • Zinc Finger Protein 580 2 3 5
  • LDL-Induced EC Protein 4

External Ids for ZNF580 Gene

Previous GeneCards Identifiers for ZNF580 Gene

  • GC19P060845
  • GC19P060848
  • GC19P056152
  • GC19P052462

Summaries for ZNF580 Gene

GeneCards Summary for ZNF580 Gene

ZNF580 (Zinc Finger Protein 580) is a Protein Coding gene. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot for ZNF580 Gene

  • Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF580 Gene

Genomics for ZNF580 Gene

Regulatory Elements for ZNF580 Gene

Enhancers for ZNF580 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055519 1.6 FANTOM5 Ensembl ENCODE 43.7 -114.7 -114694 1.0 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 FOS ZNF548 SP3 FIZ1 ZNF471 NAT14 ZNF580 ZNF667 ZNF582-AS1 ZNF667-AS1 ZNF542P U2AF2 ZNF583
GH19G055639 1.4 Ensembl ENCODE 47.4 +7.5 7459 6.5 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 ZNF580 U2AF2 KMT5C FIZ1 ZNF471 CCDC106 PIR41897
GH19G055215 1.5 ENCODE dbSUPER 30.5 -418.2 -418199 2.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 LENG8-AS1 U2AF2 ENSG00000235681 ENSG00000267523 ZNF580 NAT14 ZNF581 FIZ1 ENSG00000267096 ENSG00000267265
GH19G055652 1.4 ENCODE dbSUPER 27.8 +22.1 22103 8.0 CREB3L1 MLX AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF580 U2AF2 NAT14 ENSG00000269696 ZNF582-AS1 FIZ1 ZNF667 ZNF470 ZNF667-AS1 ZFP28
GH19G055503 1.3 Ensembl ENCODE 24 -130.9 -130935 1.6 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF416 FIZ1 ZNF667 ZNF667-AS1 ZNF582-AS1 NAT14 ZNF542P ZNF583 U2AF2 LOC729999 ZNF580
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF580 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF580 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF580 Gene

55,634,903 bp from pter
55,643,470 bp from pter
8,568 bases
Plus strand

Genomic View for ZNF580 Gene

Genes around ZNF580 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF580 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF580 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF580 Gene

Proteins for ZNF580 Gene

  • Protein details for ZNF580 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 580
    Protein Accession:
    Secondary Accessions:
    • B2RC05
    • Q9NPP7

    Protein attributes for ZNF580 Gene

    172 amino acids
    Molecular mass:
    18756 Da
    Quaternary structure:
    • Interacts with SMAD2.
    • Sequence=CAB94389.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF580 Gene

Post-translational modifications for ZNF580 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF580 Gene

No data available for DME Specific Peptides for ZNF580 Gene

Domains & Families for ZNF580 Gene

Gene Families for ZNF580 Gene

Protein Domains for ZNF580 Gene

Suggested Antigen Peptide Sequences for ZNF580 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF580: view

No data available for UniProtKB/Swiss-Prot for ZNF580 Gene

Function for ZNF580 Gene

Molecular function for ZNF580 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in presence of reactive oxygen species (ROS), like H(2)O(2), through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level).

Gene Ontology (GO) - Molecular Function for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21599657
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF580: view
genes like me logo Genes that share phenotypes with ZNF580: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF580 Gene

Localization for ZNF580 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF580 Gene

Nucleus. Note=Colocalized with SMAD2 in the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF580 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20382120
genes like me logo Genes that share ontologies with ZNF580: view

Pathways & Interactions for ZNF580 Gene

SuperPathways for ZNF580 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 20382120
GO:0002690 positive regulation of leukocyte chemotaxis IDA 21830064
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with ZNF580: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF580 Gene

Drugs & Compounds for ZNF580 Gene

No Compound Related Data Available

Transcripts for ZNF580 Gene

Unigene Clusters for ZNF580 Gene

Zinc finger protein 580:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF580 Gene

No ASD Table

Relevant External Links for ZNF580 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF580 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF580 Gene

Protein differential expression in normal tissues from HIPED for ZNF580 Gene

This gene is overexpressed in Fetal ovary (33.9), Fetal Brain (25.0), and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF580 Gene

Protein tissue co-expression partners for ZNF580 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF580 Gene:


SOURCE GeneReport for Unigene cluster for ZNF580 Gene:


mRNA Expression by UniProt/SwissProt for ZNF580 Gene:

Tissue specificity: Expressed in endothelial cells.

Evidence on tissue expression from TISSUES for ZNF580 Gene

  • Heart(4.4)
genes like me logo Genes that share expression patterns with ZNF580: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF580 Gene

Orthologs for ZNF580 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF580 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF580 34 35
  • 100 (n)
(Canis familiaris)
Mammalia ZNF580 35
  • 98 (a)
(Bos Taurus)
Mammalia ZNF580 34 35
  • 91.67 (n)
(Mus musculus)
Mammalia Zfp580 34 16 35
  • 90.81 (n)
(Rattus norvegicus)
Mammalia Zfp580 34
  • 90.81 (n)
(Monodelphis domestica)
Mammalia ZNF580 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 10 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 13 (a)
(Danio rerio)
Actinopterygii ZNF581 35
  • 10 (a)
Species where no ortholog for ZNF580 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF580 Gene

Gene Tree for ZNF580 (if available)
Gene Tree for ZNF580 (if available)

Paralogs for ZNF580 Gene

Paralogs for ZNF580 Gene Pseudogenes for ZNF580 Gene

genes like me logo Genes that share paralogs with ZNF580: view

Variants for ZNF580 Gene

Sequence variations from dbSNP and Humsavar for ZNF580 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000112651 -- 55,641,738(+) AGCCA(A/G)GTTGG intron-variant, upstream-variant-2KB
rs1000683479 -- 55,639,217(+) TACTG(C/T)CATCT intron-variant, upstream-variant-2KB
rs1001512786 -- 55,642,941(+) GCGCC(A/C)GCGCC intron-variant, upstream-variant-2KB, reference, missense
rs1001617916 -- 55,642,641(+) CGGGG(-/C)CCCGA intron-variant, upstream-variant-2KB, reference, frameshift-variant
rs1001687946 -- 55,639,906(+) GCCAC(C/T)GTGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF580 Gene

Variant ID Type Subtype PubMed ID
nsv2553 CNV insertion 18451855
nsv828643 CNV loss 20364138
nsv953625 CNV deletion 24416366

Variation tolerance for ZNF580 Gene

Gene Damage Index Score: 2.73; 46.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF580 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF580 Gene

Disorders for ZNF580 Gene

Relevant External Links for ZNF580

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF580 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF580 Gene

Publications for ZNF580 Gene

  1. ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-I^ signal molecule Smad2. (PMID: 21599657) Luo Y. … Zhang W. (Cell Biol. Int. 2011) 2 3 4 64
  2. ROS-induced ZNF580 expression: a key role for H2O2/NF-I_B signaling pathway in vascular endothelial inflammation. (PMID: 21830064) DangLi R. … WenCheng Z. (Mol. Cell. Biochem. 2012) 3 4 64
  3. Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. (PMID: 20382120) Sun H.Y. … Zhang W.C. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-I^1/ALK5/Smad2 pathway. (PMID: 24771066) Luo Y. … Zhang W. (Mol. Cell. Biochem. 2014) 3 64

Products for ZNF580 Gene

Sources for ZNF580 Gene

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