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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF578 Gene

protein-coding GIFtS: 35
GCID: GC19P052959

zinc finger protein 578

Search for ZNF578
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 578¹ ²
FLJ31384¹

External Ids:	HGNC: 26449¹	Entrez Gene: 147660²	Ensembl: ENSG00000258405⁷	UniProtKB: Q96N58³

Export aliases for ZNF578 gene to outside databases

Previous GC identifers: GC19P057124 GC19P057709 GC19P057580 GC19P057649 GC19P049287

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF578 gene promoter:
Ik-1 GATA-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZNF578

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF578

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC chromosome: 19

ZNF578 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF578 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P052959: view genomic region (about GC identifiers)

Start:	52,956,829 bp from pter	End:	53,020,131 bp from pter
Size:	63,303 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58 (See protein sequence)

Recommended Name: Zinc finger protein 578

Size: 590 amino acids; 68531 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAB71051.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B4DR51 I3L1Y6

Explore the universe of human proteins at neXtProt for ZNF578: NX_Q96N58

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96N58

ZNF578 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001093164.1

ENSEMBL proteins:

ENSP00000459216

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF578 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF578 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR000742 EG-like_dom

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96N58

ProtoNet protein and cluster: Q96N58

2 Blocks protein families:

IPB006210 Type I EGF

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF578 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF578

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF578 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about ZNF578 / ZN578

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF578 gene (2 alternative transcripts):

NM_152472.1 NM_001099694.1

Unigene Cluster for ZNF578:

Zinc finger protein 578

Hs.157287 [show with all ESTs]

Unigene Representative Sequence: NM_001099694

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000421239(uc002pzm.2 uc002pzn.2 uc002pzp.4 uc002pzo.1 uc010epp.1)

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Additional cDNA sequence:

AB091373.1 AB091374.1 AB091375.1 AB091376.1 AK299106.1 AL833487.1 BC103904.2 BC115704.1

8 DOTS entries:

DT.99938267 DT.100797476 DT.75180139 DT.121450725 DT.409705 DT.91650270 DT.101964636 DT.102825318

24/70 AceView cDNA sequences (see all 70):

CD244192 BQ958705 BQ690668 BQ008299 AI003260 BC067346 AI953831 BP871716

BC054884 AI244141 BU754034 CO249550 CO245168 BV198598 CO249449 CF595699

AK001753 CR749856 AK055946 BG324525 BC080612 CO249357 AK095562 BV193457

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF578 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAGGAGGG

About this image

ZNF578 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for ZNF578

SOURCE GeneReport for Unigene cluster: Hs.157287

SABiosciences Custom PCR Arrays for ZNF578

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF578 (if available)
TreeFam Gene Tree for ZNF578 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF578 gene

ZNF534² ZNF321P² ZNF468² ZNF880² ZNF766² ZNF320² ZNF525² ZNF860²

ZNF415² ZNF600² ZNF28² ZNF528² ZNF611² ZNF677² ZNF83² ZNF816²

ZNF610² ZNF701² ZNF765² ZNF480² ZNF813²

18/535 SIMAP similar genes for ZNF578 using alignment to 3 protein entries: ZN578_HUMAN (see all proteins) (see all similar genes):

kr-znf3 ZNF702P ZNF78L1 ZNF765 ZNF813 ZNF845

DKFZp686M04222 ZNF429 ZNF468 HZF36 ZNF816 ZNF808

ZFS-6 ZNF611 DKFZp666C237 ZNF232 ZNF626 ZNF600

ZNF578 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141220289^1,2		--	53005100(+)	`ACTCAC/TGTTAC`	2	T M	mis¹		0	--	--	--	--
rs202138665^1,2	C	--	53007935(+)	`TGGCTA/GTAGAA`	2	I V	mis¹		1		EU	593
rs180768207^1,2		--	53007964(+)	`AAATTC/GCTGAA`	2	F L	mis¹		0	--	--	--	--
rs201289789^1,2	F	--	53007974(+)	`ACCCTG/TCGCAG`	2	A S	mis¹		1		EU	593
rs199824288^1,2	C	--	53008008(+)	`GTTGGA/GGAACT`	2	E G	mis¹		1		EU	593
rs111538922^1,2	C,	--	53013899(+)	`CAGGGA/GTGTTG`	2	M V	mis¹		2		WA	120
rs147551656^1,2		--	53014000(+)	`GAAAGA/TAATGG`	2	R S	mis¹		0	--	--	--	--
rs73584860^1,2	C,	--	53014019(+)	`CATCCG/ATGCCA`	2	/M /V	mis¹		1		WA	2
rs193283387^1,2	C,	--	53014055(+)	`CAGACC/TGACAT`	2	R *	stg¹		1		EU	593
rs185647415^1,2		--	53014101(+)	`TCAGCC/TTGGAT`	2	P L	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF578 (52956829 - 53020131 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF578: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF578 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF578)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 147660	HGNC: 26449	AceView: FLJ10891andZNF578andLOC388558	Ensembl:ENSG00000258405	euGenes: HUgn147660
ECgene: ZNF578	H-InvDB: ZNF578

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF578	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF578 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF578 gene:
Search GeneIP for patents involving ZNF578

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	Browse SwitchGear 3'UTR luciferase reporter plasmids for ZNF578
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Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF578

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ZNF578 Gene

zinc finger protein 578

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ZNF578 Gene

zinc finger protein 578

Aliasesfor ZNF578 gene

Summariesfor ZNF578 gene

Genomic Viewsfor ZNF578 gene

Proteinsfor ZNF578 gene

Protein Domains /Familiesfor ZNF578 gene

Functionfor ZNF578 gene

Pathways & Interactionsfor ZNF578 gene

Drugs & Compoundsfor ZNF578 gene

Transcriptsfor ZNF578 gene

Expression for ZNF578 gene

Orthologsfor ZNF578 gene

Paralogsfor ZNF578 gene

Genomic Variantsfor ZNF578 gene

Disorders / Diseasesfor ZNF578 gene

Publicationsfor ZNF578 gene

External Searches for ZNF578 gene

Genome Databases showing ZNF578 gene

Other Databases showing ZNF578 gene

Specialized Databases showing ZNF578 gene

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Productsfor ZNF578 gene

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Aliases
for ZNF578 gene

Summaries
for ZNF578 gene

Genomic Views
for ZNF578 gene

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for ZNF578 gene

Protein Domains /
Families
for ZNF578 gene

Function
for ZNF578 gene

Pathways & Interactions
for ZNF578 gene

Drugs & Compounds
for ZNF578 gene

Transcripts
for ZNF578 gene

Expression
for ZNF578 gene

Orthologs
for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

Disorders / Diseases
for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene