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Aliases for ZNF578 Gene

Aliases for ZNF578 Gene

  • Zinc Finger Protein 578 2 3 5

External Ids for ZNF578 Gene

Previous GeneCards Identifiers for ZNF578 Gene

  • GC19P057124
  • GC19P057709
  • GC19P057580
  • GC19P057649
  • GC19P052959
  • GC19P049287

Summaries for ZNF578 Gene

GeneCards Summary for ZNF578 Gene

ZNF578 (Zinc Finger Protein 578) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF813.

UniProtKB/Swiss-Prot for ZNF578 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF578 Gene

Genomics for ZNF578 Gene

Regulatory Elements for ZNF578 Gene

Enhancers for ZNF578 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051687 1.8 FANTOM5 ENCODE dbSUPER 11.6 -763.0 -763016 6.9 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ZNF808 ZNF836 ZNF616 ZNF841 ZNF137P ENSG00000268970 ZNF766 ENSG00000269825 ZNF528 ZNF175
GH19G052733 1.4 FANTOM5 ENCODE 11.8 +281.8 281764 2.8 HDGF ARID4B SIN3A ZNF48 ELK1 SP3 SP5 REST ZNF518A ZNF592 ZNF611 ZNF137P ENSG00000268970 ZNF701 TPM3P9 ZNF525 ZNF665 TPM3P6 ZNF28 ZNF845
GH19G052137 1.4 FANTOM5 ENCODE 11.6 -313.9 -313875 3.3 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF808 ZNF137P ENSG00000268970 ZNF816 ZNF350 ZNF836 ZNF600 ZNF468 ZNF616 ZNF841
GH19G051985 1.1 ENCODE 11.8 -466.8 -466769 1.5 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF207 ZNF143 ZNF137P ENSG00000268970 ZNF701 ZNF611 ZNF28 ZNF578 ZNF816 ENSG00000269825 ZNF841 ZNF836
GH19G052026 1.1 ENCODE 11.8 -425.7 -425683 2.8 HDGF PKNOX1 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF137P ZNF841 ZNF432 ENSG00000268970 ZNF701 ZNF611 ZNF28 ZNF578 ZNF816 ENSG00000269825
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF578 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF578 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111296 294 1200 CTCF SP3 SIN3A ELF1 ZBTB40 ZNF518A NR2F2 GABPA ETS1 CBX1

Transcription factor binding sites by QIAGEN in the ZNF578 gene promoter:

Genomic Location for ZNF578 Gene

52,453,506 bp from pter
52,516,878 bp from pter
63,373 bases
Plus strand

Genomic View for ZNF578 Gene

Genes around ZNF578 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF578 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF578 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF578 Gene

Proteins for ZNF578 Gene

  • Protein details for ZNF578 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 578
    Protein Accession:
    Secondary Accessions:
    • B4DR51
    • I3L1Y6

    Protein attributes for ZNF578 Gene

    590 amino acids
    Molecular mass:
    68531 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF578 Gene

Post-translational modifications for ZNF578 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF578 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF578 Gene

Domains & Families for ZNF578 Gene

Gene Families for ZNF578 Gene

Protein Domains for ZNF578 Gene

Suggested Antigen Peptide Sequences for ZNF578 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF578: view

Function for ZNF578 Gene

Molecular function for ZNF578 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF578: view

Phenotypes for ZNF578 Gene

genes like me logo Genes that share phenotypes with ZNF578: view

Animal Model Products

CRISPR Products

miRNA for ZNF578 Gene

miRTarBase miRNAs that target ZNF578

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF578 Gene

Localization for ZNF578 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF578 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF578 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF578: view

Pathways & Interactions for ZNF578 Gene

SuperPathways for ZNF578 Gene

No Data Available

Interacting Proteins for ZNF578 Gene

Gene Ontology (GO) - Biological Process for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF578: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF578 Gene

Drugs & Compounds for ZNF578 Gene

No Compound Related Data Available

Transcripts for ZNF578 Gene

Unigene Clusters for ZNF578 Gene

Zinc finger protein 578:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF578 Gene

No ASD Table

Relevant External Links for ZNF578 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF578 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF578 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF578 Gene

This gene is overexpressed in Testis (x7.8).

Protein differential expression in normal tissues from HIPED for ZNF578 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF578 Gene

Protein tissue co-expression partners for ZNF578 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF578 Gene:


SOURCE GeneReport for Unigene cluster for ZNF578 Gene:

genes like me logo Genes that share expression patterns with ZNF578: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF578 Gene

Orthologs for ZNF578 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF578 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 73 (a)
(Canis familiaris)
Mammalia -- 35
  • 53 (a)
(Bos Taurus)
Mammalia -- 35
  • 42 (a)
Species where no ortholog for ZNF578 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF578 Gene

Gene Tree for ZNF578 (if available)
Gene Tree for ZNF578 (if available)

Paralogs for ZNF578 Gene

(523) SIMAP similar genes for ZNF578 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF578: view

Variants for ZNF578 Gene

Sequence variations from dbSNP and Humsavar for ZNF578 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000002374 -- 52,480,238(+) AAATA(G/T)TATGT intron-variant
rs1000005141 -- 52,508,748(+) TGATA(C/T)TGCAT intron-variant
rs1000063774 -- 52,466,795(+) TTAAC(A/G)CTTGA intron-variant
rs1000077397 -- 52,473,217(+) GTTTG(C/T)CATAC intron-variant
rs1000094713 -- 52,472,065(+) CTTAT(A/G/T)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF578 Gene

Variant ID Type Subtype PubMed ID
dgv3627n100 CNV gain 25217958
esv2718785 CNV deletion 23290073
esv2762048 CNV loss 21179565
esv3644693 CNV loss 21293372
esv3644696 CNV loss 21293372
esv3644697 CNV loss 21293372
esv3893233 CNV loss 25118596
nsv1058567 CNV gain 25217958
nsv1063648 CNV gain 25217958
nsv1114030 CNV deletion 24896259
nsv436854 CNV insertion 17901297
nsv509751 CNV insertion 20534489
nsv580026 CNV loss 21841781
nsv978841 CNV duplication 23825009

Variation tolerance for ZNF578 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF578 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF578 Gene

Disorders for ZNF578 Gene

Relevant External Links for ZNF578

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF578 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF578 Gene

Publications for ZNF578 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF578 Gene

Sources for ZNF578 Gene

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