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ZNF578 Gene

protein-coding GIFtS: 36
GCID: GC19P052959

Zinc Finger Protein 578

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Zinc Finger Protein 578¹ ²

External Ids:	HGNC: 26449¹	Entrez Gene: 147660²	Ensembl: ENSG00000258405⁷	UniProtKB: Q96N58³

Export aliases for ZNF578 gene to outside databases

Previous GC identifers: GC19P057124 GC19P057709 GC19P057580 GC19P057649 GC19P049287

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF578 Gene:

ZNF578 (zinc finger protein 578) is a protein-coding gene. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000019.9 NT_011109.17 NC_018930.2

Regulatory elements:

Regulatory transcription factor binding sites in the ZNF578 gene promoter:
Ik-1 GATA-1
Other transcription factors

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Search Chromatin IP Primers for ZNF578

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF578

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41

ZNF578 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF578 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P052959: view genomic region (about GC identifiers)

Start:	52,956,829 bp from pter	End:	53,020,131 bp from pter
Size:	63,303 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58 (See protein sequence)

Recommended Name: Zinc finger protein 578

Size: 590 amino acids; 68531 Da

Sequence caution: Sequence=BAB71051.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B4DR51 I3L1Y6

Explore the universe of human proteins at neXtProt for ZNF578: NX_Q96N58

Explore proteomics data for ZNF578 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See ZNF578 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001093164.1

ENSEMBL proteins:

ENSP00000459216 ENSP00000470790

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

5 InterPro protein domains:

IPR000742 EG-like_dom

IPR001909 Krueppel-associated_box

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96N58

ProtoNet protein and cluster: Q96N58

2 Blocks protein domains:

IPB006210 Type I EGF

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

Find genes that share domains with ZNF578 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN578_HUMAN, Q96N58

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0046872	metal ion binding	IEA	--

Find genes that share ontologies with ZNF578 About GenesLikeMe

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

ZN578_HUMAN, Q96N58: Nucleus (Probable)

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

Find genes that share ontologies with ZNF578 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

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Interactions:

Search GeneGlobe Interaction Network for ZNF578

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	IEA	--

Find genes that share ontologies with ZNF578 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for ZNF578 gene (6 alternative transcripts):

NM_001099694.1 NM_152472.1 XM_005258527.1 XM_006723019.1 XM_006723020.1 XM_006723021.1

Unigene Cluster for ZNF578:

Zinc finger protein 578

Hs.157287 [show with all ESTs]

Unigene Representative Sequence: NM_001099694

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000421239(uc002pzm.2 uc002pzn.2 uc002pzp.4 uc002pzo.1 uc010epp.1)

ENST00000594118 ENST00000596382 ENST00000602221 ENST00000596674 ENST00000601120

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Additional mRNA sequence:

AB091373.1 AB091374.1 AB091375.1 AB091376.1 AK299106.1 AL833487.1 BC103904.2 BC115704.1

8 DOTS entries:

DT.99938267 DT.100797476 DT.75180139 DT.121450725 DT.409705 DT.91650270 DT.101964636 DT.102825318

Selected AceView cDNA sequences (see all 70):

AI953831 AI003260 BQ690668 CD244192 BQ958705 BC067346 BP871716 BQ008299

NM_152472 CR749856 BV198598 AK001753 AK095562 CO245168 CO249449 BX955279

CO249550 BQ016962 BQ023016 BQ685199 NM_018260 CO249446 AL833487 CF595699

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF578 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGAGGAGGG

About this image

ZNF578 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZNF578 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.157287

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for ZNF578 gene from Selected species (see all 3) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
dog (Canis familiaris)	Mammalia	--	Uncharacterized protein	53(a)	many ↔ many	1(104870859-104886591)

ENSEMBL Gene Tree for ZNF578 (if available)
TreeFam Gene Tree for ZNF578 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for ZNF578 gene

ZNF534² ZNF321P² ZNF468² ZNF880² ZNF766² ZNF320² ZNF525² ZNF860²

ZNF415² ZNF600² ZNF28² ZNF528² ZNF611² ZNF677² ZNF83² ZNF816²

ZNF610² ZNF701² ZNF765² ZNF480² ZNF813²

Selected SIMAP similar genes for ZNF578 using alignment to 3 protein entries: ZN578_HUMAN (see all proteins) (see all similar genes):

ZNF611 kr-znf3 ZNF702P ZNF808 ZNF765 ZNF845

ZNF616 DKFZp686M04222 ZNF816 ZNF701 HZF36 ZNF761

ZNF525 ZNF813 ZNF860 DKFZp666C237 ZNF232 ZNF321P

Find genes that share paralogs with ZNF578 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10594903^1,2	C	--	49334669(+)	`TTTTT-/T/TT GAGAT`	1	--	int¹		1		NA	2
rs59465772^1,2	C	--	52954873(+)	`CACACC/AACCAC`	1	--	us2k¹		2		CSA WA	120
rs114018490^1,2	F	--	52954881(+)	`CACCTA/GTGGAG`	1	--	us2k¹		1		WA	118
rs114653548^1,2	F	--	52954927(+)	`TCCTTC/TTGGAT`	1	--	us2k¹		1		WA	118
rs324103^1,2	C,F,A,H	--	52954937(+)	`TGTTAC/TGGAGA`	1	--	us2k¹		26		NS EA NA WA CSA	2349
rs182700734^1,2		--	52954980(+)	`CTTTGC/TTGATG`	1	--	us2k¹		0	--	--	--	--
rs143169667^1,2		--	52955085(+)	`ATCGAA/GTTGCA`	1	--	us2k¹		0	--	--	--	--
rs146196700^1,2		--	52955090(+)	`ATTGCA/GCAGCT`	1	--	us2k¹		0	--	--	--	--
rs149737151^1,2	C	--	52955324(+)	`CTGCA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs188837968^1,2		--	52955365(+)	`AAAGCA/GTTTCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF578 (52956829 - 53020131 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for ZNF578: About this table

Variant ID	Type	Subtype	PubMed ID
esv2718785	CNV	Deletion	23290073
nsv509751	CNV	Insertion	20534489
nsv436854	CNV	Insertion	17901297

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF578 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF578)

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (Nature 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 147660	HGNC: 26449	AceView: FLJ10891andZNF578andLOC388558	Ensembl:ENSG00000258405	euGenes: HUgn147660
ECgene: ZNF578	H-InvDB: ZNF578

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF578	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF578 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF578 gene:
Search GeneIP for patents involving ZNF578

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ZNF578 Gene

Zinc Finger Protein 578

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Export list of displayed genes

ZNF578 Gene

Zinc Finger Protein 578

Aliasesfor ZNF578 gene

Summariesfor ZNF578 gene

Genomic Viewsfor ZNF578 gene

Proteinsfor ZNF578 gene

ZNF578 Human Recombinant Protein Products:

ZNF578 Antibody Products:

ZNF578 Assay Products:

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Localizationfor ZNF578 gene

Pathways & Interactionsfor ZNF578 gene

Drugs & Compoundsfor ZNF578 gene

Transcriptsfor ZNF578 gene

Expression for ZNF578 gene

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Genomic Variantsfor ZNF578 gene

Disorders / Diseasesfor ZNF578 gene

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Genome Databases showing ZNF578 gene

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Specialized Databases showing ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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for ZNF578 gene

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