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ZNF578 Gene

protein-coding   GIFtS: 36
GCID: GC19P052959

Zinc Finger Protein 578

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Aliases
for ZNF578 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5781 2

External Ids:    HGNC: 264491   Entrez Gene: 1476602   Ensembl: ENSG000002584057   UniProtKB: Q96N583   

Export aliases for ZNF578 gene to outside databases

Previous GC identifers: GC19P057124 GC19P057709 GC19P057580 GC19P057649 GC19P049287


Summaries
for ZNF578 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF578 Gene:
ZNF578 (zinc finger protein 578) is a protein-coding gene. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58
Function: May be involved in transcriptional regulation




Genomic Views
for ZNF578 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF578 gene promoter:
         Ik-1   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF578

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF578


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF578 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF578 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052959:  view genomic region     (about GC identifiers)

Start:
 52,956,829 bp from pter      End:
 53,020,131 bp from pter
Size:
 63,303 bases      Orientation:
 plus strand

Proteins
for ZNF578 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58 (See protein sequence)
Recommended Name: Zinc finger protein 578  
Size: 590 amino acids; 68531 Da
Sequence caution: Sequence=BAB71051.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DR51 I3L1Y6

Explore the universe of human proteins at neXtProt for ZNF578: NX_Q96N58

Explore proteomics data for ZNF578 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See ZNF578 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001093164.1  
    ENSEMBL proteins: 
     ENSP00000459216   ENSP00000470790  

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    Domains /
    Families
    for ZNF578 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96N58

    ProtoNet protein and cluster: Q96N58

    2 Blocks protein domains:
    IPB006210 Type I EGF
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN578_HUMAN, Q96N58
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF578           About GenesLikeMe


    Function
    for ZNF578 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN578_HUMAN, Q96N58
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF578           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF578

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    Localization
    for ZNF578 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN578_HUMAN, Q96N58: Nucleus (Probable)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ZNF578           About GenesLikeMe


    Pathways & Interactions
    for ZNF578 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

        Search GeneGlobe Interaction Network for ZNF578

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF578           About GenesLikeMe



    Drugs & Compounds
    for ZNF578 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF578 (ZN578)



    Transcripts
    for ZNF578 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF578 gene (2 alternative transcripts): 
    NM_152472.1  NM_001099694.1  

    Unigene Cluster for ZNF578:

    Zinc finger protein 578
    Hs.157287  [show with all ESTs]
    Unigene Representative Sequence: NM_001099694
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421239(uc002pzm.2 uc002pzn.2 uc002pzp.4 uc002pzo.1 uc010epp.1)
    ENST00000594118 ENST00000596382 ENST00000602221 ENST00000596674 ENST00000601120

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    Additional mRNA sequence: 

    AB091373.1 AB091374.1 AB091375.1 AB091376.1 AK299106.1 AL833487.1 BC103904.2 BC115704.1 

    8 DOTS entries:

    DT.99938267  DT.100797476  DT.75180139  DT.121450725  DT.409705  DT.91650270  DT.101964636  DT.102825318 

    Selected AceView cDNA sequences (see all 70):

    AI953831 AI003260 BQ690668 CD244192 BQ958705 BC067346 BP871716 BQ008299 
    NM_152472 CR749856 BV198598 AK001753 AK095562 CO245168 CO249449 BX955279 
    CO249550 BQ016962 BQ023016 BQ685199 NM_018260 CO249446 AL833487 CF595699 

    GeneLoc Exon Structure


    Expression
    for ZNF578 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF578 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGGAGGG
    ZNF578 Expression
    About this image

    ZNF578 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZNF578 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.157287
        Custom PCR Arrays for ZNF578
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    In Situ
    Assay Products:     
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    Orthologs
    for ZNF578 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF578 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    dog
    (Canis familiaris)    		 Mammalia --
    		 Uncharacterized protein
    		 53(a)
    		 many ↔ many
    		 1(104870859-104886591)


    ENSEMBL Gene Tree for ZNF578 (if available)
    TreeFam Gene Tree for ZNF578 (if available)

    Paralogs
    for ZNF578 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF578 gene
    ZNF5342  ZNF321P2  ZNF4682  ZNF8802  ZNF7662  ZNF3202  ZNF5252  ZNF8602  
    ZNF4152  ZNF6002  ZNF282  ZNF5282  ZNF6112  ZNF6772  ZNF832  ZNF8162  
    ZNF6102  ZNF7012  ZNF7652  ZNF4802  ZNF8132  
    Selected SIMAP similar genes for ZNF578 using alignment to 3 protein entries:     ZN578_HUMAN (see all proteins) (see all similar genes):
    ZNF611    kr-znf3    ZNF702P    ZNF808    ZNF765    ZNF845
    ZNF616    DKFZp686M04222    ZNF816    ZNF701    HZF36    ZNF761
    ZNF525    ZNF813    ZNF860    DKFZp666C237    ZNF232    ZNF321P

    Find genes that share paralogs with ZNF578           About GenesLikeMe



    Genomic Variants
    for ZNF578 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF578 (see all 2017)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs105949031,2
    		C--49334669(+) TTTTT-/T/TT  
                GAGAT     		1 -- int11NA 2
    rs594657721,2
    		C--52954873(+) CACACC/AACCAC 1 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs1140184901,2
    		F--52954881(+) CACCTA/GTGGAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1146535481,2
    		F--52954927(+) TCCTTC/TTGGAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs3241031,2
    		C,F,A,H--52954937(+) TGTTAC/TGGAGA 1 -- us2k126Minor allele frequency- T:0.16NS EA NA WA CSA 2349
    rs1827007341,2
    		--52954980(+) CTTTGC/TTGATG 1 -- us2k10--------
    rs1431696671,2
    		--52955085(+) ATCGAA/GTTGCA 1 -- us2k10--------
    rs1461967001,2
    		--52955090(+) ATTGCA/GCAGCT 1 -- us2k10--------
    rs1497371511,2
    		C--52955324(+) CTGCA-/TTTTTT 1 -- us2k10--------
    rs1888379681,2
    		--52955365(+) AAAGCA/GTTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF578 (52956829 - 53020131 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF578:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718785CNV Deletion23290073
    nsv509751CNV Insertion20534489
    nsv436854CNV Insertion17901297

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF578

    Disorders / Diseases
    for ZNF578 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Publications
    for ZNF578 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF578 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF578)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    External Searches for ZNF578 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNF578 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147660 HGNC: 26449 AceView: FLJ10891andZNF578andLOC388558 Ensembl:ENSG00000258405 euGenes: HUgn147660
    ECgene: ZNF578 H-InvDB: ZNF578

    Other Databases showing ZNF578 gene

    (According to HUGE)
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    Specialized Databases showing ZNF578 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF578 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF578 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for ZNF578 gene:
    Search GeneIP for patents involving ZNF578

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZNF578 gene

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    Advanced Cell Diagnostics, Animal models from genOway)
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