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ZNF578 Gene(Protein Coding)

Zinc Finger Protein 578

GCID:
GC19P052459
GIFtS:
42
Genes Participants
UDN Logo

Aliases for ZNF578 Gene

Aliases for ZNF578 Gene

  • Zinc Finger Protein 578 2 3 5

External Ids for ZNF578 Gene

Previous GeneCards Identifiers for ZNF578 Gene

  • GC19P057124
  • GC19P057709
  • GC19P057580
  • GC19P057649
  • GC19P052959
  • GC19P049287

Summaries for ZNF578 Gene

GeneCards Summary for ZNF578 Gene

ZNF578 (Zinc Finger Protein 578) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF578 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF578 Gene

Genomics for ZNF578 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZNF578 Gene

Enhancers for ZNF578 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF578 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF578 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF578 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF578 gene promoter:

Genomic Location for ZNF578 Gene

Chromosome:
19
Start:
52,453,506 bp from pter
End:
52,516,878 bp from pter
Size:
63,373 bases
Orientation:
Plus strand

Genomic View for ZNF578 Gene

Genes around ZNF578 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF578 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF578 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF578 Gene

Proteins for ZNF578 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF578 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N58-ZN578_HUMAN
    Recommended name:
    Zinc finger protein 578
    Protein Accession:
    Q96N58
    Secondary Accessions:
    • B4DR51
    • I3L1Y6

    Protein attributes for ZNF578 Gene

    Size:
    590 amino acids
    Molecular mass:
    68531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF578 Gene

Proteomics data for ZNF578 Gene at MOPED

Protein Expression for ZNF578 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF578 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF578 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF578 Gene

Domains & Families for ZNF578 Gene

Gene Families for ZNF578 Gene

HGNC:

Protein Domains for ZNF578 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF578 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96N58

UniProtKB/Swiss-Prot:

ZN578_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF578: view

Function for ZNF578 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ZNF578 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF578 Gene

GenomeRNAi human phenotypes for ZNF578:
genes like me logo Genes that share phenotypes with ZNF578: view

Animal Model Products

CRISPR Products

miRNA for ZNF578 Gene

miRTarBase miRNAs that target ZNF578

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF578 Gene

Localization for ZNF578 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF578 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF578 Gene COMPARTMENTS Subcellular localization image for ZNF578 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF578: view

Pathways & Interactions for ZNF578 Gene

SuperPathways for ZNF578 Gene

PathCards logoMore details on SuperPathways for ZNF578
No Data Available

Interacting Proteins for ZNF578 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000459216%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264705%0d%0a9606.ENSP00000455507%0d%0a9606.ENSP00000276072%0d%0a9606.ENSP00000418379%0d%0a
Selected Interacting proteins: ENSP00000459216 for ZNF578 Gene via STRING

Gene Ontology (GO) - Biological Process for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF578: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF578 Gene

Drugs & Compounds for ZNF578 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF578 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ZNF578 Gene

(9) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF578 Gene

Zinc finger protein 578:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF578 Gene

No ASD Table

Relevant External Links for ZNF578 Gene

GeneLoc Exon Structure for
ZNF578
ECgene alternative splicing isoforms for
ZNF578

Expression for ZNF578 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ZNF578 Gene

mRNA expression in normal human tissues for ZNF578 Gene
mRNA expression by GTEx for ZNF578 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF578 Gene

This gene is overexpressed in Testis (x7.8).

Protein differential expression in normal tissues from HIPED for ZNF578 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF578 Gene



SOURCE GeneReport for Unigene cluster for ZNF578 Gene Hs.157287

genes like me logo Genes that share expression patterns with ZNF578: view

Protein tissue co-expression partners for ZNF578 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF578 Gene

Orthologs for ZNF578 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF578 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia -- 36
  • 42 (a)
 ManyToMany
dog
(Canis familiaris)
 Mammalia -- 36
  • 53 (a)
 ManyToMany
chimpanzee
(Pan troglodytes)
 Mammalia -- 36
  • 73 (a)
 ManyToMany
Species with no ortholog for ZNF578:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF578 Gene

ENSEMBL:
Gene Tree for ZNF578 (if available)
TreeFam:
Gene Tree for ZNF578 (if available)

Paralogs for ZNF578 Gene

Paralogs for ZNF578 Gene

(523) SIMAP similar genes for ZNF578 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF578: view

Variants for ZNF578 Gene

Sequence variations from dbSNP and Humsavar for ZNF578 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs161931 - 52,511,093(-) GGCTT(C/T)GCCAG reference, missense
rs781121 -- 52,503,687(-) AAGTC(A/G)AATGG intron-variant
rs781125 -- 52,506,627(-) ttagc(C/T)gggca intron-variant
rs802583 -- 52,486,302(+) ctctc(C/G/T)gagat intron-variant, upstream-variant-2KB
rs802584 -- 52,486,497(+) AAAAG(C/G)AACTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF578 Gene

Variant ID Type Subtype PubMed ID
nsv509751 CNV Insertion 20534489
esv2718785 CNV Deletion 23290073
nsv436854 CNV Insertion 17901297

Variation tolerance for ZNF578 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF578 Gene

Disorders for ZNF578 Gene

Relevant External Links for ZNF578

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF578

No disorders were found for ZNF578 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF578 Gene

Publications for ZNF578 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

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