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Aliases for ZNF578 Gene

Aliases for ZNF578 Gene

  • Zinc Finger Protein 578 2 3

External Ids for ZNF578 Gene

Summaries for ZNF578 Gene

GeneCards Summary for ZNF578 Gene

ZNF578 (Zinc Finger Protein 578) is a Protein Coding gene. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF578 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF578 Gene

Genomics for ZNF578 Gene

Genomic Location for ZNF578 Gene

Start:
52,453,553 bp from pter
End:
52,516,878 bp from pter
Size:
63,326 bases
Orientation:
Plus strand

Genomic View for ZNF578 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF578 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF578 Gene

Regulatory Elements for ZNF578 Gene

Transcription factor binding sites by QIAGEN in the ZNF578 gene promoter:

Proteins for ZNF578 Gene

  • Protein details for ZNF578 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N58-ZN578_HUMAN
    Recommended name:
    Zinc finger protein 578
    Protein Accession:
    Q96N58
    Secondary Accessions:
    • B4DR51
    • I3L1Y6

    Protein attributes for ZNF578 Gene

    Size:
    590 amino acids
    Molecular mass:
    68531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF578 Gene

Proteomics data for ZNF578 Gene at MOPED

Post-translational modifications for ZNF578 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF578 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF578 Gene

Domains for ZNF578 Gene

Gene Families for ZNF578 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN578_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q96N58
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q96N58
Similarity:
  • Contains 12 C2H2-type zinc fingers.:
    • Q96N58
genes like me logo Genes that share domains with ZNF578: view

Function for ZNF578 Gene

Molecular function for ZNF578 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF578: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF578 Gene

Localization for ZNF578 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF578 Gene

Gene Ontology (GO) - Cellular Components for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF578: view

Pathways for ZNF578 Gene

SuperPathways for ZNF578 Gene

No Data Available

Interacting Proteins for ZNF578 Gene

Gene Ontology (GO) - Biological Process for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF578: view

No data available for Pathways by source for ZNF578 Gene

Transcripts for ZNF578 Gene

Unigene Clusters for ZNF578 Gene

Zinc finger protein 578:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF578 Gene

No ASD Table

Relevant External Links for ZNF578 Gene

GeneLoc Exon Structure for
ZNF578
ECgene alternative splicing isoforms for
ZNF578

Expression for ZNF578 Gene

mRNA expression in normal human tissues for ZNF578 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF578 Gene

This gene is overexpressed in Testis (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF578 Gene

SOURCE GeneReport for Unigene cluster for ZNF578 Gene Hs.157287

genes like me logo Genes that share expressions with ZNF578: view

Orthologs for ZNF578 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF578 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 73 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 53 (a)
ManyToMany
Species with no ortholog for ZNF578:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF578 Gene

ENSEMBL:
Gene Tree for ZNF578 (if available)
TreeFam:
Gene Tree for ZNF578 (if available)

Paralogs for ZNF578 Gene

Selected SIMAP similar genes for ZNF578 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF578: view

Variants for ZNF578 Gene

Sequence variations from dbSNP and Humsavar for ZNF578 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs36680 -- 52,492,851(+) AAGGT(C/T)CTACC intron-variant
rs36681 -- 52,492,737(+) CCGCC(A/T)CGCGC intron-variant
rs161929 -- 52,494,525(+) TTTGG(A/G)TACAG intron-variant
rs161930 -- 52,512,876(-) AACAC(C/T)TGCAT utr-variant-3-prime
rs161931 - 52,511,093(-) GGCTT(C/T)GCCAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF578 Gene

Variant ID Type Subtype PubMed ID
nsv509751 CNV Insertion 20534489
esv2718785 CNV Deletion 23290073
nsv436854 CNV Insertion 17901297

Relevant External Links for ZNF578 Gene

HapMap Linkage Disequilibrium report
ZNF578

Disorders for ZNF578 Gene

No disorders were found for ZNF578 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF578 Gene

Publications for ZNF578 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZNF578 Gene

Sources for ZNF578 Gene

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