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Aliases for ZNF577 Gene

Aliases for ZNF577 Gene

  • Zinc Finger Protein 577 2 3

External Ids for ZNF577 Gene

Summaries for ZNF577 Gene

GeneCards Summary for ZNF577 Gene

ZNF577 (Zinc Finger Protein 577) is a Protein Coding gene. Diseases associated with ZNF577 include hemorrhagic thrombocythemia. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ENSG00000256825.

UniProtKB/Swiss-Prot for ZNF577 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF577 Gene

Genomics for ZNF577 Gene

Genomic Location for ZNF577 Gene

Start:
51,855,802 bp from pter
End:
51,890,950 bp from pter
Size:
35,149 bases
Orientation:
Minus strand

Genomic View for ZNF577 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF577 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF577 Gene

Regulatory Elements for ZNF577 Gene

Transcription factor binding sites by QIAGEN in the ZNF577 gene promoter:

Proteins for ZNF577 Gene

  • Protein details for ZNF577 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSK1-ZN577_HUMAN
    Recommended name:
    Zinc finger protein 577
    Protein Accession:
    Q9BSK1
    Secondary Accessions:
    • A8K0B4
    • A8K6Z7
    • C9JFB9

    Protein attributes for ZNF577 Gene

    Size:
    485 amino acids
    Molecular mass:
    54939 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH04992.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF82168.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW72049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF577 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF577 Gene

Proteomics data for ZNF577 Gene at MOPED

Post-translational modifications for ZNF577 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF577 Gene

Domains for ZNF577 Gene

Gene Families for ZNF577 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN577_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q9BSK1
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9BSK1
Similarity:
  • Contains 8 C2H2-type zinc fingers.:
    • Q9BSK1
genes like me logo Genes that share domains with ZNF577: view

Function for ZNF577 Gene

Molecular function for ZNF577 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF577: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF577 Gene

Localization for ZNF577 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF577 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF577 Gene COMPARTMENTS Subcellular localization image for ZNF577 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF577: view

Pathways for ZNF577 Gene

SuperPathways for ZNF577 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF577: view

Pathways by source for ZNF577 Gene

2 Reactome pathways for ZNF577 Gene

Interacting Proteins for ZNF577 Gene

Gene Ontology (GO) - Biological Process for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF577: view

Transcripts for ZNF577 Gene

Unigene Clusters for ZNF577 Gene

Zinc finger protein 577:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF577 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for ZNF577 Gene

GeneLoc Exon Structure for
ZNF577
ECgene alternative splicing isoforms for
ZNF577

Expression for ZNF577 Gene

mRNA expression in normal human tissues for ZNF577 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF577 Gene

SOURCE GeneReport for Unigene cluster for ZNF577 Gene Hs.729135

genes like me logo Genes that share expressions with ZNF577: view

Orthologs for ZNF577 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF577 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF577 36
  • 98.9 (n)
  • 97.73 (a)
ZNF577 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF577 36
  • 76.95 (n)
  • 67.11 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 68 (a)
OneToMany
-- 37
  • 31 (a)
OneToMany
ZNF577 36
  • 85 (n)
  • 78.41 (a)
Species with no ortholog for ZNF577:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF577 Gene

ENSEMBL:
Gene Tree for ZNF577 (if available)
TreeFam:
Gene Tree for ZNF577 (if available)

Paralogs for ZNF577 Gene

Paralogs for ZNF577 Gene

Selected SIMAP similar genes for ZNF577 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF577: view

Variants for ZNF577 Gene

Sequence variations from dbSNP and Humsavar for ZNF577 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs765009 -- 51,858,581(+) GGGCA(A/G)AAATC intron-variant
rs765010 -- 51,858,105(+) TGAAC(A/T)AGCTG intron-variant
rs1055408 -- 51,872,171(-) AATTT(A/G)TAGAA utr-variant-3-prime, intron-variant
rs1056294 -- 51,855,916(-) atgaa(A/G)accat nc-transcript-variant
rs2288868 - 51,873,254(+) GCATT(C/T)GCTGC reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF577 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990
dgv1113e1 CNV Complex 17122850
nsv912298 CNV Loss 21882294

Relevant External Links for ZNF577 Gene

HapMap Linkage Disequilibrium report
ZNF577
Human Gene Mutation Database (HGMD)
ZNF577

Disorders for ZNF577 Gene

(1) University of Copenhagen DISEASES for ZNF577 Gene

Relevant External Links for ZNF577

Human Genome Epidemiology (HuGE) Navigator
ZNF577
genes like me logo Genes that share disorders with ZNF577: view

No data available for UniProtKB/Swiss-Prot for ZNF577 Gene

Publications for ZNF577 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. (PMID: 21424380) Sehrawat B. … Damaraju S. (Hum. Genet. 2011) 3

Products for ZNF577 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF577
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF577
    • Block miRNA regulation of ZNF577 using miScript Target Protectors

    Sources for ZNF577 Gene

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