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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF577 Gene

protein-coding GIFtS: 50
GCID: GC19M052359

zinc finger protein 577

Explore 3 diseases affiliated with
ZNF577 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 577¹ ²
MGC4400¹

External Ids:	HGNC: 28673¹	Entrez Gene: 84765²	Ensembl: ENSG00000161551⁷	UniProtKB: Q9BSK1³

ORGUL members:
	NONCODE:n406650

Export aliases for ZNF577 gene to outside databases

Previous GC identifers: GC19M057067 GC19M057069 GC19M048689

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF577 gene promoter:
AP-1 ATF-2 c-Jun Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF577 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF577

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF577

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC chromosome: 19

ZNF577 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF577 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M052359: view genomic region (about GC identifiers)

Start:	52,359,055 bp from pter	End:	52,394,203 bp from pter
Size:	35,149 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1 (See protein sequence)

Recommended Name: Zinc finger protein 577

Size: 485 amino acids; 54939 Da

Subcellular location: Nucleus (Probable)

Caution: It is uncertain whether Met-1 or Met-8 is the initiator

Sequence caution: Sequence=AAH04992.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAF82168.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW72049.1;

Type=Erroneous gene model prediction;

Secondary accessions: A8K0B4 A8K6Z7 C9JFB9

Alternative splicing: 2 isoforms: Q9BSK1-1 Q9BSK1-2

Explore the universe of human proteins at neXtProt for ZNF577: NX_Q9BSK1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BSK1

ZNF577 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001129062.1 NP_116068.2

ENSEMBL proteins:

ENSP00000394828 ENSP00000301399 ENSP00000413476 ENSP00000389652 ENSP00000404509

ENSP00000413560 ENSP00000467321 ENSP00000415307 ENSP00000407476 ENSP00000467575

Reactome Protein details: Q9BSK1
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	Uscn Proteins for ZNF577

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF577 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF577 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9BSK1

ProtoNet protein and cluster: Q9BSK1

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 8 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1

Function: May be involved in transcriptional regulation

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In Situ Assay
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF577 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF577

	Generic Transcription Pathway
	Gene Expression

ZNF577 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF577

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF577 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF577
Search CenterWatch for drugs/clinical trials and news about ZNF577 / ZN577

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF577 gene (2 alternative transcripts):

NM_001135590.1 NM_032679.2

Unigene Cluster for ZNF577:

Zinc finger protein 577

Hs.729135 [show with all ESTs]

Unigene Representative Sequence: AK055304

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000485702 ENST00000586437 ENST00000477228 ENST00000588129 ENST00000412216(uc010ydd.1)

ENST00000301399(uc002pxx.4 uc010yde.2) ENST00000420592(uc002pxv.3 uc002pxw.3)

ENST00000451628 ENST00000458390 ENST00000453272(uc010ydf.1) ENST00000592321

ENST00000446514 ENST00000419138 ENST00000591320 ENST00000588878 ENST00000484095

ENST00000589784

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF577

Additional cDNA sequence:

AK055304.1 AK289479.1 AK291812.1 BC004992.1 BC035367.1 FJ423743.1 NR_024181.1

15 DOTS entries:

DT.75100745 DT.305873 DT.40307137 DT.92428507 DT.40238300 DT.91851245 DT.40265108 DT.100750093

DT.101963041 DT.91743346 DT.92428505 DT.75183389 DT.99993146 DT.121106398 DT.438066

24/94 AceView cDNA sequences (see all 94):

AI004737 AI040835 AW591333 BX106555 AK056853 BX498176 BU948792 CA448577

BU949047 BM710441 AA599669 AI014858 BM985347 AI243510 BX488270 BE300708

BE827702 BE728299 BE386534 AI707563 BP380047 AI022589 BE274111 BE275560

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF577 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d
SP1:									-		-		-						-
SP2:																			-
SP3:													-						-
SP4:													-
SP5:																			-																								-

ECgene alternative splicing isoforms for ZNF577

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF577 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATTTATGG

About this image
See ZNF577 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF577

SOURCE GeneReport for Unigene cluster: Hs.729135

SABiosciences Custom PCR Arrays for ZNF577

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF577

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF577 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- -- (see all 8)	--	27(a) 23(a) (see all 8)	many ↔ many many ↔ many (see all 8)	Un(41687425-41690654) Un(18847108-18852277)

ENSEMBL Gene Tree for ZNF577 (if available)
TreeFam Gene Tree for ZNF577 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF577 gene

ZNF175² ZNF674² LOC100287515² ZNF614² ZNF432² ZNF613² ZNF26² ZNF350²

ZNF81² ZNF649² ZNF605² ZNF84² ZNF630² ZFP37² ZNF484² ENSG00000229631²

ZNF182² ZNF41² ZNF268² ZNF300² LOC100996464² ZNF615²

18/474 SIMAP similar genes for ZNF577 using alignment to 7 protein entries: ZN577_HUMAN (see all proteins) (see all similar genes):

ZNF776 ZNF529 ZNF793 ZNF235 ZNF78L1 ZNF586

ZNF420 ZNF84 ZNF419 ZNF10 ZNF169 ZNF33B

ZNF124 ZNF573 ZNF225 ZNF707 ZNF844 ZNF559

ZNF577 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34540338^1,2	C,	--	52358593(+)	`TGAGC-/CAGT AAGTT`	1	--	int¹		1		CSA	2
rs74256615^1,2		--	52358594(+)	`TGAGCA/CAGTTT`	1	--	int¹		0	--	--	--	--
rs192473947^1,2		--	52358652(+)	`TGTGTA/GTGTGT`	1	--	int¹		0	--	--	--	--
rs55937420^1,2	C	--	52358661(+)	`TGTGTGTGT/- CTACT`	1	--	int¹		1		NA	2
rs139189107^1,2	C,	--	52358675(+)	`ATGCT-/CAAG CAGTT`	1	--	int¹		0	--	--	--	--
rs114542656^1,2	C,F,	--	52358924(+)	`GCAGGC/ATTAGG`	1	--	int¹		1		WA	118
rs114443581^1,2	C,	--	52359076(+)	`AGATAC/TATAAT`	1	--	nc-transcript-variant		0	--	--	--	--
rs149756626^1,2		--	52359127(+)	`CTTATC/TTGTCT`	1	--	nc-transcript-variant		0	--	--	--	--
rs1056294^1,2	C,F,O,A,H,	--	52359169(-)	`ATGAAG/AACCAT`	1	--	nc-transcript-variant		24		MN NS EA NA WA CSA	2527
rs75089224^1,2	F,	--	52359207(+)	`TTCCAA/GCGGTA`	1	--	nc-transcript-variant		1		EA	120

HapMap Linkage Disequilibrium report for ZNF577 (52359055 - 52394203 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZNF577
5 CNVs: 8875 4086 3195 34482 53103
Human Gene Mutation Database (HGMD): ZNF577

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF577

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF577 for disorders About GeneDecksing

3 diseases for ZNF577: About MalaCards

hemorrhagic thrombocythemia breast cancer susceptibility breast cancer

1 disease from the University of Copenhagen DISEASES database for ZNF577:

Hemorrhagic thrombocythemia

Human Genome Epidemiology (HuGE) Navigator: ZNF577 (1 document)

Export disorders for ZNF577 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF577 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF577)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. (PubMed id 21424380)¹ Sehrawat B....Damaraju S. (2011)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84765	HGNC: 28673	AceView: ZNF577	Ensembl:ENSG00000161551	euGenes: HUgn84765
ECgene: ZNF577	H-InvDB: ZNF577

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF577	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF577 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF577 gene:
Search GeneIP for patents involving ZNF577

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF577 gene at Home site.

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ZNF577 Gene

zinc finger protein 577

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ZNF577 Gene

zinc finger protein 577

Aliasesfor ZNF577 gene

Summariesfor ZNF577 gene

Genomic Viewsfor ZNF577 gene

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Protein Domains /Familiesfor ZNF577 gene

Functionfor ZNF577 gene

Pathways & Interactionsfor ZNF577 gene

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for ZNF577 gene

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for ZNF577 gene

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