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ZNF577 Gene

protein-coding   GIFtS: 47
GCID: GC19M052359

Zinc Finger Protein 577

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 5771 2

External Ids:    HGNC: 286731   Entrez Gene: 847652   Ensembl: ENSG000001615517   UniProtKB: Q9BSK13   
ORGUL members:         

Export aliases for ZNF577 gene to outside databases

Previous GC identifers: GC19M057067 GC19M057069 GC19M048689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF577 Gene:
ZNF577 (zinc finger protein 577) is a protein-coding gene. Diseases associated with ZNF577 include hemorrhagic thrombocythemia, and breast cancer. An important paralog of this gene is ZNF350.

UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF577 gene promoter:
         AP-1   ATF-2   c-Jun   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF577 promoter sequence
   Search Chromatin IP Primers for ZNF577

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF577


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF577 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF577 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052359:  view genomic region     (about GC identifiers)

Start:
52,359,055 bp from pter      End:
52,394,203 bp from pter
Size:
35,149 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1 (See protein sequence)
Recommended Name: Zinc finger protein 577  
Size: 485 amino acids; 54939 Da
Caution: It is uncertain whether Met-1 or Met-8 is the initiator
Sequence caution: Sequence=AAH04992.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAF82168.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW72049.1;
Type=Erroneous gene model prediction;
Secondary accessions: A8K0B4 A8K6Z7 C9JFB9
Alternative splicing: 2 isoforms:  Q9BSK1-1   Q9BSK1-2   

Explore the universe of human proteins at neXtProt for ZNF577: NX_Q9BSK1

Explore proteomics data for ZNF577 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF577 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129062.1  NP_116068.2  

    ENSEMBL proteins: 
     ENSP00000394828   ENSP00000301399   ENSP00000413476   ENSP00000389652   ENSP00000404509  
     ENSP00000413560   ENSP00000467321   ENSP00000415307   ENSP00000407476   ENSP00000467575  
    Reactome Protein details: Q9BSK1

    ZNF577 Human Recombinant Protein Products:

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    Novus Biologicals ZNF577 Protein
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    Cloud-Clone Corp. CLIAs for ZNF577


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BSK1

    ProtoNet protein and cluster: Q9BSK1

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF577 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN577_HUMAN, Q9BSK1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF577 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF577
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF577
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF577

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF577

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF577


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN577_HUMAN, Q9BSK1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF577 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF577 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF577
        Generic Transcription Pathway



    ZNF577 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF577
    Interactions:

        Search GeneGlobe Interaction Network for ZNF577

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF577 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF577 (ZN577)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF577 gene (2 alternative transcripts): 
    NM_001135590.1  NM_032679.2  

    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485702 ENST00000586437 ENST00000477228 ENST00000588129 ENST00000412216(uc010ydd.1)
    ENST00000301399(uc002pxx.4 uc010yde.2) ENST00000420592(uc002pxv.3 uc002pxw.3)
    ENST00000451628 ENST00000458390 ENST00000453272(uc010ydf.1) ENST00000592321
    ENST00000446514 ENST00000419138 ENST00000591320 ENST00000588878 ENST00000484095
    ENST00000589784
    miRNA
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZNF577
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF577
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF577 (NM_032679)
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    Primer
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    OriGene qPCR primer pairs and template standards for ZNF577
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF577
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF577
      QuantiFast Probe-based Assays in human, mouse, rat ZNF577

    Selected AceView cDNA sequences (see all 94):

    AI040835 BM710441 BU948792 BX498176 CA448577 AI004737 BU949047 AW591333 
    BX106555 AK056853 AA599669 AI014858 BM985347 AA813172 CB241730 AW052062 
    BX488270 AI298671 BU501016 BG334063 AK055304 AL712337 BE275560 BE300708 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF577 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                          -     -     -                 -                                                                                             
    SP2:                                                        -                                                                                             
    SP3:                                      -                 -                                                                                             
    SP4:                                      -                                                                                                               
    SP5:                                                        -                                                                       -                     


    ECgene alternative splicing isoforms for ZNF577

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF577 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATTTATGG
    ZNF577 Expression
    About this image

    ZNF577 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF577 Protein Expression
        Custom PCR Arrays for ZNF577
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF577

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF577 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5771 zinc finger protein 577 85(n)
    78.41(a)
      491432  XM_005616214.1  XP_005616271.1 


    ENSEMBL Gene Tree for ZNF577 (if available)
    TreeFam Gene Tree for ZNF577 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF577 gene
    ZNF3502  ENSG000002568252  
    Selected SIMAP similar genes for ZNF577 using alignment to 7 protein entries:     ZN577_HUMAN (see all proteins) (see all similar genes):
    ZNF776    ZNF529    ZNF793    ZNF814    ZNF419    ZNF415
    ZNF773    ZNF235    ZNF586    ZNF780B    ZNF78L1    ZNF83
    ZNF420    ZNF84    ZNF169    ZNF551    ZNF10    ZNF780A

    ZNF577 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF577 (see all 906)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345403381,2
    C--52358593(+) TGAGC-/CAGT  
            
    AAGTT
    1 -- int11Minor allele frequency- CAGT:0.50CSA 2
    rs742566151,2
    --52358594(+) TGAGCA/CAGTTT 1 -- int10--------
    rs1924739471,2
    --52358652(+) TGTGTA/GTGTGT 1 -- int10--------
    rs559374201,2
    C--52358661(+) TGTGTGTGT/-  
            
    CTACT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs1391891071,2
    C--52358675(+) ATGCT-/CAAG  
            
    CAGTT
    1 -- int10--------
    rs1145426561,2
    C,F--52358924(+) GCAGGC/ATTAGG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1144435811,2
    C--52359076(+) AGATAC/TATAAT 1 -- nc-transcript-variant0--------
    rs1497566261,2
    C--52359127(+) CTTATC/TTGTCT 1 -- nc-transcript-variant0--------
    rs10562941,2
    C,F,O,A,H--52359169(-) atgaaG/Aaccat 1 -- nc-transcript-variant24Minor allele frequency- A:0.41MN NS EA NA WA CSA 2527
    rs750892241,2
    C,F--52359207(+) TTCCAA/GCGGTA 1 -- nc-transcript-variant1Minor allele frequency- G:0.03EA 120

    HapMap Linkage Disequilibrium report for ZNF577 (52359055 - 52394203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF577:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912298CNV Loss21882294
    nsv458733CNV Gain19166990
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    nsv470151CNV Gain18288195
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ZNF577
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF577
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF577

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF577:    
    About MalaCards
    hemorrhagic thrombocythemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ZNF577:
    Hemorrhagic thrombocythemia

    ZNF577 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ZNF577 (1 document)

    Export disorders for ZNF577 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF577 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF577)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    5. Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. (PubMed id 21424380)1 Sehrawat B....Damaraju S. (Hum. Genet. 2011)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84765 HGNC: 28673 AceView: ZNF577 Ensembl:ENSG00000161551 euGenes: HUgn84765
    ECgene: ZNF577 H-InvDB: ZNF577

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF577 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF577 gene:
    Search GeneIP for patents involving ZNF577

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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