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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF577 Gene

protein-coding   GIFtS: 50
GCID: GC19M052359

Zinc Finger Protein 577

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 5771 2

External Ids:    HGNC: 286731   Entrez Gene: 847652   Ensembl: ENSG000001615517   UniProtKB: Q9BSK13   
ORGUL members:         
NONCODE14:n406650      

Export aliases for ZNF577 gene to outside databases

Previous GC identifers: GC19M057067 GC19M057069 GC19M048689


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF577 Gene: 
ZNF577 (zinc finger protein 577) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ZNF577 include hemorrhagic thrombocythemia, and breast cancer susceptibility, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZFP1.

UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF577 gene promoter:
         AP-1   ATF-2   c-Jun   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF577 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF577

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF577


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF577 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF577 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052359:  view genomic region     (about GC identifiers)

Start:
52,359,055 bp from pter      End:
52,394,203 bp from pter
Size:
35,149 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1 (See protein sequence)
Recommended Name: Zinc finger protein 577  
Size: 485 amino acids; 54939 Da
Subcellular location: Nucleus (Probable)
Caution: It is uncertain whether Met-1 or Met-8 is the initiator
Sequence caution: Sequence=AAH04992.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAF82168.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW72049.1;
Type=Erroneous gene model prediction;
Secondary accessions: A8K0B4 A8K6Z7 C9JFB9
Alternative splicing: 2 isoforms:  Q9BSK1-1   Q9BSK1-2   

Explore the universe of human proteins at neXtProt for ZNF577: NX_Q9BSK1

Explore proteomics data for ZNF577 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BSK1

  • ZNF577 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF577 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129062.1  NP_116068.2  

    ENSEMBL proteins: 
     ENSP00000394828   ENSP00000301399   ENSP00000413476   ENSP00000389652   ENSP00000404509  
     ENSP00000413560   ENSP00000467321   ENSP00000415307   ENSP00000407476   ENSP00000467575  
    Reactome Protein details: Q9BSK1
    Human Recombinant Protein Products for ZNF577: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ZNF577 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF577 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BSK1

    ProtoNet protein and cluster: Q9BSK1

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN577_HUMAN, Q9BSK1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF577 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN577_HUMAN, Q9BSK1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF577 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF577 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF577
        Generic Transcription Pathway
    Gene Expression



    ZNF577 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF577

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF577 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF577 (ZN577)

    Search CenterWatch for drugs/clinical trials and news about ZNF577 / ZN577

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF577 gene (2 alternative transcripts): 
    NM_001135590.1  NM_032679.2  

    Unigene Cluster for ZNF577:

    Zinc finger protein 577
    Hs.729135  [show with all ESTs]
    Unigene Representative Sequence: AK055304
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485702 ENST00000586437 ENST00000477228 ENST00000588129 ENST00000412216(uc010ydd.1)
    ENST00000301399(uc002pxx.4 uc010yde.2) ENST00000420592(uc002pxv.3 uc002pxw.3)
    ENST00000451628 ENST00000458390 ENST00000453272(uc010ydf.1) ENST00000592321
    ENST00000446514 ENST00000419138 ENST00000591320 ENST00000588878 ENST00000484095
    ENST00000589784
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK055304.1 AK289479.1 AK291812.1 BC004992.1 BC035367.1 FJ423743.1 NR_024181.1 

    14 DOTS entries:

    DT.75100745  DT.305873  DT.40307137  DT.92428507  DT.40238300  DT.91851245  DT.40265108  DT.100750093 
    DT.101963041  DT.91743346  DT.92428505  DT.75183389  DT.99993146  DT.121106398 

    24/94 AceView cDNA sequences (see all 94):

    BX498176 AI014858 AA599669 BX106555 AK056853 BM985347 BU948792 AI004737 
    AW591333 AI040835 BM710441 BU949047 CA448577 AI472686 BP380047 BE827702 
    AA813172 AK093036 AI801250 BG334063 BU501016 BX488270 AI243510 AJ706004 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF577 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                          -     -     -                 -                                                                                             
    SP2:                                                        -                                                                                             
    SP3:                                      -                 -                                                                                             
    SP4:                                      -                                                                                                               
    SP5:                                                        -                                                                       -                     


    ECgene alternative splicing isoforms for ZNF577

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF577 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATTTATGG
    ZNF577 Expression
    About this image


    See ZNF577 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF577

    SOURCE GeneReport for Unigene cluster: Hs.729135
        SABiosciences Custom PCR Arrays for ZNF577
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF577 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5771 zinc finger protein 577 85(n)
    78.41(a)
      491432  XM_548553.3  XP_548553.3 


    ENSEMBL Gene Tree for ZNF577 (if available)
    TreeFam Gene Tree for ZNF577 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF577 gene
    ZFP12  ZNF1572  ZNF3502  ZNF252  ENSG000002568252  
    18/491 SIMAP similar genes for ZNF577 using alignment to 7 protein entries:     ZN577_HUMAN (see all proteins) (see all similar genes):
    ZNF776    ZNF529    ZNF793    ZNF814    ZNF415    ZNF773
    ZNF419    ZNF235    ZNF586    ZNF780B    ZNF78L1    ZNF83
    ZNF420    ZNF84    ZNF10    ZNF169    ZNF780A    ZNF33B

    ZNF577 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/906 SNPs in ZNF577 are shown (see all 906)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345403381,2
    C--52358593(+) TGAGC-/CAGT  
            
    AAGTT
    1 -- int11Minor allele frequency- CAGT:0.50CSA 2
    rs742566151,2
    --52358594(+) TGAGCA/CAGTTT 1 -- int10--------
    rs1924739471,2
    --52358652(+) TGTGTA/GTGTGT 1 -- int10--------
    rs559374201,2
    C--52358661(+) TGTGTGTGT/-  
            
    CTACT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs1391891071,2
    C--52358675(+) ATGCT-/CAAG  
            
    CAGTT
    1 -- int10--------
    rs1145426561,2
    C,F--52358924(+) GCAGGC/ATTAGG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1144435811,2
    C--52359076(+) AGATAC/TATAAT 1 -- nc-transcript-variant0--------
    rs1497566261,2
    C--52359127(+) CTTATC/TTGTCT 1 -- nc-transcript-variant0--------
    rs10562941,2
    C,F,O,A,H--52359169(-) atgaaG/Aaccat 1 -- nc-transcript-variant24Minor allele frequency- A:0.41MN NS EA NA WA CSA 2527
    rs750892241,2
    C,F--52359207(+) TTCCAA/GCGGTA 1 -- nc-transcript-variant1Minor allele frequency- G:0.03EA 120

    HapMap Linkage Disequilibrium report for ZNF577 (52359055 - 52394203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF577:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912298CNV Loss21882294
    nsv458733CNV Gain19166990
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    nsv470151CNV Gain18288195
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ZNF577
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF577
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF577

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ZNF577:    About MalaCards
    hemorrhagic thrombocythemia    breast cancer susceptibility    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ZNF577:
    Hemorrhagic thrombocythemia

    ZNF577 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ZNF577 (1 document)

    Export disorders for ZNF577 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF577 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF577)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (2013)
    5. Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. (PubMed id 21424380)1 Sehrawat B....Damaraju S. (2011)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84765 HGNC: 28673 AceView: ZNF577 Ensembl:ENSG00000161551 euGenes: HUgn84765
    ECgene: ZNF577 H-InvDB: ZNF577

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF577 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF577 gene:
    Search GeneIP for patents involving ZNF577

    GeneCards and IP:
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