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Aliases for ZNF577 Gene

Aliases for ZNF577 Gene

  • Zinc Finger Protein 577 2 3 5

External Ids for ZNF577 Gene

Previous GeneCards Identifiers for ZNF577 Gene

  • GC19M057067
  • GC19M057069
  • GC19M052359
  • GC19M048689

Summaries for ZNF577 Gene

GeneCards Summary for ZNF577 Gene

ZNF577 (Zinc Finger Protein 577) is a Protein Coding gene. Diseases associated with ZNF577 include hemorrhagic thrombocythemia. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF615.

UniProtKB/Swiss-Prot for ZNF577 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF577 Gene

Genomics for ZNF577 Gene

Regulatory Elements for ZNF577 Gene

Transcription factor binding sites by QIAGEN in the ZNF577 gene promoter:

Genomic Location for ZNF577 Gene

Chromosome:
19
Start:
51,855,802 bp from pter
End:
51,890,950 bp from pter
Size:
35,149 bases
Orientation:
Minus strand

Genomic View for ZNF577 Gene

Genes around ZNF577 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF577 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF577 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF577 Gene

Proteins for ZNF577 Gene

  • Protein details for ZNF577 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSK1-ZN577_HUMAN
    Recommended name:
    Zinc finger protein 577
    Protein Accession:
    Q9BSK1
    Secondary Accessions:
    • A8K0B4
    • A8K6Z7
    • C9JFB9

    Protein attributes for ZNF577 Gene

    Size:
    485 amino acids
    Molecular mass:
    54939 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH04992.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF82168.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW72049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF577 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF577 Gene

Proteomics data for ZNF577 Gene at MOPED

Post-translational modifications for ZNF577 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF577 Gene

Domains & Families for ZNF577 Gene

Gene Families for ZNF577 Gene

Protein Domains for ZNF577 Gene

Suggested Antigen Peptide Sequences for ZNF577 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSK1

UniProtKB/Swiss-Prot:

ZN577_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF577: view

Function for ZNF577 Gene

Molecular function for ZNF577 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF577 Gene

GenomeRNAi human phenotypes for ZNF577:
genes like me logo Genes that share phenotypes with ZNF577: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF577 Gene

Localization for ZNF577 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF577 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF577 Gene COMPARTMENTS Subcellular localization image for ZNF577 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF577 Gene

Pathways & Interactions for ZNF577 Gene

SuperPathways for ZNF577 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF577: view

Pathways by source for ZNF577 Gene

2 Reactome pathways for ZNF577 Gene

Interacting Proteins for ZNF577 Gene

Gene Ontology (GO) - Biological Process for ZNF577 Gene

None

No data available for SIGNOR curated interactions for ZNF577 Gene

Drugs & Compounds for ZNF577 Gene

No Compound Related Data Available

Transcripts for ZNF577 Gene

Unigene Clusters for ZNF577 Gene

Zinc finger protein 577:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF577 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for ZNF577 Gene

GeneLoc Exon Structure for
ZNF577
ECgene alternative splicing isoforms for
ZNF577

Expression for ZNF577 Gene

mRNA expression in normal human tissues for ZNF577 Gene

Protein differential expression in normal tissues from HIPED for ZNF577 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF577 Gene



SOURCE GeneReport for Unigene cluster for ZNF577 Gene Hs.729135

genes like me logo Genes that share expression patterns with ZNF577: view

Protein tissue co-expression partners for ZNF577 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF577 Gene

Orthologs for ZNF577 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF577 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF577 35
  • 98.9 (n)
  • 97.73 (a)
ZNF577 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF577 35
  • 76.95 (n)
  • 67.11 (a)
dog
(Canis familiaris)
Mammalia ZNF577 35
  • 85 (n)
  • 78.41 (a)
-- 36
  • 68 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
Species with no ortholog for ZNF577:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF577 Gene

ENSEMBL:
Gene Tree for ZNF577 (if available)
TreeFam:
Gene Tree for ZNF577 (if available)

Paralogs for ZNF577 Gene

Paralogs for ZNF577 Gene

(492) SIMAP similar genes for ZNF577 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF577: view

Variants for ZNF577 Gene

Sequence variations from dbSNP and Humsavar for ZNF577 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs9807853 - 51,872,919(+) CATTC(A/T)CTGCA intron-variant, reference, missense
rs17856123 - 51,877,314(+) CTTCT(A/G)CTATC nc-transcript-variant, reference, missense
rs17849895 - 51,873,623(+) GTCAC(A/G)CTTGA intron-variant, reference, missense
rs9807847 - 51,873,289(+) GGGTT(C/T)TCTGA intron-variant, reference, missense
rs2288868 - 51,873,254(+) GCATT(C/T)GCTGC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF577 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990
dgv1113e1 CNV Complex 17122850
nsv912298 CNV Loss 21882294

Variation tolerance for ZNF577 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.64; 91.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF577 Gene

HapMap Linkage Disequilibrium report
ZNF577
Human Gene Mutation Database (HGMD)
ZNF577

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF577 Gene

Disorders for ZNF577 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF577 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemorrhagic thrombocythemia
  • essential thrombocythaemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF577

Human Genome Epidemiology (HuGE) Navigator
ZNF577
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF577
genes like me logo Genes that share disorders with ZNF577: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF577 Gene

Publications for ZNF577 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3
  4. Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. (PMID: 21424380) Sehrawat B. … Damaraju S. (Hum. Genet. 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF577 Gene

Sources for ZNF577 Gene

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