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Aliases for ZNF577 Gene

Aliases for ZNF577 Gene

  • Zinc Finger Protein 577 2 3 5

External Ids for ZNF577 Gene

Previous GeneCards Identifiers for ZNF577 Gene

  • GC19M057067
  • GC19M057069
  • GC19M052359
  • GC19M048689
  • GC19M051855

Summaries for ZNF577 Gene

GeneCards Summary for ZNF577 Gene

ZNF577 (Zinc Finger Protein 577) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF350.

UniProtKB/Swiss-Prot for ZNF577 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF577 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF577 Gene

Genomics for ZNF577 Gene

Regulatory Elements for ZNF577 Gene

Enhancers for ZNF577 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H051687 1.8 FANTOM5 ENCODE dbSUPER 83.1 +200.5 200460 6 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF207 ZNF143 SP3 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ZNF175 ENSG00000269825 ZNF836 ENSG00000268970
GH19H051393 1.5 FANTOM5 ENCODE 80.3 +495.9 495903 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 ZNF143 FOS SP3 ZNF577 ZNF766 ZNF841 ZNF616 ZNF175 ZNF432 ZNF836 ZNF613 ZNF614 SPACA6P-AS
GH19H051360 1.7 Ensembl ENCODE dbSUPER 34.1 +526.0 526007 8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D ZNF175 ZNF577 ZNF766 ZNF836 ZNF841 ZNF616 LOC100419835 ZNF614 ZNF350 ZNF649
GH19H052137 1.4 FANTOM5 ENCODE 38.2 -248.7 -248682 3 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 ZNF137P ZNF160 ZNF808 ENSG00000268970 ZNF600 ZNF350 ZNF816 ZNF836 ZNF577 ZNF841
GH19H051784 1.5 Ensembl ENCODE dbSUPER 32.9 +105.0 104963 3 PKNOX1 ATF1 TCF12 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 JUNB FPR3 ZNF577 ZNF175 ZNF841 ZNF137P ZNF616 ZNF432 ZNF649 ZNF578 ZNF766
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF577 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF577 gene promoter:

Genomic Location for ZNF577 Gene

Chromosome:
19
Start:
51,804,816 bp from pter
End:
51,890,950 bp from pter
Size:
86,135 bases
Orientation:
Minus strand

Genomic View for ZNF577 Gene

Genes around ZNF577 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF577 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF577 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF577 Gene

Proteins for ZNF577 Gene

  • Protein details for ZNF577 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSK1-ZN577_HUMAN
    Recommended name:
    Zinc finger protein 577
    Protein Accession:
    Q9BSK1
    Secondary Accessions:
    • A8K0B4
    • A8K6Z7
    • C9JFB9

    Protein attributes for ZNF577 Gene

    Size:
    485 amino acids
    Molecular mass:
    54939 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH04992.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF82168.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW72049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF577 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF577 Gene

Post-translational modifications for ZNF577 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF577 Gene

Domains & Families for ZNF577 Gene

Gene Families for ZNF577 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF577 Gene

Suggested Antigen Peptide Sequences for ZNF577 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSK1

UniProtKB/Swiss-Prot:

ZN577_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF577: view

Function for ZNF577 Gene

Molecular function for ZNF577 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF577 Gene

Gene Ontology (GO) - Molecular Function for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF577: view

Phenotypes for ZNF577 Gene

GenomeRNAi human phenotypes for ZNF577:
genes like me logo Genes that share phenotypes with ZNF577: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF577
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF577 Gene

Localization for ZNF577 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF577 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF577 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF577: view

Pathways & Interactions for ZNF577 Gene

SuperPathways for ZNF577 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF577: view

Pathways by source for ZNF577 Gene

2 Reactome pathways for ZNF577 Gene

Gene Ontology (GO) - Biological Process for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF577: view

No data available for SIGNOR curated interactions for ZNF577 Gene

Drugs & Compounds for ZNF577 Gene

No Compound Related Data Available

Transcripts for ZNF577 Gene

Unigene Clusters for ZNF577 Gene

Zinc finger protein 577:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF577
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF577 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for ZNF577 Gene

GeneLoc Exon Structure for
ZNF577
ECgene alternative splicing isoforms for
ZNF577

Expression for ZNF577 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF577 Gene

Protein differential expression in normal tissues from HIPED for ZNF577 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF577 Gene



Protein tissue co-expression partners for ZNF577 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF577 Gene:

ZNF577

SOURCE GeneReport for Unigene cluster for ZNF577 Gene:

Hs.729135

Evidence on tissue expression from TISSUES for ZNF577 Gene

  • Nervous system(4.4)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF577: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF577 Gene

Orthologs for ZNF577 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF577 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF577 33 34
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia ZNF577 33
  • 85 (n)
-- 34
  • 68 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF577 33
  • 76.95 (n)
Species where no ortholog for ZNF577 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF577 Gene

ENSEMBL:
Gene Tree for ZNF577 (if available)
TreeFam:
Gene Tree for ZNF577 (if available)

Paralogs for ZNF577 Gene

Paralogs for ZNF577 Gene

(492) SIMAP similar genes for ZNF577 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF577: view

Variants for ZNF577 Gene

Sequence variations from dbSNP and Humsavar for ZNF577 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000019335 -- 51,869,944(+) AACAC(C/T)GGGTA intron-variant
rs1000051189 -- 51,875,934(+) AGACG(C/T)AGAAC intron-variant
rs1000062805 -- 51,863,593(+) AGCAA(A/C)TTGGT intron-variant
rs1000101388 -- 51,875,678(+) TATAT(A/G)TGGAC intron-variant
rs1000233164 -- 51,858,754(+) ATTCA(C/G)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF577 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644680 CNV gain 21293372
esv3644682 CNV gain 21293372
nsv1063362 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv458733 CNV gain 19166990
nsv470151 CNV gain 18288195
nsv579997 CNV gain 21841781
nsv580001 CNV gain 21841781
nsv580005 CNV loss 21841781

Variation tolerance for ZNF577 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.64; 91.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF577 Gene

Human Gene Mutation Database (HGMD)
ZNF577
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF577

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF577 Gene

Disorders for ZNF577 Gene

Relevant External Links for ZNF577

Human Genome Epidemiology (HuGE) Navigator
ZNF577
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF577

No disorders were found for ZNF577 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF577 Gene

Publications for ZNF577 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J … Elledge SJ (Nature biotechnology 2013) 3 60
  5. Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. (PMID: 21424380) Sehrawat B … Damaraju S (Human genetics 2011) 3 60

Products for ZNF577 Gene

Sources for ZNF577 Gene

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