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ZNF576 Gene

protein-coding   GIFtS: 42
GCID: GC19P044100

Zinc Finger Protein 576

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5761 2

External Ids:    HGNC: 283571   Entrez Gene: 791772   Ensembl: ENSG000001244447   UniProtKB: Q9H6093   

Export aliases for ZNF576 gene to outside databases

Previous GC identifers: GC19P048793 GC19P048794 GC19P040531


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF576 Gene:
ZNF576 (zinc finger protein 576) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity.

UniProtKB/Swiss-Prot: ZN576_HUMAN, Q9H609
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF576 gene promoter:
         STAT1   COMP1   c-Myb   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF576 promoter sequence
   Search Chromatin IP Primers for ZNF576

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF576


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

ZNF576 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF576 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044100:  view genomic region     (about GC identifiers)

Start:
44,100,544 bp from pter      End:
44,105,309 bp from pter
Size:
4,766 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN576_HUMAN, Q9H609 (See protein sequence)
Recommended Name: Zinc finger protein 576  
Size: 170 amino acids; 18890 Da
Caution: Overlaps in opposite strand with ZNF428
Secondary accessions: Q9BU03

Explore the universe of human proteins at neXtProt for ZNF576: NX_Q9H609

Explore proteomics data for ZNF576 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF576 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138819.1  NP_077303.1  

    ENSEMBL proteins: 
     ENSP00000375827   ENSP00000436182   ENSP00000435899   ENSP00000435934   ENSP00000435463  
     ENSP00000337852  

    ZNF576 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H609

    ProtoNet protein and cluster: Q9H609

    UniProtKB/Swiss-Prot: ZN576_HUMAN, Q9H609
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    Find genes that share domains with ZNF576           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN576_HUMAN, Q9H609
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF576           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ZNF576:
     Decreased viability with pacli  Increased 8N DNA content  Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF576

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    8 qRT-PCR Assays for microRNAs that regulate ZNF576:
    hsa-miR-4314 hsa-miR-1184 hsa-miR-2117 hsa-miR-324-3p hsa-miR-4297 hsa-miR-548s hsa-miR-548u hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF576 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN576_HUMAN, Q9H609: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    Find genes that share ontologies with ZNF576           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF576
    Interactions:

        Search GeneGlobe Interaction Network for ZNF576

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF576 (ENSP000003378524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARGENSP000003326954STRING: ENSP00000332695
    SUOXENSP000002669714STRING: ENSP00000266971
    --ENSP000002027884STRING: ENSP00000202788
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with ZNF576           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF576 (ZN576)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF576 gene (2 alternative transcripts): 
    NM_001145347.1  NM_024327.2  

    Unigene Cluster for ZNF576:

    Zinc finger protein 576
    Hs.11110  [show with all ESTs]
    Unigene Representative Sequence: NM_024327
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391965 ENST00000525771(uc002owy.2) ENST00000533118 ENST00000528387
    ENST00000529930 ENST00000336564(uc002owz.2) ENST00000595041
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ZNF576:
    hsa-miR-4314 hsa-miR-1184 hsa-miR-2117 hsa-miR-324-3p hsa-miR-4297 hsa-miR-548s hsa-miR-548u hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF576 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF576

    Additional mRNA sequence: 

    AK026353.1 BC002981.1 

    4 DOTS entries:

    DT.95161447  DT.214639  DT.100721099  DT.100738878 

    Selected AceView cDNA sequences (see all 100):

    CR621953 BM771408 CK819102 NM_024327 AI570403 AI554959 BM790812 AA622028 
    BQ931210 BM127725 AK026353 AI671509 BX098285 AI074089 CB306065 CA415407 
    CA867529 CA943543 BM127772 AI299572 AW237825 BM903643 CK819103 AW573295 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF576 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c · 3d
    SP1:                    -     -     -     -           -                           
    SP2:                    -     -     -     -           -                           
    SP3:                                      -           -                           
    SP4:                                                  -                           
    SP5:                                                  -                           


    ECgene alternative splicing isoforms for ZNF576

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF576 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGGGGTG
    ZNF576 Expression
    About this image

    ZNF576 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF576 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11110
        Custom PCR Arrays for ZNF576
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF576 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5761 zinc finger protein 576 89.02(n)
    84.71(a)
      484467  XM_541581.4  XP_541581.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF576 (1 of 2)6
    ZNF576 (2 of 2)6
    zinc finger protein 576
    22(a)
    2(a)
    many → 1
    many → 1
    16(27402724-27409126) ENSDARG00000078164
    16(27376764-27402493) ENSDARG00000097819


    ENSEMBL Gene Tree for ZNF576 (if available)
    TreeFam Gene Tree for ZNF576 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF576 (see all 57)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3047231,2
    C,F,A,H--44102338(+) gacagC/Tattca 2 -- int125Minor allele frequency- T:0.24NS EA NA WA CSA 2357
    rs1876916281,2
    --44102526(+) TAGTCA/GTAATT 2 -- int10--------
    rs1112583501,2
    C--44102569(+) TCCAAC/TGGTCC 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1913745651,2
    C--44102967(+) CCTCTA/CCCCCA 2 -- int10--------
    rs783245091,2
    C,F--44102970(+) CTCCCC/TCACAT 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1119983261,2
    C,F--44102977(+) ACATTC/TCTCAG 2 -- int13Minor allele frequency- T:0.06CSA WA 122
    rs22409321,2
    C,F,H--44103010(+) CACCCG/ACTGCC 4 /H /R mis1 ese314Minor allele frequency- A:0.00EA NS NA 6120
    rs178497051,2,,4
    C,F--44103139(+) CTTCCC/TCTCCT 4 P L mis1 trp35Minor allele frequency- T:0.04NS WA NA 5116
    rs115426701,2
    C,F--44103164(+) ACCCAC/TCAGCG 4 H syn1 ese35Minor allele frequency- T:0.02NA EA 864
    rs2013972151,2
    --44103177(+) GCCACA/GGTCCA 4 S G mis10--------

    HapMap Linkage Disequilibrium report for ZNF576 (44100544 - 44105309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF576:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833839CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF576
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF576

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF576 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF576)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79177 HGNC: 28357 AceView: ZNF576 Ensembl:ENSG00000124444 euGenes: HUgn79177
    ECgene: ZNF576 H-InvDB: ZNF576

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF576 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF576 gene:
    Search GeneIP for patents involving ZNF576

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    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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