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Aliases for ZNF575 Gene

Aliases for ZNF575 Gene

  • Zinc Finger Protein 575 2 3 5

External Ids for ZNF575 Gene

Previous GeneCards Identifiers for ZNF575 Gene

  • GC19P048730
  • GC19P048731
  • GC19P044030
  • GC19P040468

Summaries for ZNF575 Gene

GeneCards Summary for ZNF575 Gene

ZNF575 (Zinc Finger Protein 575) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF575 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF575 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF575 Gene

Genomics for ZNF575 Gene

GeneHancer (GH) Regulatory Elements for ZNF575 Gene

Promoters and enhancers for ZNF575 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043524 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.1 1129 4.3 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 ZNF207 ZNF143 ETHE1 ZNF575 ZNF180 ZNF45 ZNF225 ZNF155 ZNF227 ZNF224 ZNF223 ZNF230
GH19I043532 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 594.8 +8.1 8069 2.9 HDGF PKNOX1 SIN3A ZNF2 YY1 POLR2B ZNF213 E2F8 ZNF207 ZNF143 ZNF575 ZNF45 ZNF180 ZNF224 ZNF155 ZNF225 XRCC1 ZNF234 ZNF227 ZNF223
GH19I043574 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 43.6 +50.2 50167 2.7 HDGF SMAD1 ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF207 ZNF143 XRCC1 ENSG00000269583 PINLYP ZNF575 ZNF180 ZNF155 ZNF224 ZNF45 ZNF230 ZNF234
GH19I043560 Enhancer 1.4 FANTOM5 Ensembl ENCODE 55.4 +37.2 37177 3.9 KLF17 RAD21 ZBTB40 ZNF23 GLIS2 ATF7 ZNF391 FOS IKZF2 RUNX3 ZNF575 ZNF576 ZNF235 ZNF227 ZNF226 ZNF223 IRGQ ETHE1 PLAUR SRRM5
GH19I043579 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 42.3 +55.4 55414 2.2 POLR2A FOXK2 BHLHE40 ZBTB33 PRDM10 PINLYP XRCC1 ZNF575 ETHE1 GC19M043585 ENSG00000268361
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF575 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF575 gene promoter:

Genomic Locations for ZNF575 Gene

Genomic Locations for ZNF575 Gene
chr19:43,525,497-43,536,138
(GRCh38/hg38)
Size:
10,642 bases
Orientation:
Plus strand
chr19:44,029,649-44,040,290
(GRCh37/hg19)

Genomic View for ZNF575 Gene

Genes around ZNF575 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF575 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF575 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF575 Gene

Proteins for ZNF575 Gene

  • Protein details for ZNF575 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XF7-ZN575_HUMAN
    Recommended name:
    Zinc finger protein 575
    Protein Accession:
    Q86XF7
    Secondary Accessions:
    • B4DX54

    Protein attributes for ZNF575 Gene

    Size:
    245 amino acids
    Molecular mass:
    26763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF575 Gene

Post-translational modifications for ZNF575 Gene

No Post-translational modifications

Other Protein References for ZNF575 Gene

No data available for DME Specific Peptides for ZNF575 Gene

Domains & Families for ZNF575 Gene

Gene Families for ZNF575 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF575 Gene

Suggested Antigen Peptide Sequences for ZNF575 Gene

Graphical View of Domain Structure for InterPro Entry

Q86XF7

UniProtKB/Swiss-Prot:

ZN575_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF575: view

Function for ZNF575 Gene

Molecular function for ZNF575 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF575 Gene

Gene Ontology (GO) - Molecular Function for ZNF575 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF575: view
genes like me logo Genes that share phenotypes with ZNF575: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF575 Gene

Localization for ZNF575 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF575 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF575 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF575 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF575: view

Pathways & Interactions for ZNF575 Gene

SuperPathways for ZNF575 Gene

No Data Available

Interacting Proteins for ZNF575 Gene

Gene Ontology (GO) - Biological Process for ZNF575 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF575: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF575 Gene

Drugs & Compounds for ZNF575 Gene

No Compound Related Data Available

Transcripts for ZNF575 Gene

Unigene Clusters for ZNF575 Gene

Zinc finger protein 575:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF575 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for ZNF575 Gene

GeneLoc Exon Structure for
ZNF575
ECgene alternative splicing isoforms for
ZNF575

Expression for ZNF575 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF575 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF575 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF575 Gene:

ZNF575

SOURCE GeneReport for Unigene cluster for ZNF575 Gene:

Hs.213534

Evidence on tissue expression from TISSUES for ZNF575 Gene

  • Pancreas(4)
genes like me logo Genes that share expression patterns with ZNF575: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF575 Gene

Orthologs for ZNF575 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF575 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF575 33 34
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia ZNF575 33 34
  • 88.39 (n)
dog
(Canis familiaris)
Mammalia ZNF575 33 34
  • 88.16 (n)
mouse
(Mus musculus)
Mammalia Zfp575 33 16 34
  • 84.66 (n)
rat
(Rattus norvegicus)
Mammalia Zfp575 33
  • 83.26 (n)
Species where no ortholog for ZNF575 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF575 Gene

ENSEMBL:
Gene Tree for ZNF575 (if available)
TreeFam:
Gene Tree for ZNF575 (if available)

Paralogs for ZNF575 Gene

(201) SIMAP similar genes for ZNF575 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF575: view

No data available for Paralogs for ZNF575 Gene

Variants for ZNF575 Gene

Sequence variations from dbSNP and Humsavar for ZNF575 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000369944 -- 43,534,869(+) G/A intron_variant
rs1000559241 -- 43,533,554(+) G/A intron_variant
rs1001165854 -- 43,532,591(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001858346 -- 43,530,310(+) C/T upstream_transcript_variant
rs1001890979 -- 43,533,344(+) G/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF575 Gene

Variant ID Type Subtype PubMed ID
dgv3603n100 CNV gain 25217958
nsv1056785 CNV gain 25217958
nsv1057657 CNV gain 25217958

Variation tolerance for ZNF575 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF575 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF575

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF575 Gene

Disorders for ZNF575 Gene

Additional Disease Information for ZNF575

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF575 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF575 Gene

Publications for ZNF575 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF575 Gene

Sources for ZNF575 Gene

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