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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF575 Gene

protein-coding GIFtS: 41
GCID: GC19P044030

zinc finger protein 575

Search for ZNF575
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 575¹ ²
FLJ32567¹

External Ids:	HGNC: 27606¹	Entrez Gene: 284346²	Ensembl: ENSG00000176472⁷	UniProtKB: Q86XF7³

Export aliases for ZNF575 gene to outside databases

Previous GC identifers: GC19P048730 GC19P048731 GC19P040468

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN575_HUMAN, Q86XF7

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF575 gene promoter:
TBP Sp1 Pax-2 AP-2gamma GATA-1 AREB6 TFIID AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF575 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF575

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF575

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31 Ensembl cytogenetic band: 19q13.31 HGNC chromosome: 19

ZNF575 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF575 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P044030: view genomic region (about GC identifiers)

Start:	44,029,649 bp from pter	End:	44,040,290 bp from pter
Size:	10,642 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN575_HUMAN, Q86XF7 (See protein sequence)

Recommended Name: Zinc finger protein 575

Size: 245 amino acids; 26763 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: B4DX54

Explore the universe of human proteins at neXtProt for ZNF575: NX_Q86XF7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86XF7

ZNF575 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_777605.1

ENSEMBL proteins:

ENSP00000413956 ENSP00000315870

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF575 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF575 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q86XF7

ProtoNet protein and cluster: Q86XF7

UniProtKB/Swiss-Prot: ZN575_HUMAN, Q86XF7

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 6 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN575_HUMAN, Q86XF7

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF575 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF575

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF575 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF575
Search CenterWatch for drugs/clinical trials and news about ZNF575 / ZN575

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF575 gene:

NM_174945.2

Unigene Cluster for ZNF575:

Zinc finger protein 575

Hs.213534 [show with all ESTs]

Unigene Representative Sequence: AK057129

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000458714(uc002owq.3) ENST00000314228(uc002ows.3)

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Additional cDNA sequence:

AK057129.1 AK301820.1 BC043611.1

4 DOTS entries:

DT.97817051 DT.121435266 DT.40188749 DT.97784521

20 AceView cDNA sequences:

BC043611 CR597282 NM_174945 AI917012 AK057129 BF942142 BX423260 BQ224873

AW135286 AL534128 BX423259 BM926599 AA062878 AL565389 AW844792 AW844786

AW384847 BI755820 BQ320326 BI116653

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF575 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b
SP1:
SP2:							-

ECgene alternative splicing isoforms for ZNF575

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF575 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGTGAAAA

About this image
See ZNF575 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF575

SOURCE GeneReport for Unigene cluster: Hs.213534

SABiosciences Custom PCR Arrays for ZNF575

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for ZNF575 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp575^{1 , 5}	zinc finger protein 575^{1, 5}	84.66(n)¹ 84.52(a)¹		7 (11.63 cM)⁵ 101544¹ NM_001033205.3¹ NP_001028377.1¹ 24583838⁵

ENSEMBL Gene Tree for ZNF575 (if available)
TreeFam Gene Tree for ZNF575 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF575 gene

ZNF768² ZNF581² ZNF787² ZNF358² ZNF524² ZNF580² ZNF70²

18/233 SIMAP similar genes for ZNF575 using alignment to 3 protein entries: ZN575_HUMAN (see all proteins) (see all similar genes):

ZFS-6 ZNF56 ZNF586 ZNF78L1 HZF16 ZFS-1

ZNF10 ZNF286A ZNF286B ZNF43 ZNF72 ZNF737

ZNF85 kr-znf3 DKFZp686B16128 HKR1 HZF17 MST154

ZNF575 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185450325^1,2		--	44035383(+)	`GGTTAC/GAGTGG`	1	--	us2k¹		0	--	--	--	--
rs139609299^1,2		--	44035399(+)	`TATCTC/TGCCAC`	1	--	us2k¹		0	--	--	--	--
rs190162346^1,2		--	44035469(+)	`AGTGGC/GTCACC`	1	--	us2k¹		0	--	--	--	--
rs182845987^1,2		--	44035637(+)	`GCTGAA/GGCAGG`	1	--	us2k¹		0	--	--	--	--
rs187483862^1,2		--	44035692(+)	`TTGCGC/TCACTG`	1	--	us2k¹		0	--	--	--	--
rs150839729^1,2	C,	--	44035741(+)	`AAAAA-/AGAG AGAGA`	1	--	us2k¹		0	--	--	--	--
rs202185269^1,2	C	--	44035744(-)	`TCTCTC/TTCTTT`	1	--	us2k¹		0	--	--	--	--
rs192919542^1,2		--	44035758(+)	`AGACCA/GAAGTG`	1	--	us2k¹		0	--	--	--	--
rs183865650^1,2		--	44035762(+)	`CGAAGG/TGTCAC`	1	--	us2k¹		0	--	--	--	--
rs188863972^1,2		--	44035903(+)	`GTAAAC/TCAAAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF575 (44029649 - 44040290 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF575: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF575 for disorders About MalaCards

ZNF575 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: ZNF575 (1 document)

Export disorders for ZNF575 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF575 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF575)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)¹ Hosgood H.D....Lan Q. (2009)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284346	HGNC: 27606	AceView: ZNF575	Ensembl:ENSG00000176472	euGenes: HUgn284346
ECgene: ZNF575	H-InvDB: ZNF575

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF575	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF575 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF575 gene:
Search GeneIP for patents involving ZNF575

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	SwitchGear Promoter luciferase reporter plasmids for ZNF575

Search ThermoFisher Antibodies for ZNF575

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF575

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF575 gene at Home site.

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ZNF575 Gene

zinc finger protein 575

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ZNF575 Gene

zinc finger protein 575

Aliasesfor ZNF575 gene

Summariesfor ZNF575 gene

Genomic Viewsfor ZNF575 gene

Proteinsfor ZNF575 gene

Protein Domains /Familiesfor ZNF575 gene

Functionfor ZNF575 gene

Pathways & Interactionsfor ZNF575 gene

Drugs & Compoundsfor ZNF575 gene

Transcriptsfor ZNF575 gene

Expression for ZNF575 gene

Orthologsfor ZNF575 gene

Paralogsfor ZNF575 gene

Genomic Variantsfor ZNF575 gene

Disorders / Diseasesfor ZNF575 gene

Publicationsfor ZNF575 gene

External Searches for ZNF575 gene

Genome Databases showing ZNF575 gene

Other Databases showing ZNF575 gene

Specialized Databases showing ZNF575 gene

Intellectual Propertyfor ZNF575 gene

Productsfor ZNF575 gene

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Aliases
for ZNF575 gene

Summaries
for ZNF575 gene

Genomic Views
for ZNF575 gene

Proteins
for ZNF575 gene

Protein Domains /
Families
for ZNF575 gene

Function
for ZNF575 gene

Pathways & Interactions
for ZNF575 gene

Drugs & Compounds
for ZNF575 gene

Transcripts
for ZNF575 gene

Expression
for ZNF575 gene

Orthologs
for ZNF575 gene

Paralogs
for ZNF575 gene

Genomic Variants
for ZNF575 gene

Disorders / Diseases
for ZNF575 gene

Publications
for ZNF575 gene

Intellectual Property
for ZNF575 gene

Products
for ZNF575 gene