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Aliases for ZNF574 Gene

Aliases for ZNF574 Gene

  • Zinc Finger Protein 574 2 3 5
  • FP972 3

External Ids for ZNF574 Gene

Previous GeneCards Identifiers for ZNF574 Gene

  • GC19P047273
  • GC19P047264
  • GC19P042572
  • GC19P039012

Summaries for ZNF574 Gene

GeneCards Summary for ZNF574 Gene

ZNF574 (Zinc Finger Protein 574) is a Protein Coding gene. An important paralog of this gene is ZNF526.

UniProtKB/Swiss-Prot for ZNF574 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF574 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF574 Gene

Genomics for ZNF574 Gene

Regulatory Elements for ZNF574 Gene

Enhancers for ZNF574 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H041294 2.1 FANTOM5 Ensembl ENCODE dbSUPER 94.3 -765.2 -765181 16.8 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZNF526 HNRNPUL1 SNRPA ENSG00000269843 ZNF574 CCDC97 COQ8B TGFB1 AXL ITPKC
GH19H041261 1.8 FANTOM5 ENCODE dbSUPER 71.3 -803.6 -803628 7.3 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 ZNF526 ZNF574 HNRNPUL1 SNRPA CCDC97 ENSG00000269843 CYP2F2P NUMBL ENSG00000271299 CYP2G2P
GH19H041348 1.4 ENCODE dbSUPER 89.2 -716.9 -716864 6.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF143 ZNF207 SP3 ZNF574 ZNF526 SNRPA HNRNPUL1 CCDC97 ENSG00000269843 COQ8B ITPKC CIC CYP2G1P
GH19H042276 1.8 FANTOM5 ENCODE dbSUPER 66.8 +213.4 213437 11.1 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B ZNF416 ZNF143 ZNF526 ZNF574 MEGF8 CCDC97 CEACAMP1 CEACAMP10 CIC PSG6 GRIK5 DEDD2
GH19H042267 1.9 FANTOM5 ENCODE dbSUPER 56.3 +202.4 202411 6.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YBX1 ZBTB7B YY1 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PAFAH1B3 PRR19 GSK3A TMEM145
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF574 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF574 Gene

Genomic Locations for ZNF574 Gene
chr19:42,068,477-42,081,567
(GRCh38/hg38)
Size:
13,091 bases
Orientation:
Plus strand
chr19:42,572,629-42,585,719
(GRCh37/hg19)

Genomic View for ZNF574 Gene

Genes around ZNF574 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF574 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF574 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF574 Gene

Proteins for ZNF574 Gene

  • Protein details for ZNF574 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN55-ZN574_HUMAN
    Recommended name:
    Zinc finger protein 574
    Protein Accession:
    Q6ZN55
    Secondary Accessions:
    • Q6IPE0
    • Q6ZN10
    • Q7L5Z5
    • Q8NCE3
    • Q9H6N0

    Protein attributes for ZNF574 Gene

    Size:
    896 amino acids
    Molecular mass:
    98900 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF574 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF574 Gene

Post-translational modifications for ZNF574 Gene

  • Ubiquitination at Lys405 and Lys558
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF574 Gene

Domains & Families for ZNF574 Gene

Gene Families for ZNF574 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF574 Gene

Suggested Antigen Peptide Sequences for ZNF574 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZN55

UniProtKB/Swiss-Prot:

ZN574_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF574: view

Function for ZNF574 Gene

Molecular function for ZNF574 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF574 Gene

Gene Ontology (GO) - Molecular Function for ZNF574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF574: view
genes like me logo Genes that share phenotypes with ZNF574: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF574 Gene

Localization for ZNF574 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF574 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF574 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF574: view

Pathways & Interactions for ZNF574 Gene

SuperPathways for ZNF574 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF574: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF574 Gene

Drugs & Compounds for ZNF574 Gene

No Compound Related Data Available

Transcripts for ZNF574 Gene

Unigene Clusters for ZNF574 Gene

Zinc finger protein 574:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF574 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2:
SP3: - - - -
SP4: - - -

Relevant External Links for ZNF574 Gene

GeneLoc Exon Structure for
ZNF574
ECgene alternative splicing isoforms for
ZNF574

Expression for ZNF574 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF574 Gene

Protein differential expression in normal tissues from HIPED for ZNF574 Gene

This gene is overexpressed in Lung (42.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF574 Gene



Protein tissue co-expression partners for ZNF574 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF574 Gene:

ZNF574

SOURCE GeneReport for Unigene cluster for ZNF574 Gene:

Hs.13323

Evidence on tissue expression from TISSUES for ZNF574 Gene

  • Nervous system(4.7)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with ZNF574: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF574 Gene

Orthologs for ZNF574 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF574 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF574 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF574 33 34
  • 89.77 (n)
dog
(Canis familiaris)
Mammalia ZNF574 33 34
  • 88.04 (n)
mouse
(Mus musculus)
Mammalia Zfp574 33 16 34
  • 87.6 (n)
rat
(Rattus norvegicus)
Mammalia Zfp574 33
  • 87.46 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF574 34
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF574 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf574 33
  • 56.56 (n)
zebrafish
(Danio rerio)
Actinopterygii znf574 34
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G8AL.10 34
  • 14 (a)
OneToMany
Species where no ortholog for ZNF574 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF574 Gene

ENSEMBL:
Gene Tree for ZNF574 (if available)
TreeFam:
Gene Tree for ZNF574 (if available)

Paralogs for ZNF574 Gene

Variants for ZNF574 Gene

Sequence variations from dbSNP and Humsavar for ZNF574 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000238800 -- 42,068,839(+) ACGGG(A/G)TGGGG intron-variant, reference, missense
rs1000480941 -- 42,081,351(+) CCTCC(A/G)GCATC utr-variant-3-prime
rs1000571702 -- 42,069,746(+) GGGCC(A/G)CCCCC intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1000800980 -- 42,075,327(+) AAGGA(A/G)GTGGA intron-variant, upstream-variant-2KB
rs1000853440 -- 42,075,577(+) AGTCT(G/T)GAACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF574 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV gain 19592680
nsv520239 CNV loss 19592680
nsv474593 CNV novel sequence insertion 20440878
esv25421 CNV loss 19812545

Variation tolerance for ZNF574 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF574 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF574

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF574 Gene

Disorders for ZNF574 Gene

Relevant External Links for ZNF574

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF574

No disorders were found for ZNF574 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF574 Gene

Publications for ZNF574 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ZNF574 Gene

Sources for ZNF574 Gene

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