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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF574 Gene

protein-coding   GIFtS: 45
GCID: GC19P042572

Zinc Finger Protein 574

  Search for ZNF574
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5741 2
FP9722

External Ids:    HGNC: 261661   Entrez Gene: 647632   Ensembl: ENSG000001057327   UniProtKB: Q6ZN553   

Export aliases for ZNF574 gene to outside databases

Previous GC identifers: GC19P047273 GC19P047264 GC19P039012


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF574 Gene: 
ZNF574 (zinc finger protein 574) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF526.

UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF574 gene promoter:
         E2F-3a   c-Fos   AP-1   ATF-2   E2F-2   E2F-1   E2F   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF574

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF574


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

ZNF574 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF574 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042572:  view genomic region     (about GC identifiers)

Start:
42,572,629 bp from pter      End:
42,585,719 bp from pter
Size:
13,091 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55 (See protein sequence)
Recommended Name: Zinc finger protein 574  
Size: 896 amino acids; 98900 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q6IPE0 Q6ZN10 Q7L5Z5 Q8NCE3 Q9H6N0
Alternative splicing: 2 isoforms:  Q6ZN55-1   Q6ZN55-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF574: NX_Q6ZN55

Explore proteomics data for ZNF574 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZN55

  • ZNF574 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF574 Protein Expression
    REFSEQ proteins: NP_073589.4  
    ENSEMBL proteins: 
     ENSP00000222339   ENSP00000469029   ENSP00000471611   ENSP00000351939  

    Human Recombinant Protein Products for ZNF574: 
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    Novus Biologicals ZNF574 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF574 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF574 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ZNF574 
    Cloud-Clone Corp. CLIAs for ZNF574


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZN55

    ProtoNet protein and cluster: Q6ZN55

    UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers


    ZNF574 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN574_HUMAN, Q6ZN55
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF574 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF574:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF574 
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    miRNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF574


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF574

    2 Interacting proteins for ZNF574 (Q6ZN553) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL2O146413I2D: score=1 
    DVL3Q929973I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF574 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF574 (ZN574)

    Search CenterWatch for drugs/clinical trials and news about ZNF574 / ZN574

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF574 gene: 
    NM_022752.5  

    Unigene Cluster for ZNF574:

    Zinc finger protein 574
    Hs.13323  [show with all ESTs]
    Unigene Representative Sequence: AK131418
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222339(uc002osk.4) ENST00000600245 ENST00000597391 ENST00000359044(uc002osm.4)

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF574
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF574
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF574
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    Primer
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    Additional mRNA sequence: 

    AF447880.1 AK025712.1 AK027895.1 AK074788.1 AK131369.1 AK131418.1 AK225342.1 AL137516.1 
    BC001184.1 BC071962.1 

    11 DOTS entries:

    DT.97771992  DT.312938  DT.101956598  DT.121475357  DT.95283997  DT.121475352  DT.100685920  DT.100766655 
    DT.91908495  DT.95312980  DT.97841960 

    24/168 AceView cDNA sequences (see all 168):

    BU856963 CA487471 AK131418 BQ716329 BQ058894 BC001184 AK025712 CD557618 
    BU173019 BU956381 BE328004 BC071962 BM128439 CA428243 AK131369 BE796894 
    AL558191 BM128274 BU153121 AA291767 CF528918 BU155902 BM997670 AA312445 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF574    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                          -                           
    SP2:                                                      
    SP3:        -     -     -     -                           
    SP4:              -     -     -                           


    ECgene alternative splicing isoforms for ZNF574

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF574 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACTGCTG
    ZNF574 Expression
    About this image


    See ZNF574 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF574

    SOURCE GeneReport for Unigene cluster: Hs.13323
        SABiosciences Custom PCR Arrays for ZNF574
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF574

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF574 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5741 , 5 zinc finger protein 5741, 5 88.08(n)1
    94.19(a)1
      7 (13.73 cM)5
    2329761  NM_001168506.11  NP_001161978.11 
     250772055 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF5746
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343909.1(121519-124272)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056027.12   -- 72.58(n)    BC056027.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5660711 zinc finger protein 574-like 47.71(n)
    39.16(a)
      566071  XM_689335.5  XP_694427.4 


    ENSEMBL Gene Tree for ZNF574 (if available)
    TreeFam Gene Tree for ZNF574 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF574 gene
    ZNF5262  
    18/62 SIMAP similar genes for ZNF574 using alignment to 2 protein entries:     ZN574_HUMAN (see all proteins) (see all similar genes):
    DKFZp564M2178    FP972    ZNF78L1    ZNF818P    ZNF    ZNF808
    DKFZp434J0650    ZFS-2    ZNF72    ZNF697    ZNF323    ZNF844
    ZNF702P    ZNF833P    ZNF22    ZNF514    ZNF600    ZNF740

    ZNF574 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/235 SNPs in ZNF574 are shown (see all 235)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433712031,2
    --42578417(+) TCCTGA/GCCAAC 1 -- us2k10--------
    rs1806882301,2
    --42578487(+) CTGTAA/GTCACA 1 -- us2k10--------
    rs2000321311,2
    C--42578609(+) CTCAT-/AAATAA
    AATAAAATA
    AAATA
    1 -- us2k10--------
    rs1467024531,2
    C--42578652(+) TAAAAC/TAAAAA 1 -- us2k10--------
    rs777651451,2
    C,F--42578863(+) TGAGAA/GGGTTA 1 -- us2k12Minor allele frequency- G:0.04WA NA 238
    rs1865817891,2
    C--42579116(+) CTGCAA/GCCTCG 1 -- us2k10--------
    rs1909903461,2
    C--42579129(+) CTCCTC/GGGTGC 1 -- us2k10--------
    rs1831451881,2
    C--42579307(+) TGGGAC/TTGCAG 1 -- us2k10--------
    rs1866486571,2
    --42579430(+) GGACAC/TATGGG 1 -- us2k10--------
    rs1917222561,2
    --42579483(+) AGGTGC/GAGTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF574 (42572629 - 42585719 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF574:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520239CNV Loss19592680
    nsv911782CNV Loss21882294
    nsv911783CNV Loss21882294
    esv25421CNV Loss19812545
    nsv522854CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF574 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF574)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64763 HGNC: 26166 AceView: ZNF574 Ensembl:ENSG00000105732 euGenes: HUgn64763
    ECgene: ZNF574 H-InvDB: ZNF574

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF574 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF574 gene:
    Search GeneIP for patents involving ZNF574

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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