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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF574 Gene

protein-coding GIFtS: 45
GCID: GC19P042572

zinc finger protein 574

Search for ZNF574
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 574¹ ²
FLJ22059¹
FP972²

External Ids:	HGNC: 26166¹	Entrez Gene: 64763²	Ensembl: ENSG00000105732⁷	UniProtKB: Q6ZN55³

Export aliases for ZNF574 gene to outside databases

Previous GC identifers: GC19P047273 GC19P047264 GC19P039012

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF574 gene promoter:
E2F-3a c-Fos AP-1 ATF-2 E2F-2 E2F-1 E2F c-Jun
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZNF574

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF574

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC chromosome: 19

ZNF574 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF574 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P042572: view genomic region (about GC identifiers)

Start:	42,572,864 bp from pter	End:	42,585,719 bp from pter
Size:	12,856 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55 (See protein sequence)

Recommended Name: Zinc finger protein 574

Size: 896 amino acids; 98900 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: Q6IPE0 Q6ZN10 Q7L5Z5 Q8NCE3 Q9H6N0

Alternative splicing: 2 isoforms: Q6ZN55-1 Q6ZN55-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF574: NX_Q6ZN55

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZN55

ZNF574 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_073589.4

ENSEMBL proteins:

ENSP00000222339 ENSP00000351939

Human Recombinant Protein Products for ZNF574:

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	Uscn Proteins for ZNF574

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF574 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF574 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6ZN55

ProtoNet protein and cluster: Q6ZN55

UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 20 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN574_HUMAN, Q6ZN55

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF574 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ZNF574:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF574

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF574

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF574

2 Interacting proteins for ZNF574 (Q6ZN55³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DVL2	O14641³	I2D: score=1
DVL3	Q92997³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF574 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF574
Search CenterWatch for drugs/clinical trials and news about ZNF574 / ZN574

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF574 gene:

NM_022752.5

Unigene Cluster for ZNF574:

Zinc finger protein 574

Hs.13323 [show with all ESTs]

Unigene Representative Sequence: AK131418

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000222339(uc002osk.4) ENST00000359044(uc002osm.4)

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Additional cDNA sequence:

AF447880.1 AK025712.1 AK027895.1 AK074788.1 AK131369.1 AK131418.1 AK225342.1 AL137516.1

BC001184.1 BC071962.1

11 DOTS entries:

DT.97771992 DT.312938 DT.101956598 DT.121475357 DT.95283997 DT.121475352 DT.100685920 DT.100766655

DT.91908495 DT.95312980 DT.97841960

24/168 AceView cDNA sequences (see all 168):

BC071962 BE328004 CA487471 AK131418 BU899262 CB155888 NM_022752 BU155902

CA428243 BE796894 BE794806 BQ716329 BU153121 BM128439 BM128670 T27152

CD557618 BM128274 BQ058894 BQ896500 BU856963 CF528918 BE513290 BU173019

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF574 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d
SP1:									-
SP2:
SP3:			-		-		-		-
SP4:					-		-		-

ECgene alternative splicing isoforms for ZNF574

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF574 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGACTGCTG

About this image

ZNF574 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF574 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF574

SOURCE GeneReport for Unigene cluster: Hs.13323

SABiosciences Custom PCR Arrays for ZNF574

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF574 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ZNF574⁶	--	57(a)	1 ↔ 1	GL343909.1(121519-124272)
African clawed frog (Xenopus laevis)	Amphibia	BC056027.1²	--	72.58(n)		BC056027.1
zebrafish (Danio rerio)	Actinopterygii	LOC566071¹	zinc finger protein 574-like	47.71(n) 39.16(a)		566071 XM_689335.5 XP_694427.4
honey bee (Apis mellifera)	Insecta	--	--	12(a)	1 → many	GroupUn.402(17945-20623)

ENSEMBL Gene Tree for ZNF574 (if available)
TreeFam Gene Tree for ZNF574 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF574 gene

ZNF526²

18/77 SIMAP similar genes for ZNF574 using alignment to 2 protein entries: ZN574_HUMAN (see all proteins) (see all similar genes):

DKFZp564M2178 FP972 ZNF78L1 ZNF818P ZNF ZNF808

DKFZp434J0650 ZFS-2 ZNF72 ZNF697 ZNF323 ZNF844

ZNF702P ZNF833P ZNF22 ZNF514 ZNF600 ZNF740

ZNF574 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143371203^1,2		--	42578417(+)	`TCCTGA/GCCAAC`	1	--	us2k¹		0	--	--	--	--
rs180688230^1,2		--	42578487(+)	`CTGTAA/GTCACA`	1	--	us2k¹		0	--	--	--	--
rs146702453^1,2		--	42578652(+)	`TAAAAC/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs77765145^1,2	F	--	42578863(+)	`TGAGAA/GGGTTA`	1	--	us2k¹		2		WA NA	238
rs186581789^1,2		--	42579116(+)	`CTGCAA/GCCTCG`	1	--	us2k¹		0	--	--	--	--
rs190990346^1,2		--	42579129(+)	`CTCCTC/GGGTGC`	1	--	us2k¹		0	--	--	--	--
rs183145188^1,2		--	42579307(+)	`TGGGAC/TTGCAG`	1	--	us2k¹		0	--	--	--	--
rs186648657^1,2		--	42579430(+)	`GGACAC/TATGGG`	1	--	us2k¹		0	--	--	--	--
rs191722256^1,2		--	42579483(+)	`AGGTGC/GAGTGG`	1	--	us2k¹		0	--	--	--	--
rs183063003^1,2		--	42579497(+)	`CCGCCC/GGTTAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF574 (42572864 - 42585719 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF574
1 CNV: 73374

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF574 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZNF574)

Utopia: connect your pdf to the dynamic
world of online information

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)² Cantin G.T....Yates J.R. III (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64763	HGNC: 26166	AceView: ZNF574	Ensembl:ENSG00000105732	euGenes: HUgn64763
ECgene: ZNF574	H-InvDB: ZNF574

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF574	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF574 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF574 gene:
Search GeneIP for patents involving ZNF574

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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ThermoFisher Antibodies for ZNF574

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF574 gene at Home site.

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ZNF574 Gene

zinc finger protein 574

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ZNF574 Gene

zinc finger protein 574

Aliasesfor ZNF574 gene

Summariesfor ZNF574 gene

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Protein Domains /Familiesfor ZNF574 gene

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for ZNF574 gene

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for ZNF574 gene

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for ZNF574 gene

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for ZNF574 gene

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for ZNF574 gene

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