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ZNF574 Gene

protein-coding   GIFtS: 47
GCID: GC19P042572

Zinc Finger Protein 574

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5741 2
FP9722

External Ids:    HGNC: 261661   Entrez Gene: 647632   Ensembl: ENSG000001057327   UniProtKB: Q6ZN553   

Export aliases for ZNF574 gene to outside databases

Previous GC identifers: GC19P047273 GC19P047264 GC19P039012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF574 Gene:
ZNF574 (zinc finger protein 574) is a protein-coding gene. An important paralog of this gene is ZNF526.

UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF574 gene promoter:
         E2F-3a   c-Fos   AP-1   ATF-2   E2F-2   E2F-1   E2F   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF574

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF574


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

ZNF574 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF574 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042572:  view genomic region     (about GC identifiers)

Start:
42,572,629 bp from pter      End:
42,585,719 bp from pter
Size:
13,091 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55 (See protein sequence)
Recommended Name: Zinc finger protein 574  
Size: 896 amino acids; 98900 Da
Secondary accessions: Q6IPE0 Q6ZN10 Q7L5Z5 Q8NCE3 Q9H6N0
Alternative splicing: 2 isoforms:  Q6ZN55-1   Q6ZN55-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF574: NX_Q6ZN55

Explore proteomics data for ZNF574 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys405, Lys558
  • Modification sites at PhosphoSitePlus

  • See ZNF574 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073589.4  
    ENSEMBL proteins: 
     ENSP00000222339   ENSP00000469029   ENSP00000471611   ENSP00000351939  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZN55

    ProtoNet protein and cluster: Q6ZN55

    UniProtKB/Swiss-Prot: ZN574_HUMAN, Q6ZN55
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers


    Find genes that share domains with ZNF574           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN574_HUMAN, Q6ZN55
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF574           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF574:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF574

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN574_HUMAN, Q6ZN55: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF574           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF574
    Interactions:

        Search GeneGlobe Interaction Network for ZNF574

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ZNF574 (Q6ZN553 ENSP000003519394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL2O146413I2D: score=1 
    DVL3Q929973I2D: score=1 
    BMPR2ENSP000003637084STRING: ENSP00000363708
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF574           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF574 (ZN574)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF574 gene: 
    NM_022752.5  

    Unigene Cluster for ZNF574:

    Zinc finger protein 574
    Hs.13323  [show with all ESTs]
    Unigene Representative Sequence: AK131418
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222339(uc002osk.4) ENST00000600245 ENST00000597391 ENST00000359044(uc002osm.4)

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    Additional mRNA sequence: 

    AF447880.1 AK025712.1 AK027895.1 AK074788.1 AK131369.1 AK131418.1 AK225342.1 AL137516.1 
    BC001184.1 BC071962.1 

    11 DOTS entries:

    DT.97771992  DT.312938  DT.101956598  DT.121475357  DT.95283997  DT.121475352  DT.100685920  DT.100766655 
    DT.91908495  DT.95312980  DT.97841960 

    Selected AceView cDNA sequences (see all 168):

    BU856963 AA312445 CK819378 BE294828 CR605938 BU153121 BM718687 BU899262 
    CA428243 AK025712 CF528918 BU956381 CF134582 BE513290 CB155888 BM128274 
    AK131418 BE328004 CD557618 T27152 BM997670 BE796894 CA487471 BE794806 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF574    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                          -                           
    SP2:                                                      
    SP3:        -     -     -     -                           
    SP4:              -     -     -                           


    ECgene alternative splicing isoforms for ZNF574

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF574 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACTGCTG
    ZNF574 Expression
    About this image

    ZNF574 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF574 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13323
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF574 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5741 , 5 zinc finger protein 5741, 5 87.6(n)1
    93.52(a)1
      7 (13.73 cM)5
    2329761  NM_001168506.11  NP_001161978.11 
     250772055 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF5746
    zinc finger protein 574
    57(a)
    1 ↔ 1
    GL343909.1(121519-124272)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056027.12   -- 72.58(n)    BC056027.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf5746
    zinc finger protein 574
    21(a)
    many ↔ many
    16(13001565-13048589) ENSDARG00000087074
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G8AL.106
    Protein Y48G8AL.10 (Y48G8AL.10) mRNA, complete cds...
    14(a)
    1 → many
    I(1136365-1154386) WBGene00021689


    ENSEMBL Gene Tree for ZNF574 (if available)
    TreeFam Gene Tree for ZNF574 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF574 gene
    ZNF5262  
    Selected SIMAP similar genes for ZNF574 using alignment to 2 protein entries:     ZN574_HUMAN (see all proteins) (see all similar genes):
    DKFZp564M2178    FP972    ZNF78L1    ZNF818P    ZNF    ZNF808
    DKFZp434J0650    ZFS-2    ZNF72    ZNF697    ZNF323    ZNF844
    ZNF702P    ZNF833P    ZNF22    ZNF514    ZNF600    ZNF740

    Find genes that share paralogs with ZNF574           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF574 (see all 235)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433712031,2
    --42578417(+) TCCTGA/GCCAAC 1 -- us2k10--------
    rs1806882301,2
    --42578487(+) CTGTAA/GTCACA 1 -- us2k10--------
    rs2000321311,2
    C--42578609(+) CTCAT-/AAATAA
    AATAAAATA
    AAATA
    1 -- us2k10--------
    rs1467024531,2
    C--42578652(+) TAAAAC/TAAAAA 1 -- us2k10--------
    rs777651451,2
    C,F--42578863(+) TGAGAA/GGGTTA 1 -- us2k12Minor allele frequency- G:0.04WA NA 238
    rs1865817891,2
    C--42579116(+) CTGCAA/GCCTCG 1 -- us2k10--------
    rs1909903461,2
    C--42579129(+) CTCCTC/GGGTGC 1 -- us2k10--------
    rs1831451881,2
    C--42579307(+) TGGGAC/TTGCAG 1 -- us2k10--------
    rs1866486571,2
    --42579430(+) GGACAC/TATGGG 1 -- us2k10--------
    rs1917222561,2
    --42579483(+) AGGTGC/GAGTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF574 (42572629 - 42585719 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF574:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520239CNV Loss19592680
    nsv911782CNV Loss21882294
    nsv911783CNV Loss21882294
    esv25421CNV Loss19812545
    nsv522854CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF574 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF574)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64763 HGNC: 26166 AceView: ZNF574 Ensembl:ENSG00000105732 euGenes: HUgn64763
    ECgene: ZNF574 H-InvDB: ZNF574

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF574 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF574 gene:
    Search GeneIP for patents involving ZNF574

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

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