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Aliases for ZNF574 Gene

Aliases for ZNF574 Gene

  • Zinc Finger Protein 574 2 3 5
  • FP972 3

External Ids for ZNF574 Gene

Previous GeneCards Identifiers for ZNF574 Gene

  • GC19P047273
  • GC19P047264
  • GC19P042572
  • GC19P039012

Summaries for ZNF574 Gene

GeneCards Summary for ZNF574 Gene

ZNF574 (Zinc Finger Protein 574) is a Protein Coding gene. An important paralog of this gene is ZNF526.

UniProtKB/Swiss-Prot for ZNF574 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF574 Gene

Genomics for ZNF574 Gene

Regulatory Elements for ZNF574 Gene

Enhancers for ZNF574 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF574 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF574 Gene

42,068,477 bp from pter
42,081,567 bp from pter
13,091 bases
Plus strand

Genomic View for ZNF574 Gene

Genes around ZNF574 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF574 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF574 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF574 Gene

Proteins for ZNF574 Gene

  • Protein details for ZNF574 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 574
    Protein Accession:
    Secondary Accessions:
    • Q6IPE0
    • Q6ZN10
    • Q7L5Z5
    • Q8NCE3
    • Q9H6N0

    Protein attributes for ZNF574 Gene

    896 amino acids
    Molecular mass:
    98900 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF574 Gene


neXtProt entry for ZNF574 Gene

Proteomics data for ZNF574 Gene at MOPED

Post-translational modifications for ZNF574 Gene

  • Ubiquitination at Lys 405 and Lys 558
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF574 Gene

No data available for DME Specific Peptides for ZNF574 Gene

Domains & Families for ZNF574 Gene

Gene Families for ZNF574 Gene

Protein Domains for ZNF574 Gene

Suggested Antigen Peptide Sequences for ZNF574 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 20 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 20 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF574: view

Function for ZNF574 Gene

Molecular function for ZNF574 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF574: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF574 Gene

Localization for ZNF574 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF574 Gene

Subcellular locations from

Jensen Localization Image for ZNF574 Gene COMPARTMENTS Subcellular localization image for ZNF574 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF574 Gene

Pathways & Interactions for ZNF574 Gene

SuperPathways for ZNF574 Gene

No Data Available

Interacting Proteins for ZNF574 Gene

Gene Ontology (GO) - Biological Process for ZNF574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF574: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF574 Gene

Drugs & Compounds for ZNF574 Gene

No Compound Related Data Available

Transcripts for ZNF574 Gene

Unigene Clusters for ZNF574 Gene

Zinc finger protein 574:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF574 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP3: - - - -
SP4: - - -

Relevant External Links for ZNF574 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF574 Gene

mRNA expression in normal human tissues for ZNF574 Gene

Protein differential expression in normal tissues from HIPED for ZNF574 Gene

This gene is overexpressed in Lung (42.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF574 Gene

SOURCE GeneReport for Unigene cluster for ZNF574 Gene Hs.13323

genes like me logo Genes that share expression patterns with ZNF574: view

Protein tissue co-expression partners for ZNF574 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF574 Gene

Orthologs for ZNF574 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF574 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF574 35
  • 89.77 (n)
  • 95.54 (a)
ZNF574 36
  • 95 (a)
(Canis familiaris)
Mammalia ZNF574 35
  • 88.04 (n)
  • 93.97 (a)
ZNF574 36
  • 87 (a)
(Mus musculus)
Mammalia Zfp574 35
  • 87.6 (n)
  • 93.52 (a)
Zfp574 16
Zfp574 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Zfp574 35
  • 87.46 (n)
  • 93.84 (a)
(Monodelphis domestica)
Mammalia ZNF574 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZNF574 36
  • 97 (a)
(Anolis carolinensis)
Reptilia ZNF574 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf574 35
  • 56.56 (n)
  • 53.46 (a)
(Danio rerio)
Actinopterygii znf574 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea Y48G8AL.10 36
  • 14 (a)
Species with no ortholog for ZNF574:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF574 Gene

Gene Tree for ZNF574 (if available)
Gene Tree for ZNF574 (if available)

Paralogs for ZNF574 Gene

Paralogs for ZNF574 Gene

genes like me logo Genes that share paralogs with ZNF574: view

Variants for ZNF574 Gene

Sequence variations from dbSNP and Humsavar for ZNF574 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745226 - 42,079,601(+) TCACC(A/G)GGAGG reference, missense
rs3745228 - 42,080,960(+) CCACC(A/G)GCGCC reference, missense
rs35898322 - 42,080,738(+) GGCCA(C/G)TCGTG reference, missense
rs139958544 -- 42,079,718(+) TGGCC(A/T)GGCCT reference, missense
rs140109448 -- 42,080,062(+) ACCAA(C/T)GTTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF574 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
nsv911783 CNV Loss 21882294
esv25421 CNV Loss 19812545

Variation tolerance for ZNF574 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF574 Gene

Disorders for ZNF574 Gene

Relevant External Links for ZNF574

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF574 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF574 Gene

Publications for ZNF574 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ZNF574 Gene

Sources for ZNF574 Gene