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Aliases for ZNF573 Gene

Aliases for ZNF573 Gene

  • Zinc Finger Protein 573 2 3 5

External Ids for ZNF573 Gene

Previous GeneCards Identifiers for ZNF573 Gene

  • GC19M042922
  • GC19M042923
  • GC19M038229
  • GC19M034678

Summaries for ZNF573 Gene

GeneCards Summary for ZNF573 Gene

ZNF573 (Zinc Finger Protein 573) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF30.

UniProtKB/Swiss-Prot for ZNF573 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF573 Gene

Genomics for ZNF573 Gene

Regulatory Elements for ZNF573 Gene

Enhancers for ZNF573 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G038673 2.1 FANTOM5 Ensembl ENCODE dbSUPER 89.4 -877.6 -877587 42.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF573 ZNF607 EID2B ACTN4 ENSG00000267152 RN7SL566P RPS16 LOC100631378 CAPN12 SUPT5H
GH19G038262 1.4 ENCODE dbSUPER 72.5 -448.6 -448566 6.7 HDGF FOXA2 PKNOX1 MLX AGO1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZNF573 ZNF607 ZNF793 ZNF569 C19orf33 ZNF570 CATSPERG LOC100631378 PPP1R14A LOC284412
GH19G038647 1.8 FANTOM5 ENCODE dbSUPER 47.3 -842.5 -842493 25.6 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 ZNF781 ZNF607 ENSG00000267152 ZNF573 EID2B ENSG00000267892 CAPN12 ACTN4 RPS16 MED29
GH19G037973 1.9 FANTOM5 Ensembl ENCODE dbSUPER 37 -161.3 -161267 10.0 HDGF PKNOX1 WRNIP1 DMAP1 YBX1 ZNF2 YY1 CBX5 ZNF143 ZNF207 ZNF585B ZNF793 ZNF585A ZNF607 ZNF420 ZNF781 ENSG00000267152 ZNF573 ZNF383 WDR87
GH19G038725 1.4 ENCODE dbSUPER 45.4 -914.0 -913991 11.8 HDGF PKNOX1 AGO1 SIN3A ZNF2 ZNF416 ZNF143 FOS PAF1 ZNF263 ZNF573 EID2B MED29 CAPN12 ENSG00000267892 LGALS7 SUPT5H FBXO17 LOC100631378 RPS16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF573 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF573 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109177 36 2000 CREB3L1 DMAP1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZNF610 GLIS1

Genomic Location for ZNF573 Gene

Chromosome:
19
Start:
37,735,131 bp from pter
End:
37,817,300 bp from pter
Size:
82,170 bases
Orientation:
Minus strand

Genomic View for ZNF573 Gene

Genes around ZNF573 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF573 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF573 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF573 Gene

Proteins for ZNF573 Gene

  • Protein details for ZNF573 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YE8-ZN573_HUMAN
    Recommended name:
    Zinc finger protein 573
    Protein Accession:
    Q86YE8
    Secondary Accessions:
    • B7WPE1
    • K7EJ45
    • Q6P1P1
    • Q7Z7Q3
    • Q8N2Q1
    • Q96BM3
    • Q96NH0

    Protein attributes for ZNF573 Gene

    Size:
    665 amino acids
    Molecular mass:
    78181 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH42170.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF573 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF573 Gene

Post-translational modifications for ZNF573 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF573 Gene

Domains & Families for ZNF573 Gene

Gene Families for ZNF573 Gene

Protein Domains for ZNF573 Gene

Suggested Antigen Peptide Sequences for ZNF573 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YE8

UniProtKB/Swiss-Prot:

ZN573_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF573: view

Function for ZNF573 Gene

Molecular function for ZNF573 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF573 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF573: view
genes like me logo Genes that share phenotypes with ZNF573: view

Animal Model Products

CRISPR Products

miRNA for ZNF573 Gene

miRTarBase miRNAs that target ZNF573

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF573 Gene

Localization for ZNF573 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF573 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF573 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF573 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF573: view

Pathways & Interactions for ZNF573 Gene

SuperPathways for ZNF573 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF573: view

Pathways by source for ZNF573 Gene

2 Reactome pathways for ZNF573 Gene

Gene Ontology (GO) - Biological Process for ZNF573 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF573: view

No data available for SIGNOR curated interactions for ZNF573 Gene

Transcripts for ZNF573 Gene

Unigene Clusters for ZNF573 Gene

Zinc finger protein 573:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF573 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -

Relevant External Links for ZNF573 Gene

GeneLoc Exon Structure for
ZNF573
ECgene alternative splicing isoforms for
ZNF573

Expression for ZNF573 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF573 Gene

Protein differential expression in normal tissues from HIPED for ZNF573 Gene

This gene is overexpressed in Ovary (21.2), Plasma (19.1), Spleen (17.9), and Testis (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF573 Gene



Protein tissue co-expression partners for ZNF573 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF573 Gene:

ZNF573

SOURCE GeneReport for Unigene cluster for ZNF573 Gene:

Hs.531262

Evidence on tissue expression from TISSUES for ZNF573 Gene

  • Intestine(4.2)
  • Lung(4.2)
  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF573: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF573 Gene

Orthologs for ZNF573 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF573 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF573 34
  • 84.4 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 53 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
OneToMany
Species where no ortholog for ZNF573 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF573 Gene

ENSEMBL:
Gene Tree for ZNF573 (if available)
TreeFam:
Gene Tree for ZNF573 (if available)

Paralogs for ZNF573 Gene

(555) SIMAP similar genes for ZNF573 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF573 Gene

genes like me logo Genes that share paralogs with ZNF573: view

Variants for ZNF573 Gene

Sequence variations from dbSNP and Humsavar for ZNF573 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000029789 -- 37,753,870(+) CAAGA(A/G)AAGTA intron-variant
rs1000110596 -- 37,757,483(+) TGAGC(C/T)ACCGC intron-variant
rs1000119704 -- 37,776,239(+) ATACT(A/G)CAAGA intron-variant
rs1000155632 -- 37,760,833(+) AAAAA(A/G)AAAAT intron-variant
rs1000173103 -- 37,770,219(+) GATTG(A/T)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF573 Gene

Variant ID Type Subtype PubMed ID
esv1564972 CNV deletion 17803354
esv2437108 CNV deletion 19546169
esv2718522 CNV deletion 23290073
esv2718523 CNV deletion 23290073
esv2718524 CNV deletion 23290073
esv2718525 CNV deletion 23290073
esv2718526 CNV deletion 23290073
esv2718527 CNV deletion 23290073
esv2718528 CNV deletion 23290073
esv3644292 CNV loss 21293372
esv3644293 CNV loss 21293372
nsv1129199 CNV insertion 24896259
nsv579468 CNV gain 21841781
nsv833820 CNV loss 17160897

Variation tolerance for ZNF573 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.61; 78.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF573 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF573

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF573 Gene

Disorders for ZNF573 Gene

Relevant External Links for ZNF573

Genetic Association Database (GAD)
ZNF573
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF573

No disorders were found for ZNF573 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF573 Gene

Publications for ZNF573 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 46 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for ZNF573 Gene

Sources for ZNF573 Gene

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