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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF573 Gene

protein-coding   GIFtS: 45
GCID: GC19M038229

Zinc Finger Protein 573

  Search for ZNF573
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5731 2

External Ids:    HGNC: 264201   Entrez Gene: 1262312   Ensembl: ENSG000001891447   UniProtKB: Q86YE83   

Export aliases for ZNF573 gene to outside databases

Previous GC identifers: GC19M042922 GC19M042923 GC19M034678


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF573 Gene: 
ZNF573 (zinc finger protein 573) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot: ZN573_HUMAN, Q86YE8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF573 gene promoter:
         NF-1   NF-1/L   Sox5   C/EBPbeta   AML1a   STAT5A   GATA-1   MZF-1   Zic1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF573 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF573

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF573


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.13   HGNC cytogenetic band: 19q13.12

ZNF573 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF573 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M038229:  view genomic region     (about GC identifiers)

Start:
38,226,734 bp from pter      End:
38,307,940 bp from pter
Size:
81,207 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN573_HUMAN, Q86YE8 (See protein sequence)
Recommended Name: Zinc finger protein 573  
Size: 645 amino acids; 75883 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B7WPE1 Q6P1P1 Q7Z7Q3 Q8N2Q1 Q96BM3 Q96NH0
Alternative splicing: 4 isoforms:  Q86YE8-1   Q86YE8-2   Q86YE8-3   Q86YE8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF573: NX_Q86YE8

Explore proteomics data for ZNF573 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YE8

  • ZNF573 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF573 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001166160.1  NP_001166161.1  NP_001166162.1  NP_001166163.1  NP_689573.3  

    ENSEMBL proteins: 
     ENSP00000465371   ENSP00000465020   ENSP00000467929   ENSP00000465148   ENSP00000375983  
     ENSP00000465857   ENSP00000466356   ENSP00000367706   ENSP00000466316   ENSP00000468391  
     ENSP00000440464   ENSP00000349861   ENSP00000340171  
    Reactome Protein details: Q86YE8
    Human Recombinant Protein Products for ZNF573: 
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    Novus Biologicals ZNF573 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF573 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF573 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86YE8

    ProtoNet protein and cluster: Q86YE8

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN573_HUMAN, Q86YE8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 19 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF573 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN573_HUMAN, Q86YE8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF573 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF573 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF573 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF573
        Generic Transcription Pathway
    Gene Expression



    ZNF573 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF573

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF573 (ENSP000003401714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN3ENSP000003803494STRING: ENSP00000380349
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF573 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF573 (ZN573)

    Search CenterWatch for drugs/clinical trials and news about ZNF573 / ZN573

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF573 gene (5 alternative transcripts): 
    NM_001172689.1  NM_001172690.1  NM_001172691.1  NM_001172692.1  NM_152360.3  

    Unigene Cluster for ZNF573:

    Zinc finger protein 573
    Hs.531262  [show with all ESTs]
    Unigene Representative Sequence: NM_152360
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000590674 ENST00000590414 ENST00000589632 ENST00000586155 ENST00000392138(uc010efs.2)
    ENST00000489148 ENST00000585724 ENST00000378445 ENST00000591516 ENST00000588218
    ENST00000494605 ENST00000480587 ENST00000587684 ENST00000586785 ENST00000588443
    ENST00000589435 ENST00000536220(uc002ohd.3 uc002ohe.3 uc002ohg.3)
    ENST00000357309(uc021utv.1)
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): ZNF573 (NM_001172690)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF573
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF573
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF573
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF573

    Additional mRNA sequence: 

    AK055483.1 AK074539.1 BC015418.1 BC029468.2 BC042170.2 BC051263.1 BC064962.1 

    9 DOTS entries:

    DT.440399  DT.100751077  DT.91648031  DT.95359292  DT.121497648  DT.121497656  DT.121497631  DT.422718 
    DT.91988427 

    24/37 AceView cDNA sequences (see all 37):

    BQ070435 BC064962 R44345 BC042170 AV726592 R24546 NM_152360 AW965212 
    BC015418 BV191541 BI766045 AK074539 BE296394 BF982442 BC051263 BU176268 
    AK055483 BF305240 T93706 H19309 AW023483 BE515346 BG420082 H19015 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF573 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f
    SP1:                          -                       -                                       
    SP2:              -                       -     -                                             
    SP3:              -                       -     -     -                                       
    SP4:              -           -           -     -     -                                       
    SP5:              -     -     -           -     -     -                                       


    ECgene alternative splicing isoforms for ZNF573

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF573 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF573 Expression
    About this image


    See ZNF573 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF573

    SOURCE GeneReport for Unigene cluster: Hs.531262
        SABiosciences Custom PCR Arrays for ZNF573
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF573 (if available)
    TreeFam Gene Tree for ZNF573 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF573 gene
    ZNF4202  ZNF780A2  ZNF6652  ZNF724P2  ZNF72  ZNF232  ZNF4322  ZNF33A2  
    ZNF2342  ZNF302  ZNF4292  ZNF5402  ZNF2512  ZNF6052  ZNF842  ZNF1892  
    ZNF5712  ZNF6302  ZNF932  ZNF162  ZNF2832  ZNF3472  ZNF4842  ZNF1352  
    ZNF1842  ZNF585B2  ZNF412  ZNF6152  ZNF5692  ZNF4702  
    18/556 SIMAP similar genes for ZNF573 using alignment to 9 protein entries:     ZN573_HUMAN (see all proteins) (see all similar genes):
    AVGR5    FAM138A    FAM138B    FAM138C    FAM138F    ZFP90
    ZNF320    ZNF519    ZNF83    ZNF845    ZNF583    FAM138D
    ZFS-4    ZNF78L1    ZNF780A    FIK    ZNF789    MGC12518

    ZNF573 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/813 SNPs in ZNF573 are shown (see all 813)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs583465171,2
    C--38228877(+) AGTGGC/TGCGAT 5 -- ds50010--------
    rs604206401,2
    C--38228895(+) CACTGC/TAAGCT 5 -- ds50010--------
    rs1834320251,2
    --38228920(+) CACGCC/TATTCT 5 -- ds50010--------
    rs1879743321,2
    --38228954(+) TGGGAA/TTGCAG 5 -- ds50010--------
    rs1422526771,2
    --38229022(+) CGTGTC/TAGCCA 5 -- ds50010--------
    rs1928215951,2
    --38229048(+) CCTGAC/TCTCGT 5 -- ds50010--------
    rs1829179801,2
    C--38229106(+) ACCGCA/GCCCAG 5 -- ds50010--------
    rs556970761,2
    --38229133(+) TTTTTA/TAAAAA 5 -- ds50010--------
    rs1926055841,2
    --38229156(+) TGGATG/TTTGTA 5 -- ds50010--------
    rs1392190891,2
    C--38229186(+) TCCTG-/TTTTTTT 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF573 (38226734 - 38307940 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ZNF573:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2437108CNV Deletion19546169
    esv2718525CNV Deletion23290073
    esv2718528CNV Deletion23290073
    esv2718524CNV Deletion23290073
    esv2718522CNV Deletion23290073
    esv1564972CNV Deletion17803354
    esv2718527CNV Deletion23290073
    esv2718523CNV Deletion23290073
    esv2718526CNV Deletion23290073
    nsv833820CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF573 for disorders           About MalaCards

    ZNF573 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF573

    Export disorders for ZNF573 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF573 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF573)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)4 Yashin A.I....Ukraintseva S.V. (2010)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126231 HGNC: 26420 AceView: ZNF573 Ensembl:ENSG00000189144 euGenes: HUgn126231
    ECgene: ZNF573 H-InvDB: ZNF573

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF573 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF573 gene:
    Search GeneIP for patents involving ZNF573

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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