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ZNF57 Gene

protein-coding   GIFtS: 45
GCID: GC19P002900

Zinc Finger Protein 57

(Previous name: zinc finger protein 424)
(Previous symbol: ZNF424)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 571 2
Zinc Finger Protein 4241 2 3
ZNF4241 2 3

External Ids:    HGNC: 131251   Entrez Gene: 1262952   Ensembl: ENSG000001719707   UniProtKB: Q68EA53   

Export aliases for ZNF57 gene to outside databases

Previous GC identifers: GC19U990105 GC19P002852 GC19P002671


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF57 Gene:
ZNF57 (zinc finger protein 57) is a protein-coding gene. Diseases associated with ZNF57 include nonsyndromic deafness. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZNF57_HUMAN, Q68EA5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF57
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF57 promoter sequence
   Search Chromatin IP Primers for ZNF57

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF57


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ZNF57 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF57 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P002900:  view genomic region     (about GC identifiers)

Start:
2,900,896 bp from pter      End:
2,918,474 bp from pter
Size:
17,579 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZNF57_HUMAN, Q68EA5 (See protein sequence)
Recommended Name: Zinc finger protein 57  
Size: 555 amino acids; 64428 Da
Secondary accessions: Q8N6R9

Explore the universe of human proteins at neXtProt for ZNF57: NX_Q68EA5

Explore proteomics data for ZNF57 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF57 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775751.1  
    ENSEMBL proteins: 
     ENSP00000303696   ENSP00000430905   ENSP00000430223   ENSP00000468191  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q68EA5

    ProtoNet protein and cluster: Q68EA5

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZNF57_HUMAN, Q68EA5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF57 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF57_HUMAN, Q68EA5
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF57:
    zinc finger protein 57 (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF57 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF57_HUMAN, Q68EA5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF57 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF57
    Interactions:

        Search GeneGlobe Interaction Network for ZNF57

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF57 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF57



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF57 gene: 
    NM_173480.2  

    Unigene Cluster for ZNF57:

    Zinc finger protein 57
    Hs.591378  [show with all ESTs]
    Unigene Representative Sequence: BX537601
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306908(uc002lwr.3 uc010xha.2) ENST00000522294 ENST00000523428
    ENST00000590305
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    Additional mRNA sequence: 

    AK302165.1 AK314848.1 BC028974.1 BX537601.1 EF534355.1 

    2 DOTS entries:

    DT.95178481  DT.97785688 

    12 AceView cDNA sequences:

    BM459174 BC028974 BI460449 BX537601 BG721222 NM_173480 BM473599 BM787420 
    BI333134 BU903009 C00505 BF327122 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF57 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAATGCTC
    ZNF57 Expression
    About this image

    ZNF57 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF57 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591378
        Custom PCR Arrays for ZNF57
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF57

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF57 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    1 → many
    AAWZ02038665(3150-4763)
    zebrafish
    (Danio rerio)
    Actinopterygii CT573234.26
    CR388132.26
    Uncharacterized protein
    35(a)
    35(a)
    many ↔ many
    many ↔ many
    Zv9_scaffold3530(1425476-1452687) ENSDARG00000093555
    4(28399744-28423465) ENSDARG00000092942
            Species with no ortholog for ZNF57

    ENSEMBL Gene Tree for ZNF57 (if available)
    TreeFam Gene Tree for ZNF57 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF57 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  
    ZNF7992  ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF6272  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF57 using alignment to 4 protein entries:     ZNF57_HUMAN (see all proteins) (see all similar genes):
    LOC126295    ZFS-4    DKFZp666C237    HZF36    ZNF833P    ZNF558
    ZNF818P    DKFZp686D2168    ZNF146    ZNF204    ZNF397    ZNF702P
    ZSCAN29    DKFZp434G1930    DKFZp434J0650    HZF30    ZNF391    ZNF660

    ZNF57 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF57
    PGOHUM00000234117 PGOHUM00000235783


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF57 (see all 648)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499565071,2
    C,Funtested12917494(+) TTACCA/C/TCCAGG 2 H P mis11NA 4536
    rs1997963481,2
    --2669360(+) TGTCT-/ACAAAA 1 -- us2k10--------
    rs1118371711,2
    C--2669372(+) AAAAAC/AAACAC 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs2000030441,2
    C--2669388(+) AAAAC-/AAGAGAG 1 -- us2k10--------
    rs2009224701,2
    C--2669465(+) TTTAA-/TTTTTT 1 -- us2k10--------
    rs104209751,2
    C--2898942(+) cactgC/Taacct 1 -- us2k10--------
    rs129773701,2
    C,F--2898967(+) caagcG/Cattct 1 -- us2k12Minor allele frequency- C:0.50NA 4
    rs1470121981,2
    --2899141(+) TATAGA/GTGTGA 1 -- us2k10--------
    rs129857271,2
    C--2899148(+) gtgagA/Ccacca 1 -- us2k14Minor allele frequency- C:0.00NA CSA 7
    rs1871248101,2
    --2899198(+) ACGGAG/TTCTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF57 (2900896 - 2918474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF57 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000566CNV Deletion20482838
    esv2555501CNV Deletion19546169
    esv1105151CNV Deletion17803354
    nsv821398CNV Deletion20802225
    esv2674415CNV Deletion23128226
    esv2658906CNV Deletion23128226
    esv2717919CNV Deletion23290073
    nsv511619CNV Loss21212237
    nsv910692CNV Loss21882294
    nsv512558CNV Loss21212237

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ZNF57:    About MalaCards
    nonsyndromic deafness

    1 disease from the University of Copenhagen DISEASES database for ZNF57:
    Nonsyndromic deafness

    ZNF57 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF57

    Export disorders for ZNF57 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF57 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF57)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1, 3 Lichter P.... Ward D.C. (Genomics 1992)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway. (PubMed id 20356463)1 Wang Y....Wu X. (BMB Rep 2010)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1 Bray P.L.... Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126295 HGNC: 13125 AceView: LOC126295 Ensembl:ENSG00000171970 euGenes: HUgn126295
    ECgene: ZNF57 H-InvDB: ZNF57

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF57 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF57 gene:
    Search GeneIP for patents involving ZNF57

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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