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Aliases for ZNF57 Gene

Aliases for ZNF57 Gene

  • Zinc Finger Protein 57 2 3 5
  • Zinc Finger Protein 424 2 3 4
  • ZNF424 3 4

External Ids for ZNF57 Gene

Previous HGNC Symbols for ZNF57 Gene

  • ZNF424

Previous GeneCards Identifiers for ZNF57 Gene

  • GC19U990105
  • GC19P002852
  • GC19P002671

Summaries for ZNF57 Gene

GeneCards Summary for ZNF57 Gene

ZNF57 (Zinc Finger Protein 57) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF57 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF57 Gene

Genomics for ZNF57 Gene

Regulatory Elements for ZNF57 Gene

Enhancers for ZNF57 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF57 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF57 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF57 Gene

2,900,898 bp from pter
2,918,646 bp from pter
17,749 bases
Plus strand

Genomic View for ZNF57 Gene

Genes around ZNF57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF57 Gene

Proteins for ZNF57 Gene

  • Protein details for ZNF57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 57
    Protein Accession:
    Secondary Accessions:
    • Q8N6R9

    Protein attributes for ZNF57 Gene

    555 amino acids
    Molecular mass:
    64428 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF57 Gene

Proteomics data for ZNF57 Gene at MOPED

Post-translational modifications for ZNF57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF57 Gene

No data available for DME Specific Peptides for ZNF57 Gene

Domains & Families for ZNF57 Gene

Gene Families for ZNF57 Gene

Protein Domains for ZNF57 Gene

Suggested Antigen Peptide Sequences for ZNF57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF57: view

Function for ZNF57 Gene

Molecular function for ZNF57 Gene

GENATLAS Biochemistry:
zinc finger protein 57 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF57: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF57 Gene

Localization for ZNF57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF57 Gene

Subcellular locations from

Jensen Localization Image for ZNF57 Gene COMPARTMENTS Subcellular localization image for ZNF57 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF57 Gene

Pathways & Interactions for ZNF57 Gene

SuperPathways for ZNF57 Gene

No Data Available

Interacting Proteins for ZNF57 Gene

Gene Ontology (GO) - Biological Process for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF57: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF57 Gene

Drugs & Compounds for ZNF57 Gene

No Compound Related Data Available

Transcripts for ZNF57 Gene

mRNA/cDNA for ZNF57 Gene

Unigene Clusters for ZNF57 Gene

Zinc finger protein 57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF57 Gene

No ASD Table

Relevant External Links for ZNF57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF57 Gene

mRNA expression in normal human tissues for ZNF57 Gene

Protein differential expression in normal tissues from HIPED for ZNF57 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF57 Gene

SOURCE GeneReport for Unigene cluster for ZNF57 Gene Hs.591378

genes like me logo Genes that share expression patterns with ZNF57: view

Protein tissue co-expression partners for ZNF57 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF57 Gene

Orthologs for ZNF57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF57 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF57 35
  • 98.56 (n)
  • 97.84 (a)
ZNF57 36
  • 90 (a)
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
-- 36
  • 45 (a)
-- 36
  • 40 (a)
-- 36
  • 41 (a)
(Mus musculus)
Mammalia Zfp81 36
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
(Danio rerio)
Actinopterygii CR388132.2 36
  • 35 (a)
CT573234.2 36
  • 35 (a)
Species with no ortholog for ZNF57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF57 Gene

Gene Tree for ZNF57 (if available)
Gene Tree for ZNF57 (if available)

Paralogs for ZNF57 Gene

(481) SIMAP similar genes for ZNF57 Gene using alignment to 4 proteins: Pseudogenes for ZNF57 Gene

genes like me logo Genes that share paralogs with ZNF57: view

Variants for ZNF57 Gene

Sequence variations from dbSNP and Humsavar for ZNF57 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_052760 -
VAR_052761 -
VAR_061931 -
rs7256762 -- 2,900,918(+) GCGGG(A/T)CGTTT utr-variant-5-prime
rs7257435 -- 2,904,275(+) GGTGA(C/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF57 Gene

Variant ID Type Subtype PubMed ID
nsv910692 CNV Loss 21882294
esv2674415 CNV Deletion 23128226
esv2658906 CNV Deletion 23128226
esv1000566 CNV Deletion 20482838
esv2555501 CNV Deletion 19546169
nsv511619 CNV Loss 21212237
nsv512558 CNV Loss 21212237
esv22112 CNV Gain 19812545
esv2717919 CNV Deletion 23290073
esv1105151 CNV Deletion 17803354
nsv821398 CNV Deletion 20802225

Variation tolerance for ZNF57 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.31; 76.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF57 Gene

Disorders for ZNF57 Gene

Relevant External Links for ZNF57

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF57 Gene

Publications for ZNF57 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  4. ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway. (PMID: 20356463) Wang Y. … Wu X. (BMB Rep 2010) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF57 Gene

Sources for ZNF57 Gene