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Aliases for ZNF57 Gene

Aliases for ZNF57 Gene

  • Zinc Finger Protein 57 2 3
  • Zinc Finger Protein 424 2 3 4
  • ZNF424 3 4

External Ids for ZNF57 Gene

Previous Symbols for ZNF57 Gene

  • ZNF424

Summaries for ZNF57 Gene

GeneCards Summary for ZNF57 Gene

ZNF57 (Zinc Finger Protein 57) is a Protein Coding gene. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF57 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF57 Gene

Genomics for ZNF57 Gene

Genomic Location for ZNF57 Gene

2,900,898 bp from pter
2,918,476 bp from pter
17,579 bases
Plus strand

Genomic View for ZNF57 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF57 Gene

No data available for Regulatory Elements for ZNF57 Gene

Proteins for ZNF57 Gene

  • Protein details for ZNF57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 57
    Protein Accession:
    Secondary Accessions:
    • Q8N6R9

    Protein attributes for ZNF57 Gene

    555 amino acids
    Molecular mass:
    64428 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF57 Gene

Proteomics data for ZNF57 Gene at MOPED

Post-translational modifications for ZNF57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF57 Gene

No data available for DME Specific Peptides for ZNF57 Gene

Domains for ZNF57 Gene

Gene Families for ZNF57 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF57 Gene

Suggested Antigen Peptide Sequences for ZNF57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.:
    • Q68EA5
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q68EA5
  • Contains 13 C2H2-type zinc fingers.:
    • Q68EA5
genes like me logo Genes that share domains with ZNF57: view

Function for ZNF57 Gene

Molecular function for ZNF57 Gene

GENATLAS Biochemistry: zinc finger protein 57 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF57: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF57 Gene

Localization for ZNF57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF57 Gene

Subcellular locations from

Jensen Localization Image for ZNF57 Gene COMPARTMENTS Subcellular localization image for ZNF57 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF57: view

Pathways for ZNF57 Gene

SuperPathways for ZNF57 Gene

No Data Available

Interacting Proteins for ZNF57 Gene

Gene Ontology (GO) - Biological Process for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF57: view

No data available for Pathways by source for ZNF57 Gene

Transcripts for ZNF57 Gene

mRNA/cDNA for ZNF57 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF57 Gene

Zinc finger protein 57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF57 Gene

No ASD Table

Relevant External Links for ZNF57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF57 Gene

mRNA expression in normal human tissues for ZNF57 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF57 Gene

SOURCE GeneReport for Unigene cluster for ZNF57 Gene Hs.591378

genes like me logo Genes that share expressions with ZNF57: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF57 Gene

Orthologs for ZNF57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF57 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF57 35
  • 98.56 (n)
  • 97.84 (a)
ZNF57 36
  • 90 (a)
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
(Mus musculus)
Mammalia Zfp81 36
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
-- 36
  • 45 (a)
-- 36
  • 40 (a)
-- 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
(Danio rerio)
Actinopterygii CR388132.2 36
  • 35 (a)
CT573234.2 36
  • 35 (a)
Species with no ortholog for ZNF57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF57 Gene

Gene Tree for ZNF57 (if available)
Gene Tree for ZNF57 (if available)

Paralogs for ZNF57 Gene

Selected SIMAP similar genes for ZNF57 Gene using alignment to 4 proteins: Pseudogenes for ZNF57 Gene

genes like me logo Genes that share paralogs with ZNF57: view

Variants for ZNF57 Gene

Sequence variations from dbSNP and Humsavar for ZNF57 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2316872 -- 2,907,483(-) GAAAA(A/G)TAATT intron-variant
rs2316873 -- 2,906,588(-) CCAGC(C/T)AGGGA intron-variant
rs3855680 -- 2,906,477(-) AATAC(G/T)TGATC intron-variant
rs4061136 -- 2,902,148(-) GTTCT(C/G)TGAGC intron-variant
rs4806887 -- 2,902,421(+) TTTAT(C/T)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF57 Gene

Variant ID Type Subtype PubMed ID
nsv910692 CNV Loss 21882294
esv2674415 CNV Deletion 23128226
esv2658906 CNV Deletion 23128226
esv1000566 CNV Deletion 20482838
esv2555501 CNV Deletion 19546169
nsv511619 CNV Loss 21212237
nsv512558 CNV Loss 21212237
esv22112 CNV Gain 19812545
esv2717919 CNV Deletion 23290073
esv1105151 CNV Deletion 17803354
nsv821398 CNV Deletion 20802225

Relevant External Links for ZNF57 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF57 Gene

Disorders for ZNF57 Gene

(1) University of Copenhagen DISEASES for ZNF57 Gene

Relevant External Links for ZNF57

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZNF57: view

No data available for UniProtKB/Swiss-Prot for ZNF57 Gene

Publications for ZNF57 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3
  3. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P.L. … Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway. (PMID: 20356463) Wang Y. … Wu X. (BMB Rep 2010) 3

Products for ZNF57 Gene

Sources for ZNF57 Gene

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