ZNF57 Gene
protein-coding GIFtS: 43
GCID: GC19P002900
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|
zinc finger protein 57(Previous name: zinc finger protein 424 )
(Previous symbol: ZNF424)
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Aliases
for ZNF57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 571 2 | | Zinc Finger Protein 4241 2 3 | | ZNF4241 2 3 |
Export aliases for ZNF57 gene to outside databasesPrevious GC identifers: GC19U990105 GC19P002852 GC19P002671 |
Summaries
for ZNF57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF57_HUMAN, Q68EA5Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF57
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3ZNF57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P002900: view genomic region
(about GC identifiers)
Start:
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2,900,896 bp from pter |
End:
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2,918,474 bp from pter |
Size:
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17,579 bases |
Orientation:
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plus strand |
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Proteins
for ZNF57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF57_HUMAN, Q68EA5 (See
protein sequence)Recommended Name: Zinc finger protein 57 Size: 555 amino acids; 64428 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8N6R9Explore the universe of human proteins at neXtProt for ZNF57: NX_Q68EA5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q68EA5
ZNF57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775751.1
ENSEMBL proteins: ENSP00000303696 ENSP00000430905 ENSP00000430223 ENSP00000468191
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF57 for ontologies About GeneDecksing
ZNF57 Antibody Products:
Assay Products for ZNF57: |
Protein
Domains /
Families
for ZNF57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF57 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q68EA5ProtoNet protein and cluster: Q68EA5 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZNF57_HUMAN, Q68EA5Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 13 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF57_HUMAN, Q68EA5Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF57:zinc finger protein 57 (C2H2 type,Kruppel-like)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF57
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF57 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF57 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF57
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF57 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF57
Search CenterWatch for drugs/clinical trials and news about ZNF57
|
Transcripts
for ZNF57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF57 gene: NM_173480.2 Unigene Cluster for ZNF57: Zinc finger protein 57 Hs.591378 [show with all ESTs]Unigene Representative Sequence: BX5376014 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306908(uc002lwr.3 uc010xha.2) ENST00000522294 ENST00000523428
ENST00000590305
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF57
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF57
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF57 (NM_016536) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF57 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF57 |
Additional cDNA sequence: AK302165.1 AK314848.1 BC028974.1 BX537601.1 EF534355.1 2 DOTS entries: DT.95178481 DT.97785688 12 AceView cDNA sequences: BM459174 BM473599 BU903009 BG721222 BC028974 BX537601 BI333134 BI460449 BM787420 NM_173480 C00505 BF327122
GeneLoc Exon Structure
|
Expression
for ZNF57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAATGCTC
About this image
See ZNF57 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF57
SOURCE GeneReport for Unigene cluster: Hs.591378
SABiosciences Custom PCR Arrays for ZNF57
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF57
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF57 |
Orthologs
for ZNF57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF57 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG178296 |
-- |
12(a) |
1 → many |
X(519588-522052) |
worm
(Caenorhabditis elegans) |
Secernentea |
F39B2.16 |
-- |
12(a) |
1 → many |
I(14791027-14793977) |
ENSEMBL Gene Tree for ZNF57 (if available)
TreeFam Gene Tree for ZNF57 (if available) |
Paralogs
for ZNF57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF57 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ZNF142 ENSG000001968262
- ZNF7002 ZNF692 ZNF4402 ZNF4432 ZNF442 ZNF4392 ZNF8232 ZNF4912
- ENSG000001884742 ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912
- ZNF4422 ZNF4332 ZNF5632 ZNF6272 ZNF1362 ENSG000002573552 ZNF5562 ZNF6702
- ZNF7632 ZNF1242 ZNF6992 ZNF8442 ZNF772
18/478 SIMAP similar genes for ZNF57 using alignment to 4 protein entries: ZNF57_HUMAN (see all proteins)
(see all similar genes):LOC126295 ZFS-4 DKFZp666C237 HZF36 ZNF833P ZNF558
ZNF818P DKFZp686D2168 ZNF146 ZNF204 ZNF397 ZNF702P
ZSCAN29 DKFZp434G1930 DKFZp434J0650 HZF30 ZNF391 ZNF660
ZNF57 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF57
PGOHUM00000234117 PGOHUM00000235783
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Genomic Variants
for ZNF57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF57 (2900896 - 2918474 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for ZNF57
3 CNVs: 67437 23559 102770
9 Indels: 89033 89035 78033 89034 78034 78035 78031 89032 78032 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF57 |
|
Disorders
/ Diseases
for ZNF57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF57 for disorders About MalaCards
ZNF57 for disorders About GeneDecksing
1 disease from the University of Copenhagen DISEASES database for ZNF57:Nonsyndromic deafness Export disorders for ZNF57 gene to outside databases
|
Publications
for ZNF57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF57 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1, 3 Lichter P....Ward D.C. (1992)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway. (PubMed id 20356463)1 Wang Y....Wu X. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1 Bray P.L.... Dawid I.B. (1991)
|
External Searches for ZNF57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF57 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF57 gene:
Search GeneIP for patents involving ZNF57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZNF57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF57 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF57 |
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