Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF569 Gene

Aliases for ZNF569 Gene

  • Zinc Finger Protein 569 2 3 5
  • DNA-Binding Protein 3
  • ZAP1 3
  • ZNF 3

External Ids for ZNF569 Gene

Previous GeneCards Identifiers for ZNF569 Gene

  • GC19M042336
  • GC19M042593
  • GC19M037902
  • GC19M034352

Summaries for ZNF569 Gene

GeneCards Summary for ZNF569 Gene

ZNF569 (Zinc Finger Protein 569) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZNF569 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF569 Gene

Genomics for ZNF569 Gene

Regulatory Elements for ZNF569 Gene

Promoters for ZNF569 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF569 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF569 Gene

Chromosome:
19
Start:
37,410,876 bp from pter
End:
37,469,275 bp from pter
Size:
58,400 bases
Orientation:
Minus strand

Genomic View for ZNF569 Gene

Genes around ZNF569 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF569 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF569 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF569 Gene

Proteins for ZNF569 Gene

  • Protein details for ZNF569 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MCW4-ZN569_HUMAN
    Recommended name:
    Zinc finger protein 569
    Protein Accession:
    Q5MCW4
    Secondary Accessions:
    • A8K1S2
    • Q15925
    • Q17RR6
    • Q96MQ2

    Protein attributes for ZNF569 Gene

    Size:
    686 amino acids
    Molecular mass:
    79583 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK056615; Type=Erroneous termination; Positions=276; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF569 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF569 Gene

Proteomics data for ZNF569 Gene at MOPED

Post-translational modifications for ZNF569 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF569 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF569 Gene

Domains & Families for ZNF569 Gene

Gene Families for ZNF569 Gene

Protein Domains for ZNF569 Gene

Suggested Antigen Peptide Sequences for ZNF569 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MCW4

UniProtKB/Swiss-Prot:

ZN569_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF569: view

Function for ZNF569 Gene

Molecular function for ZNF569 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF569: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZNF569

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF569 Gene

Localization for ZNF569 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF569 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF569 Gene COMPARTMENTS Subcellular localization image for ZNF569 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF569 Gene

Pathways & Interactions for ZNF569 Gene

SuperPathways for ZNF569 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF569: view

Pathways by source for ZNF569 Gene

2 Reactome pathways for ZNF569 Gene

Interacting Proteins for ZNF569 Gene

Gene Ontology (GO) - Biological Process for ZNF569 Gene

None

No data available for SIGNOR curated interactions for ZNF569 Gene

Drugs & Compounds for ZNF569 Gene

No Compound Related Data Available

Transcripts for ZNF569 Gene

Unigene Clusters for ZNF569 Gene

Zinc finger protein 569:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF569 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2:
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: -
SP10: - - - - - - - - - - - - - -
SP11:

Relevant External Links for ZNF569 Gene

GeneLoc Exon Structure for
ZNF569
ECgene alternative splicing isoforms for
ZNF569

Expression for ZNF569 Gene

mRNA expression in normal human tissues for ZNF569 Gene

SOURCE GeneReport for Unigene cluster for ZNF569 Gene Hs.511848

genes like me logo Genes that share expression patterns with ZNF569: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF569 Gene

Orthologs for ZNF569 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF569 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF569 36
  • 100 (a)
OneToOne
ZNF569 35
  • 99.85 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ZNF569 36
  • 92 (a)
OneToOne
ZNF569 35
  • 91.82 (n)
  • 91.82 (a)
mouse
(Mus musculus)
Mammalia Zfp74 36
  • 85 (a)
OneToOne
Zfp74 16
Zfp74 35
  • 80.56 (n)
  • 84.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp74 35
  • 81.02 (n)
  • 85.21 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733241 35
  • 60.54 (n)
  • 54.55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009566 35
  • 51.76 (n)
  • 45.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta crol 35
  • 45.77 (n)
  • 41.13 (a)
Species with no ortholog for ZNF569:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF569 Gene

ENSEMBL:
Gene Tree for ZNF569 (if available)
TreeFam:
Gene Tree for ZNF569 (if available)

Paralogs for ZNF569 Gene

(559) SIMAP similar genes for ZNF569 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF569 Gene

genes like me logo Genes that share paralogs with ZNF569: view

Variants for ZNF569 Gene

Sequence variations from dbSNP and Humsavar for ZNF569 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035589 A breast cancer sample
VAR_035590 A breast cancer sample
rs2112920 -- 37,464,346(-) caggc(C/G)tggta intron-variant
rs2112921 -- 37,464,232(-) ATCCT(A/G)GGCAA intron-variant
rs2112922 -- 37,456,929(-) GTGCA(A/G)TGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF569 Gene

Variant ID Type Subtype PubMed ID
dgv1081e1 CNV Complex 17122850
nsv833819 CNV Gain 17160897

Variation tolerance for ZNF569 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF569 Gene

HapMap Linkage Disequilibrium report
ZNF569

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF569 Gene

Disorders for ZNF569 Gene

Relevant External Links for ZNF569

Genetic Association Database (GAD)
ZNF569
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF569

No disorders were found for ZNF569 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF569 Gene

Publications for ZNF569 Gene

  1. ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. (PMID: 16793018) Huang X. … Wu X. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF569 Gene

Sources for ZNF569 Gene

Back to Top

Content