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Aliases for ZNF569 Gene

Aliases for ZNF569 Gene

  • Zinc Finger Protein 569 2 3 5
  • DNA-Binding Protein 3
  • ZAP1 3
  • ZNF 3

External Ids for ZNF569 Gene

Previous GeneCards Identifiers for ZNF569 Gene

  • GC19M042336
  • GC19M042593
  • GC19M037902
  • GC19M034352

Summaries for ZNF569 Gene

GeneCards Summary for ZNF569 Gene

ZNF569 (Zinc Finger Protein 569) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF568.

UniProtKB/Swiss-Prot for ZNF569 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF569 Gene

Genomics for ZNF569 Gene

Regulatory Elements for ZNF569 Gene

Enhancers for ZNF569 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G038262 1.4 ENCODE dbSUPER 31.5 -796.6 -796591 6.7 HDGF FOXA2 PKNOX1 MLX AGO1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZNF573 ZNF607 ZNF793 ZNF569 C19orf33 ZNF570 CATSPERG LOC100631378 PPP1R14A LOC284412
GH19G037973 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.3 -509.3 -509292 10.0 HDGF PKNOX1 WRNIP1 DMAP1 YBX1 ZNF2 YY1 CBX5 ZNF143 ZNF207 ZNF585B ZNF793 ZNF585A ZNF607 ZNF420 ZNF781 ENSG00000267152 ZNF383 ZNF573 WDR87
GH19G038275 0.9 dbSUPER 31.9 -806.9 -806943 0.6 ZNF493 ZFP64 ZEB1 ZNF121 ZNF366 ZNF138 ZNF354C SCRT2 KLF7 ZNF202 ZNF573 ZNF571 ZNF793 ZNF607 C19orf33 ENSG00000267152 ZNF569 ENSG00000267682 ZNF570 ZNF571-AS1
GH19G038336 1.2 ENCODE 23.5 -867.2 -867150 2.5 MLX DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 NFYC C19orf33 ZNF793 ZNF607 ZNF571 ZNF569 ZNF573 CATSPERG ENSG00000267152 ZNF571-AS1 ZNF793-AS1
GH19G037505 1.1 ENCODE 23.7 -37.3 -37325 2.4 PKNOX1 SIN3A ZNF2 YY1 ZNF302 ZNF416 ZNF143 ZNF548 FOS SP3 ZNF793 ZNF529 ZNF383 ZNF790-AS1 ZNF345 ZNF461 ZNF607 ZNF567 ZNF850 ZNF585B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF569 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF569 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109168 1074 4400 CREB3L1 FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3

Genomic Location for ZNF569 Gene

37,410,876 bp from pter
37,469,275 bp from pter
58,400 bases
Minus strand

Genomic View for ZNF569 Gene

Genes around ZNF569 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF569 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF569 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF569 Gene

Proteins for ZNF569 Gene

  • Protein details for ZNF569 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 569
    Protein Accession:
    Secondary Accessions:
    • A8K1S2
    • Q15925
    • Q17RR6
    • Q96MQ2

    Protein attributes for ZNF569 Gene

    686 amino acids
    Molecular mass:
    79583 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK056615; Type=Erroneous termination; Positions=276; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF569 Gene


neXtProt entry for ZNF569 Gene

Post-translational modifications for ZNF569 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF569 Gene

Domains & Families for ZNF569 Gene

Gene Families for ZNF569 Gene

Protein Domains for ZNF569 Gene

Suggested Antigen Peptide Sequences for ZNF569 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF569: view

Function for ZNF569 Gene

Molecular function for ZNF569 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF569 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF569: view
genes like me logo Genes that share phenotypes with ZNF569: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZNF569

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF569 Gene

Localization for ZNF569 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF569 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF569 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF569 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF569: view

Pathways & Interactions for ZNF569 Gene

SuperPathways for ZNF569 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF569: view

Pathways by source for ZNF569 Gene

2 Reactome pathways for ZNF569 Gene

Gene Ontology (GO) - Biological Process for ZNF569 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF569: view

No data available for SIGNOR curated interactions for ZNF569 Gene

Drugs & Compounds for ZNF569 Gene

No Compound Related Data Available

Transcripts for ZNF569 Gene

Unigene Clusters for ZNF569 Gene

Zinc finger protein 569:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF569 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: -
SP10: - - - - - - - - - - - - - -

Relevant External Links for ZNF569 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF569 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF569 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF569 Gene:


SOURCE GeneReport for Unigene cluster for ZNF569 Gene:


Evidence on tissue expression from TISSUES for ZNF569 Gene

  • Nervous system(4.5)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF569: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF569 Gene

Orthologs for ZNF569 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF569 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF569 34 35
  • 99.85 (n)
(Bos Taurus)
Mammalia ZNF569 34 35
  • 91.82 (n)
(Rattus norvegicus)
Mammalia Zfp74 34
  • 81.02 (n)
(Mus musculus)
Mammalia Zfp74 34 16 35
  • 80.56 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733241 34
  • 60.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009566 34
  • 51.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta crol 34
  • 45.77 (n)
Species where no ortholog for ZNF569 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF569 Gene

Gene Tree for ZNF569 (if available)
Gene Tree for ZNF569 (if available)

Paralogs for ZNF569 Gene

(559) SIMAP similar genes for ZNF569 Gene using alignment to 6 proteins: Pseudogenes for ZNF569 Gene

genes like me logo Genes that share paralogs with ZNF569: view

Variants for ZNF569 Gene

Sequence variations from dbSNP and Humsavar for ZNF569 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035589 A breast cancer sample
VAR_035590 A breast cancer sample
rs1000095520 -- 37,463,600(+) TTTTT(A/G)TTGTT intron-variant
rs1000137171 -- 37,456,837(+) GTGGC(A/C)GGCGC intron-variant
rs1000159930 -- 37,417,364(+) CAAAA(G/T)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF569 Gene

Variant ID Type Subtype PubMed ID
esv2758759 CNV loss 17122850
nsv579465 CNV loss 21841781
nsv833819 CNV gain 17160897

Variation tolerance for ZNF569 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF569 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF569 Gene

Disorders for ZNF569 Gene

Relevant External Links for ZNF569

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF569 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF569 Gene

Publications for ZNF569 Gene

  1. ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. (PMID: 16793018) Huang X. … Wu X. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 3 4 64
  4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF569 Gene

Sources for ZNF569 Gene

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