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Aliases for ZNF568 Gene

Aliases for ZNF568 Gene

  • Zinc Finger Protein 568 2 3 5

External Ids for ZNF568 Gene

Previous GeneCards Identifiers for ZNF568 Gene

  • GC19P042034
  • GC19P042100
  • GC19P037407
  • GC19P033876

Summaries for ZNF568 Gene

GeneCards Summary for ZNF568 Gene

ZNF568 (Zinc Finger Protein 568) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZNF568 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF568 Gene

Genomics for ZNF568 Gene

Regulatory Elements for ZNF568 Gene

Enhancers for ZNF568 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF568 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF568 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF568 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF568 Gene

36,916,329 bp from pter
36,998,700 bp from pter
82,372 bases
Plus strand

Genomic View for ZNF568 Gene

Genes around ZNF568 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF568 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF568 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF568 Gene

Proteins for ZNF568 Gene

  • Protein details for ZNF568 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 568
    Protein Accession:
    Secondary Accessions:
    • B4DS92
    • E7ER33
    • Q6N060
    • Q8NA64

    Protein attributes for ZNF568 Gene

    644 amino acids
    Molecular mass:
    74369 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31218.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH31218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAE45810.1; Type=Frameshift; Positions=436; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF568 Gene


neXtProt entry for ZNF568 Gene

Proteomics data for ZNF568 Gene at MOPED

Post-translational modifications for ZNF568 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF568 Gene

Domains & Families for ZNF568 Gene

Gene Families for ZNF568 Gene

Protein Domains for ZNF568 Gene

Suggested Antigen Peptide Sequences for ZNF568 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF568: view

Function for ZNF568 Gene

Molecular function for ZNF568 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF568: view

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF568 Gene

Localization for ZNF568 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF568 Gene

Subcellular locations from

Jensen Localization Image for ZNF568 Gene COMPARTMENTS Subcellular localization image for ZNF568 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF568 Gene

Pathways & Interactions for ZNF568 Gene

SuperPathways for ZNF568 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF568: view

Pathways by source for ZNF568 Gene

2 Reactome pathways for ZNF568 Gene

Interacting Proteins for ZNF568 Gene

Gene Ontology (GO) - Biological Process for ZNF568 Gene


No data available for SIGNOR curated interactions for ZNF568 Gene

Drugs & Compounds for ZNF568 Gene

No Compound Related Data Available

Transcripts for ZNF568 Gene

mRNA/cDNA for ZNF568 Gene

(6) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF568 Gene

Zinc finger protein 568:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF568 Gene

No ASD Table

Relevant External Links for ZNF568 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF568 Gene

mRNA expression in normal human tissues for ZNF568 Gene

Protein differential expression in normal tissues from HIPED for ZNF568 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF568 Gene

SOURCE GeneReport for Unigene cluster for ZNF568 Gene Hs.404220

genes like me logo Genes that share expression patterns with ZNF568: view

Protein tissue co-expression partners for ZNF568 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF568 Gene

Orthologs for ZNF568 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF568 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF568 35
  • 99.59 (n)
  • 99.84 (a)
ZNF568 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp569 35
  • 82.5 (n)
  • 80.36 (a)
(Bos Taurus)
Mammalia ZNF568 36
  • 92 (a)
(Canis familiaris)
Mammalia ZNF568 36
  • 84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
-- 36
  • 49 (a)
-- 36
  • 45 (a)
-- 36
  • 45 (a)
-- 36
  • 46 (a)
-- 36
  • 46 (a)
-- 36
  • 46 (a)
-- 36
  • 44 (a)
-- 36
  • 44 (a)
-- 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
Species with no ortholog for ZNF568:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF568 Gene

Gene Tree for ZNF568 (if available)
Gene Tree for ZNF568 (if available)

Paralogs for ZNF568 Gene

(568) SIMAP similar genes for ZNF568 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF568: view

Variants for ZNF568 Gene

Sequence variations from dbSNP and Humsavar for ZNF568 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs547483 - 36,950,463(+) ACATA(C/T)GCGAA intron-variant, reference, missense
rs1644634 - 36,951,078(+) ACACC(A/G)AGTAT intron-variant, reference, missense
rs826262 -- 36,928,540(+) ACTAC(A/G)ATTTT intron-variant
rs826263 -- 36,928,934(+) AGATT(G/T)ATCAG intron-variant
rs826289 -- 36,935,488(+) ttggg(C/T)ggcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF568 Gene

Variant ID Type Subtype PubMed ID
nsv521605 CNV Loss 19592680
nsv911651 CNV Loss 21882294
nsv458569 CNV Loss 19166990
nsv523848 CNV Loss 19592680
nsv833818 CNV Gain 17160897
dgv3856n71 CNV Gain 21882294
esv2718512 CNV Deletion 23290073
esv2677892 CNV Deletion 23128226
nsv509740 CNV Insertion 20534489
esv2718513 CNV Deletion 23290073
esv2370712 CNV Deletion 18987734
esv2718514 CNV Deletion 23290073
esv990224 CNV Deletion 20482838
nsv138138 CNV Loss 16902084
nsv138492 CNV Loss 16902084
nsv911653 CNV Gain 21882294

Variation tolerance for ZNF568 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF568 Gene

Disorders for ZNF568 Gene

Relevant External Links for ZNF568

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF568 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF568 Gene

Publications for ZNF568 Gene

  1. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso G.M. … Brousseau M.E. (J. Lipid Res. 2010) 3 48 67
  2. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  3. Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage. (PMID: 23071813) Chien H.C. … Shen C.K. (PLoS ONE 2012) 3
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF568 Gene

Sources for ZNF568 Gene