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Aliases for ZNF568 Gene

Aliases for ZNF568 Gene

  • Zinc Finger Protein 568 2 3 5

External Ids for ZNF568 Gene

Previous GeneCards Identifiers for ZNF568 Gene

  • GC19P042034
  • GC19P042100
  • GC19P037407
  • GC19P033876

Summaries for ZNF568 Gene

GeneCards Summary for ZNF568 Gene

ZNF568 (Zinc Finger Protein 568) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF569.

UniProtKB/Swiss-Prot for ZNF568 Gene

  • Has transcriptional repression activity, together with the corepressor TRIM28. Essential during embryonic development, where it regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF568 Gene

Genomics for ZNF568 Gene

Regulatory Elements for ZNF568 Gene

Enhancers for ZNF568 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G035946 1.6 FANTOM5 Ensembl ENCODE 42 -968.9 -968937 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 ZNF567 ZNF345 TMEM147-AS1 ZNF850 ZNF529 ZNF790-AS1 HAUS5 ZNF461 ZNF790 LINC00665
GH19G037593 1.1 ENCODE 53.9 +678.4 678371 2.0 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF302 ZNF383 ZNF567 ZNF345 ZNF585B ZNF850 ZNF571 ZNF793 ZNF607 ZNF790-AS1 LINC01535
GH19G037370 1.1 ENCODE 52 +454.7 454655 1.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF383 ZNF567 ZNF585B ZNF793 ZNF345 ZNF850 ZNF571 ZNF790-AS1 ZNF529 ZNF461
GH19G036052 1.2 ENCODE 47.2 -861.5 -861525 3.9 MLX AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC MEF2D ZFP82 ZNF345 ZNF461 ZNF529 ZNF567 ZNF568 ZNF420 ZNF790-AS1 RBM42 LINC01534
GH19G037653 1.2 ENCODE 46.1 +739.0 738953 2.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 ZNF383 ZNF567 ZNF345 ZNF585B ZNF850 ZNF571 LINC01535 ZNF585A ZNF607 ZNF790-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF568 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF568 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109152 71 2001 PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF302 ZNF416 ZNF143 ZNF548 ZNF263

Genomic Location for ZNF568 Gene

Chromosome:
19
Start:
36,916,329 bp from pter
End:
36,998,700 bp from pter
Size:
82,372 bases
Orientation:
Plus strand

Genomic View for ZNF568 Gene

Genes around ZNF568 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF568 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF568 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF568 Gene

Proteins for ZNF568 Gene

  • Protein details for ZNF568 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCX4-ZN568_HUMAN
    Recommended name:
    Zinc finger protein 568
    Protein Accession:
    Q3ZCX4
    Secondary Accessions:
    • B4DS92
    • E7ER33
    • Q6N060
    • Q8NA64

    Protein attributes for ZNF568 Gene

    Size:
    644 amino acids
    Molecular mass:
    74369 Da
    Quaternary structure:
    • Interacts with TRIM28.
    SequenceCaution:
    • Sequence=AAH31218.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH31218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAE45810.1; Type=Frameshift; Positions=436; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF568 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF568 Gene

Post-translational modifications for ZNF568 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF568 Gene

Domains & Families for ZNF568 Gene

Gene Families for ZNF568 Gene

Protein Domains for ZNF568 Gene

Suggested Antigen Peptide Sequences for ZNF568 Gene

Graphical View of Domain Structure for InterPro Entry

Q3ZCX4

UniProtKB/Swiss-Prot:

ZN568_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF568: view

Function for ZNF568 Gene

Molecular function for ZNF568 Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repression activity, together with the corepressor TRIM28. Essential during embryonic development, where it regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.

Gene Ontology (GO) - Molecular Function for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF568: view
genes like me logo Genes that share phenotypes with ZNF568: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF568 Gene

Localization for ZNF568 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF568 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF568 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF568: view

Pathways & Interactions for ZNF568 Gene

SuperPathways for ZNF568 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF568: view

Pathways by source for ZNF568 Gene

2 Reactome pathways for ZNF568 Gene

Gene Ontology (GO) - Biological Process for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZNF568: view

No data available for SIGNOR curated interactions for ZNF568 Gene

Transcripts for ZNF568 Gene

mRNA/cDNA for ZNF568 Gene

(15) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF568 Gene

Zinc finger protein 568:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF568 Gene

No ASD Table

Relevant External Links for ZNF568 Gene

GeneLoc Exon Structure for
ZNF568
ECgene alternative splicing isoforms for
ZNF568

Expression for ZNF568 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF568 Gene

Protein differential expression in normal tissues from HIPED for ZNF568 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF568 Gene



Protein tissue co-expression partners for ZNF568 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF568 Gene:

ZNF568

SOURCE GeneReport for Unigene cluster for ZNF568 Gene:

Hs.404220

Evidence on tissue expression from TISSUES for ZNF568 Gene

  • Nervous system(4.5)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZNF568: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF568 Gene

Orthologs for ZNF568 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF568 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF568 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia ZNF568 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF568 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp569 34
  • 82.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
Species where no ortholog for ZNF568 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF568 Gene

ENSEMBL:
Gene Tree for ZNF568 (if available)
TreeFam:
Gene Tree for ZNF568 (if available)

Paralogs for ZNF568 Gene

(568) SIMAP similar genes for ZNF568 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF568: view

Variants for ZNF568 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF568 Gene

ZN568_HUMAN-Q3ZCX4
Isoform 3 is highly polymorphic with three major alleles: H, C1 and C1. The H allele is found at higher frequencies in Japanese (0.71) and Taiwan Chinese (0.72) populations compared to European (0.45) and African (0.39) populations. The H allele may be associated with smaller head size in infants.

Sequence variations from dbSNP and Humsavar for ZNF568 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000004322 -- 36,959,801(+) TGCTC(A/G/T)TAAGT intron-variant
rs1000020396 -- 36,968,635(+) GGTTA(C/T)TTACC intron-variant
rs1000056648 -- 36,960,314(+) GGTTT(C/T)ACCAT intron-variant
rs1000148084 -- 36,959,426(+) TTTTT(C/G)AGGAT intron-variant
rs1000155235 -- 36,961,137(+) TATTG(C/T)AATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF568 Gene

Variant ID Type Subtype PubMed ID
esv2370712 CNV deletion 18987734
esv2677892 CNV deletion 23128226
esv2718512 CNV deletion 23290073
esv2718513 CNV deletion 23290073
esv2718514 CNV deletion 23290073
esv3222174 CNV deletion 24192839
esv3556348 CNV deletion 23714750
esv3556350 CNV deletion 23714750
esv3556351 CNV deletion 23714750
esv3644274 CNV loss 21293372
esv3893201 CNV gain 25118596
esv990224 CNV deletion 20482838
nsv1064851 CNV loss 25217958
nsv1070675 CNV deletion 25765185
nsv1138701 CNV deletion 24896259
nsv1149441 CNV deletion 26484159
nsv138138 CNV deletion 16902084
nsv138492 CNV deletion 16902084
nsv458569 CNV loss 19166990
nsv509740 CNV insertion 20534489
nsv521605 CNV loss 19592680
nsv523848 CNV loss 19592680
nsv579461 CNV gain 21841781
nsv579462 CNV loss 21841781
nsv579463 CNV loss 21841781
nsv833818 CNV gain 17160897
nsv956598 CNV deletion 24416366

Variation tolerance for ZNF568 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF568 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF568

Disorders for ZNF568 Gene

Relevant External Links for ZNF568

Genetic Association Database (GAD)
ZNF568
Human Genome Epidemiology (HuGE) Navigator
ZNF568
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF568

No disorders were found for ZNF568 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF568 Gene

Publications for ZNF568 Gene

  1. Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage. (PMID: 23071813) Chien H.C. … Shen C.K. (PLoS ONE 2012) 3 4 64
  2. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso G.M. … Brousseau M.E. (J. Lipid Res. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3 64
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3 64

Products for ZNF568 Gene

Sources for ZNF568 Gene

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