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Aliases for ZNF568 Gene

Aliases for ZNF568 Gene

  • Zinc Finger Protein 568 2 3

External Ids for ZNF568 Gene

Previous GeneCards Identifiers for ZNF568 Gene

  • GC19P042034
  • GC19P042100
  • GC19P037407
  • GC19P033876

Summaries for ZNF568 Gene

GeneCards Summary for ZNF568 Gene

ZNF568 (Zinc Finger Protein 568) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot for ZNF568 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF568 Gene

Genomics for ZNF568 Gene

Regulatory Elements for ZNF568 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF568 Gene

Start:
36,916,329 bp from pter
End:
36,998,700 bp from pter
Size:
82,372 bases
Orientation:
Plus strand

Genomic View for ZNF568 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF568 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF568 Gene

Proteins for ZNF568 Gene

  • Protein details for ZNF568 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCX4-ZN568_HUMAN
    Recommended name:
    Zinc finger protein 568
    Protein Accession:
    Q3ZCX4
    Secondary Accessions:
    • B4DS92
    • E7ER33
    • Q6N060
    • Q8NA64

    Protein attributes for ZNF568 Gene

    Size:
    644 amino acids
    Molecular mass:
    74369 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31218.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH31218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAE45810.1; Type=Frameshift; Positions=436; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF568 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF568 Gene

Proteomics data for ZNF568 Gene at MOPED

Post-translational modifications for ZNF568 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF568 Gene

Domains for ZNF568 Gene

Gene Families for ZNF568 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF568 Gene

Graphical View of Domain Structure for InterPro Entry

Q3ZCX4

UniProtKB/Swiss-Prot:

ZN568_HUMAN :
  • Q3ZCX4
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF568: view

Function for ZNF568 Gene

Molecular function for ZNF568 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF568: view

Phenotypes for ZNF568 Gene

GenomeRNAi human phenotypes for ZNF568:
genes like me logo Genes that share phenotypes with ZNF568: view

Animal Model Products

CRISPR Products

miRNA for ZNF568 Gene

miRTarBase miRNAs that target ZNF568

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF568 Gene

Localization for ZNF568 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF568 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF568 Gene COMPARTMENTS Subcellular localization image for ZNF568 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF568: view

Pathways for ZNF568 Gene

SuperPathways for ZNF568 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF568: view

Pathways by source for ZNF568 Gene

2 Reactome pathways for ZNF568 Gene

Interacting Proteins for ZNF568 Gene

Gene Ontology (GO) - Biological Process for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF568: view

Transcripts for ZNF568 Gene

mRNA/cDNA for ZNF568 Gene

Unigene Clusters for ZNF568 Gene

Zinc finger protein 568:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF568

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF568
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF568 Gene

No ASD Table

Relevant External Links for ZNF568 Gene

GeneLoc Exon Structure for
ZNF568
ECgene alternative splicing isoforms for
ZNF568

Expression for ZNF568 Gene

mRNA expression in normal human tissues for ZNF568 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF568 Gene

SOURCE GeneReport for Unigene cluster for ZNF568 Gene Hs.404220

genes like me logo Genes that share expressions with ZNF568: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF568 Gene

Orthologs for ZNF568 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF568 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF568 35
  • 99.59 (n)
  • 99.84 (a)
ZNF568 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF568 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF568 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp569 35
  • 82.5 (n)
  • 80.36 (a)
Species with no ortholog for ZNF568:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF568 Gene

ENSEMBL:
Gene Tree for ZNF568 (if available)
TreeFam:
Gene Tree for ZNF568 (if available)

Paralogs for ZNF568 Gene

Selected SIMAP similar genes for ZNF568 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF568: view

Variants for ZNF568 Gene

Sequence variations from dbSNP and Humsavar for ZNF568 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs472226 -- 36,967,811(+) TTGTT(G/T)CATCA intron-variant
rs474017 -- 36,963,217(+) taaat(A/G)ccaag intron-variant
rs475026 -- 36,968,115(+) TAATA(C/T)GTATA intron-variant
rs476194 -- 36,919,831(+) gctgc(C/T)gtaaa intron-variant
rs477893 -- 36,946,831(+) atttt(C/T)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF568 Gene

Variant ID Type Subtype PubMed ID
nsv521605 CNV Loss 19592680
nsv911651 CNV Loss 21882294
nsv458569 CNV Loss 19166990
nsv523848 CNV Loss 19592680
nsv833818 CNV Gain 17160897
dgv3856n71 CNV Gain 21882294
esv2718512 CNV Deletion 23290073
esv2677892 CNV Deletion 23128226
nsv509740 CNV Insertion 20534489
esv2718513 CNV Deletion 23290073
esv2370712 CNV Deletion 18987734
esv2718514 CNV Deletion 23290073
esv990224 CNV Deletion 20482838
nsv138138 CNV Loss 16902084
nsv138492 CNV Loss 16902084
nsv911653 CNV Gain 21882294

Relevant External Links for ZNF568 Gene

HapMap Linkage Disequilibrium report
ZNF568

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF568 Gene

Disorders for ZNF568 Gene

Relevant External Links for ZNF568

Genetic Association Database (GAD)
ZNF568
Human Genome Epidemiology (HuGE) Navigator
ZNF568
genes like me logo Genes that share disorders with ZNF568: view

No data available for UniProtKB/Swiss-Prot for ZNF568 Gene

Publications for ZNF568 Gene

  1. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso G.M. … Brousseau M.E. (J. Lipid Res. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF568 Gene

Sources for ZNF568 Gene

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