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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF568 Gene

protein-coding GIFtS: 45
GCID: GC19P037407

zinc finger protein 568

Explore 2 diseases affiliated with
ZNF568 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 568¹ ²
DKFZp686B0797¹

External Ids:	HGNC: 25392¹	Entrez Gene: 374900²	Ensembl: ENSG00000198453⁷	UniProtKB: Q3ZCX4³

Export aliases for ZNF568 gene to outside databases

Previous GC identifers: GC19P042034 GC19P042100 GC19P033876

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN568_HUMAN, Q3ZCX4

Function: May be involved in transcriptional regulation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF568 gene promoter:
AhR STAT1 Pax-2 Pax-2a Arnt c-Ets-1 HEN1 AREB6 NRF-2 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF568 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF568

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF568

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC chromosome: 19

ZNF568 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF568 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P037407: view genomic region (about GC identifiers)

Start:	37,407,231 bp from pter	End:	37,489,602 bp from pter
Size:	82,372 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN568_HUMAN, Q3ZCX4 (See protein sequence)

Recommended Name: Zinc finger protein 568

Size: 644 amino acids; 74369 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAH31218.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAH31218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=CAE45810.1; Type=Frameshift; Positions=436;

Secondary accessions: Q6N060 Q8NA64

Alternative splicing: 2 isoforms: Q3ZCX4-1 Q3ZCX4-2

Explore the universe of human proteins at neXtProt for ZNF568: NX_Q3ZCX4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q3ZCX4

ZNF568 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001191764.1 NP_001191765.1 NP_001191766.1 NP_001191767.1 NP_001191768.1 NP_940941.2

ENSEMBL proteins:

ENSP00000407012 ENSP00000467578 ENSP00000334685 ENSP00000394514 ENSP00000389794

ENSP00000413396 ENSP00000466901 ENSP00000465833 ENSP00000399643 ENSP00000465977

ENSP00000407153 ENSP00000466125

Reactome Protein details: Q3ZCX4
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF568 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF568 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q3ZCX4

ProtoNet protein and cluster: Q3ZCX4

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN568_HUMAN, Q3ZCX4

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 15 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN568_HUMAN, Q3ZCX4

Function: May be involved in transcriptional regulation (By similarity)

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF568

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF568 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF568:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF568

	Generic Transcription Pathway
	Gene Expression

ZNF568 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF568

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF568 (ENSP00000334685⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBX5	ENSP00000209875⁴	STRING: ENSP00000209875

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF568 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF568
Search CenterWatch for drugs/clinical trials and news about ZNF568 / ZN568

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF568 gene (6 alternative transcripts):

NM_001204835.1 NM_001204836.1 NM_001204837.1 NM_001204838.1 NM_001204839.1 NM_198539.3

Unigene Clusters for ZNF568:

Zinc finger protein 568

Hs.404220 [show with all ESTs], Hs.733385 [show with all ESTs]

Unigene Representative Sequences: AL832834, NM_198539

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000427117(uc010eff.2 uc010efh.2) ENST00000587130 ENST00000333987

ENST00000415168(uc002ofc.3 uc021uts.1 uc002ofd.3 uc010efe.3)

ENST00000444991 ENST00000455427(uc010efg.3 uc010xtn.2 uc010efi.2 uc010efj.2)

ENST00000587857 ENST00000586353 ENST00000433993 ENST00000592567 ENST00000455817

ENST00000588596 ENST00000591887

miRNA Products:		OriGene 3'-UTR Clone: ZNF568 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF568
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF568 (see all 12):
		hsa-miR-3671 hsa-miR-26a-2* hsa-miR-181c hsa-miR-181a hsa-miR-138-2* hsa-miR-181d hsa-miR-3692 hsa-miR-587

		SwitchGear 3'UTR luciferase reporter plasmid: ZNF568 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector (see all 6): ZNF568 (NM_198539)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF568
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Additional cDNA sequence:

AK093123.1 AK299626.1 BC016334.1 BC031218.1 BC108696.1 BC111777.1 BC131547.1 BX640681.1

13 DOTS entries:

DT.101976933 DT.101978886 DT.99938265 DT.99937140 DT.99929791 DT.40297255 DT.121446765 DT.91661992

DT.97767451 DT.99950955 DT.100019347 DT.121446789 DT.91748567

5 AceView cDNA sequences:

BG698983 BQ880230 BF131904 BE782341 BE565307

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF568 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See ZNF568 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF568

SOURCE GeneReport for Unigene clusters: Hs.404220 Hs.733385

SABiosciences Custom PCR Arrays for ZNF568

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF568

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF568 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- -- (see all 8)	--	42(a) 37(a) (see all 8)	many ↔ many many ↔ many (see all 8)	Un(41687425-41690654) Un(16877163-16880802)
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	BX077211.1²	--	75.4(n)		BX077211.1

ENSEMBL Gene Tree for ZNF568 (if available)
TreeFam Gene Tree for ZNF568 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF568 gene

ZNF570² ZNF287² ZNF181² ZFP28² ZNF471² ZNF7² ZNF250² ZNF879²

ZNF302² ZNF354C² ZNF74² ZNF583² ZFP90² ZNF189² ZNF354A² ZNF354B²

ZNF135² ZNF34² ZNF527² ZNF8² ZNF470² ZNF569²

18/566 SIMAP similar genes for ZNF568 using alignment to 11 protein entries: ZN568_HUMAN (see all proteins) (see all similar genes):

IFT122 CCPG1 KLHDC1 WDR6 NSD1 SPSB4

SUN3 ATL2 BUB1B C11orf80 C12orf23 CNOT2

COX7A2 FANCA MTA3 PPIP5K2 SENP7 ZNHIT3

ZNF568 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185883569^1,2		--	37409203(+)	`TATATA/GCAGTT`	6	--	int¹		0	--	--	--	--
rs150647696^1,2	C,	--	37409353(+)	`TCATT-/GT TACACGTTAT`	6	--	int¹		0	--	--	--	--
rs544964^1,2	C,F,A,H,	--	37409561(+)	`CATCTA/GAACCA`	6	--	int¹		21		NS EA NA WA CSA	1212
rs79866373^1,2	F,	--	37409694(+)	`TCTGTA/TCCCCC`	6	--	int¹		1		WA	118
rs144199899^1,2		--	37409698(+)	`TACCCC/GCCTTT`	6	--	int¹		0	--	--	--	--
rs61408379^1,2	C,F,	--	37409708(+)	`TCCCCC/TGGCCT`	6	--	int¹		4		WA CSA	123
rs148717067^1,2		--	37409741(+)	`CTGTCC/TCTGAA`	6	--	int¹		0	--	--	--	--
rs79927419^1,2		--	37409758(+)	`TATTCT/AAAATA`	6	--	int¹		1		NA	120
rs142373865^1,2		--	37409844(+)	`CATCCA/GTGTTA`	6	--	int¹		0	--	--	--	--
rs111762920^1,2	C,	--	37409867(+)	`ATTTCC/TTCCTT`	6	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF568 (37407231 - 37489602 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF568: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF568 for disorders About GeneDecksing

2 diseases for ZNF568: About MalaCards

coronary heart disease cholesterol

Human Genome Epidemiology (HuGE) Navigator: ZNF568 (1 document)

Export disorders for ZNF568 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF568 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF568)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Targeted disruption in mice of a neural stem cell-main taining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human line age. (PubMed id 23071813)¹ Chien H.C....Shen C.K. (2012)
Common genetic variation in multiple metabolic pathwa ys influences susceptibility to low HDL-cholesterol and coronary heart disease. (PubMed id 20855565)¹ Peloso G.M....Brousseau M.E. (2010)
Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)¹ Nozawa R.S....Obuse C. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 374900	HGNC: 25392	AceView: ZNF568	Ensembl:ENSG00000198453	euGenes: HUgn374900
ECgene: ZNF568	H-InvDB: ZNF568

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF568	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF568 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF568 gene:
Search GeneIP for patents involving ZNF568

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF568 gene at Home site.

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ZNF568 Gene

zinc finger protein 568

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ZNF568 Gene

zinc finger protein 568

Aliasesfor ZNF568 gene

Summariesfor ZNF568 gene

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Protein Domains /Familiesfor ZNF568 gene

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