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Aliases for ZNF566 Gene

Aliases for ZNF566 Gene

  • Zinc Finger Protein 566 2 3 5

External Ids for ZNF566 Gene

Previous GeneCards Identifiers for ZNF566 Gene

  • GC19M041629
  • GC19M041631
  • GC19M036936
  • GC19M033404
  • GC19M036674
  • GC19M036706

Summaries for ZNF566 Gene

GeneCards Summary for ZNF566 Gene

ZNF566 (Zinc Finger Protein 566) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF566 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF566 Gene

Genomics for ZNF566 Gene

Regulatory Elements for ZNF566 Gene

Enhancers for ZNF566 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF566 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF566 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF566 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF566 Gene

Chromosome:
19
Start:
36,436,034 bp from pter
End:
36,489,902 bp from pter
Size:
53,869 bases
Orientation:
Minus strand

Genomic View for ZNF566 Gene

Genes around ZNF566 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF566 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF566 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF566 Gene

Proteins for ZNF566 Gene

  • Protein details for ZNF566 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969W8-ZN566_HUMAN
    Recommended name:
    Zinc finger protein 566
    Protein Accession:
    Q969W8
    Secondary Accessions:
    • B7ZL95
    • Q2M3J1

    Protein attributes for ZNF566 Gene

    Size:
    418 amino acids
    Molecular mass:
    49219 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF566 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF566 Gene

Proteomics data for ZNF566 Gene at MOPED

Post-translational modifications for ZNF566 Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF566

No data available for DME Specific Peptides for ZNF566 Gene

Domains & Families for ZNF566 Gene

Gene Families for ZNF566 Gene

Protein Domains for ZNF566 Gene

Suggested Antigen Peptide Sequences for ZNF566 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969W8

UniProtKB/Swiss-Prot:

ZN566_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF566: view

Function for ZNF566 Gene

Molecular function for ZNF566 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF566: view

Animal Model Products

CRISPR Products

miRNA for ZNF566 Gene

miRTarBase miRNAs that target ZNF566

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF566 Gene

Localization for ZNF566 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF566 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF566 Gene COMPARTMENTS Subcellular localization image for ZNF566 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF566 Gene

Pathways & Interactions for ZNF566 Gene

SuperPathways for ZNF566 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF566: view

Pathways by source for ZNF566 Gene

2 Reactome pathways for ZNF566 Gene

Interacting Proteins for ZNF566 Gene

Gene Ontology (GO) - Biological Process for ZNF566 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF566: view

No data available for SIGNOR curated interactions for ZNF566 Gene

Drugs & Compounds for ZNF566 Gene

No Compound Related Data Available

Transcripts for ZNF566 Gene

Unigene Clusters for ZNF566 Gene

Zinc finger protein 566:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF566 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: -
SP8: - -
SP9: -

Relevant External Links for ZNF566 Gene

GeneLoc Exon Structure for
ZNF566
ECgene alternative splicing isoforms for
ZNF566

Expression for ZNF566 Gene

mRNA expression in normal human tissues for ZNF566 Gene

Protein differential expression in normal tissues from HIPED for ZNF566 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF566 Gene



SOURCE GeneReport for Unigene cluster for ZNF566 Gene Hs.533939

genes like me logo Genes that share expression patterns with ZNF566: view

Protein tissue co-expression partners for ZNF566 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF566 Gene

Orthologs for ZNF566 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF566 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF566 35
  • 91.31 (n)
  • 89.23 (a)
ZNF566 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp566 35
  • 81.69 (n)
  • 80.31 (a)
Zfp566 16
Zfp566 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF566 35
  • 99.2 (n)
  • 99.28 (a)
ZNF566 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910651 35
  • 80.57 (n)
  • 79.53 (a)
dog
(Canis familiaris)
Mammalia ZNF566 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZAP1 36
  • 12 (a)
OneToMany
Species with no ortholog for ZNF566:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF566 Gene

ENSEMBL:
Gene Tree for ZNF566 (if available)
TreeFam:
Gene Tree for ZNF566 (if available)

Paralogs for ZNF566 Gene

(547) SIMAP similar genes for ZNF566 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF566 Gene

genes like me logo Genes that share paralogs with ZNF566: view

Variants for ZNF566 Gene

Sequence variations from dbSNP and Humsavar for ZNF566 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7258723 -- 36,453,428(+) agatc(A/G)cgcca intron-variant
rs7259057 -- 36,444,538(+) gcggg(C/T)ggatc intron-variant
rs7259664 -- 36,453,429(+) GATCG(C/T)GCCAC intron-variant
rs12975998 -- 36,467,621(+) cccca(A/T)ctcta intron-variant
rs12981245 -- 36,486,745(+) tggac(A/T)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF566 Gene

Variant ID Type Subtype PubMed ID
nsv833816 CNV Gain 17160897
nsv911648 CNV Loss 21882294
esv2675393 CNV Deletion 23128226
nsv833817 CNV Loss 17160897

Variation tolerance for ZNF566 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF566 Gene

Disorders for ZNF566 Gene

Relevant External Links for ZNF566

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF566

No disorders were found for ZNF566 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF566 Gene

Publications for ZNF566 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PMID: 21549307) Rowbotham S.P. … Mermoud J.E. (Mol. Cell 2011) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for ZNF566 Gene

Sources for ZNF566 Gene

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