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ZNF566 Gene

protein-coding   GIFtS: 50
GCID: GC19M036936

Zinc Finger Protein 566

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 5661 2

External Ids:    HGNC: 259191   Entrez Gene: 849242   Ensembl: ENSG000001860177   UniProtKB: Q969W83   
ORGUL members:         

Export aliases for ZNF566 gene to outside databases

Previous GC identifers: GC19M041629 GC19M041631 GC19M033404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF566 Gene:
ZNF566 (zinc finger protein 566) is a protein-coding gene. Diseases associated with ZNF566 include malaria. An important paralog of this gene is ZNF707.

UniProtKB/Swiss-Prot: ZN566_HUMAN, Q969W8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF566 gene promoter:
         RORalpha1   c-Myb   CUTL1   LUN-1   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF566 promoter sequence
   Search Chromatin IP Primers for ZNF566

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF566


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

ZNF566 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF566 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036936:  view genomic region     (about GC identifiers)

Start:
36,936,021 bp from pter      End:
36,980,804 bp from pter
Size:
44,784 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN566_HUMAN, Q969W8 (See protein sequence)
Recommended Name: Zinc finger protein 566  
Size: 418 amino acids; 49219 Da
Secondary accessions: B7ZL95 Q2M3J1
Alternative splicing: 2 isoforms:  Q969W8-1   Q969W8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF566: NX_Q969W8

Explore proteomics data for ZNF566 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys62
  • Modification sites at PhosphoSitePlus

  • See ZNF566 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138815.1  NP_001138816.1  NP_001138817.1  NP_116227.1  

    ENSEMBL proteins: 
     ENSP00000467764   ENSP00000465343   ENSP00000376010   ENSP00000401259   ENSP00000411526  
     ENSP00000400651   ENSP00000394207   ENSP00000415520  
    Reactome Protein details: Q969W8

    ZNF566 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q969W8

    ProtoNet protein and cluster: Q969W8

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN566_HUMAN, Q969W8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF566 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN566_HUMAN, Q969W8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF566 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF566:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF566
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    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF566 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF566 (see all 37):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-let-7d hsa-let-7g hsa-miR-372 hsa-miR-629* hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidZNF566 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF566

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF566


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN566_HUMAN, Q969W8: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF566 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF566 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF566
        Generic Transcription Pathway



    ZNF566 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF566
    Interactions:

        Search GeneGlobe Interaction Network for ZNF566

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ZNF566 (Q969W83 ENSP000003760104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343I2D: score=1 
    CBX5ENSP000002098754STRING: ENSP00000209875
    SMARCAD1ENSP000003519474STRING: ENSP00000351947
    KIF2CENSP000003612984STRING: ENSP00000361298
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF566 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF566 (ZN566)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF566 gene (4 alternative transcripts): 
    NM_001145343.1  NM_001145344.1  NM_001145345.1  NM_032838.4  

    Unigene Cluster for ZNF566:

    Zinc finger protein 566
    Hs.533939  [show with all ESTs]
    Unigene Representative Sequence: NM_001145345
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587567 ENST00000493391 ENST00000392170 ENST00000424129 ENST00000452939
    ENST00000427002 ENST00000472909 ENST00000460937 ENST00000480361 ENST00000494354
    ENST00000454319(uc010xte.2 uc010xtf.2 uc002oeb.4 uc002oec.4 uc010xtg.2)
    ENST00000434377(uc002oea.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF566 (see all 37):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-let-7d hsa-let-7g hsa-miR-372 hsa-miR-629* hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidZNF566 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF566
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF566
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    OriGene clones in human, mouse for ZNF566 (see all 22)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ZNF566 (NM_001145343)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF566
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF566
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF566
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF566
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF566
      QuantiFast Probe-based Assays in human, mouse, rat ZNF566

    Additional mRNA sequence: 

    AK027685.1 AK074497.1 AK299393.1 AK316262.1 BC007064.2 BC104886.1 BC104888.1 BC143658.1 
    BX649070.1 

    8 DOTS entries:

    DT.310439  DT.310437  DT.121484399  DT.75158775  DT.97837226  DT.100728836  DT.121484397  DT.91671515 

    Selected AceView cDNA sequences (see all 38):

    AI587016 BQ102319 BC007064 BQ269572 AK074497 BP351422 F08173 F08664 
    C02183 BQ277256 BG705438 BX509648 BQ286207 Z44774 AK027685 N63953 
    F04409 F04879 CA397615 BP354192 BG289057 BX649070 BU161761 F08221 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF566 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                          -           -           -                 -                                 
    SP2:                                      -           -                 -                                 
    SP3:                                      -           -                 -                                 
    SP4:                          -     -     -           -                 -                                 
    SP5:                                      -     -     -     -     -                                       


    ECgene alternative splicing isoforms for ZNF566

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF566 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACTTCAGC
    ZNF566 Expression
    About this image

    ZNF566 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF566 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533939
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZNF566 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5661 , 5 zinc finger protein 5661, 5 81.69(n)1
    80.31(a)1
      7 (17.26 cM)5
    725561  NM_152814.21  NP_690027.11 
     300773375 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZAP16
    Zinc-regulated transcription factor; binds to zinc...
    12(a)
    1 → many
    X(330431-333073) YJL056C


    ENSEMBL Gene Tree for ZNF566 (if available)
    TreeFam Gene Tree for ZNF566 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF566 gene
    ZNF7072  ZFP922  ZNF3022  ZNF1402  ZNF8292  ZNF22  
    Selected SIMAP similar genes for ZNF566 using alignment to 5 protein entries:     ZN566_HUMAN (see all proteins) (see all similar genes):
    ZNF826P    ZNF78L1    MGC12518    ZNF232    ZNF91    smap-7
    GLI4    HZF36    ZNF70    kr-znf3    DKFZp686H10254    FIK
    ZNF391    ZSCAN21    zf30    ZNF721    ZFP30    DKFZp666C237

    ZNF566 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF566
    PGOHUM00000263005


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF566 (see all 809)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923728891,2
    C--36935560(+) TCAGGA/GGGCTG 4 -- ds50010--------
    rs29459531,2
    C,F,A--36935626(-) AGTGCT/CGTGGC 4 -- ds50017Minor allele frequency- C:0.43NA WA CSA 14
    rs1836933261,2
    C--36935683(+) AAATAC/GATATA 4 -- ds50010--------
    rs1866816731,2
    --36935764(+) TCACCC/TTATAA 4 -- ds50010--------
    rs1895256621,2
    C--36935800(+) ATTACC/TAGCAT 4 -- ds50010--------
    rs1826958051,2
    --36936091(+) TTTATA/TTCCAA 4 -- ut310--------
    rs1869696111,2
    --36936345(+) ACATAA/TATGAA 4 -- ut310--------
    rs1929698771,2
    --36936391(+) GAAATA/CTTCCA 4 -- ut310--------
    rs1386211341,2
    C--36936395(+) TCTTCC/TAGAAG 4 -- ut310--------
    rs1918071391,2
    C--36936559(+) TCTACC/TAAAAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF566 (36936021 - 36980804 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF566:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675393CNV Deletion23128226
    nsv911648CNV Loss21882294
    nsv833817CNV Loss17160897
    nsv833816CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF566
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF566

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ZNF566:    About MalaCards
    malaria


    ZNF566 for disorders           About GeneDecksing


    Export disorders for ZNF566 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF566 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF566)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    5. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P.... Mermoud J.E. (Mol. Cell 2011)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    9. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84924 HGNC: 25919 AceView: ZNF566 Ensembl:ENSG00000186017 euGenes: HUgn84924
    ECgene: ZNF566 H-InvDB: ZNF566

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF566 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF566 gene:
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    GeneCards and IP:
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