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ZNF565 Gene

protein-coding   GIFtS: 47
GCID: GC19M036673

Zinc Finger Protein 565

  Search for ZNF565
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5651 2

External Ids:    HGNC: 267261   Entrez Gene: 1479292   Ensembl: ENSG000001963577   OMIM: 6142755   UniProtKB: Q8N9K53   

Export aliases for ZNF565 gene to outside databases

Previous GC identifers: GC19M041366 GC19M041360 GC19M033177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF565 Gene:
ZNF565 (zinc finger protein 565) is a protein-coding gene. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZN565_HUMAN, Q8N9K5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF565 gene promoter:
         USF1   USF-1   USF2   USF-1:USF-2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF565 promoter sequence
   Search Chromatin IP Primers for ZNF565

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF565


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

ZNF565 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF565 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036673:  view genomic region     (about GC identifiers)

Start:
36,673,187 bp from pter      End:
36,737,159 bp from pter
Size:
63,973 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN565_HUMAN, Q8N9K5 (See protein sequence)
Recommended Name: Zinc finger protein 565  
Size: 499 amino acids; 57827 Da
Secondary accessions: Q6NUS2

Explore the universe of human proteins at neXtProt for ZNF565: NX_Q8N9K5

Explore proteomics data for ZNF565 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF565 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035939.1  NP_689690.3  

    ENSEMBL proteins: 
     ENSP00000376013   ENSP00000347234   ENSP00000465906   ENSP00000468673   ENSP00000306869  
    Reactome Protein details: Q8N9K5

    ZNF565 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF565

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    LSBio Antibodies in human, mouse, rat for ZNF565

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    Cloud-Clone Corp. CLIAs for ZNF565


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N9K5

    ProtoNet protein and cluster: Q8N9K5

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN565_HUMAN, Q8N9K5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF565 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN565_HUMAN, Q8N9K5
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF565 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF565:
     Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF565
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF565
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF565

    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF565 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF565:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF565 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF565
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF565

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF565

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF565


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN565_HUMAN, Q8N9K5: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF565 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF565 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF565
        Generic Transcription Pathway



    ZNF565 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF565
    Interactions:

        Search GeneGlobe Interaction Network for ZNF565

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF565 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF565 (ZN565)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF565 gene (2 alternative transcripts): 
    NM_001042474.2  NM_152477.4  

    Unigene Cluster for ZNF565:

    Zinc finger protein 565
    Hs.596338  [show with all ESTs]
    Unigene Representative Sequence: AK057290
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392173(uc002odo.3) ENST00000355114 ENST00000591473 ENST00000585994
    ENST00000587803 ENST00000586648 ENST00000304116(uc002odn.3 uc010ees.3 uc002odp.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF565 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF565:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF565 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF565
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF565
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF565 (see all 13)
    OriGene ORF clones in mouse, rat for ZNF565
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF565 (NM_152477)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF565
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF565
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF565
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF565
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF565
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF565
      QuantiFast Probe-based Assays in human, mouse, rat ZNF565

    Additional mRNA sequence: 

    AK057290.1 AK094310.1 AK308212.1 

    2 DOTS entries:

    DT.100020997  DT.210816 

    Selected AceView cDNA sequences (see all 45):

    CA396857 CA306561 AK094310 AA476586 CD251687 AA448909 AA353953 BC068453 
    AI032079 AK057290 BG432401 AA973170 AI022739 BF064261 CB960081 CB959667 
    BX091997 BM128300 AW051368 BI827546 BE466825 H65544 AW957690 CK819275 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF565 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:        -     -     -                 -                                       
    SP2:                    -                 -                                       
    SP3:                                      -                                       
    SP4:                    -     -           -                                       
    SP5:                          -           -                                       


    ECgene alternative splicing isoforms for ZNF565

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF565 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTGGGAA
    ZNF565 Expression
    About this image

    ZNF565 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF565 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596338
        Custom PCR Arrays for ZNF565
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF565

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF565 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp841 , 5 zinc finger protein 841, 5 62.31(n)1
    55.31(a)1
      7 (17.25 cM)5
    743521  NM_023750.21  NP_076239.11 
     297685525 


    ENSEMBL Gene Tree for ZNF565 (if available)
    TreeFam Gene Tree for ZNF565 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF565 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF286B2  ZNF7902  ZNF3832  ZNF1812  
    ZNF2872  ZNF5822  ZNF4712  ZFP822  ZNF286A2  ZNF2502  ZNF8792  ZNF354C2  
    ZNF742  ZNF5832  ZNF3912  ZNF5542  ZNF4542  ZFP902  ENSG000001876072  ZFP142  
    ZNF3312  ZNF354A2  ZNF4612  ZNF354B2  ZNF342  ZNF5272  
    Selected SIMAP similar genes for ZNF565 using alignment to 4 protein entries:     ZN565_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    MGC12518    ZNF738    ZNF78L1    ZNF721    FIK
    kr-znf3    ZNF675    ZNF320    ZNF267    ZNF93    ZNF283
    KRBOX4    ZNF616    ZNF208    ZFP3    ZNF397    ZNF484

    ZNF565 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF565
    PGOHUM00000260464


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF565 (see all 743)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391033301,2
    Cuntested136685205(+) GAGACA/GACATC 4 V syn10--------
    rs1457250891,2
    Cuntested136688513(+) ACGTCA/G/TATTCC 2 -- int10--------
    rs3738188301,2
    C--33198910(+) ACAAC-/AAAAAA 2 -- int10--------
    rs3722928241,2
    C--36672687(+) GATCCA/GCCGCC 2 -- int10--------
    rs345794561,2
    C,F--36672696(+) GCCTCG/AGCCTC 2 -- int13Minor allele frequency- A:0.33NA 6
    rs1810091041,2
    --36672737(+) CTATGC/TCCAGC 2 -- int10--------
    rs106805831,2
    C--36672770(+) TTTTT-/T/TT  
            
    GAGAC
    2 -- int11NA 2
    rs43492681,2
    C,F--36672796(+) tcaacG/Caggct 2 -- int13Minor allele frequency- C:0.08NA WA 122
    rs1401951021,2
    C--36673000(+) CTGCCA/GGCCTT 2 -- int10--------
    rs58279511,2
    C--36673150(+) TTTTT-/CTTAGC 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF565 (36673187 - 36737159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF565:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010122CNV Insertion20482838
    nsv509739CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF565
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF565

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614275    OMIM disorders: --


    ZNF565 for disorders           About GeneDecksing


    Export disorders for ZNF565 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF565 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF565)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147929 HGNC: 26726 AceView: ZNF565 Ensembl:ENSG00000196357 euGenes: HUgn147929
    ECgene: ZNF565 H-InvDB: ZNF565

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF565 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF565 gene:
    Search GeneIP for patents involving ZNF565

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