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Aliases for ZNF564 Gene

Aliases for ZNF564 Gene

  • Zinc Finger Protein 564 2 3 5

External Ids for ZNF564 Gene

Previous GeneCards Identifiers for ZNF564 Gene

  • GC19M012498
  • GC19M012499
  • GC19M012572
  • GC19M012636
  • GC19M012208

Summaries for ZNF564 Gene

GeneCards Summary for ZNF564 Gene

ZNF564 (Zinc Finger Protein 564) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF823.

UniProtKB/Swiss-Prot for ZNF564 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF564 Gene

Genomics for ZNF564 Gene

Regulatory Elements for ZNF564 Gene

Enhancers for ZNF564 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G012781 1.9 FANTOM5 ENCODE dbSUPER 72.1 -237.8 -237756 16.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ZNF136 ZNF844 CCDC130 ZNF564 ZNF442 ZNF625 MRI1 ZNF44 C19orf43 WDR83OS
GH19G012983 2 FANTOM5 Ensembl ENCODE dbSUPER 40.4 -433.3 -433261 3.2 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF625 ZNF136 ZNF844 ZNF442 ZNF788 ENSG00000242615 ZNF709 ZNF799 ZNF564 CCDC130
GH19G013160 2.1 FANTOM5 Ensembl ENCODE dbSUPER 24 -615.8 -615754 13.8 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC CCDC130 ZNF44 ZNF799 ZNF791 WDR83OS ZNF564 TRMT1 C19orf43 ZNF709 ZNF442
GH19G012609 1.8 FANTOM5 Ensembl ENCODE 27.8 -60.8 -60819 4.8 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF136 ZNF700 ZNF564 C19orf43 WDR83OS ZNF799 ZNF44 ZNF844 HNRNPA1P10 ZNF791
GH19G013115 1.8 FANTOM5 ENCODE dbSUPER 27.2 -567.4 -567394 7.7 CREB3L1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ZNF610 CCDC130 WDR83OS ZNF791 ZNF564 ZNF44 ZNF136 MRI1 TRMT1 ZNF799 RFX1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF564 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF564 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107270 242 2201 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2

Genomic Location for ZNF564 Gene

Chromosome:
19
Start:
12,525,370 bp from pter
End:
12,551,542 bp from pter
Size:
26,173 bases
Orientation:
Minus strand

Genomic View for ZNF564 Gene

Genes around ZNF564 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF564 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF564 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF564 Gene

Proteins for ZNF564 Gene

  • Protein details for ZNF564 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ8-ZN564_HUMAN
    Recommended name:
    Zinc finger protein 564
    Protein Accession:
    Q8TBZ8
    Secondary Accessions:
    • B9EGT4
    • Q6P1K6

    Protein attributes for ZNF564 Gene

    Size:
    553 amino acids
    Molecular mass:
    63735 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28367.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF564 Gene

Post-translational modifications for ZNF564 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF564 Gene

No data available for DME Specific Peptides for ZNF564 Gene

Domains & Families for ZNF564 Gene

Gene Families for ZNF564 Gene

Protein Domains for ZNF564 Gene

Suggested Antigen Peptide Sequences for ZNF564 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBZ8

UniProtKB/Swiss-Prot:

ZN564_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF564: view

Function for ZNF564 Gene

Molecular function for ZNF564 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF564 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF564: view

Phenotypes for ZNF564 Gene

genes like me logo Genes that share phenotypes with ZNF564: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF564 Gene

Localization for ZNF564 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF564 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF564 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF564 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF564: view

Pathways & Interactions for ZNF564 Gene

SuperPathways for ZNF564 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF564: view

Pathways by source for ZNF564 Gene

2 Reactome pathways for ZNF564 Gene

Gene Ontology (GO) - Biological Process for ZNF564 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF564: view

No data available for SIGNOR curated interactions for ZNF564 Gene

Drugs & Compounds for ZNF564 Gene

No Compound Related Data Available

Transcripts for ZNF564 Gene

Unigene Clusters for ZNF564 Gene

Zinc finger protein 564:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF564 Gene

No ASD Table

Relevant External Links for ZNF564 Gene

GeneLoc Exon Structure for
ZNF564
ECgene alternative splicing isoforms for
ZNF564

Expression for ZNF564 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF564 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF564 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF564 Gene:

ZNF564

SOURCE GeneReport for Unigene cluster for ZNF564 Gene:

Hs.655615

Evidence on tissue expression from TISSUES for ZNF564 Gene

  • Intestine(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF564: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF564 Gene

Orthologs for ZNF564 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF564 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF564 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia LOC611075 34
  • 77.17 (n)
cow
(Bos Taurus)
Mammalia ZNF709 34
  • 71.63 (n)
-- 35
  • 56 (a)
ManyToMany
Species where no ortholog for ZNF564 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF564 Gene

ENSEMBL:
Gene Tree for ZNF564 (if available)
TreeFam:
Gene Tree for ZNF564 (if available)

Paralogs for ZNF564 Gene

(609) SIMAP similar genes for ZNF564 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF564: view

Variants for ZNF564 Gene

Sequence variations from dbSNP and Humsavar for ZNF564 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000004564 -- 12,550,386(+) CGCGG(G/T)GGCTC intron-variant, upstream-variant-2KB
rs1000118934 -- 12,531,291(+) TAATC(A/C)CAGCA intron-variant
rs1000161973 -- 12,547,113(+) TGTCC(A/G)GGCTA intron-variant
rs1000407186 -- 12,531,557(+) ACTCT(A/G)TCTCC intron-variant
rs1000621817 -- 12,541,408(+) AGCTC(A/G)GCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF564 Gene

Variant ID Type Subtype PubMed ID
dgv3436n100 CNV gain 25217958
dgv3437n100 CNV gain 25217958
esv2657782 CNV deletion 23128226
esv2669161 CNV deletion 23128226
esv2676012 CNV deletion 23128226
esv3643705 CNV loss 21293372
esv3643706 CNV loss 21293372
nsv2419 CNV deletion 18451855
nsv475741 CNV novel sequence insertion 20440878
nsv510755 CNV deletion 20534489
nsv828440 CNV loss 20364138
nsv960794 CNV duplication 23825009

Variation tolerance for ZNF564 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF564 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF564

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF564 Gene

Disorders for ZNF564 Gene

Relevant External Links for ZNF564

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF564

No disorders were found for ZNF564 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF564 Gene

Publications for ZNF564 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZNF564 Gene

Sources for ZNF564 Gene

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