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Aliases for ZNF561 Gene

Aliases for ZNF561 Gene

  • Zinc Finger Protein 561 2 3 5

External Ids for ZNF561 Gene

Previous GeneCards Identifiers for ZNF561 Gene

  • GC19M009582
  • GC19M009579
  • GC19M009715
  • GC19M009298

Summaries for ZNF561 Gene

GeneCards Summary for ZNF561 Gene

ZNF561 (Zinc Finger Protein 561) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF562.

UniProtKB/Swiss-Prot for ZNF561 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF561 Gene

Genomics for ZNF561 Gene

Regulatory Elements for ZNF561 Gene

Enhancers for ZNF561 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF561 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF561 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF561 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF561 Gene

9,604,680 bp from pter
9,621,399 bp from pter
16,720 bases
Minus strand

Genomic View for ZNF561 Gene

Genes around ZNF561 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF561 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF561 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF561 Gene

Proteins for ZNF561 Gene

  • Protein details for ZNF561 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 561
    Protein Accession:
    Secondary Accessions:
    • B4E2Q8
    • Q6PJS0

    Protein attributes for ZNF561 Gene

    486 amino acids
    Molecular mass:
    55197 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12144.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH32668.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF561 Gene


neXtProt entry for ZNF561 Gene

Proteomics data for ZNF561 Gene at MOPED

Post-translational modifications for ZNF561 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF561 Gene

Domains & Families for ZNF561 Gene

Gene Families for ZNF561 Gene

Protein Domains for ZNF561 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF561: view

Function for ZNF561 Gene

Molecular function for ZNF561 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF561: view
genes like me logo Genes that share phenotypes with ZNF561: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF561 Gene

Localization for ZNF561 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF561 Gene

Subcellular locations from

Jensen Localization Image for ZNF561 Gene COMPARTMENTS Subcellular localization image for ZNF561 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF561 Gene

Pathways & Interactions for ZNF561 Gene

SuperPathways for ZNF561 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF561: view

Pathways by source for ZNF561 Gene

2 Reactome pathways for ZNF561 Gene

Interacting Proteins for ZNF561 Gene

Gene Ontology (GO) - Biological Process for ZNF561 Gene


No data available for SIGNOR curated interactions for ZNF561 Gene

Drugs & Compounds for ZNF561 Gene

No Compound Related Data Available

Transcripts for ZNF561 Gene

Unigene Clusters for ZNF561 Gene

Zinc finger protein 561:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF561 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - -

Relevant External Links for ZNF561 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF561 Gene

mRNA expression in normal human tissues for ZNF561 Gene

Protein differential expression in normal tissues from HIPED for ZNF561 Gene

This gene is overexpressed in Lung (47.1), Heart (15.7), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF561 Gene

SOURCE GeneReport for Unigene cluster for ZNF561 Gene Hs.720081

genes like me logo Genes that share expression patterns with ZNF561: view

Protein tissue co-expression partners for ZNF561 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF561 Gene

Orthologs for ZNF561 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF561 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF561 35
  • 99.04 (n)
  • 98.15 (a)
ZNF561 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 29 (a)
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
(Mus musculus)
Mammalia Zfp266 36
  • 49 (a)
Species with no ortholog for ZNF561:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF561 Gene

Gene Tree for ZNF561 (if available)
Gene Tree for ZNF561 (if available)

Paralogs for ZNF561 Gene

Paralogs for ZNF561 Gene

(529) SIMAP similar genes for ZNF561 Gene using alignment to 10 proteins: Pseudogenes for ZNF561 Gene

genes like me logo Genes that share paralogs with ZNF561: view

Variants for ZNF561 Gene

Sequence variations from dbSNP and Humsavar for ZNF561 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8100797 -- 9,607,911(+) tgttg(C/T)ccagg utr-variant-3-prime
rs8100913 -- 9,608,016(+) gcagg(C/T)acccg utr-variant-3-prime
rs8101008 -- 9,608,081(+) ttaac(C/T)aggac utr-variant-3-prime
rs8105951 -- 9,607,996(+) cctcc(C/T)gagta utr-variant-3-prime
rs8109456 -- 9,611,025(+) TTATC(A/G)AGGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF561 Gene

Variant ID Type Subtype PubMed ID
esv2718156 CNV Deletion 23290073
nsv138179 CNV Loss 16902084
esv994852 CNV Insertion 20482838

Variation tolerance for ZNF561 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF561 Gene

Disorders for ZNF561 Gene

Relevant External Links for ZNF561

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF561 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF561 Gene

Publications for ZNF561 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ZNF561 Gene

Sources for ZNF561 Gene