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Aliases for ZNF561 Gene

Aliases for ZNF561 Gene

  • Zinc Finger Protein 561 2 3 5

External Ids for ZNF561 Gene

Previous GeneCards Identifiers for ZNF561 Gene

  • GC19M009582
  • GC19M009579
  • GC19M009715
  • GC19M009298

Summaries for ZNF561 Gene

GeneCards Summary for ZNF561 Gene

ZNF561 (Zinc Finger Protein 561) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF562.

UniProtKB/Swiss-Prot for ZNF561 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF561 Gene

Genomics for ZNF561 Gene

Regulatory Elements for ZNF561 Gene

Enhancers for ZNF561 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010100 1.8 FANTOM5 ENCODE dbSUPER 53.9 -483.0 -482989 8.3 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 TBX21 ZNF699 ZNF561 FBXL12 LOC100419831 ZNF562 ZNF559 TIMM29 EIF3G RAVER1 ZNF846
GH19G010379 1.1 ENCODE 52.3 -759.1 -759128 1.9 HDGF PKNOX1 CREB3L1 AGO1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 FBXL12 ZNF561 TIMM29 RAVER1 EIF3G LOC100419831 ZNF562 ZNF846 CDC37 ZNF121
GH19G010267 1.4 ENCODE dbSUPER 34.1 -648.9 -648939 5.6 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ZNF699 FBXL12 LOC100419831 ZNF559 ZNF561 ZNF846 RAVER1 ZNF562 TIMM29 EIF3G
GH19G009788 1.6 FANTOM5 ENCODE dbSUPER 27 -169.6 -169644 5.9 HDGF PKNOX1 ARNT ZFP64 ARID4B FOS ZNF263 SP3 JUNB REST ZNF561 ZNF846 ZNF266 ICAM1 ZNF699 GC19M009784
GH19G009620 1.4 FANTOM5 ENCODE 28.3 -0.5 -492 3.1 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF561 EIF3G LOC100128428 ENSG00000269300 ZNF846 UBL5 ZNF561-AS1 PIR53474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF561 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF561 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106906 99 2201 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for ZNF561 Gene

Chromosome:
19
Start:
9,604,680 bp from pter
End:
9,621,399 bp from pter
Size:
16,720 bases
Orientation:
Minus strand

Genomic View for ZNF561 Gene

Genes around ZNF561 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF561 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF561 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF561 Gene

Proteins for ZNF561 Gene

  • Protein details for ZNF561 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N587-ZN561_HUMAN
    Recommended name:
    Zinc finger protein 561
    Protein Accession:
    Q8N587
    Secondary Accessions:
    • B4E2Q8
    • Q6PJS0

    Protein attributes for ZNF561 Gene

    Size:
    486 amino acids
    Molecular mass:
    55197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12144.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH32668.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF561 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF561 Gene

Post-translational modifications for ZNF561 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF561 Gene

Domains & Families for ZNF561 Gene

Gene Families for ZNF561 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N587

UniProtKB/Swiss-Prot:

ZN561_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF561: view

Function for ZNF561 Gene

Molecular function for ZNF561 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF561: view
genes like me logo Genes that share phenotypes with ZNF561: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF561 Gene

Localization for ZNF561 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF561 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF561 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF561: view

Pathways & Interactions for ZNF561 Gene

SuperPathways for ZNF561 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF561: view

Pathways by source for ZNF561 Gene

2 Reactome pathways for ZNF561 Gene

Gene Ontology (GO) - Biological Process for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF561: view

No data available for SIGNOR curated interactions for ZNF561 Gene

Drugs & Compounds for ZNF561 Gene

No Compound Related Data Available

Transcripts for ZNF561 Gene

Unigene Clusters for ZNF561 Gene

Zinc finger protein 561:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF561 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11:
SP12:

Relevant External Links for ZNF561 Gene

GeneLoc Exon Structure for
ZNF561
ECgene alternative splicing isoforms for
ZNF561

Expression for ZNF561 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF561 Gene

Protein differential expression in normal tissues from HIPED for ZNF561 Gene

This gene is overexpressed in Lung (47.1), Heart (15.7), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF561 Gene



Protein tissue co-expression partners for ZNF561 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF561 Gene:

ZNF561

SOURCE GeneReport for Unigene cluster for ZNF561 Gene:

Hs.720081

Evidence on tissue expression from TISSUES for ZNF561 Gene

  • Intestine(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF561: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF561 Gene

Orthologs for ZNF561 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF561 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF561 34 35
  • 99.04 (n)
mouse
(Mus musculus)
Mammalia Zfp266 35
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 29 (a)
OneToMany
Species where no ortholog for ZNF561 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF561 Gene

ENSEMBL:
Gene Tree for ZNF561 (if available)
TreeFam:
Gene Tree for ZNF561 (if available)

Paralogs for ZNF561 Gene

Paralogs for ZNF561 Gene

(529) SIMAP similar genes for ZNF561 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for ZNF561 Gene

genes like me logo Genes that share paralogs with ZNF561: view

Variants for ZNF561 Gene

Sequence variations from dbSNP and Humsavar for ZNF561 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000193576 -- 9,613,596(+) TCATT(A/G)CAACC intron-variant
rs1000215047 -- 9,614,225(+) TTGAG(A/G)ATTTT intron-variant
rs1000380547 -- 9,616,737(+) CAGGT(A/C)CCTGC intron-variant
rs1000403905 -- 9,617,458(+) TTTTT(A/C)TTTTG intron-variant
rs1000463808 -- 9,607,328(+) ACATC(A/G)TTTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF561 Gene

Variant ID Type Subtype PubMed ID
esv2718156 CNV deletion 23290073
esv994852 CNV insertion 20482838
nsv1060112 CNV gain 25217958
nsv138179 CNV deletion 16902084
nsv978769 CNV duplication 23825009

Variation tolerance for ZNF561 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF561 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF561

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF561 Gene

Disorders for ZNF561 Gene

Relevant External Links for ZNF561

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF561

No disorders were found for ZNF561 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF561 Gene

Publications for ZNF561 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ZNF561 Gene

Sources for ZNF561 Gene

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