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ZNF561 Gene

protein-coding   GIFtS: 42
GCID: GC19M009715

Zinc Finger Protein 561

  Search for ZNF561
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5611 2

External Ids:    HGNC: 286841   Entrez Gene: 931342   Ensembl: ENSG000001714697   UniProtKB: Q8N5873   

Export aliases for ZNF561 gene to outside databases

Previous GC identifers: GC19M009582 GC19M009579 GC19M009298


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF561 Gene:
ZNF561 (zinc finger protein 561) is a protein-coding gene. An important paralog of this gene is ZNF812.

UniProtKB/Swiss-Prot: ZN561_HUMAN, Q8N587
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF561 gene promoter:
         CHOP-10   Pbx1a   POU2F1   POU2F1a   Bach2   GATA-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF561 promoter sequence
   Search Chromatin IP Primers for ZNF561

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF561


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF561 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF561 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M009715:  view genomic region     (about GC identifiers)

Start:
9,715,356 bp from pter      End:
9,732,075 bp from pter
Size:
16,720 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN561_HUMAN, Q8N587 (See protein sequence)
Recommended Name: Zinc finger protein 561  
Size: 486 amino acids; 55197 Da
Sequence caution: Sequence=AAH12144.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH32668.1; Type=Erroneous initiation;
Secondary accessions: Q6PJS0

Explore the universe of human proteins at neXtProt for ZNF561: NX_Q8N587

Explore proteomics data for ZNF561 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF561 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689502.2  
    ENSEMBL proteins: 
     ENSP00000402974   ENSP00000393074   ENSP00000303915   ENSP00000370284   ENSP00000392013  
     ENSP00000405257   ENSP00000406079   ENSP00000391503   ENSP00000397599   ENSP00000408053  
     ENSP00000346687  
    Reactome Protein details: Q8N587

    ZNF561 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF561

     
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    LSBio Antibodies in human, mouse, rat for ZNF561

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    Search eBioscience for ELISAs for ZNF561 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N587

    ProtoNet protein and cluster: Q8N587

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN561_HUMAN, Q8N587
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF561           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN561_HUMAN, Q8N587
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF561           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF561
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    miRNA
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    miRTarBase miRNAs that target ZNF561:
    hsa-mir-423-3p (MIRT042643), hsa-mir-1 (MIRT023525), hsa-mir-155-5p (MIRT020566)

    Block miRNA regulation of human, mouse, rat ZNF561 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF561

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF561
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF561

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF561


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN561_HUMAN, Q8N587: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF561           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF561 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF561           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF561
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF561
    Interactions:

        Search GeneGlobe Interaction Network for ZNF561

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF561 (ENSP000003039154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF561           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF561 (ZN561)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF561 gene: 
    NM_152289.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000444802 ENST00000424629 ENST00000302851(uc002mlu.3 uc010dwu.3 uc010xkr.2)
    ENST00000326044 ENST00000444611 ENST00000495503 ENST00000443819 ENST00000494276
    ENST00000465974 ENST00000483768 ENST00000457965 ENST00000479943 ENST00000444519
    ENST00000421525 ENST00000470932 ENST00000435550 ENST00000471053 ENST00000480167

    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF561 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidZNF561 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZNF561
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF561
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF561
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF561
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF561
      QuantiFast Probe-based Assays in human, mouse, rat ZNF561

    Selected AceView cDNA sequences (see all 109):

    AW073513 AA495878 AI333411 AI492309 BG613608 BQ640124 AI358019 AW995916 
    BG939396 BQ023235 CA415776 AK074787 BP341959 BF437602 BC012144 CK822584 
    BX105917 AA993513 BU070403 BQ641505 BM459938 BC032668 CA395508 BF446145 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF561 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9
    SP1:              -           -                 -     -     -                       -                                                   
    SP2:              -           -     -     -     -     -     -                       -                                                   
    SP3:                          -                 -     -                                                                                 
    SP4:                          -                 -     -     -                                                                           
    SP5:              -           -                 -           -                                                                           


    ECgene alternative splicing isoforms for ZNF561

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF561 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF561 Expression
    About this image

    ZNF561 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF561 Protein Expression
        Custom PCR Arrays for ZNF561
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF561

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for ZNF561 (if available)
    TreeFam Gene Tree for ZNF561 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF561 gene
    ZNF8122  ZNF7782  ZNF2662  ZNF4262  ZNF5602  ZNF8462  ZNF1212  ZNF5592  
    ZNF5622  
    Selected SIMAP similar genes for ZNF561 using alignment to 10 protein entries:     ZN561_HUMAN (see all proteins) (see all similar genes):
    ZNF562    ZFS-4    KRBOX4    ZNF705A    ZNF812    ZNF625-ZNF20
    ZNF596    ZNF235    FIK    ZNF84    ZNF302    ZNF738
    ZNF91    ZNF675    ZNF487    ZNF846    ZNF114    ZNF615

    Find genes that share paralogs with ZNF561           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZNF561
    PGOHUM00000234151 PGOHUM00000235590


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF561 (see all 290)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159050651,2
    F--9717517(+) CTAGAA/CATGTA 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1813910921,2
    --9717521(+) AAATGC/TAATAA 1 -- int10--------
    rs1502454621,2
    C--9717651(+) CTCCTG/TCTTCA 1 -- int10--------
    rs1138063951,2
    C,F--9717659(+) TCAGCG/CTCCTG 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs285042371,2
    C,F--9717663(+) CCTCCC/TGCGTA 1 -- int13Minor allele frequency- T:0.50WA NA CSA 6
    rs1445976861,2
    C--9717712(+) TTCTG-/TATTTTT 1 -- int10--------
    rs1860696641,2
    --9717859(+) TAGAGA/TTGAGT 1 -- int10--------
    rs1385408821,2
    C--9718003(+) CACATA/CATTTC 1 -- ut310--------
    rs1143650261,2
    C,F--9718054(+) TTCTAG/CGTACT 1 -- ut311Minor allele frequency- C:0.10WA 118
    rs593455311,2
    C,F--9718073(+) AGCAGT/CAAATA 1 -- ut313Minor allele frequency- C:0.11WA 122

    HapMap Linkage Disequilibrium report for ZNF561 (9715356 - 9732075 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF561:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718156CNV Deletion23290073
    esv994852CNV Insertion20482838
    nsv138179CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF561 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF561)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93134 HGNC: 28684 AceView: ZNF561 Ensembl:ENSG00000171469 euGenes: HUgn93134
    ECgene: ZNF561 H-InvDB: ZNF561

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF561 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF561 gene:
    Search GeneIP for patents involving ZNF561

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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