ZNF561 Gene
protein-coding GIFtS: 45
GCID: GC19M009715
|
|
zinc finger protein 561
| |
Aliases
for ZNF561 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5611 2 | | MGC454081 |
Export aliases for ZNF561 gene to outside databasesPrevious GC identifers: GC19M009582 GC19M009579 GC19M009298 |
Summaries
for ZNF561 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN561_HUMAN, Q8N587Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF561 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF561 gene promoter:
CHOP-10 Pbx1a POU2F1 POU2F1a Bach2 GATA-1 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF561
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF561 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC chromosome: 19ZNF561 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M009715: view genomic region
(about GC identifiers)
Start:
|
9,715,356 bp from pter |
End:
|
9,732,075 bp from pter |
Size:
|
16,720 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF561 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN561_HUMAN, Q8N587 (See
protein sequence)Recommended Name: Zinc finger protein 561 Size: 486 amino acids; 55197 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH12144.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH32668.1; Type=Erroneous initiation;
Secondary accessions: Q6PJS0Explore the universe of human proteins at neXtProt for ZNF561: NX_Q8N587
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N587
ZNF561 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689502.2
ENSEMBL proteins: ENSP00000402974 ENSP00000393074 ENSP00000303915 ENSP00000370284 ENSP00000392013 ENSP00000405257 ENSP00000406079 ENSP00000391503 ENSP00000397599 ENSP00000408053 ENSP00000346687 Reactome Protein details: Q8N587
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF561 for ontologies About GeneDecksing
ZNF561 Antibody Products:
Assay Products for ZNF561: |
Protein
Domains /
Families
for ZNF561 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF561 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N587ProtoNet protein and cluster: Q8N587 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN561_HUMAN, Q8N587Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF561 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN561_HUMAN, Q8N587Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF561 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF561 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF561 (NM_152289) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF561 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF561 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF561 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF561 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF561 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF561
ZNF561 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF561
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF561 (ENSP000003039154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF561 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF561 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF561
Search CenterWatch for drugs/clinical trials and news about ZNF561 / ZN561
|
Transcripts
for ZNF561 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF561 gene: NM_152289.2 Unigene Cluster for ZNF561: Zinc finger protein 561 Hs.720081 [show with all ESTs]Unigene Representative Sequence: NM_15228918/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000444802 ENST00000424629 ENST00000302851(uc002mlu.3 uc010dwu.3 uc010xkr.2)
ENST00000326044 ENST00000444611 ENST00000495503 ENST00000443819 ENST00000494276
ENST00000465974 ENST00000483768 ENST00000457965 ENST00000479943 ENST00000444519
ENST00000421525 ENST00000470932 ENST00000435550 ENST00000471053 ENST00000480167
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF561 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF561 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF561 (NM_152289) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF561 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF561 |
Additional cDNA sequence: AK074787.1 AK122974.1 AK293004.1 AK304383.1 BC012144.2 BC032668.1 11 DOTS entries: DT.100752179 DT.100026608 DT.102825669 DT.97799961 DT.100680548 DT.75176267 DT.100752178 DT.121447116 DT.121447077 DT.121447096 DT.97815825 24/109 AceView cDNA sequences (see all 109): BU070403 BM459938 CK822584 AW995916 CA415776 AW197413 BC032668 AI984021 CD244189 BQ640124 AI682468 BG939396 BF437602 AI358019 BX105917 BC012144 AI492309 AA495878 BQ023235 AW073513 AA993513 AK122974 BG613608 AK074787
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF561 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9 |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF561
|
Expression
for ZNF561 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF561 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF561 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF561
SOURCE GeneReport for Unigene cluster: Hs.720081
SABiosciences Custom PCR Arrays for ZNF561
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF561
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF561 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF561 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF561 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF561 |
Orthologs
for ZNF561 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF561 (if available)
TreeFam Gene Tree for ZNF561 (if available) |
Paralogs
for ZNF561 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF561 gene
- ZNF8122 ZNF7782 ZNF2662 ZNF4262 ZNF5602 ZNF8462 ZNF1212 ZNF5592
- ZNF5622
18/525 SIMAP similar genes for ZNF561 using alignment to 10 protein entries: ZN561_HUMAN (see all proteins)
(see all similar genes):ZNF562 ZNF705A ZFS-4 KRBOX4 ZNF812 ZNF596
ZNF235 ZNF84 ZNF302 ZNF487P ZNF846 DKFZp313M0722
ZFP90 MGC12518 ZNF226 ZNF726 ZNF331 ZNF707
ZNF561 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF561
PGOHUM00000234151 PGOHUM00000235590
|
Genomic Variants
for ZNF561 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF561 (9715356 - 9732075 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF561
1 CNV: 5938 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF561 |
|
Disorders
/ Diseases
for ZNF561 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF561 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF561 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF561) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for ZNF561 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF561 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF561 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF561 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF561 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF561 gene:
Search GeneIP for patents involving ZNF561
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF561 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF561 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF561 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF561 | | | OriGene Protein Over-expression Lysate for ZNF561 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF561 | | OriGene 3'-UTR Clone for ZNF561 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF561 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF561 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF561 | | OriGene Custom Protein Services for ZNF561 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF561 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF561 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF561 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF561 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF561 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF561 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF561 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF561 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF561 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF561 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF561 |
|
|
|
|
