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Aliases for ZNF561 Gene

Aliases for ZNF561 Gene

  • Zinc Finger Protein 561 2 3 5

External Ids for ZNF561 Gene

Previous GeneCards Identifiers for ZNF561 Gene

  • GC19M009582
  • GC19M009579
  • GC19M009715
  • GC19M009298

Summaries for ZNF561 Gene

GeneCards Summary for ZNF561 Gene

ZNF561 (Zinc Finger Protein 561) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF812P.

UniProtKB/Swiss-Prot for ZNF561 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF561 Gene

Genomics for ZNF561 Gene

Regulatory Elements for ZNF561 Gene

Enhancers for ZNF561 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010100 1.2 FANTOM5 ENCODE 62.6 -483.0 -482989 8.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 FBXL12 ZNF699 ZNF561 LOC100419831 ZNF559 TIMM29 YIPF2 ZNF562 EIF3G ZNF121
GH19F009620 1 FANTOM5 ENCODE 56.8 -0.5 -492 3.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF561 ZNF558 FBXL12 EIF3G ENSG00000269300 ZNF699 ZNF846 LOC100128428 MIR1181 LOC100419831
GH19F010379 0.2 ENCODE 47.6 -759.1 -759128 1.9 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FBXL12 ZNF561 LOC100419831 RAVER1 TIMM29 ZNF426 YIPF2 ZNF121 ZNF562 EIF3G
GH19F009674 0.7 ENCODE 40.2 -53.4 -53375 2.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF561 ZNF558 FBXL12 ZNF699 ZNF846 ENSG00000269300 ZNF559 EIF3G MIR1181 LOC100419831
GH19F009788 1.1 FANTOM5 ENCODE 37 -169.6 -169644 5.9 PKNOX1 ATF1 ARNT ZFP64 ARID4B ZNF48 GATA2 FOS ZNF263 SP3 ZNF561 FBXL12 EIF3G MIR1181 ZNF699 ZNF558 ZNF846 ZNF266 ICAM1 GC19M009784
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF561 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF561 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417787 98 2600 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for ZNF561 Gene

Chromosome:
19
Start:
9,604,680 bp from pter
End:
9,621,399 bp from pter
Size:
16,720 bases
Orientation:
Minus strand

Genomic View for ZNF561 Gene

Genes around ZNF561 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF561 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF561 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF561 Gene

Proteins for ZNF561 Gene

  • Protein details for ZNF561 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N587-ZN561_HUMAN
    Recommended name:
    Zinc finger protein 561
    Protein Accession:
    Q8N587
    Secondary Accessions:
    • B4E2Q8
    • Q6PJS0

    Protein attributes for ZNF561 Gene

    Size:
    486 amino acids
    Molecular mass:
    55197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12144.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH32668.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF561 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF561 Gene

Post-translational modifications for ZNF561 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF561 Gene

Domains & Families for ZNF561 Gene

Gene Families for ZNF561 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N587

UniProtKB/Swiss-Prot:

ZN561_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF561: view

Function for ZNF561 Gene

Molecular function for ZNF561 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF561: view
genes like me logo Genes that share phenotypes with ZNF561: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF561 Gene

Localization for ZNF561 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF561 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF561 Gene COMPARTMENTS Subcellular localization image for ZNF561 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF561: view

Pathways & Interactions for ZNF561 Gene

SuperPathways for ZNF561 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF561: view

Pathways by source for ZNF561 Gene

2 Reactome pathways for ZNF561 Gene

Gene Ontology (GO) - Biological Process for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF561: view

No data available for SIGNOR curated interactions for ZNF561 Gene

Transcripts for ZNF561 Gene

Unigene Clusters for ZNF561 Gene

Zinc finger protein 561:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF561 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11:
SP12:

Relevant External Links for ZNF561 Gene

GeneLoc Exon Structure for
ZNF561
ECgene alternative splicing isoforms for
ZNF561

Expression for ZNF561 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF561 Gene

Protein differential expression in normal tissues from HIPED for ZNF561 Gene

This gene is overexpressed in Lung (47.1), Heart (15.7), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF561 Gene



Protein tissue co-expression partners for ZNF561 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF561 Gene:

ZNF561

SOURCE GeneReport for Unigene cluster for ZNF561 Gene:

Hs.720081
genes like me logo Genes that share expression patterns with ZNF561: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF561 Gene

Orthologs for ZNF561 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF561 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF561 34 35
  • 99.04 (n)
mouse
(Mus musculus)
Mammalia Zfp266 35
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 29 (a)
OneToMany
Species where no ortholog for ZNF561 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF561 Gene

ENSEMBL:
Gene Tree for ZNF561 (if available)
TreeFam:
Gene Tree for ZNF561 (if available)

Paralogs for ZNF561 Gene

Paralogs for ZNF561 Gene

(529) SIMAP similar genes for ZNF561 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for ZNF561 Gene

genes like me logo Genes that share paralogs with ZNF561: view

Variants for ZNF561 Gene

Sequence variations from dbSNP and Humsavar for ZNF561 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401188 -- 9,612,470(+) gcctc(A/G)acctc intron-variant
rs10401707 -- 9,621,174(+) TGGGC(A/G)GACTC upstream-variant-2KB, utr-variant-5-prime
rs10407111 -- 9,620,637(+) CGCCA(C/T)ATGAC intron-variant, upstream-variant-2KB
rs10409457 -- 9,622,320(+) TCTCt(A/C)tatat intron-variant, upstream-variant-2KB
rs10412683 -- 9,608,028(+) cacca(C/T)gccag utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF561 Gene

Variant ID Type Subtype PubMed ID
esv2718156 CNV deletion 23290073
esv994852 CNV insertion 20482838
nsv1060112 CNV gain 25217958
nsv138179 CNV deletion 16902084
nsv978769 CNV duplication 23825009

Variation tolerance for ZNF561 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF561 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF561

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF561 Gene

Disorders for ZNF561 Gene

Relevant External Links for ZNF561

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF561

No disorders were found for ZNF561 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF561 Gene

Publications for ZNF561 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ZNF561 Gene

Sources for ZNF561 Gene

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