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Aliases for ZNF559-ZNF177 Gene

Aliases for ZNF559-ZNF177 Gene

  • ZNF559-ZNF177 Readthrough 2 3
  • ZNF177 4

External Ids for ZNF559-ZNF177 Gene

Summaries for ZNF559-ZNF177 Gene

Entrez Gene Summary for ZNF559-ZNF177 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSeq, Jan 2011]

GeneCards Summary for ZNF559-ZNF177 Gene

ZNF559-ZNF177 (ZNF559-ZNF177 Readthrough) is a Protein Coding gene. An important paralog of this gene is ZNF558.

UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF559-ZNF177 Gene

Genomics for ZNF559-ZNF177 Gene

Genomic Location for ZNF559-ZNF177 Gene

9,324,174 bp from pter
9,382,617 bp from pter
58,444 bases
Plus strand

Genomic View for ZNF559-ZNF177 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF559-ZNF177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF559-ZNF177 Gene

No data available for Regulatory Elements for ZNF559-ZNF177 Gene

Proteins for ZNF559-ZNF177 Gene

  • Protein details for ZNF559-ZNF177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 177
    Protein Accession:
    Secondary Accessions:
    • B4DY57
    • E9PDG0
    • I3L0I4
    • Q96ER2

    Protein attributes for ZNF559-ZNF177 Gene

    481 amino acids
    Molecular mass:
    54782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF559-ZNF177 Gene


neXtProt entry for ZNF559-ZNF177 Gene

Proteomics data for ZNF559-ZNF177 Gene at MOPED

Protein Expression for ZNF559-ZNF177 Gene

Post-translational modifications for ZNF559-ZNF177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF559-ZNF177 Gene

Domains for ZNF559-ZNF177 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.:
    • Q13360
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q13360
  • Contains 10 C2H2-type zinc fingers.:
    • Q13360
genes like me logo Genes that share domains with ZNF559-ZNF177: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ZNF559-ZNF177 Gene

Function for ZNF559-ZNF177 Gene

Molecular function for ZNF559-ZNF177 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF559-ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF559-ZNF177: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF559-ZNF177 Gene

Localization for ZNF559-ZNF177 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene

Gene Ontology (GO) - Cellular Components for ZNF559-ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ZNF559-ZNF177: view

No data available for Subcellular locations from COMPARTMENTS for ZNF559-ZNF177 Gene

Pathways for ZNF559-ZNF177 Gene

SuperPathways for ZNF559-ZNF177 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF559-ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8661005
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with ZNF559-ZNF177: view

No data available for Pathways by source for ZNF559-ZNF177 Gene

Transcripts for ZNF559-ZNF177 Gene

mRNA/cDNA for ZNF559-ZNF177 Gene

(2) REFSEQ mRNAs :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF559-ZNF177 Gene

No ASD Table

Relevant External Links for ZNF559-ZNF177 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF559-ZNF177 Gene

mRNA expression in normal human tissues for ZNF559-ZNF177 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF559-ZNF177 Gene

genes like me logo Genes that share expressions with ZNF559-ZNF177: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF559-ZNF177 Gene

Orthologs for ZNF559-ZNF177 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF559-ZNF177 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
(Canis familiaris)
Mammalia -- 36
  • 47 (a)
(Mus musculus)
Mammalia LOC102639598 35
  • 59.86 (n)
  • 56.4 (a)
Zfp931 36
  • 42 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
-- 36
  • 37 (a)
-- 36
  • 29 (a)
-- 36
  • 31 (a)
-- 36
  • 38 (a)
-- 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
(Danio rerio)
Actinopterygii ZNF557 36
  • 25 (a)
Species with no ortholog for ZNF559-ZNF177:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF559-ZNF177 Gene

Gene Tree for ZNF559-ZNF177 (if available)
Gene Tree for ZNF559-ZNF177 (if available)

Paralogs for ZNF559-ZNF177 Gene

Paralogs for ZNF559-ZNF177 Gene

genes like me logo Genes that share paralogs with ZNF559-ZNF177: view

Variants for ZNF559-ZNF177 Gene

Sequence variations from dbSNP and Humsavar for ZNF559-ZNF177 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1865040 -- 9,346,570(-) AGCCT(A/G)TAACT intron-variant
rs1865041 -- 9,346,179(-) ACAAT(G/T)AGATA intron-variant
rs6512063 -- 9,347,199(+) CACTG(A/C)ACCTG intron-variant
rs7247196 -- 9,357,427(+) cggct(A/T)actgc intron-variant
rs7247274 -- 9,356,170(+) gtgag(C/G)cactg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF559-ZNF177 Gene

Variant ID Type Subtype PubMed ID
nsv911020 CNV Gain 21882294
nsv523472 CNV Loss 19592680
nsv521091 CNV Loss 19592680
esv2678521 CNV Deletion 23128226
nsv911023 CNV Loss 21882294
esv2674742 CNV Deletion 23128226
nsv819521 CNV Gain 19587683

Relevant External Links for ZNF559-ZNF177 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene

Disorders for ZNF559-ZNF177 Gene

No disorders were found for ZNF559-ZNF177 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene

Publications for ZNF559-ZNF177 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. (PMID: 8661005) Baban S. … Mager D.L. (Genomics 1996) 3 4
  3. Repetitive elements in the 5' untranslated region of a human zinc- finger gene modulate transcription and translation efficiency. (PMID: 11549323) Landry J.R. … Mager D.L. (Genomics 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for ZNF559-ZNF177 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF559-ZNF177
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF559-ZNF177
    • Block miRNA regulation of ZNF559-ZNF177 using miScript Target Protectors

    Sources for ZNF559-ZNF177 Gene

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