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Aliases for ZNF559 Gene

Aliases for ZNF559 Gene

  • Zinc Finger Protein 559 2 3 5
  • Putative Protein Product Of Nbla00121 3
  • NBLA00121 3

External Ids for ZNF559 Gene

Previous GeneCards Identifiers for ZNF559 Gene

  • GC19P009296
  • GC19P009434
  • GC19P009016

Summaries for ZNF559 Gene

GeneCards Summary for ZNF559 Gene

ZNF559 (Zinc Finger Protein 559) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF426.

UniProtKB/Swiss-Prot for ZNF559 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF559 Gene

Genomics for ZNF559 Gene

Regulatory Elements for ZNF559 Gene

Enhancers for ZNF559 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010267 1.4 ENCODE dbSUPER 42.1 +946.6 946566 5.6 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ZNF699 FBXL12 LOC100419831 ZNF559 ZNF561 ZNF846 RAVER1 ZNF562 TIMM29 EIF3G
GH19G009323 1.1 ENCODE 53.2 +0.4 363 2.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF266 ZNF559 ZNF561 HNRNPM FBXL12 ZNF558 ZNF699 ZNF121 ZNF562 EIF3G
GH19G010100 1.8 FANTOM5 ENCODE dbSUPER 31 +780.6 780616 8.3 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 TBX21 ZNF699 ZNF561 FBXL12 LOC100419831 ZNF562 ZNF559 TIMM29 EIF3G RAVER1 ZNF846
GH19G008608 1.4 FANTOM5 ENCODE 31.2 -713.0 -712976 4.7 HDGF ATF1 FOXA2 SIN3A DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 KLF7 ZNF699 ZNF558 ZNF559 HNRNPM ZNF177 XAB2 ELAVL1 ADAMTS10 ENSG00000267510 ZNF426
GH19G010005 1.4 FANTOM5 ENCODE 30.3 +684.5 684541 4.8 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 COL5A3 LOC100419831 ZNF559 ZNF177 ZNF121 ZNF846 ENSG00000267510 YIPF2 ZNF562 TIMM29
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF559 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF559 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106895 429 1999 HDGF FOXA2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for ZNF559 Gene

Chromosome:
19
Start:
9,323,772 bp from pter
End:
9,351,162 bp from pter
Size:
27,391 bases
Orientation:
Plus strand

Genomic View for ZNF559 Gene

Genes around ZNF559 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF559 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF559 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF559 Gene

Proteins for ZNF559 Gene

  • Protein details for ZNF559 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR84-ZN559_HUMAN
    Recommended name:
    Zinc finger protein 559
    Protein Accession:
    Q9BR84
    Secondary Accessions:
    • K7EMG6

    Protein attributes for ZNF559 Gene

    Size:
    538 amino acids
    Molecular mass:
    62318 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF559 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF559 Gene

Post-translational modifications for ZNF559 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF559 Gene

Domains & Families for ZNF559 Gene

Gene Families for ZNF559 Gene

Protein Domains for ZNF559 Gene

Suggested Antigen Peptide Sequences for ZNF559 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BR84

UniProtKB/Swiss-Prot:

ZN559_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF559: view

Function for ZNF559 Gene

Molecular function for ZNF559 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF559 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF559: view

Phenotypes for ZNF559 Gene

genes like me logo Genes that share phenotypes with ZNF559: view

Animal Model Products

CRISPR Products

miRNA for ZNF559 Gene

miRTarBase miRNAs that target ZNF559

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF559 Gene

Localization for ZNF559 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF559 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF559 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF559 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF559: view

Pathways & Interactions for ZNF559 Gene

SuperPathways for ZNF559 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF559: view

Pathways by source for ZNF559 Gene

2 Reactome pathways for ZNF559 Gene

Gene Ontology (GO) - Biological Process for ZNF559 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF559: view

No data available for SIGNOR curated interactions for ZNF559 Gene

Drugs & Compounds for ZNF559 Gene

No Compound Related Data Available

Transcripts for ZNF559 Gene

Unigene Clusters for ZNF559 Gene

Zinc finger protein 559:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF559 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - - - -
SP20: - - - - -
SP21: - - - - -
SP22: - - - -
SP23: - - - - - - - -
SP24: - - - - - - - - - - - - - - -
SP25: - -

ExUns: 11b · 11c · 11d · 11e · 11f · 11g · 11h · 11i · 11j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for ZNF559 Gene

GeneLoc Exon Structure for
ZNF559
ECgene alternative splicing isoforms for
ZNF559

Expression for ZNF559 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF559 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF559 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for ZNF559 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF559 Gene



Protein tissue co-expression partners for ZNF559 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF559 Gene:

ZNF559

SOURCE GeneReport for Unigene cluster for ZNF559 Gene:

Hs.172979

Evidence on tissue expression from TISSUES for ZNF559 Gene

  • Nervous system(4.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ZNF559: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF559 Gene

Orthologs for ZNF559 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF559 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF559 34
  • 99.48 (n)
-- 35
  • 98 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
Species where no ortholog for ZNF559 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF559 Gene

ENSEMBL:
Gene Tree for ZNF559 (if available)
TreeFam:
Gene Tree for ZNF559 (if available)

Paralogs for ZNF559 Gene

Paralogs for ZNF559 Gene

(540) SIMAP similar genes for ZNF559 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF559: view

Variants for ZNF559 Gene

Sequence variations from dbSNP and Humsavar for ZNF559 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000013275 -- 9,325,018(+) AGATT(C/G)CCCCA intron-variant
rs1000065651 -- 9,323,089(+) AAATT(A/C)TCACG upstream-variant-2KB
rs1000103492 -- 9,327,484(+) CCTCA(A/G)GTGAT intron-variant
rs1000179104 -- 9,344,239(+) ATCTC(-/AAAAA)AAGAA intron-variant
rs1000246152 -- 9,341,413(+) TATCT(C/T)AGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF559 Gene

Variant ID Type Subtype PubMed ID
esv2674742 CNV deletion 23128226
esv2678521 CNV deletion 23128226
esv3643633 CNV loss 21293372
nsv521091 CNV loss 19592680
nsv523472 CNV loss 19592680
nsv819521 CNV gain 19587683
nsv961176 CNV duplication 23825009
nsv963002 CNV duplication 23825009

Variation tolerance for ZNF559 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF559 Gene

Human Gene Mutation Database (HGMD)
ZNF559
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF559

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF559 Gene

Disorders for ZNF559 Gene

Relevant External Links for ZNF559

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF559

No disorders were found for ZNF559 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF559 Gene

Publications for ZNF559 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64

Products for ZNF559 Gene

Sources for ZNF559 Gene

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