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Aliases for ZNF558 Gene

Aliases for ZNF558 Gene

  • Zinc Finger Protein 558 2 3 5

External Ids for ZNF558 Gene

Previous GeneCards Identifiers for ZNF558 Gene

  • GC19M008782
  • GC19M008920
  • GC19M008497

Summaries for ZNF558 Gene

GeneCards Summary for ZNF558 Gene

ZNF558 (Zinc Finger Protein 558) is a Protein Coding gene. Diseases associated with ZNF558 include Leber Congenital Amaurosis. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF114.

UniProtKB/Swiss-Prot for ZNF558 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF558 Gene

Genomics for ZNF558 Gene

Regulatory Elements for ZNF558 Gene

Enhancers for ZNF558 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF558 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF558 Gene

8,806,170 bp from pter
8,832,328 bp from pter
26,159 bases
Minus strand

Genomic View for ZNF558 Gene

Genes around ZNF558 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF558 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF558 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF558 Gene

Proteins for ZNF558 Gene

  • Protein details for ZNF558 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 558
    Protein Accession:
    Secondary Accessions:
    • A8K5F0
    • B7Z798

    Protein attributes for ZNF558 Gene

    402 amino acids
    Molecular mass:
    45755 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF558 Gene


neXtProt entry for ZNF558 Gene

Proteomics data for ZNF558 Gene at MOPED

Post-translational modifications for ZNF558 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF558 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF558 Gene

Domains & Families for ZNF558 Gene

Gene Families for ZNF558 Gene

Protein Domains for ZNF558 Gene

Suggested Antigen Peptide Sequences for ZNF558 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF558: view

Function for ZNF558 Gene

Molecular function for ZNF558 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF558 Gene

GenomeRNAi human phenotypes for ZNF558:
genes like me logo Genes that share phenotypes with ZNF558: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF558 Gene

Localization for ZNF558 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF558 Gene

Subcellular locations from

Jensen Localization Image for ZNF558 Gene COMPARTMENTS Subcellular localization image for ZNF558 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF558 Gene

Pathways & Interactions for ZNF558 Gene

SuperPathways for ZNF558 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF558: view

Pathways by source for ZNF558 Gene

2 Reactome pathways for ZNF558 Gene

Interacting Proteins for ZNF558 Gene

Gene Ontology (GO) - Biological Process for ZNF558 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF558: view

No data available for SIGNOR curated interactions for ZNF558 Gene

Drugs & Compounds for ZNF558 Gene

No Compound Related Data Available

Transcripts for ZNF558 Gene

Unigene Clusters for ZNF558 Gene

Zinc finger protein 558:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF558 Gene

No ASD Table

Relevant External Links for ZNF558 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF558 Gene

mRNA expression in normal human tissues for ZNF558 Gene

Protein differential expression in normal tissues from HIPED for ZNF558 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF558 Gene

SOURCE GeneReport for Unigene cluster for ZNF558 Gene Hs.659797

genes like me logo Genes that share expression patterns with ZNF558: view

Protein tissue co-expression partners for ZNF558 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF558 Gene

Orthologs for ZNF558 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF558 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF558 35
  • 86.73 (n)
  • 86.82 (a)
ZNF558 36
  • 87 (a)
(Mus musculus)
Mammalia Zfp558 35
  • 82.26 (n)
  • 80.35 (a)
Zfp558 16
Zfp558 36
  • 79 (a)
(Pan troglodytes)
Mammalia ZNF558 35
  • 98.92 (n)
  • 99.25 (a)
ZNF558 36
  • 99 (a)
(Bos Taurus)
Mammalia ZNF558 36
  • 86 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
-- 36
  • 48 (a)
-- 36
  • 37 (a)
-- 36
  • 36 (a)
-- 36
  • 47 (a)
-- 36
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
(Danio rerio)
Actinopterygii ZNF557 36
  • 20 (a)
Species with no ortholog for ZNF558:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF558 Gene

Gene Tree for ZNF558 (if available)
Gene Tree for ZNF558 (if available)

Paralogs for ZNF558 Gene

Paralogs for ZNF558 Gene

(535) SIMAP similar genes for ZNF558 Gene using alignment to 2 proteins: Pseudogenes for ZNF558 Gene

genes like me logo Genes that share paralogs with ZNF558: view

Variants for ZNF558 Gene

Sequence variations from dbSNP and Humsavar for ZNF558 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256781 -- 8,810,271(+) TACCA(C/T)ACTAT utr-variant-3-prime
rs12976402 -- 8,823,846(+) TGTGA(C/T)GTTGC intron-variant, upstream-variant-2KB
rs12978839 -- 8,821,848(+) TGACA(C/T)TTTCT intron-variant, utr-variant-5-prime
rs12982062 -- 8,823,613(+) AGTCA(C/G)CCCCT intron-variant, upstream-variant-2KB
rs67067711 -- 8,830,414(+) TCAAT(C/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF558 Gene

Variant ID Type Subtype PubMed ID
nsv469648 CNV Complex 16826518
nsv2402 CNV Loss 18451855
nsv428362 CNV Gain+Loss 18775914
nsv483078 CNV Complex 15286789
nsv171 CNV Loss 15895083
nsv911019 CNV Gain 21882294
nsv833738 CNV Gain 17160897
nsv833739 CNV Gain+Loss 17160897
dgv48n68 CNV Gain 17160897
dgv1056e1 CNV Complex 17122850

Variation tolerance for ZNF558 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF558 Gene

Disorders for ZNF558 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF558 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF558

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF558: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF558 Gene

Publications for ZNF558 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF558 Gene

Sources for ZNF558 Gene