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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF557 Gene

protein-coding   GIFtS: 48
GCID: GC19P007069

Zinc Finger Protein 557

  Search for ZNF557
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5571 2

External Ids:    HGNC: 286321   Entrez Gene: 792302   Ensembl: ENSG000001305447   UniProtKB: Q8N9883   

Export aliases for ZNF557 gene to outside databases

Previous GC identifers: GC19P007021 GC19P007022 GC19P006803


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF557 Gene: 
ZNF557 (zinc finger protein 557) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF177.

UniProtKB/Swiss-Prot: ZN557_HUMAN, Q8N988
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF557 gene promoter:
         Bach1   STAT1   HTF   STAT1beta   STAT3   SEF-1 (1)   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF557 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF557

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF557


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF557 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF557 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007069:  view genomic region     (about GC identifiers)

Start:
7,069,455 bp from pter      End:
7,087,979 bp from pter
Size:
18,525 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN557_HUMAN, Q8N988 (See protein sequence)
Recommended Name: Zinc finger protein 557  
Size: 423 amino acids; 48627 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH58040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAC04567.1; Type=Frameshift; Positions=23;
Secondary accessions: Q6PEJ3 Q9BTZ1
Alternative splicing: 2 isoforms:  Q8N988-1   Q8N988-2   

Explore the universe of human proteins at neXtProt for ZNF557: NX_Q8N988

Explore proteomics data for ZNF557 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N988

  • ZNF557 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF557 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001037852.1  NP_001037853.1  NP_077317.2  

    ENSEMBL proteins: 
     ENSP00000252840   ENSP00000398965   ENSP00000404065  
    Reactome Protein details: Q8N988
    Human Recombinant Protein Products for ZNF557: 
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    Novus Biologicals ZNF557 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF557 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF557 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N988

    ProtoNet protein and cluster: Q8N988

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN557_HUMAN, Q8N988
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF557 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN557_HUMAN, Q8N988
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF557 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF557:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF557 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF557

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF557 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF557:
    hsa-miR-188-3p
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF557


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF557 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF557
        Generic Transcription Pathway
    Gene Expression



    ZNF557 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF557

    2 Interacting proteins for ZNF557 (Q8N9882, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-61934 I2D: score=3 
    CEP70Q8NHQ13I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF557 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF557 (ZN557)

    Search CenterWatch for drugs/clinical trials and news about ZNF557 / ZN557

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF557 gene (3 alternative transcripts): 
    NM_001044387.1  NM_001044388.1  NM_024341.2  

    Unigene Cluster for ZNF557:

    Zinc finger protein 557
    Hs.591380  [show with all ESTs]
    Unigene Representative Sequence: NM_024341
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252840(uc002mga.3) ENST00000439035(uc002mgb.3) ENST00000414706(uc002mgc.3)

    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF557:
    hsa-miR-188-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF557
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF557
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    OriGene clones in human, mouse for ZNF557 (see all 16)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF557
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF557 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF557 
    Primer
    Products:
        
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF557
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF557

    Additional mRNA sequence: 

    AK095524.1 AK297283.1 AK315405.1 BC003020.1 BC031208.1 BC058040.1 

    6 DOTS entries:

    DT.101986327  DT.100033497  DT.427346  DT.202728  DT.86857134  DT.40195142 

    24/35 AceView cDNA sequences (see all 35):

    NM_024341 BC058040 BF447662 CD723600 AA135200 BC003020 AI523449 CD723611 
    BU632063 CD694100 AK095524 BI601073 BC031208 AI681886 AW296228 AA737172 
    AW517380 AI718134 BX390110 BF827143 BX352831 AW245951 AW411462 AA135314 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF557    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                            
    SP2:              -                                             


    ECgene alternative splicing isoforms for ZNF557

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF557 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGATTAAC
    ZNF557 Expression
    About this image


    See ZNF557 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF557

    SOURCE GeneReport for Unigene cluster: Hs.591380
        SABiosciences Custom PCR Arrays for ZNF557
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF557

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF557 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    30(a)
    possible ortholog
    20(51284050-51320870)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    37(a)
    possible ortholog
    GL344882.1(1643-15461)


    ENSEMBL Gene Tree for ZNF557 (if available)
    TreeFam Gene Tree for ZNF557 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF557 gene
    ZNF1772  ZNF3332  ZNF1142  ZNF8912  ZNF559-ZNF1772  ZNF5582  
    18/484 SIMAP similar genes for ZNF557 using alignment to 2 protein entries:     ZN557_HUMAN (see all proteins) (see all similar genes):
    kr-znf3    ZNF78L1    ZNF558    ZNF808    ZNF761    ZFS-5
    ZNF669    ZNF702P    ZNF28    HZF36    ZNF502    ZNF782
    ZNF331    POM121C    ZNF304    ZNF567    ZNF660    ZNF146

    ZNF557 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/557 SNPs in ZNF557 are shown (see all 557)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29676361,2
    C,F,A,H--7067773(+) ATTTAA/GGGATA 3 -- us2k126Minor allele frequency- G:0.35NS EA NA WA CSA 2770
    rs1841668771,2
    --7067910(+) ACATTA/CCATTG 3 -- us2k10--------
    rs758227201,2
    C--7068097(+) GATAGC/TAATTA 3 -- us2k10--------
    rs1154354351,2
    F--7068191(+) TAGCAC/TATAAC 3 -- us2k11Minor allele frequency- T:0.04WA 118
    rs748969471,2
    C,F--7068202(+) TCTTAC/TGTACT 3 -- us2k11Minor allele frequency- T:0.02NA 120
    rs29145721,2
    C,F,O,H--7068207(-) TTTACA/GGTACG 3 -- us2k127Minor allele frequency- N:0.00EA NA NS WA 2976
    rs1457944731,2
    C--7068268(+) AATTCA/GATGTT 3 -- us2k10--------
    rs1885207911,2
    --7068277(+) TTTATA/CATTTT 3 -- us2k10--------
    rs1809744461,2
    --7068484(+) GCACTA/GGACAA 3 -- us2k10--------
    rs1860061401,2
    --7068500(+) CAGCTG/TTGGCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF557 (7069455 - 7087979 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF557:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718082CNV Deletion23290073
    esv2751810CNV Loss17911159
    nsv910955CNV Gain21882294
    dgv393n27CNV Gain19166990
    dgv3708n71CNV Gain21882294
    esv2751809CNV Gain17911159
    dgv136e55CNV Gain17911159
    nsv517794CNV Gain+Loss19592680
    esv33729CNV Gain+Loss17666407

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF557 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF557)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. (PubMed id 15851553)1 Ozyildirim A.M....Laurie G.W. (2005)
    7. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79230 HGNC: 28632 AceView: ZNF557 Ensembl:ENSG00000130544 euGenes: HUgn79230
    ECgene: ZNF557 H-InvDB: ZNF557

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF557 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF557 gene:
    Search GeneIP for patents involving ZNF557

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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