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Aliases for ZNF557 Gene

Aliases for ZNF557 Gene

  • Zinc Finger Protein 557 2 3
  • CTB-25J19.9 3

External Ids for ZNF557 Gene

Previous GeneCards Identifiers for ZNF557 Gene

  • GC19P007021
  • GC19P007022
  • GC19P006803

Summaries for ZNF557 Gene

GeneCards Summary for ZNF557 Gene

ZNF557 (Zinc Finger Protein 557) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF558.

UniProtKB/Swiss-Prot for ZNF557 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF557 Gene

Genomics for ZNF557 Gene

Regulatory Elements for ZNF557 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF557 Gene

Start:
7,069,444 bp from pter
End:
7,087,968 bp from pter
Size:
18,525 bases
Orientation:
Plus strand

Genomic View for ZNF557 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF557 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF557 Gene

Proteins for ZNF557 Gene

  • Protein details for ZNF557 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N988-ZN557_HUMAN
    Recommended name:
    Zinc finger protein 557
    Protein Accession:
    Q8N988
    Secondary Accessions:
    • Q6PEJ3
    • Q9BTZ1

    Protein attributes for ZNF557 Gene

    Size:
    423 amino acids
    Molecular mass:
    48627 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH58040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC04567.1; Type=Frameshift; Positions=23; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF557 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF557 Gene

Proteomics data for ZNF557 Gene at MOPED

Post-translational modifications for ZNF557 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF557 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF557 Gene

Domains for ZNF557 Gene

Gene Families for ZNF557 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF557 Gene

Suggested Antigen Peptide Sequences for ZNF557 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N988

UniProtKB/Swiss-Prot:

ZN557_HUMAN :
  • Q8N988
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF557: view

Function for ZNF557 Gene

Molecular function for ZNF557 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF557: view

Phenotypes for ZNF557 Gene

genes like me logo Genes that share phenotypes with ZNF557: view

Animal Model Products

CRISPR Products

miRNA for ZNF557 Gene

miRTarBase miRNAs that target ZNF557

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF557 Gene

Localization for ZNF557 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF557 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF557 Gene COMPARTMENTS Subcellular localization image for ZNF557 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF557: view

Pathways for ZNF557 Gene

SuperPathways for ZNF557 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF557: view

Pathways by source for ZNF557 Gene

2 Reactome pathways for ZNF557 Gene

Interacting Proteins for ZNF557 Gene

Gene Ontology (GO) - Biological Process for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF557: view

Transcripts for ZNF557 Gene

Unigene Clusters for ZNF557 Gene

Zinc finger protein 557:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF557

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF557
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF557 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: -

Relevant External Links for ZNF557 Gene

GeneLoc Exon Structure for
ZNF557
ECgene alternative splicing isoforms for
ZNF557

Expression for ZNF557 Gene

mRNA expression in normal human tissues for ZNF557 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF557 Gene

SOURCE GeneReport for Unigene cluster for ZNF557 Gene Hs.591380

genes like me logo Genes that share expressions with ZNF557: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF557 Gene

Orthologs for ZNF557 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF557 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF557 35
  • 98.98 (n)
  • 98.89 (a)
ZNF557 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 37 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm14393 36
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 36
  • 19 (a)
OneToMany
Species with no ortholog for ZNF557:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF557 Gene

ENSEMBL:
Gene Tree for ZNF557 (if available)
TreeFam:
Gene Tree for ZNF557 (if available)

Paralogs for ZNF557 Gene

Selected SIMAP similar genes for ZNF557 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF557: view

Variants for ZNF557 Gene

Sequence variations from dbSNP and Humsavar for ZNF557 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs768488 -- 7,085,271(+) AGGCT(C/T)AAGGG utr-variant-3-prime
rs768489 -- 7,085,469(+) AGAAC(G/T)TCTTA utr-variant-3-prime
rs966591 -- 7,083,618(-) ACGGA(C/T)GAGAG reference, synonymous-codon
rs1049364 -- 7,087,701(+) GAGAG(A/T)GTGTG utr-variant-3-prime
rs1541831 -- 7,084,072(-) cgcag(C/G)tccct utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF557 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV Gain 17911159
nsv517794 CNV Gain+Loss 19592680
dgv393n27 CNV Gain 19166990
esv2751809 CNV Gain 17911159
esv33729 CNV Gain+Loss 17666407
dgv3708n71 CNV Gain 21882294
esv2751810 CNV Loss 17911159
nsv910955 CNV Gain 21882294
esv2718082 CNV Deletion 23290073

Relevant External Links for ZNF557 Gene

HapMap Linkage Disequilibrium report
ZNF557

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF557 Gene

Disorders for ZNF557 Gene

No disorders were found for ZNF557 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF557 Gene

Publications for ZNF557 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  5. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. (PMID: 15851553) Ozyildirim A.M. … Laurie G.W. (Invest. Ophthalmol. Vis. Sci. 2005) 3

Products for ZNF557 Gene

Sources for ZNF557 Gene

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