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ZNF557 Gene

protein-coding   GIFtS: 48
GCID: GC19P007069

Zinc Finger Protein 557

  Search for ZNF557
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5571 2
CTB-25J19.92

External Ids:    HGNC: 286321   Entrez Gene: 792302   Ensembl: ENSG000001305447   UniProtKB: Q8N9883   

Export aliases for ZNF557 gene to outside databases

Previous GC identifers: GC19P007021 GC19P007022 GC19P006803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF557 Gene:
ZNF557 (zinc finger protein 557) is a protein-coding gene. An important paralog of this gene is ZNF124.

UniProtKB/Swiss-Prot: ZN557_HUMAN, Q8N988
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF557 gene promoter:
         Bach1   STAT1   HTF   STAT1beta   STAT3   SEF-1 (1)   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF557 promoter sequence
   Search Chromatin IP Primers for ZNF557

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF557


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF557 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF557 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007069:  view genomic region     (about GC identifiers)

Start:
7,069,455 bp from pter      End:
7,087,979 bp from pter
Size:
18,525 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN557_HUMAN, Q8N988 (See protein sequence)
Recommended Name: Zinc finger protein 557  
Size: 423 amino acids; 48627 Da
Sequence caution: Sequence=AAH58040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAC04567.1; Type=Frameshift; Positions=23;
Secondary accessions: Q6PEJ3 Q9BTZ1
Alternative splicing: 2 isoforms:  Q8N988-1   Q8N988-2   

Explore the universe of human proteins at neXtProt for ZNF557: NX_Q8N988

Explore proteomics data for ZNF557 at MOPED


See ZNF557 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001037852.1  NP_001037853.1  NP_077317.2  

ENSEMBL proteins: 
 ENSP00000252840   ENSP00000398965   ENSP00000404065  
Reactome Protein details: Q8N988

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8N988

ProtoNet protein and cluster: Q8N988

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN557_HUMAN, Q8N988
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 10 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF557 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN557_HUMAN, Q8N988
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
ZNF557 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for ZNF557:
 Decreased viability of wild-ty 

Animal Models:
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miRNA
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hsa-mir-25-3p (MIRT050221)

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hsa-miR-188-3p
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Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN557_HUMAN, Q8N988: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
cytoskeleton1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

ZNF557 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF557 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF557
    Generic Transcription Pathway



ZNF557 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF557
Interactions:

    Search GeneGlobe Interaction Network for ZNF557

2 Interacting proteins for ZNF557 (Q8N9882, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SMAD9O151982, 3MINT-61934 I2D: score=3 
CEP70Q8NHQ13I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

ZNF557 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF557 (ZN557)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF557 gene (3 alternative transcripts): 
NM_001044387.1  NM_001044388.1  NM_024341.2  

Unigene Cluster for ZNF557:

Zinc finger protein 557
Hs.591380  [show with all ESTs]
Unigene Representative Sequence: NM_024341
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000252840(uc002mga.3) ENST00000439035(uc002mgb.3) ENST00000414706(uc002mgc.3)

miRNA
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hsa-miR-188-3p
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Inhib. RNA
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Additional mRNA sequence: 

AK095524.1 AK297283.1 AK315405.1 BC003020.1 BC031208.1 BC058040.1 

6 DOTS entries:

DT.101986327  DT.100033497  DT.427346  DT.202728  DT.86857134  DT.40195142 

Selected AceView cDNA sequences (see all 35):

AA135200 CD723600 BF447662 CD723611 AI523449 NM_024341 BU632063 BC003020 
BC058040 AI681886 BC031208 AW296228 AW517380 BF827143 CD694100 AA737172 
AK095524 AI718134 BX352831 BI601073 BX390110 AW245951 AW411462 BM991602 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF557    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:                                                            
SP2:              -                                             


ECgene alternative splicing isoforms for ZNF557

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF557 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTAGATTAAC
ZNF557 Expression
About this image

ZNF557 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF557 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591380
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Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF557 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
27(a)
1 → many
GL344882.1(1643-15461)
zebrafish
(Danio rerio)
Actinopterygii ZNF5576
zinc finger protein 557
19(a)
1 → many
15(997733-1002447) ENSDARG00000097394
        Species with no ortholog for ZNF557

ENSEMBL Gene Tree for ZNF557 (if available)
TreeFam Gene Tree for ZNF557 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF557 gene
ZNF1242  ZNF1772  ZNF3332  ZNF3172  ZNF8912  ZNF559-ZNF1772  ZNF5582  
Selected SIMAP similar genes for ZNF557 using alignment to 2 protein entries:     ZN557_HUMAN (see all proteins) (see all similar genes):
kr-znf3    ZNF78L1    LOC101928664    ZNF558    ZNF808    ZNF761
ZFS-5    ZNF669    ZNF702P    ZNF28    HZF36    ZNF502
ZNF782    ZNF331    POM121C    ZNF304    ZNF567    ZNF660

ZNF557 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF557 (see all 557)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs29676361,2
C,F,A,H--7067773(+) ATTTAA/GGGATA 3 -- us2k126Minor allele frequency- G:0.35NS EA NA WA CSA 2770
rs1841668771,2
--7067910(+) ACATTA/CCATTG 3 -- us2k10--------
rs758227201,2
C--7068097(+) GATAGC/TAATTA 3 -- us2k10--------
rs1154354351,2
F--7068191(+) TAGCAC/TATAAC 3 -- us2k11Minor allele frequency- T:0.04WA 118
rs748969471,2
C,F--7068202(+) TCTTAC/TGTACT 3 -- us2k11Minor allele frequency- T:0.02NA 120
rs29145721,2
C,F,O,H--7068207(-) TTTACA/GGTACG 3 -- us2k127Minor allele frequency- N:0.00EA NA NS WA 2976
rs1457944731,2
C--7068268(+) AATTCA/GATGTT 3 -- us2k10--------
rs1885207911,2
--7068277(+) TTTATA/CATTTT 3 -- us2k10--------
rs1809744461,2
--7068484(+) GCACTA/GGACAA 3 -- us2k10--------
rs1860061401,2
--7068500(+) CAGCTG/TTGGCT 3 -- us2k10--------

HapMap Linkage Disequilibrium report for ZNF557 (7069455 - 7087979 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for ZNF557:    About this table    
Variant IDTypeSubtypePubMed ID
esv2718082CNV Deletion23290073
esv2751810CNV Loss17911159
nsv910955CNV Gain21882294
dgv393n27CNV Gain19166990
dgv3708n71CNV Gain21882294
esv2751809CNV Gain17911159
dgv136e55CNV Gain17911159
nsv517794CNV Gain+Loss19592680
esv33729CNV Gain+Loss17666407

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF557 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF557)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
  6. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. (PubMed id 15851553)1 Ozyildirim A.M....Laurie G.W. (amp 2005)
  7. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79230 HGNC: 28632 AceView: ZNF557 Ensembl:ENSG00000130544 euGenes: HUgn79230
ECgene: ZNF557 H-InvDB: ZNF557

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF557 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF557 gene:
Search GeneIP for patents involving ZNF557

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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