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Aliases for ZNF557 Gene

Aliases for ZNF557 Gene

  • Zinc Finger Protein 557 2 3 5
  • CTB-25J19.9 3

External Ids for ZNF557 Gene

Previous GeneCards Identifiers for ZNF557 Gene

  • GC19P007021
  • GC19P007022
  • GC19P006803

Summaries for ZNF557 Gene

GeneCards Summary for ZNF557 Gene

ZNF557 (Zinc Finger Protein 557) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF558.

UniProtKB/Swiss-Prot for ZNF557 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF557 Gene

Genomics for ZNF557 Gene

Regulatory Elements for ZNF557 Gene

Enhancers for ZNF557 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G006270 2 FANTOM5 Ensembl ENCODE dbSUPER 64.4 -794.1 -794092 10.7 CREB3L1 MLX AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ZNF557 SNRPEP4 SAFB ENSG00000267571 VMAC GPR108 ACSBG2 SH2D3A MLLT1 VAV1
GH19G006527 1.4 ENCODE dbSUPER 57 -538.8 -538801 6.2 YBX1 ZNF143 ZNF548 SP3 MCM3 TBX21 MEF2D ZNF610 GLIS1 RCOR2 SAFB2 ZNF557 SNRPEP4 SAFB ENSG00000267571 GTF2F1 RPL36 GPR108 ENSG00000269680 VMAC
GH19G007390 1.5 FANTOM5 Ensembl ENCODE 36.8 +322.2 322150 2.0 FOXA2 ARID4B ZNF548 FOS TSHZ1 ZNF518A KAT8 MIER3 SMARCA4 ETV4 ELAVL1 ZNF557 XAB2 GTF2F1 GPR108 LRRC8E ARHGEF18 ENSG00000267852 ENSG00000268861
GH19G006515 1.6 Ensembl ENCODE dbSUPER 33.9 -552.8 -552810 2.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 SNRPEP4 ENSG00000267571 ZNF557 VMAC GPR108 SAFB2 SAFB SLC25A23 TUBB4A TNFSF9
GH19G006085 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.6 -981.7 -981651 3.7 HDGF PKNOX1 ARID4B FEZF1 ZNF2 ZNF766 FOS JUNB REST TBX21 ZNF557 SAFB RFX2 ACSBG2 ENSG00000267571 VMAC SNRPEP4 SH2D3A FUT5 SAFB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF557 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF557 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF557 Gene

7,069,444 bp from pter
7,087,968 bp from pter
18,525 bases
Plus strand

Genomic View for ZNF557 Gene

Genes around ZNF557 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF557 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF557 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF557 Gene

Proteins for ZNF557 Gene

  • Protein details for ZNF557 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 557
    Protein Accession:
    Secondary Accessions:
    • Q6PEJ3
    • Q9BTZ1

    Protein attributes for ZNF557 Gene

    423 amino acids
    Molecular mass:
    48627 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH58040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC04567.1; Type=Frameshift; Positions=23; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF557 Gene


neXtProt entry for ZNF557 Gene

Post-translational modifications for ZNF557 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF557 Gene

No data available for DME Specific Peptides for ZNF557 Gene

Domains & Families for ZNF557 Gene

Gene Families for ZNF557 Gene

Protein Domains for ZNF557 Gene

Suggested Antigen Peptide Sequences for ZNF557 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF557: view

Function for ZNF557 Gene

Molecular function for ZNF557 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF557: view
genes like me logo Genes that share phenotypes with ZNF557: view

Animal Model Products

CRISPR Products

miRNA for ZNF557 Gene

miRTarBase miRNAs that target ZNF557

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF557 Gene

Localization for ZNF557 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF557 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF557 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF557: view

Pathways & Interactions for ZNF557 Gene

SuperPathways for ZNF557 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF557: view

Pathways by source for ZNF557 Gene

2 Reactome pathways for ZNF557 Gene

Gene Ontology (GO) - Biological Process for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF557: view

No data available for SIGNOR curated interactions for ZNF557 Gene

Drugs & Compounds for ZNF557 Gene

No Compound Related Data Available

Transcripts for ZNF557 Gene

mRNA/cDNA for ZNF557 Gene

Unigene Clusters for ZNF557 Gene

Zinc finger protein 557:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF557 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP2: -

Relevant External Links for ZNF557 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF557 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF557 Gene

Protein differential expression in normal tissues from HIPED for ZNF557 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF557 Gene

Protein tissue co-expression partners for ZNF557 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF557 Gene:


SOURCE GeneReport for Unigene cluster for ZNF557 Gene:


Evidence on tissue expression from TISSUES for ZNF557 Gene

  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF557: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF557 Gene

Orthologs for ZNF557 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF557 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF557 34 35
  • 98.98 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
-- 35
  • 51 (a)
-- 35
  • 44 (a)
-- 35
  • 41 (a)
-- 35
  • 36 (a)
-- 35
  • 34 (a)
(Mus musculus)
Mammalia Gm14393 35
  • 43 (a)
(Bos Taurus)
Mammalia -- 35
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
(Danio rerio)
Actinopterygii ZNF557 35
  • 19 (a)
Species where no ortholog for ZNF557 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF557 Gene

Gene Tree for ZNF557 (if available)
Gene Tree for ZNF557 (if available)

Paralogs for ZNF557 Gene

Paralogs for ZNF557 Gene

(484) SIMAP similar genes for ZNF557 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF557: view

Variants for ZNF557 Gene

Sequence variations from dbSNP and Humsavar for ZNF557 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000324555 -- 7,074,094(+) CTCCC(A/G)GGTTC intron-variant
rs1000374614 -- 7,079,703(+) GTAAC(A/G)TCTGT intron-variant
rs1000605260 -- 7,074,387(+) GAAAC(A/G)TTCCA intron-variant
rs1000655743 -- 7,085,780(+) TCAGT(C/G)TTTTA utr-variant-3-prime
rs1000773911 -- 7,068,737(+) CAAAT(A/G)CAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF557 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV gain 17911159
dgv3421n100 CNV gain 25217958
dgv393n27 CNV gain 19166990
dgv6237n54 CNV gain 21841781
dgv6245n54 CNV gain 21841781
esv2718082 CNV deletion 23290073
esv2751809 CNV gain 17911159
esv2751810 CNV loss 17911159
esv2760525 CNV gain 21179565
esv2762977 CNV gain+loss 21179565
esv33729 CNV gain+loss 17666407
esv3574297 CNV gain 25503493
esv3643577 CNV gain 21293372
nsv1056752 CNV gain 25217958
nsv1061916 CNV gain 25217958
nsv517794 CNV gain+loss 19592680
nsv578500 CNV gain 21841781

Variation tolerance for ZNF557 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF557 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF557 Gene

Disorders for ZNF557 Gene

Relevant External Links for ZNF557

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF557 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF557 Gene

Publications for ZNF557 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64

Products for ZNF557 Gene

Sources for ZNF557 Gene

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