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Aliases for ZNF556 Gene

Aliases for ZNF556 Gene

  • Zinc Finger Protein 556 2 3 5

External Ids for ZNF556 Gene

Previous GeneCards Identifiers for ZNF556 Gene

  • GC19P002819
  • GC19P002820
  • GC19P002638

Summaries for ZNF556 Gene

GeneCards Summary for ZNF556 Gene

ZNF556 (Zinc Finger Protein 556) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF556 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF556 Gene

Genomics for ZNF556 Gene

Regulatory Elements for ZNF556 Gene

Enhancers for ZNF556 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF556 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF556 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF556 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF556 Gene

2,867,335 bp from pter
2,883,445 bp from pter
16,111 bases
Plus strand

Genomic View for ZNF556 Gene

Genes around ZNF556 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF556 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF556 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF556 Gene

Proteins for ZNF556 Gene

  • Protein details for ZNF556 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 556
    Protein Accession:
    Secondary Accessions:
    • Q96GM3

    Protein attributes for ZNF556 Gene

    456 amino acids
    Molecular mass:
    51581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF556 Gene

Proteomics data for ZNF556 Gene at MOPED

Post-translational modifications for ZNF556 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF556 Gene

No data available for DME Specific Peptides for ZNF556 Gene

Domains & Families for ZNF556 Gene

Gene Families for ZNF556 Gene

Protein Domains for ZNF556 Gene

Suggested Antigen Peptide Sequences for ZNF556 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF556: view

Function for ZNF556 Gene

Molecular function for ZNF556 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF556: view

Animal Model Products

CRISPR Products

miRNA for ZNF556 Gene

miRTarBase miRNAs that target ZNF556

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF556 Gene

Localization for ZNF556 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF556 Gene

Subcellular locations from

Jensen Localization Image for ZNF556 Gene COMPARTMENTS Subcellular localization image for ZNF556 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF556 Gene

Pathways & Interactions for ZNF556 Gene

SuperPathways for ZNF556 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF556: view

Pathways by source for ZNF556 Gene

2 Reactome pathways for ZNF556 Gene

Gene Ontology (GO) - Biological Process for ZNF556 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF556: view

No data available for SIGNOR curated interactions for ZNF556 Gene

Drugs & Compounds for ZNF556 Gene

No Compound Related Data Available

Transcripts for ZNF556 Gene

mRNA/cDNA for ZNF556 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF556 Gene

Zinc finger protein 556:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF556 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c

Relevant External Links for ZNF556 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF556 Gene

mRNA expression in normal human tissues for ZNF556 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF556 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.2), Ovary (x7.7), Brain - Cerebellum (x7.4), and Muscle - Skeletal (x5.3).

Protein differential expression in normal tissues from HIPED for ZNF556 Gene

This gene is overexpressed in Bone (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF556 Gene

SOURCE GeneReport for Unigene cluster for ZNF556 Gene Hs.287433

genes like me logo Genes that share expression patterns with ZNF556: view

Protein tissue co-expression partners for ZNF556 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF556 Gene

Orthologs for ZNF556 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF556 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF556 35
  • 78.23 (n)
  • 67.65 (a)
ZNF556 36
  • 58 (a)
(Pan troglodytes)
Mammalia ZNF556 35
  • 99.12 (n)
  • 98.46 (a)
ZNF556 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
-- 36
  • 34 (a)
-- 36
  • 31 (a)
-- 36
  • 31 (a)
(Mus musculus)
Mammalia C330013J21Rik 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
(Danio rerio)
Actinopterygii CR388132.2 36
  • 25 (a)
CT573234.2 36
  • 25 (a)
Species with no ortholog for ZNF556:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF556 Gene

Gene Tree for ZNF556 (if available)
Gene Tree for ZNF556 (if available)

Paralogs for ZNF556 Gene

(422) SIMAP similar genes for ZNF556 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF556: view

Variants for ZNF556 Gene

Sequence variations from dbSNP and Humsavar for ZNF556 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10421121 - 2,877,367(+) ATCTG(C/T)GCAAG reference, missense
rs35499960 - 2,877,395(-) CGTAC(A/C/T)GTCTT reference, missense
rs35296337 - 2,878,015(-) CCTCG(C/G/T)GGAAG reference, missense
rs35494032 - 2,878,240(-) TTTTT(C/T)GCATT reference, missense
rs7259300 -- 2,871,542(+) ggtgc(A/G)gtggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF556 Gene

Variant ID Type Subtype PubMed ID
nsv910692 CNV Loss 21882294
nsv509715 CNV Insertion 20534489

Variation tolerance for ZNF556 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF556 Gene

Disorders for ZNF556 Gene

Relevant External Links for ZNF556

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF556 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF556 Gene

Publications for ZNF556 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZNF556 Gene

Sources for ZNF556 Gene