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Aliases for ZNF556 Gene

Aliases for ZNF556 Gene

  • Zinc Finger Protein 556 2 3 5

External Ids for ZNF556 Gene

Previous GeneCards Identifiers for ZNF556 Gene

  • GC19P002819
  • GC19P002820
  • GC19P002638

Summaries for ZNF556 Gene

GeneCards Summary for ZNF556 Gene

ZNF556 (Zinc Finger Protein 556) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF555.

UniProtKB/Swiss-Prot for ZNF556 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF556 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF556 Gene

Genomics for ZNF556 Gene

Regulatory Elements for ZNF556 Gene

Enhancers for ZNF556 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H002866 1.2 Ensembl ENCODE 16 +0.3 270 2 TBP PKNOX1 ZFP64 ARID4B DMAP1 THRB RARA RFX5 SLC30A9 FOS ZNF556 ZNF555 SMIM24 ENSG00000267398
GH19H002887 1.4 FANTOM5 Ensembl ENCODE 12.2 +21.1 21084 2 FOXA2 ARID4B RAD21 GATA2 ZNF143 ATF7 CREM IKZF2 MIXL1 THAP11 ZNF555 LOC101928631 ZNF556 ZNF77 ZNF554 THOP1 SLC39A3 LOC100419704 ENSG00000267398
GH19H002693 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -172.2 -172238 3 ZNF146 ZNF311 ZNF514 NR2F2 ZFHX2 ZNF366 BCL6B ZNF512 PRDM1 ZNF77 CACTIN-AS1 DIRAS1 CACTIN GNG7 SLC39A3 ZNF556 LINGO3 ENSG00000276097 PIR43863
GH19H002819 1.1 ENCODE 12.6 -47.4 -47380 1 ARID4B SIN3A ZNF2 YY1 ZNF766 CBX5 ZNF207 ZNF143 DEK SP3 ZNF77 CACTIN SF3A2 ZNF554 CACTIN-AS1 THOP1 ZNF555 C19orf71 LOC100288123 SPPL2B
GH19H002864 0.9 ENCODE 15 -1.8 -1792 1 HDAC1 ATF1 ARNT ARID4B TCF12 ATF7 THAP11 CEBPB NCOA1 ZEB2 ZNF556 ENSG00000267063
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF556 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF556 Gene

Chromosome:
19
Start:
2,867,335 bp from pter
End:
2,883,445 bp from pter
Size:
16,111 bases
Orientation:
Plus strand

Genomic View for ZNF556 Gene

Genes around ZNF556 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF556 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF556 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF556 Gene

Proteins for ZNF556 Gene

  • Protein details for ZNF556 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAH1-ZN556_HUMAN
    Recommended name:
    Zinc finger protein 556
    Protein Accession:
    Q9HAH1
    Secondary Accessions:
    • Q96GM3

    Protein attributes for ZNF556 Gene

    Size:
    456 amino acids
    Molecular mass:
    51581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF556 Gene

Post-translational modifications for ZNF556 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF556 Gene

No data available for DME Specific Peptides for ZNF556 Gene

Domains & Families for ZNF556 Gene

Gene Families for ZNF556 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF556 Gene

Suggested Antigen Peptide Sequences for ZNF556 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAH1

UniProtKB/Swiss-Prot:

ZN556_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF556: view

Function for ZNF556 Gene

Molecular function for ZNF556 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF556 Gene

Gene Ontology (GO) - Molecular Function for ZNF556 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF556: view
genes like me logo Genes that share phenotypes with ZNF556: view

Animal Model Products

CRISPR Products

miRNA for ZNF556 Gene

miRTarBase miRNAs that target ZNF556

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF556
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF556 Gene

Localization for ZNF556 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF556 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF556 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF556 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF556: view

Pathways & Interactions for ZNF556 Gene

SuperPathways for ZNF556 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF556: view

Pathways by source for ZNF556 Gene

2 Reactome pathways for ZNF556 Gene

Gene Ontology (GO) - Biological Process for ZNF556 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF556: view

No data available for SIGNOR curated interactions for ZNF556 Gene

Drugs & Compounds for ZNF556 Gene

No Compound Related Data Available

Transcripts for ZNF556 Gene

mRNA/cDNA for ZNF556 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF556 Gene

Zinc finger protein 556:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF556
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF556 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3:

Relevant External Links for ZNF556 Gene

GeneLoc Exon Structure for
ZNF556
ECgene alternative splicing isoforms for
ZNF556

Expression for ZNF556 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF556 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF556 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.2), Ovary (x7.7), Brain - Cerebellum (x7.4), and Muscle - Skeletal (x5.3).

Protein differential expression in normal tissues from HIPED for ZNF556 Gene

This gene is overexpressed in Bone (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF556 Gene



Protein tissue co-expression partners for ZNF556 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF556 Gene:

ZNF556

SOURCE GeneReport for Unigene cluster for ZNF556 Gene:

Hs.287433

Evidence on tissue expression from TISSUES for ZNF556 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF556: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF556 Gene

Orthologs for ZNF556 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF556 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF556 33 34
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia ZNF556 33 34
  • 78.23 (n)
mouse
(Mus musculus)
Mammalia C330013J21Rik 34
  • 36 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR388132.2 34
  • 25 (a)
ManyToMany
CT573234.2 34
  • 25 (a)
ManyToMany
Species where no ortholog for ZNF556 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF556 Gene

ENSEMBL:
Gene Tree for ZNF556 (if available)
TreeFam:
Gene Tree for ZNF556 (if available)

Paralogs for ZNF556 Gene

(422) SIMAP similar genes for ZNF556 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF556: view

Variants for ZNF556 Gene

Sequence variations from dbSNP and Humsavar for ZNF556 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000295290 -- 2,866,388(+) GCAGT(C/G)GGGCA upstream-variant-2KB
rs1000433434 -- 2,873,749(+) AGGAG(C/T)TGACA intron-variant
rs1000786223 -- 2,870,375(+) TGAGC(A/C)CAGGA intron-variant
rs1000925244 -- 2,870,186(+) CCATG(C/T)CTGTA intron-variant
rs1001236152 -- 2,873,845(+) CTAGC(C/T)ACTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF556 Gene

Variant ID Type Subtype PubMed ID
nsv1063039 CNV loss 25217958
nsv509715 CNV insertion 20534489

Variation tolerance for ZNF556 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF556 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF556

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF556 Gene

Disorders for ZNF556 Gene

Relevant External Links for ZNF556

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF556

No disorders were found for ZNF556 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF556 Gene

Publications for ZNF556 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L … McKnight A (Retrovirology 2011) 3 60

Products for ZNF556 Gene

Sources for ZNF556 Gene

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