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Aliases for ZNF554 Gene

Aliases for ZNF554 Gene

  • Zinc Finger Protein 554 2 3 5

External Ids for ZNF554 Gene

Previous GeneCards Identifiers for ZNF554 Gene

  • GC19P002771
  • GC19P002772
  • GC19P002591

Summaries for ZNF554 Gene

GeneCards Summary for ZNF554 Gene

ZNF554 (Zinc Finger Protein 554) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF501.

UniProtKB/Swiss-Prot for ZNF554 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF554 Gene

Genomics for ZNF554 Gene

Regulatory Elements for ZNF554 Gene

Enhancers for ZNF554 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF554 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF554 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF554 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF554 Gene

2,819,874 bp from pter
2,836,735 bp from pter
16,862 bases
Plus strand

Genomic View for ZNF554 Gene

Genes around ZNF554 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF554 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF554 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF554 Gene

Proteins for ZNF554 Gene

  • Protein details for ZNF554 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 554
    Protein Accession:
    Secondary Accessions:
    • Q8NAT3
    • Q9BWN3

    Protein attributes for ZNF554 Gene

    538 amino acids
    Molecular mass:
    60582 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF554 Gene

Proteomics data for ZNF554 Gene at MOPED

Post-translational modifications for ZNF554 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF554 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF554

No data available for DME Specific Peptides for ZNF554 Gene

Domains & Families for ZNF554 Gene

Gene Families for ZNF554 Gene

Protein Domains for ZNF554 Gene

Suggested Antigen Peptide Sequences for ZNF554 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF554: view

Function for ZNF554 Gene

Molecular function for ZNF554 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF554: view

Animal Model Products

CRISPR Products

miRNA for ZNF554 Gene

miRTarBase miRNAs that target ZNF554

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF554 Gene

Localization for ZNF554 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF554 Gene

Subcellular locations from

Jensen Localization Image for ZNF554 Gene COMPARTMENTS Subcellular localization image for ZNF554 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF554 Gene

Pathways & Interactions for ZNF554 Gene

SuperPathways for ZNF554 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF554: view

Pathways by source for ZNF554 Gene

2 Reactome pathways for ZNF554 Gene

Interacting Proteins for ZNF554 Gene

Gene Ontology (GO) - Biological Process for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF554: view

No data available for SIGNOR curated interactions for ZNF554 Gene

Drugs & Compounds for ZNF554 Gene

No Compound Related Data Available

Transcripts for ZNF554 Gene

Unigene Clusters for ZNF554 Gene

Zinc finger protein 554:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF554 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -

Relevant External Links for ZNF554 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF554 Gene

mRNA expression in normal human tissues for ZNF554 Gene

Protein differential expression in normal tissues from HIPED for ZNF554 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF554 Gene

SOURCE GeneReport for Unigene cluster for ZNF554 Gene Hs.307043

genes like me logo Genes that share expression patterns with ZNF554: view

Protein tissue co-expression partners for ZNF554 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF554 Gene

Orthologs for ZNF554 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF554 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF554 35
  • 78.85 (n)
  • 71.15 (a)
ZNF554 36
  • 70 (a)
(Canis familiaris)
Mammalia ZNF554 35
  • 79.06 (n)
  • 71.43 (a)
ZNF554 36
  • 64 (a)
(Pan troglodytes)
Mammalia ZNF554 35
  • 98.76 (n)
  • 98.32 (a)
ZNF554 36
  • 98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 20 (a)
Species with no ortholog for ZNF554:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF554 Gene

Gene Tree for ZNF554 (if available)
Gene Tree for ZNF554 (if available)

Paralogs for ZNF554 Gene

(505) SIMAP similar genes for ZNF554 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF554: view

Variants for ZNF554 Gene

Sequence variations from dbSNP and Humsavar for ZNF554 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs867168 - 2,833,804(-) TGTCC(C/T)CTAAC reference, missense
rs867169 - 2,833,866(-) AGGAA(C/T)GGCCA reference, missense
rs7259982 -- 2,822,777(+) ggtag(A/G)aggat intron-variant, upstream-variant-2KB
rs12976106 -- 2,825,018(+) ttttt(G/T)ttttt intron-variant, upstream-variant-2KB
rs7359886 -- 2,823,430(+) ggtat(A/G)cagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF554 Gene

Variant ID Type Subtype PubMed ID
dgv3641n71 CNV Loss 21882294
dgv3643n71 CNV Loss 21882294
nsv910691 CNV Loss 21882294
nsv910692 CNV Loss 21882294
nsv910693 CNV Loss 21882294
nsv509715 CNV Insertion 20534489
esv2673992 CNV Deletion 23128226
esv2717914 CNV Deletion 23290073
nsv528638 CNV Gain 19592680
esv2717915 CNV Deletion 23290073
esv2118962 CNV Deletion 18987734
esv2717916 CNV Deletion 23290073

Variation tolerance for ZNF554 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF554 Gene

Disorders for ZNF554 Gene

Relevant External Links for ZNF554

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF554 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF554 Gene

Publications for ZNF554 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF554 Gene

Sources for ZNF554 Gene