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Aliases for ZNF554 Gene

Aliases for ZNF554 Gene

  • Zinc Finger Protein 554 2 3

External Ids for ZNF554 Gene

Previous GeneCards Identifiers for ZNF554 Gene

  • GC19P002771
  • GC19P002772
  • GC19P002591

Summaries for ZNF554 Gene

GeneCards Summary for ZNF554 Gene

ZNF554 (Zinc Finger Protein 554) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF554 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF554 Gene

Genomics for ZNF554 Gene

Regulatory Elements for ZNF554 Gene

Genomic Location for ZNF554 Gene

2,819,874 bp from pter
2,836,735 bp from pter
16,862 bases
Plus strand

Genomic View for ZNF554 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF554 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF554 Gene

Proteins for ZNF554 Gene

  • Protein details for ZNF554 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 554
    Protein Accession:
    Secondary Accessions:
    • Q8NAT3
    • Q9BWN3

    Protein attributes for ZNF554 Gene

    538 amino acids
    Molecular mass:
    60582 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF554 Gene

Proteomics data for ZNF554 Gene at MOPED

Post-translational modifications for ZNF554 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF554 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF554 Gene

Domains for ZNF554 Gene

Gene Families for ZNF554 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF554 Gene

Suggested Antigen Peptide Sequences for ZNF554 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86TJ5
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF554: view

Function for ZNF554 Gene

Molecular function for ZNF554 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF554: view

miRNA for ZNF554 Gene

miRTarBase miRNAs that target ZNF554

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF554 Gene

Localization for ZNF554 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF554 Gene

Subcellular locations from

Jensen Localization Image for ZNF554 Gene COMPARTMENTS Subcellular localization image for ZNF554 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF554: view

Pathways for ZNF554 Gene

SuperPathways for ZNF554 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF554: view

Pathways by source for ZNF554 Gene

2 Reactome pathways for ZNF554 Gene

Interacting Proteins for ZNF554 Gene

Gene Ontology (GO) - Biological Process for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF554: view

Compounds for ZNF554 Gene

(8) HMDB Compounds for ZNF554 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone
Carbon monoxide
  • Carbon monoxide
  • 1H-Purin-6-amine flavin dinucleotide
  • 1,5-dihydro-FAD
  • (protoporphyrinato)iron
genes like me logo Genes that share compounds with ZNF554: view

Transcripts for ZNF554 Gene

Unigene Clusters for ZNF554 Gene

Zinc finger protein 554:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF554 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -

Relevant External Links for ZNF554 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF554 Gene

mRNA expression in normal human tissues for ZNF554 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF554 Gene

SOURCE GeneReport for Unigene cluster for ZNF554 Gene Hs.307043

genes like me logo Genes that share expressions with ZNF554: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF554 Gene

Orthologs for ZNF554 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF554 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF554 35
  • 98.76 (n)
  • 98.32 (a)
ZNF554 36
  • 98 (a)
(Bos Taurus)
Mammalia ZNF554 35
  • 78.85 (n)
  • 71.15 (a)
ZNF554 36
  • 70 (a)
(Canis familiaris)
Mammalia ZNF554 35
  • 79.06 (n)
  • 71.43 (a)
ZNF554 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 20 (a)
Species with no ortholog for ZNF554:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF554 Gene

Gene Tree for ZNF554 (if available)
Gene Tree for ZNF554 (if available)

Paralogs for ZNF554 Gene

Selected SIMAP similar genes for ZNF554 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF554: view

Variants for ZNF554 Gene

Sequence variations from dbSNP and Humsavar for ZNF554 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs547352 -- 2,820,794(+) caagt(A/G)gctgg intron-variant
rs576132 -- 2,821,729(+) tggca(A/C)gatct intron-variant
rs576804 -- 2,821,747(+) ctgca(A/G)tctct intron-variant
rs867168 - 2,833,804(-) TGTCC(C/T)CTAAC reference, missense
rs867169 - 2,833,866(-) AGGAA(C/T)GGCCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF554 Gene

Variant ID Type Subtype PubMed ID
dgv3641n71 CNV Loss 21882294
dgv3643n71 CNV Loss 21882294
nsv910691 CNV Loss 21882294
nsv910692 CNV Loss 21882294
nsv910693 CNV Loss 21882294
nsv509715 CNV Insertion 20534489
esv2673992 CNV Deletion 23128226
esv2717914 CNV Deletion 23290073
nsv528638 CNV Gain 19592680
esv2717915 CNV Deletion 23290073
esv2118962 CNV Deletion 18987734
esv2717916 CNV Deletion 23290073

Relevant External Links for ZNF554 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF554 Gene

Disorders for ZNF554 Gene

No disorders were found for ZNF554 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF554 Gene

Publications for ZNF554 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for ZNF554 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF554
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF554
  • Block miRNA regulation of ZNF554 using miScript Target Protectors

Sources for ZNF554 Gene

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