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Aliases for ZNF552 Gene

Aliases for ZNF552 Gene

  • Zinc Finger Protein 552 2 3 5

External Ids for ZNF552 Gene

Previous GeneCards Identifiers for ZNF552 Gene

  • GC19M063011
  • GC19M063012
  • GC19M058319
  • GC19M054630

Summaries for ZNF552 Gene

GeneCards Summary for ZNF552 Gene

ZNF552 (Zinc Finger Protein 552) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF552 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF552 Gene

Genomics for ZNF552 Gene

Regulatory Elements for ZNF552 Gene

Enhancers for ZNF552 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF552 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF552 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF552 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF552 Gene

57,803,841 bp from pter
57,815,188 bp from pter
11,348 bases
Minus strand

Genomic View for ZNF552 Gene

Genes around ZNF552 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF552 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF552 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF552 Gene

Proteins for ZNF552 Gene

  • Protein details for ZNF552 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 552
    Protein Accession:
    Secondary Accessions:
    • B3KUE9
    • Q6P5A6

    Protein attributes for ZNF552 Gene

    407 amino acids
    Molecular mass:
    46198 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15093.1; Type=Frameshift; Positions=388; Evidence={ECO:0000305};

neXtProt entry for ZNF552 Gene

Proteomics data for ZNF552 Gene at MOPED

Post-translational modifications for ZNF552 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF552 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF552 Gene

Domains & Families for ZNF552 Gene

Gene Families for ZNF552 Gene

Protein Domains for ZNF552 Gene

Suggested Antigen Peptide Sequences for ZNF552 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF552: view

Function for ZNF552 Gene

Molecular function for ZNF552 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF552 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF552: view
genes like me logo Genes that share phenotypes with ZNF552: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF552 Gene

Localization for ZNF552 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF552 Gene

Subcellular locations from

Jensen Localization Image for ZNF552 Gene COMPARTMENTS Subcellular localization image for ZNF552 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF552 Gene

Pathways & Interactions for ZNF552 Gene

SuperPathways for ZNF552 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF552: view

Pathways by source for ZNF552 Gene

2 Reactome pathways for ZNF552 Gene

Interacting Proteins for ZNF552 Gene

Gene Ontology (GO) - Biological Process for ZNF552 Gene


No data available for SIGNOR curated interactions for ZNF552 Gene

Drugs & Compounds for ZNF552 Gene

No Compound Related Data Available

Transcripts for ZNF552 Gene

Unigene Clusters for ZNF552 Gene

Zinc finger protein 552:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF552 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP3: - -

Relevant External Links for ZNF552 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF552 Gene

mRNA expression in normal human tissues for ZNF552 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF552 Gene

This gene is overexpressed in Bladder (x5.4) and Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for ZNF552 Gene

This gene is overexpressed in Lung (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF552 Gene

SOURCE GeneReport for Unigene cluster for ZNF552 Gene Hs.560727

genes like me logo Genes that share expression patterns with ZNF552: view

Protein tissue co-expression partners for ZNF552 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF552 Gene

Orthologs for ZNF552 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF552 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF552 35
  • 98.85 (n)
  • 97.54 (a)
ZNF552 36
  • 98 (a)
(Canis familiaris)
Mammalia -- 36
  • 41 (a)
Species with no ortholog for ZNF552:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF552 Gene

Gene Tree for ZNF552 (if available)
Gene Tree for ZNF552 (if available)

Paralogs for ZNF552 Gene

(409) SIMAP similar genes for ZNF552 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF552: view

Variants for ZNF552 Gene

Sequence variations from dbSNP and Humsavar for ZNF552 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2288538 - 57,808,538(-) GTGTG(C/G)TGTGA reference, missense
rs7259790 -- 57,810,123(+) aaaga(A/G)aagag intron-variant
rs12978571 -- 57,811,406(+) atccg(C/T)ctgcc intron-variant
rs12979519 -- 57,813,061(+) CCTGC(A/T)TTAAG intron-variant
rs12979832 -- 57,811,211(+) tctgt(C/T)gctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF552 Gene

Variant ID Type Subtype PubMed ID
nsv912528 CNV Gain 21882294
nsv912529 CNV Loss 21882294
nsv520155 CNV Loss 19592680
nsv912530 CNV Gain 21882294
dgv4029n71 CNV Gain 21882294
nsv7311 OTHER Inversion 18451855

Variation tolerance for ZNF552 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF552 Gene

Disorders for ZNF552 Gene

Relevant External Links for ZNF552

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF552 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF552 Gene

Publications for ZNF552 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. ZNF552, a novel human KRAB/C2H2 zinc finger protein, inhibits AP-1- and SRE-mediated transcriptional activity. (PMID: 20356460) Deng Y. … Yuan W. (BMB Rep 2010) 3
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3

Products for ZNF552 Gene

Sources for ZNF552 Gene