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ZNF549 Gene

protein-coding   GIFtS: 46
GCID: GC19P058038

Zinc Finger Protein 549

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5491 2

External Ids:    HGNC: 266321   Entrez Gene: 2560512   Ensembl: ENSG000001214067   UniProtKB: Q6P9A33   

Export aliases for ZNF549 gene to outside databases

Previous GC identifers: GC19P062731 GC19P062732 GC19P054351


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF549 Gene:
ZNF549 (zinc finger protein 549) is a protein-coding gene. An important paralog of this gene is ENSG00000269533.

UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF549
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF549 promoter sequence
   Search Chromatin IP Primers for ZNF549

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF549


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF549 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF549 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P058038:  view genomic region     (about GC identifiers)

Start:
58,038,693 bp from pter      End:
58,068,910 bp from pter
Size:
30,218 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3 (See protein sequence)
Recommended Name: Zinc finger protein 549  
Size: 640 amino acids; 74439 Da
Sequence caution: Sequence=AAC24605.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KV91 O43336 Q8NAR4
Alternative splicing: 2 isoforms:  Q6P9A3-1   Q6P9A3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF549: NX_Q6P9A3

Explore proteomics data for ZNF549 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys485
  • Modification sites at PhosphoSitePlus

  • See ZNF549 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186224.1  NP_694995.2  

    ENSEMBL proteins: 
     ENSP00000240719   ENSP00000365407   ENSP00000471315   ENSP00000469280  
    Reactome Protein details: Q6P9A3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6P9A3

    ProtoNet protein and cluster: Q6P9A3

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF549           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN549_HUMAN, Q6P9A3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF549           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF549

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    miRTarBase miRNAs that target ZNF549:
    hsa-mir-26b-5p (MIRT029426), hsa-mir-1296-5p (MIRT036132), hsa-mir-124-3p (MIRT022614)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN549_HUMAN, Q6P9A3: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF549           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF549 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF549           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF549
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF549
    Interactions:

        Search GeneGlobe Interaction Network for ZNF549

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF549           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF549 (ZN549)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF549 gene (2 alternative transcripts): 
    NM_001199295.1  NM_153263.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240719(uc002qpb.2 uc002qpa.2) ENST00000376233 ENST00000594943
    ENST00000602149
    miRNA
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    Selected AceView cDNA sequences (see all 48):

    AI377978 BF515254 BM667682 BX493810 BF507745 BX490430 BC060863 AA463192 
    BM710842 AK094139 AK122766 AK092236 NM_153263 BU845836 BU150748 AA055667 
    AA055724 AA312440 BU626395 AI423388 AA306860 BQ017611 N74634 AI473995 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF549    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                                          
    SP2:              -                           
    SP3:                    -                     


    ECgene alternative splicing isoforms for ZNF549

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF549 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAATCCA
    ZNF549 Expression
    About this image

    ZNF549 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF549 Protein Expression
        Custom PCR Arrays for ZNF549
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF549 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5491 zinc finger protein 549 69.73(n)
    53.37(a)
      100685462  XM_005616833.1  XP_005616890.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX777726.12   -- 76.48(n)    BX777726.1 


    ENSEMBL Gene Tree for ZNF549 (if available)
    TreeFam Gene Tree for ZNF549 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF549 gene
    ENSG000002695332  ZNF4172  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  ZNF587B2  
    ZNF7732  ZIK12  ZNF1342  ZNF6712  ENSG000002681632  ZNF7722  ZNF5302  ZNF4192  
    ZNF5872  ZNF2112  ZNF7922  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  ZNF5472  
    ZNF5842  ENSG000002690262  ZNF3042  ZNF1322  ZNF5862  ZNF4182  ZNF2562  ZNF5522  
    ZNF1542  
    Selected SIMAP similar genes for ZNF549 using alignment to 3 protein entries:     ZN549_HUMAN (see all proteins) (see all similar genes):
    ZNF22    FLJ00301    ZNF548    ZNF169    ZNF397    ZNF324B
    ZNF814    ZNF208    ZNF300P1    ZNF616    ZNF78L1    ZNF818P
    ZSCAN23    ZNF773    FIK    ZNF17    ZNF707    ZNF230

    Find genes that share paralogs with ZNF549           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF549
    PGOHUM00000263128


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF549 (see all 379)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116707881,2
    C,F,H--58185861(+) aaaaaA/Taataa 2 -- us2k1 tfbs3 trp34Minor allele frequency- T:0.44NA CSA 9
    rs1495735811,2
    C--58185864(+) AAAAA-/TAAT  
            
    AAAAA
    2 -- us2k10--------
    rs1888629241,2
    --58185875(+) AAAAAA/TAAAAG 2 -- us2k10--------
    rs730564691,2
    C,F--58185989(+) TTTCTT/CCACTT 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs797125881,2
    C,F--58185992(+) CTTCAC/TTTGCA 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1812008571,2
    --58186092(+) ACGCTC/GTACCA 2 -- us2k10--------
    rs1157005801,2
    F--58186099(+) ACCAGC/AAGCTC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1475218921,2
    --58186176(+) CTGCAC/GCTGGA 2 -- us2k10--------
    rs802148261,2
    C--58186258(+) AAATTG/TCTTCA 2 -- us2k10--------
    rs20790341,2
    C,F,A,H--58186281(+) CTCCCT/CTATTT 2 -- us2k1 tfbs3 trp311Minor allele frequency- C:0.45NS EA NA WA CSA 493

    HapMap Linkage Disequilibrium report for ZNF549 (58038693 - 58068910 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF549:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912525CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF549 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF549)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 256051 HGNC: 26632 AceView: ZNF549 Ensembl:ENSG00000121406 euGenes: HUgn256051
    ECgene: ZNF549 H-InvDB: ZNF549

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF549 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF549 gene:
    Search GeneIP for patents involving ZNF549

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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