ZNF549 Gene
protein-coding GIFtS: 44
GCID: GC19P058038
|
|
zinc finger protein 549
| |
Aliases
for ZNF549 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5491 2 | | FLJ349171 |
Export aliases for ZNF549 gene to outside databasesPrevious GC identifers: GC19P062731 GC19P062732 GC19P054351 |
Summaries
for ZNF549 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF549 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF549
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF549
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF549 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF549 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P058038: view genomic region
(about GC identifiers)
Start:
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58,038,693 bp from pter |
End:
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58,052,131 bp from pter |
Size:
|
13,439 bases |
Orientation:
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plus strand |
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Proteins
for ZNF549 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3 (See
protein sequence)Recommended Name: Zinc finger protein 549 Size: 640 amino acids; 74439 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC24605.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KV91 O43336 Q8NAR4Alternative splicing: 2 isoforms: Q6P9A3-1 Q6P9A3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF549: NX_Q6P9A3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P9A3
ZNF549 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001186224.1 NP_694995.2
ENSEMBL proteins: ENSP00000240719 ENSP00000365407 Reactome Protein details: Q6P9A3
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF549 for ontologies About GeneDecksing
ZNF549 Antibody Products:
Assay Products for ZNF549: |
Protein
Domains /
Families
for ZNF549 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF549 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P9A3ProtoNet protein and cluster: Q6P9A3 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF549 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3Function: May be involved in transcriptional regulation
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF549
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Synthesis Service for ZNF549 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF549 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF549 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF549 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF549 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF549
ZNF549 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF549
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF549 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF549 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF549
Search CenterWatch for drugs/clinical trials and news about ZNF549 / ZN549
|
Transcripts
for ZNF549 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF549 gene (2 alternative transcripts): NM_001199295.1 NM_153263.2 Unigene Cluster for ZNF549: Zinc finger protein 549 Hs.744289 [show with all ESTs]Unigene Representative Sequence: AL8330902 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000240719(uc002qpb.2 uc002qpa.2) ENST00000376233
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF549
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF549
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF549 (NM_001199295) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF549 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF549 |
Additional cDNA sequence: AK092236.1 AK094139.1 AK122749.1 AK122766.1 AL833090.2 BC060863.1 10 DOTS entries: DT.100736975 DT.421820 DT.75156659 DT.91741938 DT.436133 DT.121431107 DT.121431137 DT.452389 DT.40129383 DT.91865600 24/48 AceView cDNA sequences (see all 48): NM_153263 AK094139 BX490430 AK122766 AI377978 BC060863 AA463192 AK092236 BX493810 BM667682 BF515254 BM710842 BF507745 AK122749 AA055667 BU845836 BX490431 N74634 AA306860 BQ017611 AI423388 BP383456 BG119584 AI478642
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF549 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for ZNF549
|
Expression
for ZNF549 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF549 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAAATCCA
About this image
See ZNF549 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF549
SOURCE GeneReport for Unigene cluster: Hs.744289
SABiosciences Custom PCR Arrays for ZNF549
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF549
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF549 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF549 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF549 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF549 |
Orthologs
for ZNF549 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF549 gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX777726.12 |
-- |
76.48(n) |
|
BX777726.1 |
ENSEMBL Gene Tree for ZNF549 (if available)
TreeFam Gene Tree for ZNF549 (if available) |
Paralogs
for ZNF549 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF549 gene
- ZNF2112 ZNF4172 ZNF7922 ZNF7492 ZNF5512 ZNF7762 ZNF5472 ZNF172
- ZNF4162 ZNF5482 ZNF3042 ZNF587B2 ZNF7732 ZNF1322 ZIK12 ZNF1342
- ZNF6712 ZNF4182 ZNF2562 ZNF1542 ZNF5522 ZNF7722 ZNF5302 ZNF4192
18/487 SIMAP similar genes for ZNF549 using alignment to 3 protein entries: ZN549_HUMAN (see all proteins)
(see all similar genes):FLJ00301 ZNF22 ZNF397 ZNF586 ZNF300P1 ZNF78L1
ZNF818P ZSCAN23 DKFZp686H10254 HZF36 ZNF55 ZSCAN21
kr-znf3 ZNF436 ZNF169 DKFZp666C237 GLI4 ZNF146
ZNF549 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF549
PGOHUM00000263128
|
Genomic Variants
for ZNF549 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF549 |
|
Disorders
/ Diseases
for ZNF549 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF549 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF549 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF549) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
|
External Searches for ZNF549 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF549 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF549 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF549 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF549 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF549 gene:
Search GeneIP for patents involving ZNF549
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF549 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZNF549 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF549 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF549 |
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