ZNF549 Gene
protein-coding GIFtS: 46
GCID: GC19P058038
|
|
Zinc Finger Protein 549
| |
Aliases
for ZNF549 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Zinc Finger Protein 5491 2 |
Export aliases for ZNF549 gene to outside databasesPrevious GC identifers: GC19P062731 GC19P062732 GC19P054351 |
Summaries
for ZNF549 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for ZNF549 Gene:
ZNF549 (zinc finger protein 549) is a protein-coding gene. An important paralog of this gene is ENSG00000269533.
UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF549 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Search for regulatory transcription factor binding sites for ZNF549
Other transcription factors
Search Chromatin IP Primers for ZNF549
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF549 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF549 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P058038: view genomic region
(about GC identifiers)
Start:
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58,038,693 bp from pter |
End:
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58,068,910 bp from pter |
Size:
|
30,218 bases |
Orientation:
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plus strand |
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Proteins
for ZNF549 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3 (See
protein sequence)Recommended Name: Zinc finger protein 549 Size: 640 amino acids; 74439 Da
Sequence caution: Sequence=AAC24605.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KV91 O43336 Q8NAR4Alternative splicing: 2 isoforms: Q6P9A3-1 Q6P9A3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF549: NX_Q6P9A3
Explore proteomics data for ZNF549 at MOPED
Post-translational modifications:  Ubiquitination2 at Lys485 Modification sites at PhosphoSitePlus
See ZNF549 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins (2 alternative transcripts):
NP_001186224.1 NP_694995.2
ENSEMBL proteins: ENSP00000240719 ENSP00000365407 ENSP00000471315 ENSP00000469280 Reactome Protein details: Q6P9A3
ZNF549 Human Recombinant
Protein Products:ZNF549 Antibody
Products:ZNF549 Assay Products: |
Domains /
Families
for ZNF549 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type
4 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q6P9A3ProtoNet protein and cluster: Q6P9A3 1 Blocks protein domain: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain
ZNF549 for domains About GeneDecksing
|
Function
for ZNF549 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN549_HUMAN, Q6P9A3Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms: About this table
ZNF549 for ontologies About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for ZNF549
| | | Predesigned siRNA for gene silencing in human, mouse, rat ZNF549 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for ZNF549 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF549  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF549 |
Localization
for ZNF549 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot ZN549_HUMAN, Q6P9A3: Nucleus (Probable)Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
|
| nucleus | 4 | | cytosol | 1 |
Gene Ontology (GO): 2 cellular component terms: About this table
ZNF549 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF549 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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SuperPaths for ZNF549 About
See pathways by source
Pathways by source See SuperPaths
Show all pathways
1  Reactome Pathway for ZNF549
ZNF549 for pathways About GeneDecksing
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF549
Interactions:
Search GeneGlobe Interaction Network for ZNF549
Gene Ontology (GO): 2 biological process terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-templated |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-templated |
IEA | -- |
ZNF549 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF549 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for ZNF549 (ZN549)
|
Transcripts
for ZNF549 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for ZNF549 gene (2 alternative transcripts): NM_001199295.1 NM_153263.2 4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000240719(uc002qpb.2 uc002qpa.2) ENST00000376233 ENST00000594943
ENST00000602149
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for ZNF549
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat ZNF549 |
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for ZNF549
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF549 | | | QuantiTect SYBR Green Assays in human, mouse, rat ZNF549 | | | QuantiFast Probe-based Assays in human, mouse, rat ZNF549 |
Selected AceView cDNA sequences (see all 48): AI377978 BF515254 BM667682 BX493810 BF507745 BX490430 BC060863 AA463192 BM710842 AK094139 AK122766 AK092236 NM_153263 BU845836 BU150748 AA055667 AA055724 AA312440 BU626395 AI423388 AA306860 BQ017611 N74634 AI473995
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF549 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for ZNF549
|
Expression
for ZNF549 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF549 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGAAATCCA
About this image ZNF549 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
Custom PCR Arrays for ZNF549
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for ZNF549
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF549 | | | QuantiTect SYBR Green Assays in human, mouse, rat ZNF549 | | | QuantiFast Probe-based Assays in human, mouse, rat ZNF549 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF549 |
Orthologs
for ZNF549 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for ZNF549 gene from Selected species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
dog
(Canis familiaris) |
Mammalia |
ZNF5491 |
zinc finger protein 549 |
69.73(n)
53.37(a) |
|
100685462 XM_005616833.1 XP_005616890.1 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX777726.12 |
-- |
76.48(n) |
|
BX777726.1 |
ENSEMBL Gene Tree for ZNF549 (if available)
TreeFam Gene Tree for ZNF549 (if available) |
Paralogs
for ZNF549 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for ZNF549 gene
- ENSG000002695332 ZNF4172 ENSG000002681332 ENSG000002681072 ZNF4162 ZNF172 ZNF5482 ZNF587B2
- ZNF7732 ZIK12 ZNF1342 ZNF6712 ENSG000002681632 ZNF7722 ZNF5302 ZNF4192
- ZNF5872 ZNF2112 ZNF7922 ZNF7492 ZNF5512 ENSG000002687502 ZNF7762 ZNF5472
- ZNF5842 ENSG000002690262 ZNF3042 ZNF1322 ZNF5862 ZNF4182 ZNF2562 ZNF5522
- ZNF1542
Selected SIMAP similar genes for ZNF549 using alignment to 3 protein entries: ZN549_HUMAN (see all proteins)
(see all similar genes):ZNF22 FLJ00301 ZNF548 ZNF169 ZNF397 ZNF324B
ZNF814 ZNF208 ZNF300P1 ZNF616 ZNF78L1 ZNF818P
ZSCAN23 ZNF773 FIK ZNF17 ZNF707 ZNF230
ZNF549 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF549
PGOHUM00000263128
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Genomic Variants
for ZNF549 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF549 (58038693 - 58068910 bp)
Structural Variations
Database of Genomic Variants (DGV) 1 variation for ZNF549: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing ZNF549 |
|
Disorders
/ Diseases
for ZNF549 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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Publications
for ZNF549 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for ZNF549 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF549) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
- A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
|
External Searches for ZNF549 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing ZNF549 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing ZNF549 gene
(According to HUGE)
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Specialized Databases showing ZNF549 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ZNF549 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for ZNF549 gene:
Search GeneIP for patents involving ZNF549
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF549 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat ZNF549 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing ZNF549 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF549 | | Predesigned siRNA for gene silencing in human, mouse, rat ZNF549 | | | QuantiFast Probe-based Assays in human, mouse, rat ZNF549 | | QuantiTect SYBR Green Assays in human, mouse, rat ZNF549 | | | Custom PCR Arrays for ZNF549 | | Search Chromatin IP Primers for ZNF549 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF549 | | Search GeneGlobe Interaction Network for ZNF549 | | | Search Regulatory tfbs for ZNF549 |
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 | | | | |
 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF549 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for ZNF549 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF549 |
| | | | LSBio Antibodies in human, mouse, rat for ZNF549 |
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