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Aliases for ZNF549 Gene

Aliases for ZNF549 Gene

  • Zinc Finger Protein 549 2 3

External Ids for ZNF549 Gene

Summaries for ZNF549 Gene

GeneCards Summary for ZNF549 Gene

ZNF549 (Zinc Finger Protein 549) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF549 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF549 Gene

Genomics for ZNF549 Gene

Genomic Location for ZNF549 Gene

Start:
57,527,275 bp from pter
End:
57,557,542 bp from pter
Size:
30,268 bases
Orientation:
Plus strand

Genomic View for ZNF549 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF549 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF549 Gene

No data available for Regulatory Elements for ZNF549 Gene

Proteins for ZNF549 Gene

  • Protein details for ZNF549 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9A3-ZN549_HUMAN
    Recommended name:
    Zinc finger protein 549
    Protein Accession:
    Q6P9A3
    Secondary Accessions:
    • B3KV91
    • O43336
    • Q8NAR4

    Protein attributes for ZNF549 Gene

    Size:
    640 amino acids
    Molecular mass:
    74439 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC24605.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF549 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF549 Gene

Proteomics data for ZNF549 Gene at MOPED

Post-translational modifications for ZNF549 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys485

Other Protein References for ZNF549 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF549 Gene

Domains for ZNF549 Gene

Gene Families for ZNF549 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF549 Gene

UniProtKB/Swiss-Prot:

ZN549_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q6P9A3
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q6P9A3
Similarity:
  • Contains 15 C2H2-type zinc fingers.:
    • Q6P9A3
genes like me logo Genes that share domains with ZNF549: view

Function for ZNF549 Gene

Molecular function for ZNF549 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF549: view

miRNA for ZNF549 Gene

miRTarBase miRNAs that target ZNF549

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF549 Gene

Localization for ZNF549 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF549 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF549 Gene COMPARTMENTS Subcellular localization image for ZNF549 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF549: view

Pathways for ZNF549 Gene

SuperPathways for ZNF549 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF549: view

Pathways by source for ZNF549 Gene

2 Reactome pathways for ZNF549 Gene

Interacting Proteins for ZNF549 Gene

Gene Ontology (GO) - Biological Process for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF549: view

Transcripts for ZNF549 Gene

Unigene Clusters for ZNF549 Gene

Zinc finger protein 549:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF549 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: -
SP3: -

Relevant External Links for ZNF549 Gene

GeneLoc Exon Structure for
ZNF549
ECgene alternative splicing isoforms for
ZNF549

Expression for ZNF549 Gene

mRNA expression in normal human tissues for ZNF549 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF549 Gene

SOURCE GeneReport for Unigene cluster for ZNF549 Gene Hs.744289

genes like me logo Genes that share expressions with ZNF549: view

Orthologs for ZNF549 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF549 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF549 36
  • 99.43 (n)
  • 98.91 (a)
ZNF549 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100299025 36
  • 67.33 (n)
  • 53.55 (a)
dog
(Canis familiaris)
Mammalia ZNF549 36
  • 69.73 (n)
  • 53.37 (a)
ZNF549 37
  • 44 (a)
OneToOne
Species with no ortholog for ZNF549:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF549 Gene

ENSEMBL:
Gene Tree for ZNF549 (if available)
TreeFam:
Gene Tree for ZNF549 (if available)

Paralogs for ZNF549 Gene

Selected SIMAP similar genes for ZNF549 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF549 Gene

genes like me logo Genes that share paralogs with ZNF549: view

Variants for ZNF549 Gene

Sequence variations from dbSNP and Humsavar for ZNF549 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs766125 -- 57,532,550(-) cccca(C/G)catgc intron-variant
rs766126 -- 57,532,414(-) CTTGG(G/T)TGAGT intron-variant
rs1859068 -- 57,529,591(+) actta(C/G/T)aatgg intron-variant
rs1859069 -- 57,529,843(+) attgc(A/G)ccact intron-variant
rs1859070 -- 57,530,047(+) ggtaa(C/G)tgaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF549 Gene

Variant ID Type Subtype PubMed ID
nsv912525 CNV Loss 21882294

Relevant External Links for ZNF549 Gene

HapMap Linkage Disequilibrium report
ZNF549

Disorders for ZNF549 Gene

No disorders were found for ZNF549 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF549 Gene

Publications for ZNF549 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for ZNF549 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF549
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF549
    • Block miRNA regulation of ZNF549 using miScript Target Protectors

    Sources for ZNF549 Gene

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