ZNF549 Gene

Aliases
for ZNF549 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19P062731 GC19P062732 GC19P054351

Summaries
for ZNF549 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZNF549 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: ZNF549 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF549

ZNF549 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P058038:  view genomic region     (about GC identifiers)

Proteins
for ZNF549 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZNF549: NX_Q6P9A3

Explore proteomics data for ZNF549 at MOPED

Post-translational modifications: 

ZNF549 Human Recombinant Protein Products:

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Domains /
Families
for ZNF549 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q6P9A3

Find genes that share domains with ZNF549           About GenesLikeMe

Function
for ZNF549 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZNF549

miRNA Products:		miRTarBase miRNAs that target ZNF549: hsa-mir-26b-5p (MIRT029426), hsa-mir-1296-5p (MIRT036132), hsa-mir-124-3p (MIRT022614)
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		Search for qRT-PCR Assays for microRNAs that regulate ZNF549
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		Predesigned siRNA for gene silencing in human, mouse, rat ZNF549

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZNF549

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF549

Localization
for ZNF549 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	4
cytosol	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for ZNF549 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ZNF549 About     See pathways by source

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	SuperPath	Contained pathways About
1	Gene Expression	Generic Transcription Pathway 0.40 Gene Expression 0.40

1 Reactome Pathway for ZNF549

Generic Transcription Pathway

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for ZNF549 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZNF549 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZNF549 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF549 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGAAATCCA

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ZNF549
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF549
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		QuantiFast Probe-based Assays in human, mouse, rat ZNF549

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF549

Orthologs
for ZNF549 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZNF549 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZNF549 gene

ENSG00000269533²  ZNF417²  ENSG00000268133²  ENSG00000268107²  ZNF416²  ZNF17²  ZNF548²  ZNF587B²  

ZNF773²  ZIK1²  ZNF134²  ZNF671²  ENSG00000268163²  ZNF772²  ZNF530²  ZNF419²  

ZNF587²  ZNF211²  ZNF792²  ZNF749²  ZNF551²  ENSG00000268750²  ZNF776²  ZNF547²  

ZNF584²  ENSG00000269026²  ZNF304²  ZNF132²  ZNF586²  ZNF418²  ZNF256²  ZNF552²  

ZNF154²  

Selected SIMAP similar genes for ZNF549 using alignment to 3 protein entries:     ZN549_HUMAN (see all proteins) (see all similar genes):

ZNF22    FLJ00301    ZNF548    ZNF169    ZNF397    ZNF324B

ZNF814    ZNF208    ZNF300P1    ZNF616    ZNF78L1    ZNF818P

ZSCAN23    ZNF773    FIK    ZNF17    ZNF707    ZNF230

Find genes that share paralogs with ZNF549           About GenesLikeMe


1 Pseudogenes.org Pseudogene for ZNF549
PGOHUM00000263128

Genomic Variants
for ZNF549 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF549 (see all 379)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs116707881,2	C,F,H	--	58185861(+)	aaaaaA/Taataa	2	--	us2k1 tfbs3 trp3		4		NA CSA	9
rs1495735811,2	C	--	58185864(+)	AAAAA-/TAAT           AAAAA	2	--	us2k1		0	--	--	--	--
rs1888629241,2		--	58185875(+)	AAAAAA/TAAAAG	2	--	us2k1		0	--	--	--	--
rs730564691,2	C,F	--	58185989(+)	TTTCTT/CCACTT	2	--	us2k1		1		NA	120
rs797125881,2	C,F	--	58185992(+)	CTTCAC/TTTGCA	2	--	us2k1		1		NA	120
rs1812008571,2		--	58186092(+)	ACGCTC/GTACCA	2	--	us2k1		0	--	--	--	--
rs1157005801,2	F	--	58186099(+)	ACCAGC/AAGCTC	2	--	us2k1		1		WA	118
rs1475218921,2		--	58186176(+)	CTGCAC/GCTGGA	2	--	us2k1		0	--	--	--	--
rs802148261,2	C	--	58186258(+)	AAATTG/TCTTCA	2	--	us2k1		0	--	--	--	--
rs20790341,2	C,F,A,H	--	58186281(+)	CTCCCT/CTATTT	2	--	us2k1 tfbs3 trp3		11		NS EA NA WA CSA	493

HapMap Linkage Disequilibrium report for ZNF549 (58038693 - 58068910 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZNF549:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv912525	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF549

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF549

Disorders / Diseases
for ZNF549 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZNF549 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ZNF549 gene integrated from 10 sources: (articles sorted by number of sources associating them with ZNF549)

Utopia: connect your pdf to the dynamic world of online information

1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (Nature 2004)

External Searches for ZNF549 gene

Genome Databases showing ZNF549 gene

Other Databases showing ZNF549 gene

Specialized Databases showing ZNF549 gene

Products
for ZNF549 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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