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Aliases for ZNF549 Gene

Aliases for ZNF549 Gene

  • Zinc Finger Protein 549 2 3 5

External Ids for ZNF549 Gene

Previous GeneCards Identifiers for ZNF549 Gene

  • GC19P062731
  • GC19P062732
  • GC19P058038
  • GC19P054351

Summaries for ZNF549 Gene

GeneCards Summary for ZNF549 Gene

ZNF549 (Zinc Finger Protein 549) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF418.

UniProtKB/Swiss-Prot for ZNF549 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF549 Gene

Genomics for ZNF549 Gene

Regulatory Elements for ZNF549 Gene

Enhancers for ZNF549 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F058325 0.2 ENCODE 36.5 +799.8 799790 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF134 ZNF17 ZNF549 ZNF606 ZNF773 ZNF256 ZNF417 ZNF551 ZNF548 ZNF211
GH19F058181 0.5 ENCODE 34.9 +656.2 656156 2.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF134 ZNF773 ZNF550 ZNF256 ZNF543 ZNF551 ZNF549 ZNF17 ZNF417 ZNF776
GH19F057583 0.5 ENCODE 29.6 +56.9 56892 1.4 TBP CBX3 ZNF76 ARID4B RAD21 ZBTB40 ZEB1 ETS1 GLIS2 ZNF416 ZNF549 ZNF17 ZIK1 LOC100128398 ZNF324B MZF1 ZSCAN22 ZNF606 ZNF544 ZNF551
GH19F057558 0.2 ENCODE 29.5 +32.6 32574 2.5 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A GLI4 ZNF48 ETS1 YY1 ELK1 ZNF549 ZNF550 VN1R1 ZNF805 ZNF530 ZNF134 ZIK1 RPS5 ZNF749 PIR36667
GH19F056594 0.9 ENCODE 29.1 -931.6 -931641 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A YBX1 FEZF1 GLI4 ZNF48 ETS1 ZNF773 ZNF550 U2AF2 ZNF543 ZNF264 ZNF17 ENSG00000267523 ZNF549 ENSG00000267096 ZFP28
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF549 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF549 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045620 720 1999 PKNOX1 ATF1 ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF48 ETS1 YY1

Genomic Location for ZNF549 Gene

57,527,081 bp from pter
57,557,542 bp from pter
30,462 bases
Plus strand

Genomic View for ZNF549 Gene

Genes around ZNF549 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF549 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF549 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF549 Gene

Proteins for ZNF549 Gene

  • Protein details for ZNF549 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 549
    Protein Accession:
    Secondary Accessions:
    • B3KV91
    • O43336
    • Q8NAR4

    Protein attributes for ZNF549 Gene

    640 amino acids
    Molecular mass:
    74439 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC24605.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF549 Gene


neXtProt entry for ZNF549 Gene

Post-translational modifications for ZNF549 Gene

  • Ubiquitination at Lys 485
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF549 Gene

No data available for DME Specific Peptides for ZNF549 Gene

Domains & Families for ZNF549 Gene

Gene Families for ZNF549 Gene

Protein Domains for ZNF549 Gene

Suggested Antigen Peptide Sequences for ZNF549 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF549: view

Function for ZNF549 Gene

Molecular function for ZNF549 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF549: view
genes like me logo Genes that share phenotypes with ZNF549: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF549 Gene

Localization for ZNF549 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF549 Gene

Subcellular locations from

Jensen Localization Image for ZNF549 Gene COMPARTMENTS Subcellular localization image for ZNF549 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF549: view

Pathways & Interactions for ZNF549 Gene

SuperPathways for ZNF549 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF549: view

Pathways by source for ZNF549 Gene

2 Reactome pathways for ZNF549 Gene

Interacting Proteins for ZNF549 Gene

Gene Ontology (GO) - Biological Process for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF549: view

No data available for SIGNOR curated interactions for ZNF549 Gene

Transcripts for ZNF549 Gene

Unigene Clusters for ZNF549 Gene

Zinc finger protein 549:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF549 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP2: -
SP3: -

Relevant External Links for ZNF549 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF549 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF549 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF549 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF549 Gene:


SOURCE GeneReport for Unigene cluster for ZNF549 Gene:

genes like me logo Genes that share expression patterns with ZNF549: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF549 Gene

Orthologs for ZNF549 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF549 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF549 34 35
  • 99.43 (n)
(Canis familiaris)
Mammalia ZNF549 34 35
  • 69.73 (n)
(Bos Taurus)
Mammalia LOC100299025 34
  • 67.33 (n)
Species where no ortholog for ZNF549 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF549 Gene

Gene Tree for ZNF549 (if available)
Gene Tree for ZNF549 (if available)

Paralogs for ZNF549 Gene

(497) SIMAP similar genes for ZNF549 Gene using alignment to 3 proteins: Pseudogenes for ZNF549 Gene

genes like me logo Genes that share paralogs with ZNF549: view

Variants for ZNF549 Gene

Sequence variations from dbSNP and Humsavar for ZNF549 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10412182 -- 57,529,686(+) tcgag(A/G)ccatc intron-variant
rs111267783 -- 57,539,332(+) GAGGT(G/T)TACCT utr-variant-3-prime
rs111549921 -- 57,530,612(+) CCTTA(A/C)ACCTG intron-variant
rs111784119 -- 57,537,502(+) AGCAG(C/T)GCCTT reference, synonymous-codon
rs111827228 -- 57,528,007(+) AGGCA(A/G)TGAGT intron-variant

Variation tolerance for ZNF549 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF549 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF549 Gene

Disorders for ZNF549 Gene

Relevant External Links for ZNF549

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF549 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF549 Gene

Publications for ZNF549 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF549 Gene

Sources for ZNF549 Gene

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