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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF549 Gene

protein-coding GIFtS: 47
GCID: GC19P058038

Zinc Finger Protein 549

Search for ZNF549
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Zinc Finger Protein 549¹ ²

External Ids:	HGNC: 26632¹	Entrez Gene: 256051²	Ensembl: ENSG00000121406⁷	UniProtKB: Q6P9A3³

Export aliases for ZNF549 gene to outside databases

Previous GC identifers: GC19P062731 GC19P062732 GC19P054351

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF549 Gene:

ZNF549 (zinc finger protein 549) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ENSG00000269533.

UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.2 NT_011109.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF549
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF549 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF549

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF549

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

ZNF549 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF549 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P058038: view genomic region (about GC identifiers)

Start:	58,038,693 bp from pter	End:	58,068,910 bp from pter
Size:	30,218 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3 (See protein sequence)

Recommended Name: Zinc finger protein 549

Size: 640 amino acids; 74439 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAC24605.1; Type=Erroneous gene model prediction;

Secondary accessions: B3KV91 O43336 Q8NAR4

Alternative splicing: 2 isoforms: Q6P9A3-1 Q6P9A3-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF549: NX_Q6P9A3

Explore proteomics data for ZNF549 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q6P9A3

ZNF549 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001186224.1 NP_694995.2

ENSEMBL proteins:

ENSP00000240719 ENSP00000365407 ENSP00000471315 ENSP00000469280

Reactome Protein details: Q6P9A3
Human Recombinant Protein Products for ZNF549:

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF549 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6P9A3

ProtoNet protein and cluster: Q6P9A3

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN549_HUMAN, Q6P9A3

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 15 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

ZNF549 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN549_HUMAN, Q6P9A3

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	--	--
GO:0046872	metal ion binding	IEA	--

ZNF549 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ZNF549 About

See pathways by source

SuperPath

Contained pathways About

Generic Transcription Pathway

Generic Transcription Pathway

0.47

Gene Expression

0.47

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for ZNF549

	Generic Transcription Pathway
	Gene Expression

ZNF549 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF549

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF549 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for ZNF549 (ZN549)

Search CenterWatch for drugs/clinical trials and news about ZNF549 / ZN549

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF549 gene (2 alternative transcripts):

NM_001199295.1 NM_153263.2

Unigene Cluster for ZNF549:

Zinc finger protein 549

Hs.744289 [show with all ESTs]

Unigene Representative Sequence: AL833090

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000240719(uc002qpb.2 uc002qpa.2) ENST00000376233 ENST00000594943

ENST00000602149

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Additional mRNA sequence:

AK092236.1 AK094139.1 AK122749.1 AK122766.1 AL833090.2 BC060863.1

10 DOTS entries:

DT.100736975 DT.421820 DT.75156659 DT.91741938 DT.436133 DT.121431107 DT.121431137 DT.452389

DT.40129383 DT.91865600

24/48 AceView cDNA sequences (see all 48):

AK092236 BX493810 AK094139 AI377978 BM710842 AK122766 NM_153263 BC060863

BM667682 BF515254 BX490430 BF507745 AA463192 AL833090 BI001974 BP383456

AI478642 BU845836 CD644072 AA306860 BU626395 AI423388 BG119584 AA055667

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF549 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c
SP1:
SP2:					-
SP3:							-

ECgene alternative splicing isoforms for ZNF549

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF549 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGAAATCCA

About this image

See ZNF549 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF549

SOURCE GeneReport for Unigene cluster: Hs.744289

SABiosciences Custom PCR Arrays for ZNF549

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF549 gene from 2/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
dog (Canis familiaris)	Mammalia	ZNF549⁶ -- (see all 3)	--	49(a) 47(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	1(100562936-100575716) 1(100545586-100552727)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX777726.1²	--	76.48(n)		BX777726.1

ENSEMBL Gene Tree for ZNF549 (if available)
TreeFam Gene Tree for ZNF549 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF549 gene

ENSG00000269533² ZNF417² ENSG00000268133² ENSG00000268107² ZNF416² ZNF17² ZNF548² ZNF587B²

ZNF773² ZIK1² ZNF134² ZNF671² ZNF772² ZNF530² ZNF419² ZNF587²

ZNF211² ZNF792² ZNF749² ZNF551² ENSG00000268750² ZNF776² ZNF547² ZNF584²

ENSG00000269026² ZNF304² ZNF132² ZNF586² ZNF418² ZNF256² ZNF552² ZNF154²

ZNF814²

18/495 SIMAP similar genes for ZNF549 using alignment to 3 protein entries: ZN549_HUMAN (see all proteins) (see all similar genes):

ZNF22 FLJ00301 ZNF548 ZNF397 ZNF169 ZNF324B

ZNF814 ZNF208 ZNF300P1 ZNF616 ZNF78L1 ZNF818P

ZSCAN23 ZNF773 FIK ZNF17 ZNF707 ZNF230

ZNF549 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZNF549
PGOHUM00000263128

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_059921⁴		--	--	see VAR_059921	2	I N	mis⁴		0	--	--	--	--
rs11670788^1,2	C,F,H	--	58185861(+)	`aaaaaA/Taataa`	2	--	us2k¹ tfbs³ trp³		4		NA CSA	9
rs149573581^1,2	C	--	58185864(+)	`AAAAA-/TAAT AAAAA`	2	--	us2k¹		0	--	--	--	--
rs188862924^1,2		--	58185875(+)	`AAAAAA/TAAAAG`	2	--	us2k¹		0	--	--	--	--
rs73056469^1,2	C,F	--	58185989(+)	`TTTCTT/CCACTT`	2	--	us2k¹		1		NA	120
rs79712588^1,2	C,F	--	58185992(+)	`CTTCAC/TTTGCA`	2	--	us2k¹		1		NA	120
rs181200857^1,2		--	58186092(+)	`ACGCTC/GTACCA`	2	--	us2k¹		0	--	--	--	--
rs115700580^1,2	F	--	58186099(+)	`ACCAGC/AAGCTC`	2	--	us2k¹		1		WA	118
rs147521892^1,2		--	58186176(+)	`CTGCAC/GCTGGA`	2	--	us2k¹		0	--	--	--	--
rs80214826^1,2	C	--	58186258(+)	`AAATTG/TCTTCA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF549 (58038693 - 58068910 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ZNF549: About this table

Variant ID	Type	Subtype	PubMed ID
nsv912525	CNV	Loss	21882294

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF549

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF549

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF549 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF549)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 256051	HGNC: 26632	AceView: ZNF549	Ensembl:ENSG00000121406	euGenes: HUgn256051
ECgene: ZNF549	H-InvDB: ZNF549

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF549	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF549 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF549 gene:
Search GeneIP for patents involving ZNF549

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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ZNF549 Gene

Zinc Finger Protein 549

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ZNF549 Gene

Zinc Finger Protein 549

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