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Aliases for ZNF549 Gene

Aliases for ZNF549 Gene

  • Zinc Finger Protein 549 2 3 5

External Ids for ZNF549 Gene

Previous GeneCards Identifiers for ZNF549 Gene

  • GC19P062731
  • GC19P062732
  • GC19P058038
  • GC19P054351

Summaries for ZNF549 Gene

GeneCards Summary for ZNF549 Gene

ZNF549 (Zinc Finger Protein 549) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF551.

UniProtKB/Swiss-Prot for ZNF549 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF549 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF549 Gene

Genomics for ZNF549 Gene

Regulatory Elements for ZNF549 Gene

Enhancers for ZNF549 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H058325 1.2 ENCODE 78 +799.8 799790 3.6 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 ZNF134 ZNF606 ZNF549 ZNF446 ZNF17 ZNF135 ZNF417 ZNF324B TRIM28 LOC100128398
GH19H058181 1.1 ENCODE 82.5 +656.2 656156 2.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF773 ZNF550 ZNF543 ZNF256 LOC105372483
GH19H058517 2 FANTOM5 Ensembl ENCODE dbSUPER 44.5 +992.6 992628 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZNF324B ZNF446 TRIM28 ZNF134 ZNF549 ZNF417 ZNF606 ZNF135 MZF1 ZNF274
GH19H056594 1 ENCODE 82.3 -931.6 -931641 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 YY1 ETS1 U2AF2 ZNF17 ZNF264 ZNF773 ZNF543 ZNF549 ENSG00000269696 ZNF550 ZFP28 ZNF470
GH19H057599 1.1 ENCODE 74.5 +73.0 72957 1.5 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 ZHX2 MXD4 ZNF606 ZNF549 ZNF135 ZNF132 ZNF418 ZNF417 ZNF446 ZNF17 LOC105372482 LOC100128398
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF549 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF549 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111806 520 1600 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 YY1 ETS1 ELK1 ZNF302

Genomic Locations for ZNF549 Gene

Genomic Locations for ZNF549 Gene
30,462 bases
Plus strand

Genomic View for ZNF549 Gene

Genes around ZNF549 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF549 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF549 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF549 Gene

Proteins for ZNF549 Gene

  • Protein details for ZNF549 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 549
    Protein Accession:
    Secondary Accessions:
    • B3KV91
    • O43336
    • Q8NAR4

    Protein attributes for ZNF549 Gene

    640 amino acids
    Molecular mass:
    74439 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC24605.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF549 Gene


neXtProt entry for ZNF549 Gene

Post-translational modifications for ZNF549 Gene

  • Ubiquitination at isoforms=2485
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF549 Gene

No data available for DME Specific Peptides for ZNF549 Gene

Domains & Families for ZNF549 Gene

Gene Families for ZNF549 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF549 Gene

Suggested Antigen Peptide Sequences for ZNF549 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF549: view

Function for ZNF549 Gene

Molecular function for ZNF549 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF549 Gene

Gene Ontology (GO) - Molecular Function for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF549: view
genes like me logo Genes that share phenotypes with ZNF549: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF549 Gene

Localization for ZNF549 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF549 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF549 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF549: view

Pathways & Interactions for ZNF549 Gene

SuperPathways for ZNF549 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF549: view

Pathways by source for ZNF549 Gene

2 Reactome pathways for ZNF549 Gene

Interacting Proteins for ZNF549 Gene

Gene Ontology (GO) - Biological Process for ZNF549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF549: view

No data available for SIGNOR curated interactions for ZNF549 Gene

Drugs & Compounds for ZNF549 Gene

No Compound Related Data Available

Transcripts for ZNF549 Gene

Unigene Clusters for ZNF549 Gene

Zinc finger protein 549:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF549 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP2: -
SP3: -

Relevant External Links for ZNF549 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF549 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF549 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF549 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF549 Gene:


SOURCE GeneReport for Unigene cluster for ZNF549 Gene:

genes like me logo Genes that share expression patterns with ZNF549: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF549 Gene

Orthologs for ZNF549 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF549 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF549 33 34
  • 99.43 (n)
(Canis familiaris)
Mammalia ZNF549 33 34
  • 69.73 (n)
(Bos Taurus)
Mammalia LOC100299025 33
  • 67.33 (n)
Species where no ortholog for ZNF549 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF549 Gene

Gene Tree for ZNF549 (if available)
Gene Tree for ZNF549 (if available)

Paralogs for ZNF549 Gene

(497) SIMAP similar genes for ZNF549 Gene using alignment to 3 proteins: Pseudogenes for ZNF549 Gene

genes like me logo Genes that share paralogs with ZNF549: view

Variants for ZNF549 Gene

Sequence variations from dbSNP and Humsavar for ZNF549 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000127514 -- 57,527,355(+) GTGGT(A/C)GTTTT utr-variant-5-prime
rs1000444697 -- 57,530,461(+) GAGTT(C/T)TGTAA intron-variant
rs1000516342 -- 57,530,037(+) GTTGA(A/G)TGTGG intron-variant
rs1000547408 -- 57,530,244(+) ATCTG(C/G)AGATT intron-variant
rs1000724662 -- 57,536,282(+) ACCCA(A/G)CTTAT intron-variant

Variation tolerance for ZNF549 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF549 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF549 Gene

Disorders for ZNF549 Gene

Relevant External Links for ZNF549

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF549 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF549 Gene

Publications for ZNF549 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for ZNF549 Gene

Sources for ZNF549 Gene

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