Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF548 Gene

Aliases for ZNF548 Gene

  • Zinc Finger Protein 548 2 3 5

External Ids for ZNF548 Gene

Previous GeneCards Identifiers for ZNF548 Gene

  • GC19P062594
  • GC19P062595
  • GC19P057902
  • GC19P054213

Summaries for ZNF548 Gene

GeneCards Summary for ZNF548 Gene

ZNF548 (Zinc Finger Protein 548) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF548 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF548 Gene

Genomics for ZNF548 Gene

Regulatory Elements for ZNF548 Gene

Enhancers for ZNF548 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F058325 1.2 ENCODE 30.9 +937.0 937021 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF134 ZNF17 ZNF549 ZNF606 ZNF773 ZNF256 ZNF417 ZNF551 ZNF548 ZNF211
GH19F057410 1 ENCODE 36.3 +21.5 21547 1.8 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ETS1 YY1 SLC30A9 GLIS2 ZNF548 ZNF805 ZNF304 ZNF264 ZNF543 ZNF134 RPS5 ZNF17 GC19P057420
GH19F058379 1.2 ENCODE 22.6 +991.2 991236 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 RPS5 TRIM28 ZNF584 ZNF548 ZNF134 ZNF324B ZNF132 ZNF587B ZNF837 ZNF417
GH19F057361 1.1 ENCODE 24.3 -26.9 -26869 3.2 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 BRCA1 ZNF2 ZNF548 ZNF304 ZFP28 ZNF667 ZIM2 ZNF667-AS1 PEG3 SMIM17 ZNF805 ZNF470
GH19F057632 1 ENCODE 25.4 +243.6 243567 1.8 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A GLI4 DMAP1 ZNF48 ETS1 YY1 ZNF548 ZNF805 ZNF264 ZNF550 TRIM28 ZNF134 ZNF211 RPS5 ZNF417 ZNF551
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF548 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF548 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001420219 351 2400 PKNOX1 WRNIP1 SIN3A DMAP1 YY1 ZNF143 FOS CEBPZ SP3 SP5

Transcription factor binding sites by QIAGEN in the ZNF548 gene promoter:

Genomic Location for ZNF548 Gene

Chromosome:
19
Start:
57,389,850 bp from pter
End:
57,402,992 bp from pter
Size:
13,143 bases
Orientation:
Plus strand

Genomic View for ZNF548 Gene

Genes around ZNF548 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF548 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF548 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF548 Gene

Proteins for ZNF548 Gene

  • Protein details for ZNF548 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEK5-ZN548_HUMAN
    Recommended name:
    Zinc finger protein 548
    Protein Accession:
    Q8NEK5
    Secondary Accessions:
    • Q96M05

    Protein attributes for ZNF548 Gene

    Size:
    533 amino acids
    Molecular mass:
    62728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF548 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF548 Gene

Post-translational modifications for ZNF548 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF548 Gene

Domains & Families for ZNF548 Gene

Gene Families for ZNF548 Gene

Protein Domains for ZNF548 Gene

Suggested Antigen Peptide Sequences for ZNF548 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEK5

UniProtKB/Swiss-Prot:

ZN548_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF548: view

Function for ZNF548 Gene

Molecular function for ZNF548 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF548 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF548: view

Phenotypes for ZNF548 Gene

genes like me logo Genes that share phenotypes with ZNF548: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF548 Gene

Localization for ZNF548 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF548 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF548 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF548 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF548: view

Pathways & Interactions for ZNF548 Gene

SuperPathways for ZNF548 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF548: view

Pathways by source for ZNF548 Gene

2 Reactome pathways for ZNF548 Gene

Interacting Proteins for ZNF548 Gene

Gene Ontology (GO) - Biological Process for ZNF548 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF548: view

No data available for SIGNOR curated interactions for ZNF548 Gene

Transcripts for ZNF548 Gene

Unigene Clusters for ZNF548 Gene

Zinc finger protein 548:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF548 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8:

Relevant External Links for ZNF548 Gene

GeneLoc Exon Structure for
ZNF548
ECgene alternative splicing isoforms for
ZNF548

Expression for ZNF548 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF548 Gene

Protein differential expression in normal tissues from HIPED for ZNF548 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF548 Gene



Protein tissue co-expression partners for ZNF548 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF548 Gene:

ZNF548

SOURCE GeneReport for Unigene cluster for ZNF548 Gene:

Hs.126905
genes like me logo Genes that share expression patterns with ZNF548: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF548 Gene

Orthologs for ZNF548 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF548 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF548 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia ZNF548 34 35
  • 81.3 (n)
cow
(Bos Taurus)
Mammalia ZNF548 34 35
  • 78.33 (n)
Species where no ortholog for ZNF548 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF548 Gene

ENSEMBL:
Gene Tree for ZNF548 (if available)
TreeFam:
Gene Tree for ZNF548 (if available)

Paralogs for ZNF548 Gene

genes like me logo Genes that share paralogs with ZNF548: view

Variants for ZNF548 Gene

Sequence variations from dbSNP and Humsavar for ZNF548 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10407882 -- 57,402,504(+) GTTCT(C/T)TCATT utr-variant-3-prime
rs10451458 -- 57,396,488(+) GAGGC(A/G)TAGGG intron-variant
rs111309285 -- 57,393,521(+) CGGGT(A/G)TGGTG intron-variant
rs111552551 -- 57,388,303(+) TTCTG(-/G)TTTTT upstream-variant-2KB
rs111706483 -- 57,400,722(+) GCCAC(C/T)GCGCC utr-variant-3-prime

Variation tolerance for ZNF548 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF548 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF548

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF548 Gene

Disorders for ZNF548 Gene

Relevant External Links for ZNF548

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF548

No disorders were found for ZNF548 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF548 Gene

Publications for ZNF548 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF548 Gene

Sources for ZNF548 Gene

Content
Loading form....