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Aliases for ZNF548 Gene

Aliases for ZNF548 Gene

  • Zinc Finger Protein 548 2 3 5

External Ids for ZNF548 Gene

Previous GeneCards Identifiers for ZNF548 Gene

  • GC19P062594
  • GC19P062595
  • GC19P057902
  • GC19P054213

Summaries for ZNF548 Gene

GeneCards Summary for ZNF548 Gene

ZNF548 (Zinc Finger Protein 548) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF548 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF548 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF548 Gene

Genomics for ZNF548 Gene

GeneHancer (GH) Regulatory Elements for ZNF548 Gene

Promoters and enhancers for ZNF548 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057388 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 566.3 +0.1 149 2.2 PKNOX1 FOXA2 SIN3A DMAP1 IRF4 YY1 ZNF143 FOS SP3 CEBPZ ZNF548 ENSG00000269533 ZNF264 ZSCAN18 ENSG00000269696 LOC100128398 ZNF835 ZNF470 ZNF805 ZNF582-AS1
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 65.8 +937.0 937021 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48 +991.2 991235 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
GH19I058361 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 35.2 +972.6 972555 2.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B LOC105372483 ENSG00000268230 RNA5SP473 ZNF497 ZNF548 ZNF417 ZNF134 TRIM28 ZSCAN22 ZNF274
GH19I057410 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 36.3 +21.5 21547 1.8 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 YY1 ETS1 SLC30A9 POLR2B ZNF17 ZNF548 ZNF805 ZNF264 ZNF543 ZNF304 ZNF134 GC19P057420 ENSG00000268533 ENSG00000269533
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF548 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF548 gene promoter:

Genomic Locations for ZNF548 Gene

Genomic Locations for ZNF548 Gene
chr19:57,389,850-57,402,992
(GRCh38/hg38)
Size:
13,143 bases
Orientation:
Plus strand
chr19:57,901,218-57,913,919
(GRCh37/hg19)

Genomic View for ZNF548 Gene

Genes around ZNF548 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF548 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF548 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF548 Gene

Proteins for ZNF548 Gene

  • Protein details for ZNF548 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEK5-ZN548_HUMAN
    Recommended name:
    Zinc finger protein 548
    Protein Accession:
    Q8NEK5
    Secondary Accessions:
    • Q96M05

    Protein attributes for ZNF548 Gene

    Size:
    533 amino acids
    Molecular mass:
    62728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF548 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF548 Gene

Post-translational modifications for ZNF548 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF548 Gene

Domains & Families for ZNF548 Gene

Gene Families for ZNF548 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF548 Gene

Suggested Antigen Peptide Sequences for ZNF548 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEK5

UniProtKB/Swiss-Prot:

ZN548_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF548: view

Function for ZNF548 Gene

Molecular function for ZNF548 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF548 Gene

Gene Ontology (GO) - Molecular Function for ZNF548 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF548: view

Phenotypes for ZNF548 Gene

genes like me logo Genes that share phenotypes with ZNF548: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF548 Gene

Localization for ZNF548 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF548 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF548 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF548 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF548: view

Pathways & Interactions for ZNF548 Gene

SuperPathways for ZNF548 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF548: view

Pathways by source for ZNF548 Gene

2 Reactome pathways for ZNF548 Gene

Interacting Proteins for ZNF548 Gene

Gene Ontology (GO) - Biological Process for ZNF548 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF548: view

No data available for SIGNOR curated interactions for ZNF548 Gene

Drugs & Compounds for ZNF548 Gene

No Compound Related Data Available

Transcripts for ZNF548 Gene

Unigene Clusters for ZNF548 Gene

Zinc finger protein 548:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF548 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8:

Relevant External Links for ZNF548 Gene

GeneLoc Exon Structure for
ZNF548
ECgene alternative splicing isoforms for
ZNF548

Expression for ZNF548 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF548 Gene

Protein differential expression in normal tissues from HIPED for ZNF548 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF548 Gene



Protein tissue co-expression partners for ZNF548 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF548 Gene:

ZNF548

SOURCE GeneReport for Unigene cluster for ZNF548 Gene:

Hs.126905
genes like me logo Genes that share expression patterns with ZNF548: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF548 Gene

Orthologs for ZNF548 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF548 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF548 33 34
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia ZNF548 33 34
  • 81.3 (n)
cow
(Bos Taurus)
Mammalia ZNF548 33 34
  • 78.33 (n)
Species where no ortholog for ZNF548 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF548 Gene

ENSEMBL:
Gene Tree for ZNF548 (if available)
TreeFam:
Gene Tree for ZNF548 (if available)

Paralogs for ZNF548 Gene

genes like me logo Genes that share paralogs with ZNF548: view

Variants for ZNF548 Gene

Sequence variations from dbSNP and Humsavar for ZNF548 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000012483 -- 57,394,534(+) A/G intron_variant
rs1000246240 -- 57,401,155(+) T/G 3_prime_UTR_variant
rs1000289195 -- 57,393,894(+) T/C intron_variant
rs1000591951 -- 57,400,726(+) C/T 3_prime_UTR_variant
rs1000979745 -- 57,389,973(+) G/A 5_prime_UTR_variant

Variation tolerance for ZNF548 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF548 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF548

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF548 Gene

Disorders for ZNF548 Gene

Additional Disease Information for ZNF548

No disorders were found for ZNF548 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF548 Gene

Publications for ZNF548 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 58

Products for ZNF548 Gene

Sources for ZNF548 Gene

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