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ZNF547 Gene

protein-coding   GIFtS: 39
GCID: GC19P057875

Zinc Finger Protein 547

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5471 2

External Ids:    HGNC: 264321   Entrez Gene: 2843062   Ensembl: ENSG000001524337   UniProtKB: Q8IVP93   

Export aliases for ZNF547 gene to outside databases

Previous GC identifers: GC19P062568 GC19P062569 GC19P054187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF547 Gene:
ZNF547 (zinc finger protein 547) is a protein-coding gene. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN547_HUMAN, Q8IVP9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF547 gene promoter:
         Nkx3-1   Nkx3-1 v4   RFX1   Nkx3-1 v1   RORalpha2   Nkx3-1 v2   Nkx3-1 v3   Msx-1   MRF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF547 promoter sequence
   Search Chromatin IP Primers for ZNF547

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF547


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF547 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF547 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P057875:  view genomic region     (about GC identifiers)

Start:
57,874,845 bp from pter      End:
57,890,933 bp from pter
Size:
16,089 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN547_HUMAN, Q8IVP9 (See protein sequence)
Recommended Name: Zinc finger protein 547  
Size: 402 amino acids; 45956 Da
Caution: The gene of ZNF547 share a non-coding exon with TRAPPC2P
Secondary accessions: A8K5Z9 Q96NC4
Alternative splicing: 2 isoforms:  Q8IVP9-1   Q8IVP9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF547: NX_Q8IVP9

Explore proteomics data for ZNF547 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF547 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775902.2  
    ENSEMBL proteins: 
     ENSP00000470884   ENSP00000282282   ENSP00000468929   ENSP00000470111  
    Reactome Protein details: Q8IVP9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IVP9

    ProtoNet protein and cluster: Q8IVP9

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN547_HUMAN, Q8IVP9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF547           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN547_HUMAN, Q8IVP9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF547           About GenesLikeMe


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF547 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN547_HUMAN, Q8IVP9: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF547           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF547 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF547           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF547
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF547
    Interactions:

        Search GeneGlobe Interaction Network for ZNF547

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF547           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF547 (ZN547)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF547 gene: 
    NM_173631.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595335 ENST00000282282(uc002qol.3) ENST00000599604 ENST00000597567

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZNF547:
    hsa-miR-199a-5p hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNF547 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF547

    Selected AceView cDNA sequences (see all 128):

    AW024530 BC032809 AA588086 AW013992 AA181899 AF058918 CF529008 AW027866 
    AI830838 BF984818 BX100516 CF130205 AK055662 AA954706 R17918 BQ012988 
    CB125616 BQ012081 AL832545 BQ012610 NM_173631 BU754006 AF291676 AI190516 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF547    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                          -                           
    SP2:                    -     -                           
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for ZNF547

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF547 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF547 Expression
    About this image

    ZNF547 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF547 Protein Expression
        Custom PCR Arrays for ZNF547
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF547 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5476
    zinc finger protein 547
    45(a)
    1 ↔ 1
    1(100722682-100745674)


    ENSEMBL Gene Tree for ZNF547 (if available)
    TreeFam Gene Tree for ZNF547 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF547 gene
    ZNF5492  ENSG000002695332  ZNF4172  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  
    ZNF587B2  ZNF7732  ZIK12  ZNF1342  ZNF6712  ENSG000002681632  ZNF7722  ZNF5302  
    ZNF4192  ZNF5872  ZNF2112  ZNF7922  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  
    ZNF5842  ENSG000002690262  ZNF3042  ZNF1322  ZNF5862  ZNF4182  ZNF2562  ZNF5522  
    ZNF1542  
    Selected SIMAP similar genes for ZNF547 using alignment to 4 protein entries:     ZN547_HUMAN (see all proteins) (see all similar genes):
    TMEM135    ZNF548    AURA2    FAM3A    BTBD2    DCTN5
    FAM210A    APOD    ASB11    CATSPERG    HOOK2    IMPA1
    ZNF789    CFLAR    EML2    UBIAD1    ZNF419    EDRF1

    Find genes that share paralogs with ZNF547           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF547 (see all 346)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3754423921,2
    C--57877243(+) TTTTTA/C/TTTTTG 1 -- int10--------
    rs1484189991,2
    --57877271(+) TGTTGC/TGCAGG 1 -- int10--------
    rs1816038561,2
    C--57877274(+) TGTGCA/GGGGGC 1 -- int10--------
    rs1417061561,2
    --57877315(+) GCAACC/TTCCAC 1 -- int10--------
    rs104230511,2
    C,F,A,H--57877326(+) ctcccA/Gggttc 1 -- int12Minor allele frequency- G:0.40NA CSA 5
    rs120521091,2
    C--57877346(+) tccttC/Tttcag 1 -- int1 trp30--------
    rs1857255831,2
    --57877478(+) CGCTCA/GCCTCG 1 -- int10--------
    rs1904198611,2
    --57877523(+) ACTGCA/GCCTGG 1 -- int10--------
    rs97495401,2
    C,A,H--57877572(+) TTTTTT/GTGTGT 1 -- int19Minor allele frequency- G:0.05NA WA CSA 19
    rs1861274771,2
    --57877574(+) TTTGTG/TTGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF547 (57874845 - 57890933 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF547: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF547
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF547

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF547 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF547)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284306 HGNC: 26432 AceView: ZNF547 Ensembl:ENSG00000152433 euGenes: HUgn284306
    ECgene: ZNF547 H-InvDB: ZNF547

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF547 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF547 gene:
    Search GeneIP for patents involving ZNF547

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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