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Aliases for ZNF546 Gene

Aliases for ZNF546 Gene

  • Zinc Finger Protein 546 2 3 5
  • Zinc Finger Protein 49 3 4
  • ZNF49 3 4
  • CTC-471F3.6 3

External Ids for ZNF546 Gene

Previous HGNC Symbols for ZNF546 Gene

  • ZNF49

Previous GeneCards Identifiers for ZNF546 Gene

  • GC19P045195
  • GC19P045196
  • GC19P040503
  • GC19P036939

Summaries for ZNF546 Gene

GeneCards Summary for ZNF546 Gene

ZNF546 (Zinc Finger Protein 546) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF607.

UniProtKB/Swiss-Prot for ZNF546 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF546 Gene

Genomics for ZNF546 Gene

Regulatory Elements for ZNF546 Gene

Enhancers for ZNF546 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF546 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF546 Gene

39,984,134 bp from pter
40,021,041 bp from pter
36,908 bases
Plus strand

Genomic View for ZNF546 Gene

Genes around ZNF546 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF546 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF546 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF546 Gene

Proteins for ZNF546 Gene

  • Protein details for ZNF546 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 546
    Protein Accession:
    Secondary Accessions:
    • A8K913

    Protein attributes for ZNF546 Gene

    836 amino acids
    Molecular mass:
    98405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF546 Gene

Proteomics data for ZNF546 Gene at MOPED

Post-translational modifications for ZNF546 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF546 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF546

No data available for DME Specific Peptides for ZNF546 Gene

Domains & Families for ZNF546 Gene

Gene Families for ZNF546 Gene

Protein Domains for ZNF546 Gene

Suggested Antigen Peptide Sequences for ZNF546 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF546: view

Function for ZNF546 Gene

Molecular function for ZNF546 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF546: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF546 Gene

Localization for ZNF546 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF546 Gene

Subcellular locations from

Jensen Localization Image for ZNF546 Gene COMPARTMENTS Subcellular localization image for ZNF546 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF546 Gene

Pathways & Interactions for ZNF546 Gene

SuperPathways for ZNF546 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF546: view

Pathways by source for ZNF546 Gene

2 Reactome pathways for ZNF546 Gene

Interacting Proteins for ZNF546 Gene

Gene Ontology (GO) - Biological Process for ZNF546 Gene


No data available for SIGNOR curated interactions for ZNF546 Gene

Drugs & Compounds for ZNF546 Gene

No Compound Related Data Available

Transcripts for ZNF546 Gene

Unigene Clusters for ZNF546 Gene

Zinc finger protein 546:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF546 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - -

Relevant External Links for ZNF546 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF546 Gene

mRNA expression in normal human tissues for ZNF546 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF546 Gene

This gene is overexpressed in Testis (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF546 Gene

SOURCE GeneReport for Unigene cluster for ZNF546 Gene Hs.666807

genes like me logo Genes that share expression patterns with ZNF546: view

Protein tissue co-expression partners for ZNF546 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF546 Gene

Orthologs for ZNF546 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF546 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF546 35
  • 82.87 (n)
  • 77.87 (a)
ZNF546 36
  • 53 (a)
(Mus musculus)
Mammalia Zfp11 35
  • 60.22 (n)
  • 54.75 (a)
Zfp11 16
Zfp11 36
  • 52 (a)
(Pan troglodytes)
Mammalia ZNF546 35
  • 99.52 (n)
  • 98.92 (a)
ZNF546 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100363065 35
  • 60.81 (n)
  • 54.33 (a)
(Canis familiaris)
Mammalia ZNF252 36
  • 41 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea egrh-2 35
  • 55.06 (n)
  • 52.59 (a)
Species with no ortholog for ZNF546:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF546 Gene

Gene Tree for ZNF546 (if available)
Gene Tree for ZNF546 (if available)

Paralogs for ZNF546 Gene

(543) SIMAP similar genes for ZNF546 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF546: view

Variants for ZNF546 Gene

Sequence variations from dbSNP and Humsavar for ZNF546 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035587 A breast cancer sample
rs17854378 - 40,013,872(+) AAAAC(A/G)AATAT reference, missense
rs2111543 - 40,013,998(+) TGAGA(A/C/G)ACCCT reference, missense
rs2111544 - 40,014,028(+) AAAGG(C/T)CTTTT reference, missense
rs17710336 - 40,014,163(+) TGGTG(A/T)GAAAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF546 Gene

Variant ID Type Subtype PubMed ID
dgv1082e1 CNV Complex 17122850

Variation tolerance for ZNF546 Gene

Residual Variation Intolerance Score: 81.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.08; 84.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF546 Gene

Disorders for ZNF546 Gene

Relevant External Links for ZNF546

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF546 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF546 Gene

Publications for ZNF546 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF546 Gene

Sources for ZNF546 Gene