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Aliases for ZNF546 Gene

Aliases for ZNF546 Gene

  • Zinc Finger Protein 546 2 3
  • Zinc Finger Protein 49 3 4
  • ZNF49 3 4
  • CTC-471F3.6 3

External Ids for ZNF546 Gene

Previous HGNC Symbols for ZNF546 Gene

  • ZNF49

Previous GeneCards Identifiers for ZNF546 Gene

  • GC19P045195
  • GC19P045196
  • GC19P040503
  • GC19P036939

Summaries for ZNF546 Gene

GeneCards Summary for ZNF546 Gene

ZNF546 (Zinc Finger Protein 546) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF546 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF546 Gene

Genomics for ZNF546 Gene

Regulatory Elements for ZNF546 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF546 Gene

Start:
39,984,134 bp from pter
End:
40,017,607 bp from pter
Size:
33,474 bases
Orientation:
Plus strand

Genomic View for ZNF546 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF546 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF546 Gene

Proteins for ZNF546 Gene

  • Protein details for ZNF546 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE3-ZN546_HUMAN
    Recommended name:
    Zinc finger protein 546
    Protein Accession:
    Q86UE3
    Secondary Accessions:
    • A8K913

    Protein attributes for ZNF546 Gene

    Size:
    836 amino acids
    Molecular mass:
    98405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF546 Gene

Proteomics data for ZNF546 Gene at MOPED

Post-translational modifications for ZNF546 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF546 Gene

No data available for DME Specific Peptides for ZNF546 Gene

Domains for ZNF546 Gene

Gene Families for ZNF546 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF546 Gene

Suggested Antigen Peptide Sequences for ZNF546 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UE3

UniProtKB/Swiss-Prot:

ZN546_HUMAN :
  • Q86UE3
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF546: view

Function for ZNF546 Gene

Molecular function for ZNF546 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF546: view

Phenotypes for ZNF546 Gene

GenomeRNAi human phenotypes for ZNF546:
genes like me logo Genes that share phenotypes with ZNF546: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF546

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF546 Gene

Localization for ZNF546 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF546 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF546 Gene COMPARTMENTS Subcellular localization image for ZNF546 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF546: view

Pathways for ZNF546 Gene

SuperPathways for ZNF546 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF546: view

Pathways by source for ZNF546 Gene

2 Reactome pathways for ZNF546 Gene

Interacting Proteins for ZNF546 Gene

Gene Ontology (GO) - Biological Process for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF546: view

Transcripts for ZNF546 Gene

Unigene Clusters for ZNF546 Gene

Zinc finger protein 546:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF546

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF546
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF546 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - -

Relevant External Links for ZNF546 Gene

GeneLoc Exon Structure for
ZNF546
ECgene alternative splicing isoforms for
ZNF546

Expression for ZNF546 Gene

mRNA expression in normal human tissues for ZNF546 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF546 Gene

This gene is overexpressed in Testis (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF546 Gene

SOURCE GeneReport for Unigene cluster for ZNF546 Gene Hs.666807

genes like me logo Genes that share expressions with ZNF546: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF546 Gene

Orthologs for ZNF546 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF546 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF546 35
  • 99.52 (n)
  • 98.92 (a)
ZNF546 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF546 35
  • 82.87 (n)
  • 77.87 (a)
ZNF546 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF252 36
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp11 35
  • 60.22 (n)
  • 54.75 (a)
Zfp11 16
Zfp11 36
  • 52 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100363065 35
  • 60.81 (n)
  • 54.33 (a)
worm
(Caenorhabditis elegans)
Secernentea egrh-2 35
  • 55.06 (n)
  • 52.59 (a)
Species with no ortholog for ZNF546:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF546 Gene

ENSEMBL:
Gene Tree for ZNF546 (if available)
TreeFam:
Gene Tree for ZNF546 (if available)

Paralogs for ZNF546 Gene

Selected SIMAP similar genes for ZNF546 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF546: view

Variants for ZNF546 Gene

Sequence variations from dbSNP and Humsavar for ZNF546 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs170899 -- 39,995,871(+) cagtg(C/G)aagtc upstream-variant-2KB
rs173061 -- 40,002,058(+) AGAGT(C/T)TGTGT intron-variant
rs183504 -- 40,002,208(+) GTGCC(A/C/G)TCATA intron-variant
rs234300 -- 40,016,105(+) ggaaa(A/G)acagg utr-variant-3-prime, downstream-variant-500B
rs234301 -- 40,016,111(+) ACAGG(A/G)GTTCG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF546 Gene

Variant ID Type Subtype PubMed ID
dgv1082e1 CNV Complex 17122850

Relevant External Links for ZNF546 Gene

HapMap Linkage Disequilibrium report
ZNF546

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF546 Gene

Disorders for ZNF546 Gene

No disorders were found for ZNF546 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF546 Gene

Publications for ZNF546 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3

Products for ZNF546 Gene

Sources for ZNF546 Gene

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