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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF546 Gene

protein-coding   GIFtS: 50
GCID: GC19P040503

Zinc Finger Protein 546


(Previous symbol: ZNF49)
  Search for ZNF546
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5461 2
ZNF491 2 3
Zinc Finger Protein 492 3

External Ids:    HGNC: 286711   Entrez Gene: 3393272   Ensembl: ENSG000001871877   UniProtKB: Q86UE33   

Export aliases for ZNF546 gene to outside databases

Previous GC identifers: GC19P045195 GC19P045196 GC19P036939


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF546 Gene: 
ZNF546 (zinc finger protein 546) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZN546_HUMAN, Q86UE3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF546 gene promoter:
         AREB6   CHOP-10   p53   FOXD1   TGIF   Ik-3   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF546 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF546

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF546


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

ZNF546 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF546 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P040503:  view genomic region     (about GC identifiers)

Start:
40,490,041 bp from pter      End:
40,523,514 bp from pter
Size:
33,474 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN546_HUMAN, Q86UE3 (See protein sequence)
Recommended Name: Zinc finger protein 546  
Size: 836 amino acids; 98405 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A8K913

Explore the universe of human proteins at neXtProt for ZNF546: NX_Q86UE3

Explore proteomics data for ZNF546 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UE3

  • ZNF546 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF546 Protein Expression
    REFSEQ proteins: NP_848639.2  
    ENSEMBL proteins: 
     ENSP00000469334   ENSP00000470423   ENSP00000469168   ENSP00000469540   ENSP00000339823  
     ENSP00000472403  
    Reactome Protein details: Q86UE3
    Human Recombinant Protein Products for ZNF546: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF546 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF546 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ZNF546 
    Cloud-Clone Corp. CLIAs for ZNF546


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86UE3

    ProtoNet protein and cluster: Q86UE3

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN546_HUMAN, Q86UE3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 22 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF546 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN546_HUMAN, Q86UE3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF546 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF546:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF546 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF546

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF546 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF546 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF546:
    hsa-miR-188-3p
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF546


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF546 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF546
        Generic Transcription Pathway
    Gene Expression



    ZNF546 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF546

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF546 (ENSP000003398234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX4ENSP000002693974STRING: ENSP00000269397
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF546 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF546 (ZN546)

    Search CenterWatch for drugs/clinical trials and news about ZNF546 / ZN546

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF546 gene: 
    NM_178544.3  

    Unigene Cluster for ZNF546:

    Zinc finger protein 546
    Hs.666807  [show with all ESTs]
    Unigene Representative Sequence: NM_178544
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597363 ENST00000599504 ENST00000596894 ENST00000593687 ENST00000601138
    ENST00000600094 ENST00000347077(uc002oms.2 uc002omt.2) ENST00000602253
    ENST00000595225
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF546:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF546 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for ZNF546
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF546
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF546 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF546 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF546
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF546

    Additional mRNA sequence: 

    AF035364.1 AK122968.1 AK172809.1 AK292528.1 BC045649.1 

    3 DOTS entries:

    DT.99987425  DT.121501069  DT.406250 

    24/26 AceView cDNA sequences (see all 26):

    AK122968 AW072437 AI342853 BU674437 AI871774 AI268476 AL039876 BC045649 
    CD677747 NM_178544 AL039875 AL713040 BU187956 AA600843 BE670785 AW613481 
    AK172809 BE091796 T56944 AI123273 BE091778 T48582 T56945 BE548749 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF546 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                          -                       -     -     -                                 
    SP2:                          -                             -     -                                 
    SP3:                                                        -     -                                 
    SP4:                          -                       -     -                                       
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for ZNF546

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF546 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGAGGAAG
    ZNF546 Expression
    About this image


    See ZNF546 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF546

    SOURCE GeneReport for Unigene cluster: Hs.666807
        SABiosciences Custom PCR Arrays for ZNF546
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF546

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF546 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp111 , 5 zinc finger protein 111, 5 60.22(n)1
    54.75(a)1
      5 (68.22 cM)5
    226481  NM_172462.41  NP_766050.11 
     1296545935 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 116)
    Uncharacterized protein
    (see all 116)
    54(a)
    53(a)
    (see all 116)
    possible ortholog
    possible ortholog
    (see all 116)
    GL343676.1(226652-245929)
    GL343330.1(1318554-1333631)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX759592.12   -- 75.23(n)    BX759592.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CU929205.16
    AL935044.26
    (see all 3)
    Uncharacterized protein
    (see all 3)
    48(a)
    31(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3(62175907-62185073)
    24(16413099-16429687)


    ENSEMBL Gene Tree for ZNF546 (if available)
    TreeFam Gene Tree for ZNF546 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF546 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF992  ZNF8362  ZNF7172  ZNF5942  ZNF6002  
    ZFP622  ZNF8412  ZNF780B2  ZNF1972  ZNF585A2  ZNF1072  ZNF8082  ZNF8452  
    ZNF6582  ZNF6242  ZNF2682  
    18/543 SIMAP similar genes for ZNF546 using alignment to 6 protein entries:     ZN546_HUMAN (see all proteins) (see all similar genes):
    NPLOC4    EML2    C10orf137    DPP9    APOD    ZNF721
    ZNF701    ZNF320    ZNF761    PKN1    SHANK2    UTY
    WARS    ZNF78L1    ZNF83    AAMDC    CRCP    FAM3A

    ZNF546 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/524 SNPs in ZNF546 are shown (see all 524)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355874
    A breast cancer sample4--see VAR_0355872 L V mis40--------
    rs104067381,2
    C,F,H--40501055(+) agaaaA/Cctccg 1 -- us2k112Minor allele frequency- C:0.27NS EA NA WA CSA 772
    rs1886406091,2
    --40501059(+) AACTCC/TGGATA 1 -- us2k10--------
    rs1507955691,2
    C--40501060(+) ACTCCA/GGATAT 1 -- us2k10--------
    rs1380926861,2
    --40501084(+) ACTAAC/TTTACA 1 -- us2k10--------
    rs800501701,2
    C,F--40501107(+) GTGTAC/TAAGTG 1 -- us2k12Minor allele frequency- T:0.03NA 122
    rs1811311301,2
    --40501147(+) TTGTCA/GTCTTT 1 -- us2k10--------
    rs2020826971,2
    --40501595(+) ATTTG-/GGGC  
            
    GGGGG
    1 -- us2k10--------
    rs1414417981,2
    C--40501596(+) TTTGG-/GGCGGGGG 1 -- cds10--------
    rs723077251,2
    C--40501597(+) TTGGG-/GGCGGGGG 1 -- cds10--------

    HapMap Linkage Disequilibrium report for ZNF546 (40490041 - 40523514 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF546:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1082e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF546
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF546

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF546 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF546)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    8. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1 Lichter P....Ward D.C. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339327 HGNC: 28671 AceView: ZNF546 Ensembl:ENSG00000187187 euGenes: HUgn339327
    ECgene: ZNF546 H-InvDB: ZNF546

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF546 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF546 gene:
    Search GeneIP for patents involving ZNF546

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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