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Aliases for ZNF543 Gene

Aliases for ZNF543 Gene

  • Zinc Finger Protein 543 2 3 5

External Ids for ZNF543 Gene

Previous GeneCards Identifiers for ZNF543 Gene

  • GC00U914381
  • GC19P062525
  • GC19P062523
  • GC19P057831
  • GC19P054146

Summaries for ZNF543 Gene

GeneCards Summary for ZNF543 Gene

ZNF543 (Zinc Finger Protein 543) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot for ZNF543 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF543 Gene

Genomics for ZNF543 Gene

Regulatory Elements for ZNF543 Gene

Enhancers for ZNF543 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F056594 0.9 ENCODE 59.7 -725.1 -725057 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A YBX1 FEZF1 GLI4 ZNF48 ETS1 ZNF773 ZNF550 U2AF2 ZNF543 ZNF264 ZNF17 ENSG00000267523 ZNF549 ENSG00000267096 ZFP28
GH19F057809 1.2 FANTOM5 ENCODE 47.2 +492.7 492721 7.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF805 ZNF264 TRIM28 ZNF256 ZNF543 ZNF417 ZNF773 ZNF17 ENSG00000269867
GH19F058181 0.5 ENCODE 38.4 +862.7 862740 2.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF134 ZNF773 ZNF550 ZNF256 ZNF543 ZNF551 ZNF549 ZNF17 ZNF417 ZNF776
GH19F056403 0.2 ENCODE 28.1 -916.3 -916348 2.0 ATF1 CREB3L1 ZNF133 ARID4B SIN3A GLI4 DMAP1 ZNF48 YY1 GTF3C2 ZNF543 ZNF582-AS1 ZNF805 LOC100506374 ZNF264 ZNF581 U2AF2 ENSG00000267523 ZNF628 ZNF548
GH19F056392 0.4 ENCODE 28.1 -927.0 -927041 1.5 ATF1 ARNT CREB3L1 ZNF133 SIN3A ZNF48 BRCA1 ZNF2 ETS1 YY1 ZNF543 ZNF582-AS1 ZNF805 LOC100506374 ZNF264 ZNF581 U2AF2 ENSG00000267523 ZNF628 ZNF548
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF543 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF543 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045609 203 1801 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3

Genomic Location for ZNF543 Gene

Chromosome:
19
Start:
57,320,497 bp from pter
End:
57,330,776 bp from pter
Size:
10,280 bases
Orientation:
Plus strand

Genomic View for ZNF543 Gene

Genes around ZNF543 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF543 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF543 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF543 Gene

Proteins for ZNF543 Gene

  • Protein details for ZNF543 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08ER8-ZN543_HUMAN
    Recommended name:
    Zinc finger protein 543
    Protein Accession:
    Q08ER8
    Secondary Accessions:
    • Q495U9
    • Q495V0
    • Q6ZMP4
    • Q8NCX4

    Protein attributes for ZNF543 Gene

    Size:
    600 amino acids
    Molecular mass:
    68404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF543 Gene

Post-translational modifications for ZNF543 Gene

  • Ubiquitination at Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF543 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF543 Gene

Domains & Families for ZNF543 Gene

Gene Families for ZNF543 Gene

Protein Domains for ZNF543 Gene

Suggested Antigen Peptide Sequences for ZNF543 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08ER8

UniProtKB/Swiss-Prot:

ZN543_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF543: view

Function for ZNF543 Gene

Molecular function for ZNF543 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF543: view

Phenotypes for ZNF543 Gene

GenomeRNAi human phenotypes for ZNF543:
genes like me logo Genes that share phenotypes with ZNF543: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF543 Gene

Localization for ZNF543 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF543 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF543 Gene COMPARTMENTS Subcellular localization image for ZNF543 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF543: view

Pathways & Interactions for ZNF543 Gene

SuperPathways for ZNF543 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF543: view

Pathways by source for ZNF543 Gene

2 Reactome pathways for ZNF543 Gene

Gene Ontology (GO) - Biological Process for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF543: view

No data available for SIGNOR curated interactions for ZNF543 Gene

Transcripts for ZNF543 Gene

mRNA/cDNA for ZNF543 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF543 Gene

Zinc finger protein 543:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF543 Gene

No ASD Table

Relevant External Links for ZNF543 Gene

GeneLoc Exon Structure for
ZNF543
ECgene alternative splicing isoforms for
ZNF543

Expression for ZNF543 Gene

mRNA expression in normal human tissues for ZNF543 Gene

Protein differential expression in normal tissues from HIPED for ZNF543 Gene

This gene is overexpressed in Spinal cord (38.3) and Frontal cortex (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF543 Gene



Protein tissue co-expression partners for ZNF543 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF543 Gene:

ZNF543

SOURCE GeneReport for Unigene cluster for ZNF543 Gene:

Hs.202544
genes like me logo Genes that share expression patterns with ZNF543: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF543 Gene

Orthologs for ZNF543 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF543 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF543 34 35
  • 98.94 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 35
  • 51 (a)
ManyToMany
CU138542.3 35
  • 45 (a)
ManyToMany
Species where no ortholog for ZNF543 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF543 Gene

ENSEMBL:
Gene Tree for ZNF543 (if available)
TreeFam:
Gene Tree for ZNF543 (if available)

Paralogs for ZNF543 Gene

Paralogs for ZNF543 Gene

(496) SIMAP similar genes for ZNF543 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF543: view

Variants for ZNF543 Gene

Sequence variations from dbSNP and Humsavar for ZNF543 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1034847 -- 57,330,861(+) gacta(C/G)ctctc downstream-variant-500B
rs10401577 -- 57,327,449(+) AAGTG(A/G)TTCTC intron-variant
rs10401742 -- 57,327,461(+) TGCCT(C/T)AGCCT intron-variant
rs10402116 -- 57,327,475(+) GAGTA(C/G)CTGGG intron-variant
rs10402639 -- 57,320,455(+) GCGGA(A/G)GTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF543 Gene

Variant ID Type Subtype PubMed ID
dgv602n67 CNV gain 20364138
esv2531361 CNV insertion 19546169
esv25537 CNV gain 19812545
esv2659236 CNV deletion 23128226
esv3644901 CNV loss 21293372
esv3893257 CNV loss 25118596
nsv580400 CNV gain 21841781
nsv819727 CNV gain 19587683
nsv819877 CNV loss 19587683
nsv821238 CNV deletion 20802225

Variation tolerance for ZNF543 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF543 Gene

Human Gene Mutation Database (HGMD)
ZNF543
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF543

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF543 Gene

Disorders for ZNF543 Gene

Relevant External Links for ZNF543

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF543

No disorders were found for ZNF543 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF543 Gene

Publications for ZNF543 Gene

  1. Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families. (PMID: 26095808) Liu R. … Wang Y. (Gene 2015) 3 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZNF543 Gene

Sources for ZNF543 Gene

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