Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF543 Gene

Aliases for ZNF543 Gene

  • Zinc Finger Protein 543 2 3

External Ids for ZNF543 Gene

Summaries for ZNF543 Gene

GeneCards Summary for ZNF543 Gene

ZNF543 (Zinc Finger Protein 543) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF460.

UniProtKB/Swiss-Prot for ZNF543 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF543 Gene

Genomics for ZNF543 Gene

Genomic Location for ZNF543 Gene

57,320,497 bp from pter
57,330,776 bp from pter
10,280 bases
Plus strand

Genomic View for ZNF543 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF543 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF543 Gene

Regulatory Elements for ZNF543 Gene

Proteins for ZNF543 Gene

  • Protein details for ZNF543 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 543
    Protein Accession:
    Secondary Accessions:
    • Q495U9
    • Q495V0
    • Q6ZMP4
    • Q8NCX4

    Protein attributes for ZNF543 Gene

    600 amino acids
    Molecular mass:
    68404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF543 Gene

Proteomics data for ZNF543 Gene at MOPED

Post-translational modifications for ZNF543 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys337 and Lys477

Other Protein References for ZNF543 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF543 Gene

Domains for ZNF543 Gene

Gene Families for ZNF543 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF543 Gene


  • Contains 1 KRAB domain.:
    • Q08ER8
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q08ER8
  • Contains 13 C2H2-type zinc fingers.:
    • Q08ER8
genes like me logo Genes that share domains with ZNF543: view

Function for ZNF543 Gene

Molecular function for ZNF543 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF543: view

miRNA for ZNF543 Gene

miRTarBase miRNAs that target ZNF543

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF543 Gene

Localization for ZNF543 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF543 Gene

Subcellular locations from

Jensen Localization Image for ZNF543 Gene COMPARTMENTS Subcellular localization image for ZNF543 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF543: view

Pathways for ZNF543 Gene

SuperPathways for ZNF543 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF543: view

Pathways by source for ZNF543 Gene

2 Reactome pathways for ZNF543 Gene

Interacting Proteins for ZNF543 Gene

Gene Ontology (GO) - Biological Process for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF543: view

Transcripts for ZNF543 Gene

mRNA/cDNA for ZNF543 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF543 Gene

Zinc finger protein 543:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF543 Gene

No ASD Table

Relevant External Links for ZNF543 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF543 Gene

mRNA expression in normal human tissues for ZNF543 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF543 Gene

SOURCE GeneReport for Unigene cluster for ZNF543 Gene Hs.202544

genes like me logo Genes that share expressions with ZNF543: view

Orthologs for ZNF543 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF543 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF543 36
  • 98.94 (n)
  • 98.5 (a)
ZNF543 37
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 42 (a)
(Danio rerio)
Actinopterygii CU138542.3 37
  • 45 (a)
si:dkey-7j22.3 37
  • 51 (a)
Species with no ortholog for ZNF543:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF543 Gene

Gene Tree for ZNF543 (if available)
Gene Tree for ZNF543 (if available)

Paralogs for ZNF543 Gene

Paralogs for ZNF543 Gene

Selected SIMAP similar genes for ZNF543 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF543: view

Variants for ZNF543 Gene

Sequence variations from dbSNP and Humsavar for ZNF543 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1034847 -- 57,330,861(+) gacta(C/G)ctctc downstream-variant-500B
rs1968090 - 57,328,199(+) GCACC(A/T)CATCA missense, reference
rs2190690 -- 57,325,074(+) AGCAG(C/G)AAAGT intron-variant
rs2361121 -- 57,330,093(-) ATGCT(C/T)CTGCA utr-variant-3-prime
rs3761061 -- 57,330,364(-) AGAAA(C/T)CACAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF543 Gene

Variant ID Type Subtype PubMed ID
nsv819727 CNV Gain 19587683
dgv602n67 CNV Gain 20364138
nsv821238 CNV Deletion 20802225
esv2659236 CNV Deletion 23128226
esv25537 CNV Gain 19812545
esv2531361 CNV Insertion 19546169
nsv819877 CNV Loss 19587683

Relevant External Links for ZNF543 Gene

HapMap Linkage Disequilibrium report

Disorders for ZNF543 Gene

No disorders were found for ZNF543 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF543 Gene

Publications for ZNF543 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PMID: 22797925) Aichem A. … Groettrup M. (J. Cell. Sci. 2012) 3

Products for ZNF543 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF543
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF543
  • Block miRNA regulation of ZNF543 using miScript Target Protectors

Sources for ZNF543 Gene

Back to Top