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Aliases for ZNF543 Gene

Aliases for ZNF543 Gene

  • Zinc Finger Protein 543 2 3 5

External Ids for ZNF543 Gene

Previous GeneCards Identifiers for ZNF543 Gene

  • GC00U914381
  • GC19P062525
  • GC19P062523
  • GC19P057831
  • GC19P054146

Summaries for ZNF543 Gene

GeneCards Summary for ZNF543 Gene

ZNF543 (Zinc Finger Protein 543) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF460.

UniProtKB/Swiss-Prot for ZNF543 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF543 Gene

Genomics for ZNF543 Gene

Regulatory Elements for ZNF543 Gene

Enhancers for ZNF543 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF543 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF543 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF543 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF543 Gene

57,320,497 bp from pter
57,330,776 bp from pter
10,280 bases
Plus strand

Genomic View for ZNF543 Gene

Genes around ZNF543 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF543 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF543 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF543 Gene

Proteins for ZNF543 Gene

  • Protein details for ZNF543 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 543
    Protein Accession:
    Secondary Accessions:
    • Q495U9
    • Q495V0
    • Q6ZMP4
    • Q8NCX4

    Protein attributes for ZNF543 Gene

    600 amino acids
    Molecular mass:
    68404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF543 Gene

Proteomics data for ZNF543 Gene at MOPED

Post-translational modifications for ZNF543 Gene

  • Ubiquitination at Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF543 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF543 Gene

Domains & Families for ZNF543 Gene

Gene Families for ZNF543 Gene

Protein Domains for ZNF543 Gene

Suggested Antigen Peptide Sequences for ZNF543 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF543: view

Function for ZNF543 Gene

Molecular function for ZNF543 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF543: view

Phenotypes for ZNF543 Gene

GenomeRNAi human phenotypes for ZNF543:
genes like me logo Genes that share phenotypes with ZNF543: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF543 Gene

Localization for ZNF543 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF543 Gene

Subcellular locations from

Jensen Localization Image for ZNF543 Gene COMPARTMENTS Subcellular localization image for ZNF543 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF543 Gene

Pathways & Interactions for ZNF543 Gene

SuperPathways for ZNF543 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF543: view

Pathways by source for ZNF543 Gene

2 Reactome pathways for ZNF543 Gene

Interacting Proteins for ZNF543 Gene

Gene Ontology (GO) - Biological Process for ZNF543 Gene


No data available for SIGNOR curated interactions for ZNF543 Gene

Drugs & Compounds for ZNF543 Gene

No Compound Related Data Available

Transcripts for ZNF543 Gene

mRNA/cDNA for ZNF543 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF543 Gene

Zinc finger protein 543:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF543 Gene

No ASD Table

Relevant External Links for ZNF543 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF543 Gene

mRNA expression in normal human tissues for ZNF543 Gene

Protein differential expression in normal tissues from HIPED for ZNF543 Gene

This gene is overexpressed in Spinal cord (38.3) and Frontal cortex (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF543 Gene

SOURCE GeneReport for Unigene cluster for ZNF543 Gene Hs.202544

genes like me logo Genes that share expression patterns with ZNF543: view

Protein tissue co-expression partners for ZNF543 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF543 Gene

Orthologs for ZNF543 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF543 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF543 35
  • 98.94 (n)
  • 98.5 (a)
ZNF543 36
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
(Danio rerio)
Actinopterygii CU138542.3 36
  • 45 (a)
si:dkey-7j22.3 36
  • 51 (a)
Species with no ortholog for ZNF543:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF543 Gene

Gene Tree for ZNF543 (if available)
Gene Tree for ZNF543 (if available)

Paralogs for ZNF543 Gene

Paralogs for ZNF543 Gene

(496) SIMAP similar genes for ZNF543 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF543: view

Variants for ZNF543 Gene

Sequence variations from dbSNP and Humsavar for ZNF543 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs6510057 - 57,326,650(+) TCAAA(C/G)CAGAG reference, missense
rs8100491 - 57,327,782(+) GGAAC(A/G)ACTGA reference, missense
rs1968090 - 57,328,199(+) GCACC(A/T)CATCA reference, missense
rs35238720 - 57,328,322(+) CAGTG(A/T)ATGTG reference, missense
rs10411486 - 57,328,778(+) TTTTG(A/T)CTTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF543 Gene

Variant ID Type Subtype PubMed ID
nsv819727 CNV Gain 19587683
dgv602n67 CNV Gain 20364138
nsv821238 CNV Deletion 20802225
esv2659236 CNV Deletion 23128226
esv25537 CNV Gain 19812545
esv2531361 CNV Insertion 19546169
nsv819877 CNV Loss 19587683

Variation tolerance for ZNF543 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF543 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF543 Gene

Disorders for ZNF543 Gene

Relevant External Links for ZNF543

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF543 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF543 Gene

Publications for ZNF543 Gene

  1. Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families. (PMID: 26095808) Liu R. … Wang Y. (Gene 2015) 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF543 Gene

Sources for ZNF543 Gene