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Aliases for ZNF536 Gene

Aliases for ZNF536 Gene

  • Zinc Finger Protein 536 2 3 5
  • KIAA0390 4

External Ids for ZNF536 Gene

Previous GeneCards Identifiers for ZNF536 Gene

  • GC19P035555
  • GC19P030864
  • GC19P027369
  • GC19P030720

Summaries for ZNF536 Gene

Entrez Gene Summary for ZNF536 Gene

  • The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]

GeneCards Summary for ZNF536 Gene

ZNF536 (Zinc Finger Protein 536) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZNF516.

UniProtKB/Swiss-Prot for ZNF536 Gene

  • May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5-CCCCCA-3.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF536 Gene

Genomics for ZNF536 Gene

Regulatory Elements for ZNF536 Gene

Enhancers for ZNF536 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G029660 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -555.7 -555701 17.2 FEZF1 YBX1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZFP41 RPL9P32 ENSG00000266910 PLEKHF1 ZNF536 C19orf12 LOC105372352 URI1 LOC105372353 GC19M029684
GH19G030448 2 Ensembl ENCODE 10.9 +225.0 224998 3.3 TEAD4 FEZF1 ZIC2 RAD21 GLIS2 POLR2A PATZ1 SCRT2 PRDM10 SCRT1 ZNF536 GC19P030448 GC19P030488
GH19G030338 1.8 dbSUPER 11.8 +115.1 115114 3.2 PKNOX1 ATF1 ZNF792 FEZF1 ZNF664 HIC1 ZNF776 SCRT2 ZNF600 SCRT1 ZNF536 GC19P030333 GC19P030351
GH19G030307 1.7 dbSUPER 11.3 +84.5 84470 4.7 CTCF ZNF777 PKNOX1 ZNF493 ZMYM3 SALL2 RAD21 SMC3 ZNF416 ZNF280C ENSG00000266910 ZNF536 GC19P030333 GC19P030276
GH19G030401 1.6 VISTA dbSUPER 11.9 +177.0 177016 1.1 PRDM6 ZNF536 GC19P030357 GC19P030448
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF536 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF536 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108557 510 401 RAD21 YY1 ZNF335 GLIS2 EGR2 ZNF263 ZNF202 SP3 ZEB2 ZNF623
ENSR00000288002 -590 601 RB1 ZSCAN4 INSM2 ZNF76 RAD21 ZNF335 GLIS2 ZNF366 KLF7 EGR2

Genomic Location for ZNF536 Gene

Chromosome:
19
Start:
30,225,044 bp from pter
End:
30,713,538 bp from pter
Size:
488,495 bases
Orientation:
Plus strand

Genomic View for ZNF536 Gene

Genes around ZNF536 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF536 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF536 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF536 Gene

Proteins for ZNF536 Gene

  • Protein details for ZNF536 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15090-ZN536_HUMAN
    Recommended name:
    Zinc finger protein 536
    Protein Accession:
    O15090
    Secondary Accessions:
    • A2RU18

    Protein attributes for ZNF536 Gene

    Size:
    1300 amino acids
    Molecular mass:
    141417 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20844.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF536 Gene

Post-translational modifications for ZNF536 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF536 Gene

Domains & Families for ZNF536 Gene

Gene Families for ZNF536 Gene

Protein Domains for ZNF536 Gene

Suggested Antigen Peptide Sequences for ZNF536 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15090

UniProtKB/Swiss-Prot:

ZN536_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF536: view

Function for ZNF536 Gene

Molecular function for ZNF536 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5-CCCCCA-3.

Gene Ontology (GO) - Molecular Function for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19398580
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 19398580
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0044323 retinoic acid-responsive element binding IEA --
genes like me logo Genes that share ontologies with ZNF536: view
genes like me logo Genes that share phenotypes with ZNF536: view

Animal Models for ZNF536 Gene

MGI Knock Outs for ZNF536:

Animal Model Products

CRISPR Products

miRNA for ZNF536 Gene

miRTarBase miRNAs that target ZNF536

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF536 Gene

Localization for ZNF536 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF536 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF536 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF536: view

Pathways & Interactions for ZNF536 Gene

SuperPathways for ZNF536 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 19398580
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IBA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with ZNF536: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF536 Gene

Drugs & Compounds for ZNF536 Gene

No Compound Related Data Available

Transcripts for ZNF536 Gene

Unigene Clusters for ZNF536 Gene

Zinc finger protein 536:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF536 Gene

No ASD Table

Relevant External Links for ZNF536 Gene

GeneLoc Exon Structure for
ZNF536
ECgene alternative splicing isoforms for
ZNF536

Expression for ZNF536 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF536 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF536 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.4) and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for ZNF536 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF536 Gene



Protein tissue co-expression partners for ZNF536 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF536 Gene:

ZNF536

SOURCE GeneReport for Unigene cluster for ZNF536 Gene:

Hs.378901

Evidence on tissue expression from TISSUES for ZNF536 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF536: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF536 Gene

Orthologs for ZNF536 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF536 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF536 34 35
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia ZNF536 34 35
  • 90.55 (n)
dog
(Canis familiaris)
Mammalia ZNF536 34 35
  • 89.63 (n)
rat
(Rattus norvegicus)
Mammalia Zfp536 34
  • 85.54 (n)
mouse
(Mus musculus)
Mammalia Zfp536 34 16 35
  • 85.22 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF536 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF536 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF536 34 35
  • 75.65 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF536 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf536 34
  • 67.34 (n)
zebrafish
(Danio rerio)
Actinopterygii znf536 34 35
  • 62.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 35
  • 26 (a)
OneToMany
Species where no ortholog for ZNF536 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF536 Gene

ENSEMBL:
Gene Tree for ZNF536 (if available)
TreeFam:
Gene Tree for ZNF536 (if available)

Paralogs for ZNF536 Gene

Paralogs for ZNF536 Gene

genes like me logo Genes that share paralogs with ZNF536: view

Variants for ZNF536 Gene

Sequence variations from dbSNP and Humsavar for ZNF536 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000008250 -- 30,360,436(+) GAAAT(C/T)GGGCC intron-variant
rs1000009871 -- 30,599,647(+) TTTAC(A/G)AGACA intron-variant
rs1000012866 -- 30,513,901(+) CTGAG(A/G)CCCTC intron-variant
rs1000029316 -- 30,388,208(+) GAGTT(A/C)AGATA intron-variant
rs1000031214 -- 30,283,801(+) CCATA(C/T)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF536 Gene

Variant ID Type Subtype PubMed ID
dgv2007e59 CNV duplication 20981092
esv1248605 CNV insertion 17803354
esv2662362 CNV deletion 23128226
esv2718441 CNV deletion 23290073
esv2718442 CNV deletion 23290073
esv2718443 CNV deletion 23290073
esv2718444 CNV deletion 23290073
esv32918 CNV gain+loss 17666407
esv3556276 CNV deletion 23714750
esv3644137 CNV loss 21293372
esv3644138 CNV loss 21293372
esv8807 CNV loss 19470904
esv989390 CNV insertion 20482838
nsv1057700 CNV gain 25217958
nsv1072879 CNV deletion 25765185
nsv1146881 CNV deletion 26484159
nsv138500 CNV deletion 16902084
nsv458534 CNV loss 19166990
nsv476424 CNV novel sequence insertion 20440878
nsv579284 CNV loss 21841781
nsv833801 CNV loss 17160897

Variation tolerance for ZNF536 Gene

Residual Variation Intolerance Score: 1.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF536 Gene

Human Gene Mutation Database (HGMD)
ZNF536
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF536

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF536 Gene

Disorders for ZNF536 Gene

Relevant External Links for ZNF536

Genetic Association Database (GAD)
ZNF536
Human Genome Epidemiology (HuGE) Navigator
ZNF536
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF536

No disorders were found for ZNF536 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF536 Gene

Publications for ZNF536 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 3 46 64
  3. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PMID: 14621294) Sakai T. … Maeda H. (DNA Res. 2003) 3 4 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. (PMID: 24939585) Fransen E. … Friedman R.A. (Eur. J. Hum. Genet. 2015) 3 64

Products for ZNF536 Gene

Sources for ZNF536 Gene

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