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Aliases for ZNF536 Gene

Aliases for ZNF536 Gene

  • Zinc Finger Protein 536 2 3 5
  • KIAA0390 4

External Ids for ZNF536 Gene

Previous GeneCards Identifiers for ZNF536 Gene

  • GC19P035555
  • GC19P030864
  • GC19P027369
  • GC19P030720

Summaries for ZNF536 Gene

Entrez Gene Summary for ZNF536 Gene

  • The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]

GeneCards Summary for ZNF536 Gene

ZNF536 (Zinc Finger Protein 536) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZNF219.

UniProtKB/Swiss-Prot for ZNF536 Gene

  • May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5-CCCCCA-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF536 Gene

Genomics for ZNF536 Gene

Regulatory Elements for ZNF536 Gene

Promoters for ZNF536 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF536 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF536 Gene

Chromosome:
19
Start:
30,225,044 bp from pter
End:
30,713,538 bp from pter
Size:
488,495 bases
Orientation:
Plus strand

Genomic View for ZNF536 Gene

Genes around ZNF536 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF536 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF536 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF536 Gene

Proteins for ZNF536 Gene

  • Protein details for ZNF536 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15090-ZN536_HUMAN
    Recommended name:
    Zinc finger protein 536
    Protein Accession:
    O15090
    Secondary Accessions:
    • A2RU18

    Protein attributes for ZNF536 Gene

    Size:
    1300 amino acids
    Molecular mass:
    141417 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20844.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF536 Gene

Proteomics data for ZNF536 Gene at MOPED

Post-translational modifications for ZNF536 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF536 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF536 Gene

Domains & Families for ZNF536 Gene

Gene Families for ZNF536 Gene

Protein Domains for ZNF536 Gene

Suggested Antigen Peptide Sequences for ZNF536 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15090

UniProtKB/Swiss-Prot:

ZN536_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF536: view

Function for ZNF536 Gene

Molecular function for ZNF536 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5-CCCCCA-3.
genes like me logo Genes that share phenotypes with ZNF536: view

Animal Models for ZNF536 Gene

MGI Knock Outs for ZNF536:

Animal Model Products

CRISPR Products

miRNA for ZNF536 Gene

miRTarBase miRNAs that target ZNF536

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF536 Gene

Localization for ZNF536 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF536 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF536 Gene COMPARTMENTS Subcellular localization image for ZNF536 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF536 Gene

Pathways & Interactions for ZNF536 Gene

SuperPathways for ZNF536 Gene

No Data Available

Interacting Proteins for ZNF536 Gene

Gene Ontology (GO) - Biological Process for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0045665 negative regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with ZNF536: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF536 Gene

Drugs & Compounds for ZNF536 Gene

No Compound Related Data Available

Transcripts for ZNF536 Gene

Unigene Clusters for ZNF536 Gene

Zinc finger protein 536:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF536 Gene

No ASD Table

Relevant External Links for ZNF536 Gene

GeneLoc Exon Structure for
ZNF536
ECgene alternative splicing isoforms for
ZNF536

Expression for ZNF536 Gene

mRNA expression in normal human tissues for ZNF536 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF536 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.4) and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for ZNF536 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF536 Gene



SOURCE GeneReport for Unigene cluster for ZNF536 Gene Hs.378901

genes like me logo Genes that share expression patterns with ZNF536: view

Protein tissue co-expression partners for ZNF536 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF536 Gene

Orthologs for ZNF536 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF536 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF536 35
  • 90.55 (n)
  • 92.68 (a)
ZNF536 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF536 35
  • 89.63 (n)
  • 90.84 (a)
ZNF536 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp536 35
  • 85.22 (n)
  • 88.84 (a)
Zfp536 16
Zfp536 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF536 35
  • 99.49 (n)
  • 99.85 (a)
ZNF536 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp536 35
  • 85.54 (n)
  • 88.83 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF536 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF536 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF536 35
  • 75.65 (n)
  • 82.86 (a)
ZNF536 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF536 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf536 35
  • 67.34 (n)
  • 71.83 (a)
zebrafish
(Danio rerio)
Actinopterygii znf536 35
  • 62.3 (n)
  • 63.25 (a)
znf536 36
  • 57 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 36
  • 26 (a)
OneToMany
Species with no ortholog for ZNF536:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF536 Gene

ENSEMBL:
Gene Tree for ZNF536 (if available)
TreeFam:
Gene Tree for ZNF536 (if available)

Paralogs for ZNF536 Gene

Paralogs for ZNF536 Gene

genes like me logo Genes that share paralogs with ZNF536: view

Variants for ZNF536 Gene

Sequence variations from dbSNP and Humsavar for ZNF536 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12489 -- 30,557,325(+) ACGGT(A/G)CACCA intron-variant, utr-variant-3-prime
rs15658 -- 30,712,207(+) TGCAC(A/C)ACACA utr-variant-3-prime
rs16796 -- 30,539,861(-) GGAGA(A/G)CCTCG intron-variant
rs33428 -- 30,446,936(+) AATGG(A/G)TAGTA intron-variant
rs33429 -- 30,448,453(-) TTTTT(C/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF536 Gene

Variant ID Type Subtype PubMed ID
nsv833801 CNV Loss 17160897
esv32918 CNV Gain+Loss 17666407
esv8807 CNV Loss 19470904
nsv458534 CNV Loss 19166990
esv2718441 CNV Deletion 23290073
esv2718442 CNV Deletion 23290073
esv2662362 CNV Deletion 23128226
esv2718443 CNV Deletion 23290073
nsv138500 CNV Loss 16902084
esv2718444 CNV Deletion 23290073
esv989390 CNV Insertion 20482838
esv1248605 CNV Insertion 17803354

Variation tolerance for ZNF536 Gene

Residual Variation Intolerance Score: 1.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF536 Gene

HapMap Linkage Disequilibrium report
ZNF536
Human Gene Mutation Database (HGMD)
ZNF536

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF536 Gene

Disorders for ZNF536 Gene

Relevant External Links for ZNF536

Genetic Association Database (GAD)
ZNF536
Human Genome Epidemiology (HuGE) Navigator
ZNF536
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF536

No disorders were found for ZNF536 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF536 Gene

Publications for ZNF536 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. (PMID: 24939585) Fransen E. … Friedman R.A. (Eur. J. Hum. Genet. 2015) 3
  3. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3

Products for ZNF536 Gene

Sources for ZNF536 Gene

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