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Aliases for ZNF536 Gene

Aliases for ZNF536 Gene

  • Zinc Finger Protein 536 2 3
  • KIAA0390 4

External Ids for ZNF536 Gene

Previous GeneCards Identifiers for ZNF536 Gene

  • GC19P035555
  • GC19P030864
  • GC19P027369
  • GC19P030720

Summaries for ZNF536 Gene

GeneCards Summary for ZNF536 Gene

ZNF536 (Zinc Finger Protein 536) is a Protein Coding gene. GO annotations related to this gene include retinoic acid-responsive element binding. An important paralog of this gene is ZNF219.

UniProtKB/Swiss-Prot for ZNF536 Gene

  • May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5-CCCCCA-3

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF536 Gene

Genomics for ZNF536 Gene

Regulatory Elements for ZNF536 Gene

Genomic Location for ZNF536 Gene

Start:
30,228,290 bp from pter
End:
30,713,538 bp from pter
Size:
485,249 bases
Orientation:
Plus strand

Genomic View for ZNF536 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF536 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF536 Gene

Proteins for ZNF536 Gene

  • Protein details for ZNF536 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15090-ZN536_HUMAN
    Recommended name:
    Zinc finger protein 536
    Protein Accession:
    O15090
    Secondary Accessions:
    • A2RU18

    Protein attributes for ZNF536 Gene

    Size:
    1300 amino acids
    Molecular mass:
    141417 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20844.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF536 Gene

Proteomics data for ZNF536 Gene at MOPED

Post-translational modifications for ZNF536 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF536 Gene

No data available for DME Specific Peptides for ZNF536 Gene

Domains for ZNF536 Gene

Gene Families for ZNF536 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF536 Gene

Suggested Antigen Peptide Sequences for ZNF536 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15090

UniProtKB/Swiss-Prot:

ZN536_HUMAN :
  • O15090
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF536: view

Function for ZNF536 Gene

Molecular function for ZNF536 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5-CCCCCA-3

Gene Ontology (GO) - Molecular Function for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19398580
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 19398580
GO:0003676 nucleic acid binding --
GO:0044323 retinoic acid-responsive element binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF536: view
genes like me logo Genes that share phenotypes with ZNF536: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF536 Gene

Localization for ZNF536 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF536 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF536 Gene COMPARTMENTS Subcellular localization image for ZNF536 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF536: view

Pathways for ZNF536 Gene

SuperPathways for ZNF536 Gene

No Data Available

Interacting Proteins for ZNF536 Gene

Gene Ontology (GO) - Biological Process for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 19398580
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0045665 negative regulation of neuron differentiation IEA --
GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ZNF536: view

No data available for Pathways by source for ZNF536 Gene

Transcripts for ZNF536 Gene

Unigene Clusters for ZNF536 Gene

Zinc finger protein 536:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF536

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF536

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF536 Gene

No ASD Table

Relevant External Links for ZNF536 Gene

GeneLoc Exon Structure for
ZNF536
ECgene alternative splicing isoforms for
ZNF536

Expression for ZNF536 Gene

mRNA expression in normal human tissues for ZNF536 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF536 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.4) and Brain - Substantia nigra (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF536 Gene

SOURCE GeneReport for Unigene cluster for ZNF536 Gene Hs.378901

genes like me logo Genes that share expressions with ZNF536: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF536 Gene

Orthologs for ZNF536 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF536 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF536 35
  • 99.49 (n)
  • 99.85 (a)
ZNF536 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF536 35
  • 90.55 (n)
  • 92.68 (a)
ZNF536 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF536 35
  • 89.63 (n)
  • 90.84 (a)
ZNF536 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp536 35
  • 85.22 (n)
  • 88.84 (a)
Zfp536 16
Zfp536 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF536 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF536 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp536 35
  • 85.54 (n)
  • 88.83 (a)
chicken
(Gallus gallus)
Aves ZNF536 35
  • 75.65 (n)
  • 82.86 (a)
ZNF536 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF536 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf536 35
  • 67.34 (n)
  • 71.83 (a)
zebrafish
(Danio rerio)
Actinopterygii znf536 35
  • 62.3 (n)
  • 63.25 (a)
znf536 36
  • 57 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 36
  • 26 (a)
OneToMany
Species with no ortholog for ZNF536:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF536 Gene

ENSEMBL:
Gene Tree for ZNF536 (if available)
TreeFam:
Gene Tree for ZNF536 (if available)

Paralogs for ZNF536 Gene

Paralogs for ZNF536 Gene

genes like me logo Genes that share paralogs with ZNF536: view

Variants for ZNF536 Gene

Sequence variations from dbSNP and Humsavar for ZNF536 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12489 -- 30,557,325(+) ACGGT(A/G)CACCA utr-variant-3-prime, intron-variant
rs16796 -- 30,539,861(-) GGAGA(A/G)CCTCG intron-variant
rs33428 -- 30,446,936(+) AATGG(A/G)TAGTA intron-variant
rs33429 -- 30,448,453(-) TTTTT(C/T)TCTCT intron-variant
rs33430 -- 30,448,536(+) TTTAC(A/G)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF536 Gene

Variant ID Type Subtype PubMed ID
nsv833801 CNV Loss 17160897
esv32918 CNV Gain+Loss 17666407
esv8807 CNV Loss 19470904
nsv458534 CNV Loss 19166990
esv2718441 CNV Deletion 23290073
esv2718442 CNV Deletion 23290073
esv2662362 CNV Deletion 23128226
esv2718443 CNV Deletion 23290073
nsv138500 CNV Loss 16902084
esv2718444 CNV Deletion 23290073
esv989390 CNV Insertion 20482838
esv1248605 CNV Insertion 17803354

Relevant External Links for ZNF536 Gene

HapMap Linkage Disequilibrium report
ZNF536
Human Gene Mutation Database (HGMD)
ZNF536

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF536 Gene

Disorders for ZNF536 Gene

Relevant External Links for ZNF536

Genetic Association Database (GAD)
ZNF536
Human Genome Epidemiology (HuGE) Navigator
ZNF536
genes like me logo Genes that share disorders with ZNF536: view

No data available for UniProtKB/Swiss-Prot for ZNF536 Gene

Publications for ZNF536 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PMID: 14621294) Sakai T. … Maeda H. (DNA Res. 2003) 3 4
  3. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 3 48
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  5. ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. (PMID: 19398580) Qin Z. … Chang Z. (Mol. Cell. Biol. 2009) 3

Products for ZNF536 Gene

  • antibodies-online peptides for ZNF536
  • antibodies-online antibodies for ZNF536
  • antibodies-online kits for ZNF536

Sources for ZNF536 Gene

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