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Aliases for ZNF534 Gene

Aliases for ZNF534 Gene

  • Zinc Finger Protein 534 2 3 5
  • KRAB Domain Only Protein 3 3 4
  • KRAB Domain Only 3 2 3
  • KRBO3 3 4

External Ids for ZNF534 Gene

Previous HGNC Symbols for ZNF534 Gene

  • KRBO3

Previous GeneCards Identifiers for ZNF534 Gene

  • GC19P057624
  • GC19P057592
  • GC19P052932
  • GC19P049265

Summaries for ZNF534 Gene

GeneCards Summary for ZNF534 Gene

ZNF534 (Zinc Finger Protein 534) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF528.

UniProtKB/Swiss-Prot for ZNF534 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF534 Gene

Genomics for ZNF534 Gene

Regulatory Elements for ZNF534 Gene

Enhancers for ZNF534 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G052396 0.9 ENCODE 20.1 -31.4 -31392 1.9 ELF3 ARID4B ZSCAN9 ZNF48 ZBTB40 YY1 ETS1 EGR1 ELK1 ZNF366 ZNF534 ZNF528 ZNF528-AS1
GH19G051687 1.8 FANTOM5 ENCODE dbSUPER 9.8 -738.7 -738697 6.9 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ZNF808 ZNF836 ZNF616 ZNF841 ZNF137P ENSG00000268970 ZNF766 ENSG00000269825 ZNF528 ZNF175
GH19G052452 0.7 ENCODE 12.6 +24.4 24356 1.2 SP3 NRF1 SIN3A ELF4 ELF1 ZBTB40 ZNF518A NR2F2 GABPA ETS1 ZNF534 ZNF578 ENSG00000269001 GC19P052460
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF534 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF534 Gene

Chromosome:
19
Start:
52,429,187 bp from pter
End:
52,452,315 bp from pter
Size:
23,129 bases
Orientation:
Plus strand

Genomic View for ZNF534 Gene

Genes around ZNF534 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF534 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF534 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF534 Gene

Proteins for ZNF534 Gene

  • Protein details for ZNF534 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KX8-ZN534_HUMAN
    Recommended name:
    Zinc finger protein 534
    Protein Accession:
    Q76KX8
    Secondary Accessions:
    • Q76KX9

    Protein attributes for ZNF534 Gene

    Size:
    674 amino acids
    Molecular mass:
    77167 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF534 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF534 Gene

Post-translational modifications for ZNF534 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF534 Gene

Domains & Families for ZNF534 Gene

Gene Families for ZNF534 Gene

Protein Domains for ZNF534 Gene

Suggested Antigen Peptide Sequences for ZNF534 Gene

Graphical View of Domain Structure for InterPro Entry

Q76KX8

UniProtKB/Swiss-Prot:

ZN534_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF534: view

Function for ZNF534 Gene

Molecular function for ZNF534 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF534: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF534 Gene

Localization for ZNF534 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF534 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF534 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF534: view

Pathways & Interactions for ZNF534 Gene

SuperPathways for ZNF534 Gene

No Data Available

Interacting Proteins for ZNF534 Gene

Gene Ontology (GO) - Biological Process for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF534: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF534 Gene

Drugs & Compounds for ZNF534 Gene

No Compound Related Data Available

Transcripts for ZNF534 Gene

mRNA/cDNA for ZNF534 Gene

(5) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF534 Gene

No ASD Table

Relevant External Links for ZNF534 Gene

GeneLoc Exon Structure for
ZNF534
ECgene alternative splicing isoforms for
ZNF534

Expression for ZNF534 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF534 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF534 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.6) and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for ZNF534 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.9) and Pancreatic juice (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF534 Gene



Protein tissue co-expression partners for ZNF534 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF534 Gene:

ZNF534

SOURCE GeneReport for Unigene cluster for ZNF534 Gene:

Hs.447583
genes like me logo Genes that share expression patterns with ZNF534: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF534 Gene

Orthologs for ZNF534 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF534 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF534 34
  • 98.76 (n)
-- 35
  • 85 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 49 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf484 34
  • 58.8 (n)
Species where no ortholog for ZNF534 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF534 Gene

ENSEMBL:
Gene Tree for ZNF534 (if available)
TreeFam:
Gene Tree for ZNF534 (if available)

Paralogs for ZNF534 Gene

(495) SIMAP similar genes for ZNF534 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF534: view

Variants for ZNF534 Gene

Sequence variations from dbSNP and Humsavar for ZNF534 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs193921143 Uncertain significance 52,431,487(+) TTACT(A/C)AGGTA reference, missense
rs1000097548 -- 52,433,419(+) TGGAG(C/T)GCAGT intron-variant
rs1000167071 -- 52,448,476(+) AGTAG(A/G)CTTAT intron-variant
rs1000344767 -- 52,431,828(+) GGACT(A/G)AGACT intron-variant
rs1000501818 -- 52,449,936(+) AATTG(C/T)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF534 Gene

Variant ID Type Subtype PubMed ID
dgv1807n106 CNV deletion 24896259
esv1406635 CNV deletion 17803354
esv2314940 CNV deletion 18987734
esv2669061 CNV deletion 23128226
esv2718782 CNV deletion 23290073
esv2718783 CNV deletion 23290073
esv2762048 CNV loss 21179565
esv3556563 CNV deletion 23714750
esv3644693 CNV loss 21293372
esv3893233 CNV loss 25118596
nsv1063648 CNV gain 25217958
nsv1071545 CNV deletion 25765185
nsv1140251 OTHER inversion 24896259
nsv1150878 CNV deletion 26484159
nsv138393 CNV deletion 16902084
nsv580026 CNV loss 21841781
nsv828615 CNV loss 20364138
nsv833873 CNV gain 17160897
nsv954642 CNV deletion 24416366
nsv960863 CNV duplication 23825009

Variation tolerance for ZNF534 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF534 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF534

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF534 Gene

Disorders for ZNF534 Gene

Relevant External Links for ZNF534

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF534

No disorders were found for ZNF534 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF534 Gene

Publications for ZNF534 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF534 Gene

Sources for ZNF534 Gene

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