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Aliases for ZNF534 Gene

Aliases for ZNF534 Gene

  • Zinc Finger Protein 534 2 3 5
  • KRAB Domain Only Protein 3 3 4
  • KRAB Domain Only 3 2 3
  • KRBO3 3 4

External Ids for ZNF534 Gene

Previous HGNC Symbols for ZNF534 Gene

  • KRBO3

Previous GeneCards Identifiers for ZNF534 Gene

  • GC19P057624
  • GC19P057592
  • GC19P052932
  • GC19P049265

Summaries for ZNF534 Gene

GeneCards Summary for ZNF534 Gene

ZNF534 (Zinc Finger Protein 534) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF534 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF534 Gene

Genomics for ZNF534 Gene

Regulatory Elements for ZNF534 Gene

Enhancers for ZNF534 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF534 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF534 Gene

Chromosome:
19
Start:
52,429,187 bp from pter
End:
52,452,315 bp from pter
Size:
23,129 bases
Orientation:
Plus strand

Genomic View for ZNF534 Gene

Genes around ZNF534 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF534 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF534 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF534 Gene

Proteins for ZNF534 Gene

  • Protein details for ZNF534 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KX8-ZN534_HUMAN
    Recommended name:
    Zinc finger protein 534
    Protein Accession:
    Q76KX8
    Secondary Accessions:
    • Q76KX9

    Protein attributes for ZNF534 Gene

    Size:
    674 amino acids
    Molecular mass:
    77167 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF534 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF534 Gene

Proteomics data for ZNF534 Gene at MOPED

Post-translational modifications for ZNF534 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF534 Gene

Domains & Families for ZNF534 Gene

Gene Families for ZNF534 Gene

Protein Domains for ZNF534 Gene

Suggested Antigen Peptide Sequences for ZNF534 Gene

Graphical View of Domain Structure for InterPro Entry

Q76KX8

UniProtKB/Swiss-Prot:

ZN534_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 17 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 17 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF534: view

Function for ZNF534 Gene

Molecular function for ZNF534 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF534 Gene

Localization for ZNF534 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF534 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF534 Gene COMPARTMENTS Subcellular localization image for ZNF534 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF534 Gene

Pathways & Interactions for ZNF534 Gene

SuperPathways for ZNF534 Gene

No Data Available

Interacting Proteins for ZNF534 Gene

Gene Ontology (GO) - Biological Process for ZNF534 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF534 Gene

Drugs & Compounds for ZNF534 Gene

No Compound Related Data Available

Transcripts for ZNF534 Gene

mRNA/cDNA for ZNF534 Gene

(6) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF534 Gene

No ASD Table

Relevant External Links for ZNF534 Gene

GeneLoc Exon Structure for
ZNF534
ECgene alternative splicing isoforms for
ZNF534

Expression for ZNF534 Gene

mRNA expression in normal human tissues for ZNF534 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF534 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.6) and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for ZNF534 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.9) and Pancreatic juice (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF534 Gene



SOURCE GeneReport for Unigene cluster for ZNF534 Gene Hs.447583

genes like me logo Genes that share expression patterns with ZNF534: view

Protein tissue co-expression partners for ZNF534 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF534 Gene

Orthologs for ZNF534 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF534 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF534 35
  • 98.76 (n)
  • 96.88 (a)
-- 36
  • 85 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 48 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf484 35
  • 58.8 (n)
  • 57.08 (a)
Species with no ortholog for ZNF534:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF534 Gene

ENSEMBL:
Gene Tree for ZNF534 (if available)
TreeFam:
Gene Tree for ZNF534 (if available)

Paralogs for ZNF534 Gene

(495) SIMAP similar genes for ZNF534 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF534: view

Variants for ZNF534 Gene

Sequence variations from dbSNP and Humsavar for ZNF534 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256788 -- 52,430,737(+) gagac(A/G)gggtt intron-variant, upstream-variant-2KB
rs12976984 -- 52,450,477(+) gatgt(G/T)ggttt intron-variant
rs7507821 -- 52,451,186(+) ccata(C/G)atttt splice-acceptor-variant
rs8101762 -- 52,449,870(+) caaaa(A/G)ttagc intron-variant
rs12981468 -- 52,433,208(+) cactc(A/C/G)agtct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF534 Gene

Variant ID Type Subtype PubMed ID
nsv833873 CNV Gain 17160897
nsv828615 CNV Loss 20364138

Variation tolerance for ZNF534 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF534 Gene

HapMap Linkage Disequilibrium report
ZNF534

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF534 Gene

Disorders for ZNF534 Gene

Relevant External Links for ZNF534

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF534

No disorders were found for ZNF534 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF534 Gene

Publications for ZNF534 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 67

Products for ZNF534 Gene

Sources for ZNF534 Gene

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