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Aliases for ZNF532 Gene

Aliases for ZNF532 Gene

  • Zinc Finger Protein 532 2 3 5
  • KIAA1629 4

External Ids for ZNF532 Gene

Previous GeneCards Identifiers for ZNF532 Gene

  • GC18P054680
  • GC18P054678
  • GC18P056529
  • GC18P053238

Summaries for ZNF532 Gene

GeneCards Summary for ZNF532 Gene

ZNF532 (Zinc Finger Protein 532) is a Protein Coding gene. Diseases associated with ZNF532 include Nut Midline Carcinoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF592.

UniProtKB/Swiss-Prot for ZNF532 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF532 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF532 Gene

Genomics for ZNF532 Gene

Regulatory Elements for ZNF532 Gene

Enhancers for ZNF532 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H058781 1.5 Ensembl ENCODE dbSUPER 20.8 -80.8 -80799 0.8 HDGF FOXA2 ARNT ZNF133 SIN3A FEZF1 YBX1 GLI4 ZNF2 GLIS2 ZNF532 MALT1 ENSG00000199713 LOC105372146 GC18P058789
GH18H058787 1.4 Ensembl ENCODE dbSUPER 20.2 -73.3 -73325 2.7 PKNOX1 ZNF133 KLF17 FEZF1 ZNF302 ZNF366 SCRT2 KLF7 USF2 OVOL3 ZNF532 ENSG00000199713 GC18P058789 LOC105372146
GH18H059052 1.4 Ensembl ENCODE dbSUPER 11.7 +191.6 191618 2.8 PKNOX1 FOXA2 ARNT ZSCAN4 FEZF1 RAD21 YY1 ZNF121 ZNF23 ZNF302 ZNF532 ENSG00000199713 ENSG00000267215 OACYLP
GH18H058804 1.5 VISTA ENCODE dbSUPER 10.9 -56.5 -56503 3.4 PKNOX1 ZSCAN26 FEZF1 BATF RUNX3 CREM TCF7L2 NRF1 JUNB ZBTB8A ZNF532 RNU6-219P LINC01926
GH18H058135 1.3 Ensembl ENCODE dbSUPER 11.7 -726.8 -726823 1.6 PKNOX1 SIN3A FEZF1 RAD21 YY1 ZNF302 ZNF143 RUNX3 DEK SMARCA5 NEDD4L ZNF532 HMGN1P30 LOC105372143
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF532 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF532 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000104031 1100 1401 POLR2A NR2F1 HNF4A ZFX

Genomic Locations for ZNF532 Gene

Genomic Locations for ZNF532 Gene
chr18:58,862,600-58,986,480
(GRCh38/hg38)
Size:
123,881 bases
Orientation:
Plus strand
chr18:56,529,832-56,653,712
(GRCh37/hg19)

Genomic View for ZNF532 Gene

Genes around ZNF532 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF532 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF532 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF532 Gene

Proteins for ZNF532 Gene

  • Protein details for ZNF532 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE3-ZN532_HUMAN
    Recommended name:
    Zinc finger protein 532
    Protein Accession:
    Q9HCE3
    Secondary Accessions:
    • Q4G0V6
    • Q7L7Z7
    • Q96QR7
    • Q9NVJ6

    Protein attributes for ZNF532 Gene

    Size:
    1301 amino acids
    Molecular mass:
    141696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36366.1; Type=Frameshift; Positions=1077; Evidence={ECO:0000305}; Sequence=BAA91755.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB13455.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF532 Gene

Post-translational modifications for ZNF532 Gene

  • Ubiquitination at isoforms=248
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF532 Gene

Domains & Families for ZNF532 Gene

Gene Families for ZNF532 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF532 Gene

Suggested Antigen Peptide Sequences for ZNF532 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCE3

UniProtKB/Swiss-Prot:

ZN532_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF532: view

Function for ZNF532 Gene

Molecular function for ZNF532 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF532 Gene

Gene Ontology (GO) - Molecular Function for ZNF532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF532: view
genes like me logo Genes that share phenotypes with ZNF532: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF532 Gene

Localization for ZNF532 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF532 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF532 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF532: view

Pathways & Interactions for ZNF532 Gene

SuperPathways for ZNF532 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF532: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF532 Gene

Drugs & Compounds for ZNF532 Gene

No Compound Related Data Available

Transcripts for ZNF532 Gene

Unigene Clusters for ZNF532 Gene

Zinc finger protein 532:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF532 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1:
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: -
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - -
SP17: - - - - -
SP18: - -
SP19: - -
SP20: - - -
SP21: -
SP22: - - -
SP23:
SP24:
SP25: - - -

ExUns: 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b · 22c · 22d
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - - -
SP12: - - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - -
SP21:
SP22: - -
SP23:
SP24:
SP25:

Relevant External Links for ZNF532 Gene

GeneLoc Exon Structure for
ZNF532
ECgene alternative splicing isoforms for
ZNF532

Expression for ZNF532 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF532 Gene

Protein differential expression in normal tissues from HIPED for ZNF532 Gene

This gene is overexpressed in Lung (28.1), Plasma (22.1), Heart (8.8), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF532 Gene



Protein tissue co-expression partners for ZNF532 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF532 Gene:

ZNF532

SOURCE GeneReport for Unigene cluster for ZNF532 Gene:

Hs.529023

Evidence on tissue expression from TISSUES for ZNF532 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF532: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF532 Gene

Orthologs for ZNF532 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF532 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC455444 33
  • 99.4 (n)
ZNF532 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp532 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF532 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF532 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF532 33 34
  • 88.73 (n)
rat
(Rattus norvegicus)
Mammalia Zfp532 33
  • 87.47 (n)
cow
(Bos Taurus)
Mammalia ZNF532 33 34
  • 83.29 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 93 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
LOC100857356 33
  • 80.96 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF532 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf532 33
  • 70.82 (n)
Str.18390 33
zebrafish
(Danio rerio)
Actinopterygii znf532 33 34
  • 65.18 (n)
Dr.11710 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
Species where no ortholog for ZNF532 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF532 Gene

ENSEMBL:
Gene Tree for ZNF532 (if available)
TreeFam:
Gene Tree for ZNF532 (if available)

Paralogs for ZNF532 Gene

Variants for ZNF532 Gene

Sequence variations from dbSNP and Humsavar for ZNF532 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs771503724 A breast cancer sample 58,934,551(+) CAGGT(C/T)GGTGC intron-variant, nc-transcript-variant, reference, missense
rs1000069462 -- 58,973,352(+) CCCGC(C/T)TTGGC intron-variant
rs1000096945 -- 58,886,777(+) CCCTG(A/G)GATCA intron-variant
rs1000108272 -- 58,968,082(+) GACAC(C/T)TAAGA intron-variant
rs1000113959 -- 58,930,360(+) AGTGG(C/G)TCACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF532 Gene

Variant ID Type Subtype PubMed ID
esv28415 CNV loss 19812545
esv3410830 CNV duplication 20981092
esv3642655 CNV loss 21293372
nsv1072269 CNV deletion 25765185
esv1419346 CNV insertion 17803354
nsv960284 CNV duplication 23825009
nsv960283 CNV duplication 23825009
nsv960282 CNV duplication 23825009
nsv833664 CNV loss 17160897
nsv2326 CNV deletion 18451855
nsv2325 CNV insertion 18451855
nsv1126486 CNV deletion 24896259

Variation tolerance for ZNF532 Gene

Residual Variation Intolerance Score: 1.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF532 Gene

Human Gene Mutation Database (HGMD)
ZNF532
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF532

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF532 Gene

Disorders for ZNF532 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF532 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF532

Genetic Association Database (GAD)
ZNF532
Human Genome Epidemiology (HuGE) Navigator
ZNF532
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF532
genes like me logo Genes that share disorders with ZNF532: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF532 Gene

Publications for ZNF532 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for ZNF532 Gene

Sources for ZNF532 Gene

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