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Aliases for ZNF532 Gene

Aliases for ZNF532 Gene

  • Zinc Finger Protein 532 2 3 5
  • KIAA1629 4

External Ids for ZNF532 Gene

Previous GeneCards Identifiers for ZNF532 Gene

  • GC18P054680
  • GC18P054678
  • GC18P056529
  • GC18P053238

Summaries for ZNF532 Gene

GeneCards Summary for ZNF532 Gene

ZNF532 (Zinc Finger Protein 532) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF592.

UniProtKB/Swiss-Prot for ZNF532 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF532 Gene

Genomics for ZNF532 Gene

Regulatory Elements for ZNF532 Gene

Enhancers for ZNF532 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF532 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF532 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF532 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF532 Gene

Chromosome:
18
Start:
58,862,600 bp from pter
End:
58,986,480 bp from pter
Size:
123,881 bases
Orientation:
Plus strand

Genomic View for ZNF532 Gene

Genes around ZNF532 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF532 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF532 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF532 Gene

Proteins for ZNF532 Gene

  • Protein details for ZNF532 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE3-ZN532_HUMAN
    Recommended name:
    Zinc finger protein 532
    Protein Accession:
    Q9HCE3
    Secondary Accessions:
    • Q4G0V6
    • Q7L7Z7
    • Q96QR7
    • Q9NVJ6

    Protein attributes for ZNF532 Gene

    Size:
    1301 amino acids
    Molecular mass:
    141696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36366.1; Type=Frameshift; Positions=1077; Evidence={ECO:0000305}; Sequence=BAA91755.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB13455.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF532 Gene

Proteomics data for ZNF532 Gene at MOPED

Post-translational modifications for ZNF532 Gene

  • Ubiquitination at Lys 248
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF532 Gene

Domains & Families for ZNF532 Gene

Gene Families for ZNF532 Gene

Protein Domains for ZNF532 Gene

Suggested Antigen Peptide Sequences for ZNF532 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCE3

UniProtKB/Swiss-Prot:

ZN532_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF532: view

Function for ZNF532 Gene

Molecular function for ZNF532 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF532: view
genes like me logo Genes that share phenotypes with ZNF532: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF532 Gene

Localization for ZNF532 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF532 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF532 Gene COMPARTMENTS Subcellular localization image for ZNF532 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF532 Gene

Pathways & Interactions for ZNF532 Gene

SuperPathways for ZNF532 Gene

No Data Available

Interacting Proteins for ZNF532 Gene

Gene Ontology (GO) - Biological Process for ZNF532 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF532 Gene

Drugs & Compounds for ZNF532 Gene

No Compound Related Data Available

Transcripts for ZNF532 Gene

Unigene Clusters for ZNF532 Gene

Zinc finger protein 532:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF532 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1:
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: -
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - -
SP17: - - - - -
SP18: - -
SP19: - -
SP20: - - -
SP21: -
SP22: - - -
SP23:
SP24:
SP25: - - -

ExUns: 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b · 22c · 22d
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - - -
SP12: - - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - -
SP21:
SP22: - -
SP23:
SP24:
SP25:

Relevant External Links for ZNF532 Gene

GeneLoc Exon Structure for
ZNF532
ECgene alternative splicing isoforms for
ZNF532

Expression for ZNF532 Gene

mRNA expression in normal human tissues for ZNF532 Gene

Protein differential expression in normal tissues from HIPED for ZNF532 Gene

This gene is overexpressed in Lung (28.1), Plasma (22.1), Heart (8.8), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF532 Gene



SOURCE GeneReport for Unigene cluster for ZNF532 Gene Hs.529023

genes like me logo Genes that share expression patterns with ZNF532: view

Protein tissue co-expression partners for ZNF532 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF532 Gene

Orthologs for ZNF532 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF532 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF532 35
  • 83.29 (n)
  • 90.55 (a)
ZNF532 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF532 35
  • 88.73 (n)
  • 94.15 (a)
ZNF532 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC455444 35
  • 99.4 (n)
  • 99.2 (a)
ZNF532 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp532 35
  • 87.47 (n)
  • 92.06 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF532 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp532 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF532 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857356 35
  • 80.96 (n)
  • 88.36 (a)
-- 36
  • 82 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF532 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18390 35
znf532 35
  • 70.82 (n)
  • 75.14 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11710 35
znf532 35
  • 65.18 (n)
  • 68.95 (a)
znf532 36
  • 66 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for ZNF532:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF532 Gene

ENSEMBL:
Gene Tree for ZNF532 (if available)
TreeFam:
Gene Tree for ZNF532 (if available)

Paralogs for ZNF532 Gene

Paralogs for ZNF532 Gene

genes like me logo Genes that share paralogs with ZNF532: view

Variants for ZNF532 Gene

Sequence variations from dbSNP and Humsavar for ZNF532 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs3737506 - 58,920,570(-) AAGAC(A/G/T)TCATT nc-transcript-variant, reference, missense
VAR_035585 A breast cancer sample
rs1544286 -- 58,882,089(-) CCCAA(A/G)CTACG intron-variant
rs7231131 -- 58,878,790(+) GGGTT(A/G)GCAGC intron-variant
rs7231463 -- 58,911,327(+) AGGAA(C/T)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF532 Gene

Variant ID Type Subtype PubMed ID
esv28415 CNV Loss 19812545
esv1419346 CNV Insertion 17803354
nsv2325 CNV Insertion 18451855
nsv833664 CNV Loss 17160897
nsv2326 CNV Loss 18451855

Variation tolerance for ZNF532 Gene

Residual Variation Intolerance Score: 1.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF532 Gene

HapMap Linkage Disequilibrium report
ZNF532
Human Gene Mutation Database (HGMD)
ZNF532

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF532 Gene

Disorders for ZNF532 Gene

Relevant External Links for ZNF532

Genetic Association Database (GAD)
ZNF532
Human Genome Epidemiology (HuGE) Navigator
ZNF532
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF532

No disorders were found for ZNF532 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF532 Gene

Publications for ZNF532 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ZNF532 Gene

Sources for ZNF532 Gene

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