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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF532 Gene

protein-coding   GIFtS: 44
GCID: GC18P056529

zinc finger protein 532

  Search for ZNF532
in our new
 Human Malady Compendium 
Biological research products
for ZNF532
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 5321 2
FLJ106971
KIAA16293

External Ids:    HGNC: 309401   Entrez Gene: 552052   Ensembl: ENSG000000746577   UniProtKB: Q9HCE33   

Export aliases for ZNF532 gene to outside databases

Previous GC identifers: GC18P054680 GC18P054678 GC18P053238


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN532_HUMAN, Q9HCE3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF532 gene promoter:
         GR   GR-beta   FOXD3   Nkx2-5   STAT5A   FOXL1   CREB   E2F-1   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF532 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF532

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF532


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.32   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21.32

ZNF532 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF532 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P056529:  view genomic region     (about GC identifiers)

Start:
56,529,832 bp from pter      End:
56,653,712 bp from pter
Size:
123,881 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN532_HUMAN, Q9HCE3 (See protein sequence)
Recommended Name: Zinc finger protein 532  
Size: 1301 amino acids; 141696 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH36366.1; Type=Frameshift; Positions=1077; Sequence=BAA91755.1; Type=Erroneous initiation;
Sequence=BAB13455.1; Type=Erroneous initiation;
Secondary accessions: Q4G0V6 Q7L7Z7 Q96QR7 Q9NVJ6

Explore the universe of human proteins at neXtProt for ZNF532: NX_Q9HCE3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HCE3

  • ZNF532 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060651.2  
    ENSEMBL proteins: 
     ENSP00000338217   ENSP00000468532   ENSP00000465236   ENSP00000465802   ENSP00000466488  
     ENSP00000466007   ENSP00000465709   ENSP00000468073   ENSP00000467229   ENSP00000468238  
     ENSP00000465873   ENSP00000468009   ENSP00000467402   ENSP00000466002   ENSP00000468551  
     ENSP00000466172   ENSP00000466808   ENSP00000464894   ENSP00000467903  

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    Uscn Proteins for ZNF532

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF532 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF532 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9HCE3

    ProtoNet protein and cluster: Q9HCE3

    UniProtKB/Swiss-Prot: ZN532_HUMAN, Q9HCE3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN532_HUMAN, Q9HCE3
    Function: May be involved in transcriptional regulation

    miRNA
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    hsa-miR-411* hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-146a hsa-miR-3074-3p hsa-miR-3138 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidZNF532 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF532 (see all 7)
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF532 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF532:
     Increased HPV18 LCR reporter a 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF532

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF532 (ENSP000003382174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF532 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF532
    Search CenterWatch for drugs/clinical trials and news about ZNF532 / ZN532 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF532 gene: 
    NM_018181.4  

    Unigene Cluster for ZNF532:

    Zinc finger protein 532
    Hs.529023  [show with all ESTs]
    Unigene Representative Sequence: NM_018181
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000336078(uc002lho.3 uc002lhp.3 uc010xeg.2 uc002lhr.3 uc002lhs.3 uc010xeh.2)
    ENST00000591083 ENST00000588601 ENST00000590285 ENST00000586085 ENST00000589288
    ENST00000591230 ENST00000588543 ENST00000590287 ENST00000591808 ENST00000592452
    ENST00000588456 ENST00000589481 ENST00000591049 ENST00000587755 ENST00000590157
    ENST00000589156 ENST00000586997

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF532
    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF532 (see all 82):
    hsa-miR-411* hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-146a hsa-miR-3074-3p hsa-miR-3138 hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidZNF532 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF532 (see all 7)
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    OriGene siRNA: ZNF532
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF532
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF532 (see all 3)
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    Additional cDNA sequence: 

    AB046849.2 AF295077.1 AK001559.1 AK122835.1 AK128058.1 AK298971.1 AK308188.1 AK308571.1 
    AY039256.1 BC036366.1 BC130618.1 BC130620.1 

    23 DOTS entries:

    DT.100775233  DT.95270177  DT.92433303  DT.97818447  DT.121085704  DT.120643453  DT.444211  DT.421198 
    DT.121270182  DT.100775235  DT.120962780  DT.121085680  DT.121214629  DT.409349  DT.91676518  DT.102826183 
    DT.121085685  DT.121085718  DT.40131941  DT.91935480  DT.121085754  DT.92433305  DT.95134318 

    24/167 AceView cDNA sequences (see all 167):

    H80748 BX117157 CD652097 AA807005 AI367474 BE698452 AK128058 AU130269 
    BQ889226 AK001559 BE466073 W23952 AA953833 BC036366 AI858801 AL134592 
    BM785676 AK122835 AA234525 F07702 AB046849 W94108 BF088546 Z40761 

    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF532 (see all 25)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:              -     -     -     -     -     -     -     -     -                 -                                                                           
    SP4:                                -     -     -     -     -     -                 -                                                                           
    SP5:                                      -     -     -     -     -                 -                                                                           

    ExUns: 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b · 22c · 22d
    SP1:                                                                          -                                                         
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ZNF532

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF532 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF532 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF532

    SOURCE GeneReport for Unigene cluster: Hs.529023
        SABiosciences Custom PCR Arrays for ZNF532
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF532

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF532 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008573561 zinc finger protein 532-like 81.16(n)
    88.51(a)
      100857356  XM_003642897.1  XP_003642945.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF5326
    --
    87(a)
    1 ↔ 1
    GL343335.1(1183685-1209131)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.183902 Transcribed sequence with weak similarity to protein more 82.66(n)    BX761330.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.117102 Transcribed sequence with weak similarity to protein more 74.94(n)    BG308645.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    11(a)
    1 → many
    Group4.1(236980-242135)


    ENSEMBL Gene Tree for ZNF532 (if available)
    TreeFam Gene Tree for ZNF532 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF532 gene
    ZNF6872  ZNF5922  
    5 SIMAP similar genes for ZNF532 using alignment to 15 protein entries:     ZN532_HUMAN (see all proteins):
    ZNF687    ZNF592    ZNF    HZF16    ZNF420

    ZNF532 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for ZNF532 (see all 7)
    PGOHUM00000238848 PGOHUM00000244511 PGOHUM00000246203 PGOHUM00000240249 PGOHUM00000240852


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2171 NCBI SNPs in ZNF532 are shown (see all 2171    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437301471,2
    --56528195(+) TCCTTC/TAGTTT 1 -- us2k10--------
    rs1876629301,2
    --56528274(+) TTTTAC/TTTCAT 1 -- us2k10--------
    rs1510614921,2
    --56528394(+) AGAGGG/TGTAGT 1 -- us2k10--------
    rs1409629701,2
    --56528403(+) GTGTCC/TGCTTA 1 -- us2k10--------
    rs2015594431,2
    --56528418(+) AAAAA-/CAACCC 1 -- us2k10--------
    rs1906258801,2
    --56528483(+) AAGACC/GGGTGC 1 -- us2k10--------
    rs1808982491,2
    --56528544(+) CTTTAC/TAAAAA 1 -- us2k10--------
    rs1501941601,2
    --56528675(+) TCTTCC/TAGCCG 1 -- us2k10--------
    rs1855953171,2
    --56528687(+) GGCTCC/TGGCTA 1 -- us2k10--------
    rs1170384941,2
    --56528688(+) GCTCCG/AGCTAA 1 -- us2k11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for ZNF532 (56529832 - 56653712 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF532
         1 CNV: 67371

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF532 for disorders           About MalaCards

    ZNF532 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ZNF532 (1 document)

    Export disorders for ZNF532 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF532 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF532)
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    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55205 HGNC: 30940 AceView: ZNF532 Ensembl:ENSG00000074657 euGenes: HUgn55205
    ECgene: ZNF532 H-InvDB: ZNF532

    (According to HUGE)
    About This Section
    HUGE: KIAA1629

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF532 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF532 gene:
    Search GeneIP for patents involving ZNF532

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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