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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF529 Gene

protein-coding   GIFtS: 47
GCID: GC19M037034

Zinc Finger Protein 529

  Search for ZNF529
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5291 2
KIAA16153

External Ids:    HGNC: 293281   Entrez Gene: 577112   Ensembl: ENSG000001860207   UniProtKB: Q6P2803   

Export aliases for ZNF529 gene to outside databases

Previous GC identifers: GC19M041727 GC19M033502


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF529 Gene: 
ZNF529 (zinc finger protein 529) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZN529_HUMAN, Q6P280
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF529 gene promoter:
         Egr-3   AhR   MEF-2   Nkx2-5   Arnt   MEF-2A   Egr-2   FAC1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF529 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF529

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF529


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

ZNF529 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF529 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M037034:  view genomic region     (about GC identifiers)

Start:
37,025,676 bp from pter      End:
37,096,178 bp from pter
Size:
70,503 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN529_HUMAN, Q6P280 (See protein sequence)
Recommended Name: Zinc finger protein 529  
Size: 563 amino acids; 65865 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH64690.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15068.1; Type=Frameshift; Positions=78;
Secondary accessions: K7EKE1 Q9H731 Q9HCF7

Explore the universe of human proteins at neXtProt for ZNF529: NX_Q6P280

Explore proteomics data for ZNF529 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P280

  • ZNF529 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF529 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001139121.1  NP_001139122.1  NP_066002.3  

    ENSEMBL proteins: 
     ENSP00000465917   ENSP00000468594   ENSP00000334695   ENSP00000465578   ENSP00000465682  
     ENSP00000468619   ENSP00000466182  
    Reactome Protein details: Q6P280
    Human Recombinant Protein Products for ZNF529: 
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    Novus Biologicals ZNF529 Protein
    Novus Biologicals ZNF529 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF529 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF529 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ZNF529 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6P280

    ProtoNet protein and cluster: Q6P280

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN529_HUMAN, Q6P280
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF529 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN529_HUMAN, Q6P280
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF529 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF529:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF529 
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    SwitchGear 3'UTR luciferase reporter plasmidZNF529 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF529


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF529 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF529
        Generic Transcription Pathway
    Gene Expression



    ZNF529 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF529

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF529 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF529 (ZN529)

    Search CenterWatch for drugs/clinical trials and news about ZNF529 / ZN529

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF529 gene (3 alternative transcripts): 
    NM_001145649.1  NM_001145650.1  NM_020951.4  

    Unigene Cluster for ZNF529:

    Zinc finger protein 529
    Hs.654960  [show with all ESTs]
    Unigene Representative Sequence: NM_001145649
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452073 ENST00000590656 ENST00000334116(uc002oeh.4 uc002oeg.4 uc010xth.2 uc010xti.2)
    ENST00000591340 ENST00000586115 ENST00000585983 ENST00000585960 ENST00000586458
    ENST00000587286
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF529:
    hsa-miR-579 hsa-miR-590-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF529 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF529
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF529
    Clone
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    OriGene clones in human, mouse for ZNF529 (see all 17)
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    GenScript: all cDNA clones in your preferred vector (see all 3): ZNF529 (NM_001145650)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF529
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF529 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF529 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF529
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF529

    Additional mRNA sequence: 

    AB046835.1 AK025110.1 AK094618.1 AL109722.1 BC036578.2 BC064690.1 NR_027239.1 

    9 DOTS entries:

    DT.40212310  DT.99971817  DT.99977061  DT.100660741  DT.121470682  DT.121470697  DT.40228167  DT.91986271 
    DT.99939157 

    24/49 AceView cDNA sequences (see all 49):

    F02879 BM803732 BX646254 AK025110 AI333427 BE835504 BM688342 NM_020951 
    BE858324 BP354728 AI333429 BX503547 BP428550 BG251457 AB046835 BP336437 
    BQ723028 AI807166 AA234931 BC036578 N48921 BU726740 N71870 BC064690 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF529    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:                                -     -                     
    SP2:                                      -                     
    SP3:                                                            
    SP4:                          -     -     -                     


    ECgene alternative splicing isoforms for ZNF529

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF529 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTACACAG
    ZNF529 Expression
    About this image


    See ZNF529 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF529

    SOURCE GeneReport for Unigene cluster: Hs.654960
        SABiosciences Custom PCR Arrays for ZNF529
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF529

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF529 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5296
    zinc finger protein 529
    80(a)
    1 ↔ 1
    1(116185191-116197901)


    ENSEMBL Gene Tree for ZNF529 (if available)
    TreeFam Gene Tree for ZNF529 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF529 gene
    ZNF792  ZNF5702  ZFP302  ZNF7902  ZNF4832  ZNF3832  ZNF1812  ZNF2872  
    ZNF5822  ZNF4712  ZFP822  ZNF2502  ZNF8792  ZNF354C2  ZNF742  ZNF5832  
    ZNF4852  ZNF4542  ZFP902  ZFP142  ZNF3312  ZNF354A2  ZNF4612  ZNF3112  
    ZNF354B2  ZNF3452  ZNF5682  ZNF342  ZNF5652  
    18/530 SIMAP similar genes for ZNF529 using alignment to 6 protein entries:     ZN529_HUMAN (see all proteins) (see all similar genes):
    ZNF577    KRBOX4    FIK    ZNF81    ZNF596    MGC12518
    ZNF208    ZNF720    ZFP90    ZNF761    ZNF528    ZNF675
    ZNF195    ZNF705A    ZNF846    ZNF506    ZNF3    ZNF140

    ZNF529 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1016 SNPs in ZNF529 are shown (see all 1016)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341798091,2
    C--33505303(+) TGTGT-/G/GT  
            
    TATGG
    6 -- ut311NA 2
    rs1901184981,2
    --37034033(+) TATATA/GCGCAA 3 -- int10--------
    rs1500574631,2
    --37034099(+) TTTCAC/TTGGTT 3 -- int10--------
    rs1817529821,2
    --37034234(+) TTGTTC/TATGAT 3 -- int10--------
    rs790909661,2
    C,F--37034261(+) ATACCG/ATTCAT 3 -- int11Minor allele frequency- A:0.01NA 120
    rs736079651,2
    C--37034303(+) CCAGTG/CGTTCT 3 -- int11Minor allele frequency- C:0.50WA 2
    rs778468871,2
    --37034322(+) TTTTTG/TTCCTC 3 -- int10--------
    rs1866452951,2
    --37034365(+) ATCTAC/TCCTCA 3 -- int10--------
    rs1454336211,2
    --37034375(+) AGCATG/TCTTCT 3 -- int10--------
    rs598813931,2
    C,F--37034510(+) TGCCAT/CAGACT 3 -- int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for ZNF529 (37025676 - 37096178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF529:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2205269CNV Deletion18987734
    esv2570514CNV Deletion19546169
    esv1008911CNV Deletion20482838
    esv1768990CNV Deletion17803354
    esv2718504CNV Deletion23290073
    esv2664896CNV Deletion23128226
    nsv833817CNV Loss17160897
    nsv911648CNV Loss21882294
    nsv138053CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF529 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF529)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57711 HGNC: 29328 AceView: ZNF529 Ensembl:ENSG00000186020 euGenes: HUgn57711
    ECgene: ZNF529 H-InvDB: ZNF529

    (According to HUGE)
    About This Section
    HUGE: KIAA1615

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF529 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF529 gene:
    Search GeneIP for patents involving ZNF529

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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