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ZNF529 Gene

protein-coding   GIFtS: 48
GCID: GC19M037157

Zinc Finger Protein 529

  Search for ZNF529
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5291 2
KIAA16153

External Ids:    HGNC: 293281   Entrez Gene: 577112   Ensembl: ENSG000001860207   UniProtKB: Q6P2803   

Export aliases for ZNF529 gene to outside databases

Previous GC identifers: GC19M041727 GC19M037034 GC19M033502


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF529 Gene:
ZNF529 (zinc finger protein 529) is a protein-coding gene. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZN529_HUMAN, Q6P280
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF529 gene promoter:
         Egr-3   AhR   MEF-2   Nkx2-5   Arnt   MEF-2A   Egr-2   FAC1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF529 promoter sequence
   Search Chromatin IP Primers for ZNF529

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF529


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

ZNF529 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF529 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M037157:  view genomic region     (about GC identifiers)

Start:
37,025,676 bp from pter      End:
37,096,178 bp from pter
Size:
70,503 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN529_HUMAN, Q6P280 (See protein sequence)
Recommended Name: Zinc finger protein 529  
Size: 563 amino acids; 65865 Da
Sequence caution: Sequence=AAH64690.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15068.1; Type=Frameshift; Positions=78;
Secondary accessions: K7EKE1 Q9H731 Q9HCF7

Explore the universe of human proteins at neXtProt for ZNF529: NX_Q6P280

Explore proteomics data for ZNF529 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF529 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139121.1  NP_001139122.1  NP_066002.3  

    ENSEMBL proteins: 
     ENSP00000465917   ENSP00000468594   ENSP00000334695   ENSP00000465578   ENSP00000465682  
     ENSP00000468619   ENSP00000466182  
    Reactome Protein details: Q6P280

    ZNF529 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for ZNF529
    Cloud-Clone Corp. CLIAs for ZNF529


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6P280

    ProtoNet protein and cluster: Q6P280

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN529_HUMAN, Q6P280
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF529 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN529_HUMAN, Q6P280
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF529 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF529:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF529
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF529

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF529:
    hsa-mir-196a-5p (MIRT048182)

    Block miRNA regulation of human, mouse, rat ZNF529 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ZNF529:
    hsa-miR-579 hsa-miR-590-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF529 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF529

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF529


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN529_HUMAN, Q6P280: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF529 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF529 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF529
        Generic Transcription Pathway



    ZNF529 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF529
    Interactions:

        Search GeneGlobe Interaction Network for ZNF529

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF529 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF529 (ZN529)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF529 gene (3 alternative transcripts): 
    NM_001145649.1  NM_001145650.1  NM_020951.4  

    Unigene Cluster for ZNF529:

    Zinc finger protein 529
    Hs.654960  [show with all ESTs]
    Unigene Representative Sequence: NM_001145649
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452073 ENST00000590656 ENST00000334116(uc002oeh.4 uc002oeg.4 uc010xth.2 uc010xti.2)
    ENST00000591340 ENST00000586115 ENST00000585983 ENST00000585960 ENST00000586458
    ENST00000587286
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF529 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ZNF529:
    hsa-miR-579 hsa-miR-590-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF529 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF529
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF529
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    GenScript: all cDNA clones in your preferred vector (see all 3): ZNF529 (NM_001145650)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF529
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF529
      QuantiFast Probe-based Assays in human, mouse, rat ZNF529

    Additional mRNA sequence: 

    AB046835.1 AK025110.1 AK094618.1 AL109722.1 BC036578.2 BC064690.1 NR_027239.1 

    9 DOTS entries:

    DT.40212310  DT.99971817  DT.99977061  DT.100660741  DT.121470682  DT.121470697  DT.40228167  DT.91986271 
    DT.99939157 

    Selected AceView cDNA sequences (see all 49):

    BM803732 F02879 NM_020951 BP354728 BE835504 BC036578 BG251457 BP336437 
    AB046835 AK025110 AI333429 BM688342 N48921 BQ723028 AI333427 BP428550 
    BC064690 AI807166 AA234931 N71870 BE858324 BX646254 BX503547 BU726740 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF529    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:                                -     -                     
    SP2:                                      -                     
    SP3:                                                            
    SP4:                          -     -     -                     


    ECgene alternative splicing isoforms for ZNF529

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF529 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTACACAG
    ZNF529 Expression
    About this image

    ZNF529 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF529 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654960
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF529

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF529 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5296
    zinc finger protein 529
    80(a)
    1 ↔ 1
    1(116185191-116197901)


    ENSEMBL Gene Tree for ZNF529 (if available)
    TreeFam Gene Tree for ZNF529 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF529 gene
    ZNF792  ZNF5702  ZFP302  ZNF286B2  ZNF7902  ZNF3832  ZNF1812  ZNF2872  
    ZNF5822  ZNF4712  ZFP822  ZNF286A2  ZNF2502  ZNF8792  ZNF354C2  ZNF742  
    ZNF5832  ZNF3912  ZNF5542  ZNF4542  ZFP902  ENSG000001876072  ZFP142  ZNF3312  
    ZNF354A2  ZNF4612  ZNF354B2  ZNF342  ZNF5272  ZNF5652  
    Selected SIMAP similar genes for ZNF529 using alignment to 6 protein entries:     ZN529_HUMAN (see all proteins) (see all similar genes):
    ZNF577    KRBOX4    FIK    ZNF81    ZNF596    MGC12518
    ZNF208    ZNF720    ZFP90    ZNF761    ZNF169    ZNF528
    ZNF675    ZNF846    ZNF506    ZNF3    ZNF140    ZNF283

    ZNF529 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF529 (see all 1016)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341798091,2
    C--33505303(+) TGTGT-/G/GT  
            
    TATGG
    6 -- ut311NA 2
    rs1901184981,2
    --37034033(+) TATATA/GCGCAA 3 -- int10--------
    rs1500574631,2
    --37034099(+) TTTCAC/TTGGTT 3 -- int10--------
    rs1817529821,2
    --37034234(+) TTGTTC/TATGAT 3 -- int10--------
    rs790909661,2
    C,F--37034261(+) ATACCG/ATTCAT 3 -- int11Minor allele frequency- A:0.01NA 120
    rs736079651,2
    C--37034303(+) CCAGTG/CGTTCT 3 -- int11Minor allele frequency- C:0.50WA 2
    rs778468871,2
    --37034322(+) TTTTTG/TTCCTC 3 -- int10--------
    rs1866452951,2
    --37034365(+) ATCTAC/TCCTCA 3 -- int10--------
    rs1454336211,2
    --37034375(+) AGCATG/TCTTCT 3 -- int10--------
    rs598813931,2
    C,F--37034510(+) TGCCAT/CAGACT 3 -- int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for ZNF529 (37025676 - 37096178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF529:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2205269CNV Deletion18987734
    esv2570514CNV Deletion19546169
    esv1008911CNV Deletion20482838
    esv1768990CNV Deletion17803354
    esv2718504CNV Deletion23290073
    esv2664896CNV Deletion23128226
    nsv833817CNV Loss17160897
    nsv911648CNV Loss21882294
    nsv138053CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF529 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF529)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57711 HGNC: 29328 AceView: ZNF529 Ensembl:ENSG00000186020 euGenes: HUgn57711
    ECgene: ZNF529 H-InvDB: ZNF529

    (According to HUGE)
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    HUGE: KIAA1615

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF529 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF529 gene:
    Search GeneIP for patents involving ZNF529

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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