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Aliases for ZNF528 Gene

Aliases for ZNF528 Gene

  • Zinc Finger Protein 528 2 3 5
  • KIAA1827 4

External Ids for ZNF528 Gene

Previous GeneCards Identifiers for ZNF528 Gene

  • GC19P057465
  • GC19P057610
  • GC19P057591
  • GC19P052901
  • GC19P049231

Summaries for ZNF528 Gene

GeneCards Summary for ZNF528 Gene

ZNF528 (Zinc Finger Protein 528) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot for ZNF528 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF528 Gene

Genomics for ZNF528 Gene

Regulatory Elements for ZNF528 Gene

Enhancers for ZNF528 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051687 1.8 FANTOM5 ENCODE dbSUPER 26.1 -707.4 -707359 6.9 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ZNF808 ZNF836 ZNF616 ZNF841 ZNF137P ENSG00000268970 ZNF766 ENSG00000269825 ZNF528 ZNF175
GH19G051766 1.1 FANTOM5 16.4 -631.2 -631225 0.4 ATF1 CREB3L1 MLX E2F7 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 FPR1 FPR2 ZNF615 ZNF175 ZNF528 SPACA6 LOC100419835 SPACA6P-AS SIGLEC10 ZNF528-AS1
GH19G051903 1.3 ENCODE dbSUPER 11.5 -492.6 -492623 4.3 HDGF FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF350-AS1 ZNF577 ZNF528 ZNF350 LOC100419835 ZNF615 ZNF175 ZNF432 FPR3 ZNF28
GH19G052598 1.3 Ensembl ENCODE 11 +202.8 202761 4.1 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 SPACA6P-AS ZNF528 ZNF137P ZNF83 ENSG00000269349 ENSG00000268970 ENSG00000269825
GH19G052396 0.9 ENCODE 14.2 -0.1 -54 1.9 ELF3 ARID4B ZSCAN9 ZNF48 ZBTB40 YY1 ETS1 EGR1 ELK1 ZNF366 ZNF534 ZNF528 ZNF528-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF528 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF528 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111295 -49 2000 ELF3 ARID4B ZSCAN9 RAD21 ZBTB40 YY1 ETS1 EGR1 ELK1 ZNF366

Transcription factor binding sites by QIAGEN in the ZNF528 gene promoter:

Genomic Location for ZNF528 Gene

Chromosome:
19
Start:
52,397,849 bp from pter
End:
52,418,412 bp from pter
Size:
20,564 bases
Orientation:
Plus strand

Genomic View for ZNF528 Gene

Genes around ZNF528 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF528 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF528 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF528 Gene

Proteins for ZNF528 Gene

  • Protein details for ZNF528 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIS6-ZN528_HUMAN
    Recommended name:
    Zinc finger protein 528
    Protein Accession:
    Q3MIS6
    Secondary Accessions:
    • B3KPN4
    • Q86T88
    • Q96JK0

    Protein attributes for ZNF528 Gene

    Size:
    628 amino acids
    Molecular mass:
    72138 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47456.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF528 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF528 Gene

Post-translational modifications for ZNF528 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF528 Gene

Domains & Families for ZNF528 Gene

Gene Families for ZNF528 Gene

Protein Domains for ZNF528 Gene

Suggested Antigen Peptide Sequences for ZNF528 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3MIS6

UniProtKB/Swiss-Prot:

ZN528_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF528: view

Function for ZNF528 Gene

Molecular function for ZNF528 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF528 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF528: view
genes like me logo Genes that share phenotypes with ZNF528: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF528 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF528
  • Consensus sequence: AGAAATGACTTCCCT Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF528 Gene

Localization for ZNF528 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF528 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF528 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF528 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF528: view

Pathways & Interactions for ZNF528 Gene

SuperPathways for ZNF528 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF528: view

Pathways by source for ZNF528 Gene

2 Reactome pathways for ZNF528 Gene

Gene Ontology (GO) - Biological Process for ZNF528 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF528: view

No data available for SIGNOR curated interactions for ZNF528 Gene

Drugs & Compounds for ZNF528 Gene

No Compound Related Data Available

Transcripts for ZNF528 Gene

Unigene Clusters for ZNF528 Gene

Zinc finger protein 528:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF528 Gene

No ASD Table

Relevant External Links for ZNF528 Gene

GeneLoc Exon Structure for
ZNF528
ECgene alternative splicing isoforms for
ZNF528

Expression for ZNF528 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF528 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF528 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF528 Gene:

ZNF528

SOURCE GeneReport for Unigene cluster for ZNF528 Gene:

Hs.662043

Evidence on tissue expression from TISSUES for ZNF528 Gene

  • Lung(4.4)
  • Nervous system(4.3)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with ZNF528: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF528 Gene

Orthologs for ZNF528 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF528 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF528 34
  • 99.15 (n)
-- 35
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 49 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 36 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.921 34
Species where no ortholog for ZNF528 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF528 Gene

ENSEMBL:
Gene Tree for ZNF528 (if available)
TreeFam:
Gene Tree for ZNF528 (if available)

Paralogs for ZNF528 Gene

(511) SIMAP similar genes for ZNF528 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZNF528 Gene

genes like me logo Genes that share paralogs with ZNF528: view

Variants for ZNF528 Gene

Sequence variations from dbSNP and Humsavar for ZNF528 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000048331 -- 52,407,435(+) GCAAC(C/T)AGTAA intron-variant
rs1000066948 -- 52,400,397(+) GCGCT(C/T)TCTCA intron-variant
rs1000137941 -- 52,397,623(+) GAAGG(A/G)ATTTT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000230105 -- 52,413,160(+) CCAGG(C/T)GCATT intron-variant
rs1000240560 -- 52,418,359(+) ATGTA(C/T)GCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF528 Gene

Variant ID Type Subtype PubMed ID
esv2762048 CNV loss 21179565
esv33518 CNV gain 17666407
esv3644693 CNV loss 21293372
esv3644695 CNV loss 21293372
nsv1114029 CNV deletion 24896259
nsv1138724 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv2536 CNV deletion 18451855
nsv521079 CNV loss 19592680
nsv828615 CNV loss 20364138
nsv833873 CNV gain 17160897
nsv978840 CNV duplication 23825009

Variation tolerance for ZNF528 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF528 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF528

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF528 Gene

Disorders for ZNF528 Gene

Relevant External Links for ZNF528

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF528

No disorders were found for ZNF528 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF528 Gene

Publications for ZNF528 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for ZNF528 Gene

Sources for ZNF528 Gene

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