ZNF528 Gene
protein-coding GIFtS: 48
GCID: GC19P052901
|
|
zinc finger protein 528
| |
Aliases
for ZNF528 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5281 2 | | KIAA18271 3 |
Export aliases for ZNF528 gene to outside databasesPrevious GC identifers: GC19P057465 GC19P057610 GC19P057591 GC19P049231 |
Summaries
for ZNF528 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN528_HUMAN, Q3MIS6Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF528 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF528 gene promoter:
AREB6 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF528
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF528 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13ZNF528 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P052901: view genomic region
(about GC identifiers)
Start:
|
52,901,102 bp from pter |
End:
|
52,921,657 bp from pter |
Size:
|
20,556 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF528 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN528_HUMAN, Q3MIS6 (See
protein sequence)Recommended Name: Zinc finger protein 528 Size: 628 amino acids; 72138 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB47456.1; Type=Erroneous initiation;
Secondary accessions: B3KPN4 Q86T88 Q96JK0Alternative splicing: 2 isoforms: Q3MIS6-1 Q3MIS6-2 Explore the universe of human proteins at neXtProt for ZNF528: NX_Q3MIS6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3MIS6
ZNF528 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115799.2
ENSEMBL proteins: ENSP00000375665 ENSP00000413711 ENSP00000375664 ENSP00000353652 ENSP00000434962 ENSP00000432992 ENSP00000404087 Reactome Protein details: Q3MIS6
Human Recombinant Protein Products for ZNF528:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF528 for ontologies About GeneDecksing
ZNF528 Antibody Products:
Assay Products for ZNF528: |
Protein
Domains /
Families
for ZNF528 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF528 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3MIS6ProtoNet protein and cluster: Q3MIS6 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN528_HUMAN, Q3MIS6Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF528 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN528_HUMAN, Q3MIS6Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF528 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF528
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF528 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF528 (NM_032423) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF528 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF528 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF528 |
|
Pathways & Interactions
for ZNF528 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF528
ZNF528 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF528
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for ZNF528 (Q3MIS63 ENSP000003536524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF528 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF528 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF528
Search CenterWatch for drugs/clinical trials and news about ZNF528 / ZN528
|
Transcripts
for ZNF528 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF528 gene: NM_032423.2 Unigene Cluster for ZNF528: Zinc finger protein 528 Hs.662043 [show with all ESTs]Unigene Representative Sequence: AK0565529 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000391788(uc002pzi.3) ENST00000436397 ENST00000391787 ENST00000360465(uc002pzh.3)
ENST00000494167 ENST00000493272 ENST00000531472 ENST00000448954 ENST00000479718
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF528
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF528 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF528 (NM_032423) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF528 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF528 |
Additional cDNA sequence: AB058730.1 AK023429.1 AK056552.1 AL833325.1 BC101712.1 BC111950.1 BX640670.1 9 DOTS entries: DT.100028924 DT.40299613 DT.100795738 DT.95129064 DT.101981942 DT.101957918 DT.100795739 DT.102842555 DT.121450934 24/43 AceView cDNA sequences (see all 43): AK023429 BX473930 BE090542 AI754163 NM_032423 AA373363 BX640670 AL833325 BU619916 CK431005 AW167773 AK056552 BG742506 AW474158 BX473754 BQ672895 BX491636 AL832630 BU742956 BG753031 BX470442 CD103675 BQ673945 AB058730
GeneLoc Exon Structure
|
Expression
for ZNF528 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF528 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTAGTAA
About this image
See ZNF528 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF528
SOURCE GeneReport for Unigene cluster: Hs.662043
SABiosciences Custom PCR Arrays for ZNF528
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF528
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF528 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF528 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF528 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF528 |
Orthologs
for ZNF528 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF528 (if available)
TreeFam Gene Tree for ZNF528 (if available) |
Paralogs
for ZNF528 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF528 gene
- ZNF5342 ZNF321P2 ZNF4682 ZNF5782 ZNF8802 ZNF7662 ZNF3202 ZNF5252
- ZNF8602 ZNF4152 ZNF6002 ZNF282 ZNF6112 ZNF6772 ZNF832 ZNF8162
- ZNF6102 ZNF7012 ZNF7652 ZNF4802 ZNF8132
18/503 SIMAP similar genes for ZNF528 using alignment to 7 protein entries: ZN528_HUMAN (see all proteins)
(see all similar genes):kr-znf3 ZNF519 ZNF534 ZNF480 ZNF78L1 ZNF818P
ZNF525 ZNF28 ZNF721 ZFS-6 ZNF766 ZFS-4
ZFS-5 ZNF701 ZNF559 ZNF880 ZNF283 ZNF232
ZNF528 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF528 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF528 (52901102 - 52921657 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF528
2 Indels: 40289 11149 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF528 |
|
Disorders
/ Diseases
for ZNF528 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF528 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF528 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF528) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF528 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF528 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF528 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF528 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF528 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF528 gene:
Search GeneIP for patents involving ZNF528
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF528 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF528 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF528 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF528 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZNF528 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF528 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF528 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF528 | | OriGene Custom Protein Services for ZNF528 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF528 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF528 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF528 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF528 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF528 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF528 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF528 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF528 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF528 |
|  |  |  |  | | | | ThermoFisher Antibodies for ZNF528 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF528 |
| |  | |
|
|
|
