Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF527 Gene

Aliases for ZNF527 Gene

  • Zinc Finger Protein 527 2 3 5
  • KIAA1829 4

External Ids for ZNF527 Gene

Previous GeneCards Identifiers for ZNF527 Gene

  • GC19P042553
  • GC19P037863
  • GC19P034311

Summaries for ZNF527 Gene

GeneCards Summary for ZNF527 Gene

ZNF527 (Zinc Finger Protein 527) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP28.

UniProtKB/Swiss-Prot for ZNF527 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF527 Gene

Genomics for ZNF527 Gene

Regulatory Elements for ZNF527 Gene

Enhancers for ZNF527 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G037333 1 ENCODE 11.5 -36.2 -36225 1.7 PKNOX1 ATF1 WRNIP1 SIN3A BRCA1 ZNF2 ETS1 GLIS2 ELK1 ZNF143 ZNF383 ZNF793 ZNF850 ZNF345 ZNF527 ZNF567 ZNF540 ZNF571 ENSG00000267682 LOC105372392
GH19G037316 1 ENCODE 11.1 -53.3 -53345 2.4 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416 ZNF143 ZNF207 LINC01535 ZNF383 ZNF793 ZFP82 ZNF345 ZNF573 ZNF567 ZNF529 ZNF461 ZNF585A
GH19G037209 1.1 ENCODE 9.9 -160.4 -160395 1.5 PKNOX1 FOXA2 ARNT ARID4B DMAP1 ZNF2 YY1 CBX5 ZNF416 ZNF143 ZNF383 LINC01535 LINC00665 ZNF850 ZNF345 ZNF529 ZNF567 ZFP82 ZNF571-AS1 LOC284412
GH19G037718 1.1 ENCODE 9.8 +348.4 348387 2.0 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF302 ZNF207 ZNF143 ZNF607 ZNF383 ZNF345 ZNF585B ZNF793 ZNF781 ZNF585A ZNF790-AS1 LINC01535 ZNF420
GH19G037312 0.8 ENCODE 11.1 -58.2 -58248 1.3 PKNOX1 ZNF133 BMI1 CBX5 ZNF143 ZNF350 THAP11 ZNF202 SP3 ZNF680 ZNF793 ZNF345 ZNF383 ZNF527 ZNF529-AS1 ZNF567 HKR1 PIR58710
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF527 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF527 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the ZNF527 gene promoter:

Genomic Location for ZNF527 Gene

37,371,048 bp from pter
37,393,066 bp from pter
22,019 bases
Plus strand

Genomic View for ZNF527 Gene

Genes around ZNF527 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF527 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF527 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF527 Gene

Proteins for ZNF527 Gene

  • Protein details for ZNF527 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 527
    Protein Accession:
    Secondary Accessions:
    • B4DVL5

    Protein attributes for ZNF527 Gene

    609 amino acids
    Molecular mass:
    70902 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF527 Gene


neXtProt entry for ZNF527 Gene

Post-translational modifications for ZNF527 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF527 Gene

Domains & Families for ZNF527 Gene

Gene Families for ZNF527 Gene

Protein Domains for ZNF527 Gene

Suggested Antigen Peptide Sequences for ZNF527 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF527: view

Function for ZNF527 Gene

Molecular function for ZNF527 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF527 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF527: view
genes like me logo Genes that share phenotypes with ZNF527: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF527 Gene

Localization for ZNF527 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF527 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF527 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZNF527 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF527: view

Pathways & Interactions for ZNF527 Gene

SuperPathways for ZNF527 Gene

No Data Available

Interacting Proteins for ZNF527 Gene

Gene Ontology (GO) - Biological Process for ZNF527 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF527: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF527 Gene

Drugs & Compounds for ZNF527 Gene

No Compound Related Data Available

Transcripts for ZNF527 Gene

Unigene Clusters for ZNF527 Gene

Zinc finger protein 527:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF527 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: - -

Relevant External Links for ZNF527 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF527 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF527 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF527 Gene:


SOURCE GeneReport for Unigene cluster for ZNF527 Gene:


Evidence on tissue expression from TISSUES for ZNF527 Gene

  • Spleen(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF527: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF527 Gene

Orthologs for ZNF527 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF527 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF527 34 35
  • 99.56 (n)
(Canis familiaris)
Mammalia ZNF570 34
  • 91.81 (n)
-- 35
  • 42 (a)
(Bos Taurus)
Mammalia ZNF527 34 35
  • 89.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3494 34
fruit fly
(Drosophila melanogaster)
Insecta CG6654 35
  • 24 (a)
Species where no ortholog for ZNF527 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF527 Gene

Gene Tree for ZNF527 (if available)
Gene Tree for ZNF527 (if available)

Paralogs for ZNF527 Gene

(476) SIMAP similar genes for ZNF527 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF527: view

Variants for ZNF527 Gene

Sequence variations from dbSNP and Humsavar for ZNF527 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000088670 -- 37,369,401(+) CCTAT(G/T)AAAAG upstream-variant-2KB
rs1000151003 -- 37,382,792(+) AGCTC(C/T)GCCTC intron-variant
rs1000273292 -- 37,389,632(+) TGAAT(A/G)TAACA reference, missense
rs1000325377 -- 37,375,213(+) GACTA(C/T)AGATG intron-variant
rs1000484673 -- 37,383,653(+) CCTGT(A/G)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF527 Gene

Variant ID Type Subtype PubMed ID
esv2758759 CNV loss 17122850
nsv1058788 CNV gain 25217958
nsv579464 CNV loss 21841781
nsv579465 CNV loss 21841781

Variation tolerance for ZNF527 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF527 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF527 Gene

Disorders for ZNF527 Gene

Relevant External Links for ZNF527

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF527 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF527 Gene

Publications for ZNF527 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 64
  3. ZNF527 GENE rs386809049 ANALYSIS IN POPULATION OF UKRAINE. (PMID: 26419067) Gulkovskyi R.V. … Livshits L.A. (Tsitol. Genet. 2015) 3 64
  4. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. (PMID: 21121903) Rasi S. … Rossi D. (Br. J. Haematol. 2011) 46 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF527 Gene

Sources for ZNF527 Gene

Loading form....