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ZNF524 Gene

protein-coding   GIFtS: 41
GCID: GC19P056111

Zinc Finger Protein 524

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5241 2

External Ids:    HGNC: 283221   Entrez Gene: 1478072   Ensembl: ENSG000001714437   UniProtKB: Q96C553   

Export aliases for ZNF524 gene to outside databases

Previous GC identifers: GC19P060805 GC19P060791 GC19P052423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF524 Gene:
ZNF524 (zinc finger protein 524) is a protein-coding gene. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot: ZN524_HUMAN, Q96C55
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF524 gene promoter:
         Spz1   MAZR   p53   Pax-5   Pax-6   NF-kappaB   E2F-1   E2F   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF524 promoter sequence
   Search Chromatin IP Primers for ZNF524

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF524


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.43

ZNF524 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF524 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056111:  view genomic region     (about GC identifiers)

Start:
56,111,388 bp from pter      End:
56,114,504 bp from pter
Size:
3,117 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN524_HUMAN, Q96C55 (See protein sequence)
Recommended Name: Zinc finger protein 524  
Size: 264 amino acids; 28709 Da
Secondary accessions: Q6NW31 Q96IL7

Explore the universe of human proteins at neXtProt for ZNF524: NX_Q96C55

Explore proteomics data for ZNF524 at MOPED


See ZNF524 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_694951.1  
ENSEMBL proteins: 
 ENSP00000467175   ENSP00000301073   ENSP00000466907  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR017956 AT_hook_DNA-bd_motif
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96C55

ProtoNet protein and cluster: Q96C55

UniProtKB/Swiss-Prot: ZN524_HUMAN, Q96C55
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 1 A.T hook DNA-binding domain
Similarity: Contains 4 C2H2-type zinc fingers


Find genes that share domains with ZNF524           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN524_HUMAN, Q96C55
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF524           About GenesLikeMe


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SwitchGear 3'UTR luciferase reporter plasmidZNF524 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN524_HUMAN, Q96C55: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with ZNF524           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF524
Interactions:

    Search GeneGlobe Interaction Network for ZNF524

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF524 (Q96C553 ENSP000003010734) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ZNF641Q96N773, ENSP000003010424I2D: score=1 STRING: ENSP00000301042
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with ZNF524           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZNF524 (ZN524)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF524 gene: 
NM_153219.2  

Unigene Cluster for ZNF524:

Zinc finger protein 524
Hs.440291  [show with all ESTs]
Unigene Representative Sequence: NM_153219
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000589521 ENST00000301073(uc002qlk.1) ENST00000591046
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SwitchGear 3'UTR luciferase reporter plasmidZNF524 3' UTR sequence
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  QuantiFast Probe-based Assays in human, mouse, rat ZNF524

Additional mRNA sequence: 

BC007396.2 BC014666.1 BC067748.1 

3 DOTS entries:

DT.40259341  DT.95254954  DT.92001731 

Selected AceView cDNA sequences (see all 33):

BM129198 BC007396 NM_153219 BC014666 BM273285 BM821263 BM977571 BM459823 
BC067748 BM141977 BI762939 BI756946 H64152 BM790568 BE899060 BM829774 
H82898 BM671263 BG821230 AW291126 BM850230 CK819807 BF591190 BV184748 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF524 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGGTACCCC
ZNF524 Expression
About this image

ZNF524 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF524 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.440291
    Custom PCR Arrays for ZNF524
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ZNF524 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zfp5241 , 5 zinc finger protein 5241, 5 81.53(n)1
85(a)1
  7 (2.90 cM)5
660561  NM_025324.21  NP_079600.11 
 50155085 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
31(a)
19(a)
1 ↔ many
1 ↔ many
GL343279.1(624270-625394)
GL343279.1(637229-650798)
zebrafish
(Danio rerio)
Actinopterygii ZNF5816
zinc finger protein 581
13(a)
1 → many
21(2735709-2742444) ENSDARG00000093967
fruit fly
(Drosophila melanogaster)
Insecta Lin296
--
5(a)
many ↔ many
4(396266-416428)


ENSEMBL Gene Tree for ZNF524 (if available)
TreeFam Gene Tree for ZNF524 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF524 gene
ZNF5812  ZNF3622  ZNF5802  ZNF3842  
12 SIMAP similar genes for ZNF524 using alignment to 2 protein entries:     ZN524_HUMAN (see all proteins):
ZNF581    ZNF    ZNF323    FIZ1    ZNF787    DKFZp451F083
ZNF408    ZNF75D    ZSCAN22    ZNF316    ZNF702P    ZNF580

Find genes that share paralogs with ZNF524           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF524 (see all 44)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs58286331,2
C--56113101(+) CAATA-/CTGGTC 1 -- int11Minor allele frequency- C:0.00NA 2
rs2015048501,2
--56113543(+) TCTGGC/TCTTAT 2 A V mis10--------
rs1507906191,2
C,F--56113548(+) CCTTAT/CCTCCT 2 /P /S mis11Minor allele frequency- C:0.00NA 4072
rs2000925601,2
C--56113555(+) TCCTCC/TTGTTC 2 P L mis11Minor allele frequency- T:0.00EU 1091
rs2000543341,2
--56113622(+) AAGGCA/CTCCCT 2 A syn10--------
rs2018642541,2
C--56113633(+) CCCTCG/TCAAGC 2 R L mis10--------
rs1172025321,2
C,F--56113848(+) CCTTCC/TCCTAC 2 P S mis13Minor allele frequency- T:0.00NA EU 4049
rs10778061,2
C,F--56114045(-) ACGCGG/ATGGTG 2 /H syn1 ese313Minor allele frequency- A:0.47NA WA CSA EA EU 904
rs2010114261,2
C--56114072(+) CCGTAC/TCAGTG 2 Y syn10--------
rs1471667861,2
F--56114195(+) CCGCCG/ATGGGA 2 /P syn11Minor allele frequency- A:0.00NA 2978

HapMap Linkage Disequilibrium report for ZNF524 (56111388 - 56114504 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for ZNF524:    About this table    
Variant IDTypeSubtypePubMed ID
nsv912499CNV Loss21882294
nsv828643CNV Loss20364138
nsv912502CNV Loss21882294
dgv4025n71CNV Loss21882294
nsv912473CNV Loss21882294
nsv912500CNV Loss21882294
nsv912501CNV Loss21882294
nsv912486CNV Loss21882294
dgv4026n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF524 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF524)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Genome-wide association study of chronic periodontitis in a general German population. (PubMed id 24024966)1 Teumer A....Kocher T. (J. Clin. Periodontol. 2013)
  4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  5. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 147807 HGNC: 28322 AceView: ZNF524 Ensembl:ENSG00000171443 euGenes: HUgn147807
ECgene: ZNF524 H-InvDB: ZNF524

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF524 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF524 gene:
Search GeneIP for patents involving ZNF524

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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