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Aliases for ZNF524 Gene

Aliases for ZNF524 Gene

  • Zinc Finger Protein 524 2 3 5

External Ids for ZNF524 Gene

Previous GeneCards Identifiers for ZNF524 Gene

  • GC19P060805
  • GC19P060791
  • GC19P056111
  • GC19P052423

Summaries for ZNF524 Gene

GeneCards Summary for ZNF524 Gene

ZNF524 (Zinc Finger Protein 524) is a Protein Coding gene. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot for ZNF524 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF524 Gene

Genomics for ZNF524 Gene

Regulatory Elements for ZNF524 Gene

Enhancers for ZNF524 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055623 0.4 ENCODE 12.2 +24.7 24706 2.0 HDGF ATF1 ZNF133 SIN3A YY1 ZNF143 KLF13 SP3 SP5 NFIL3 FIZ1 ZNF524 ZNF628 TMEM86B ZNF580 GC19M055621 ZNF784
GH19F055626 0.9 Ensembl ENCODE 12.1 +26.7 26687 0.9 SOX13 SAP130 CEBPG ZSCAN9 EED CREM THAP11 GATAD2A SOX5 NFIA FIZ1 ZNF524 ZNF628 TMEM86B KIR3DL1 ZNF784 GC19P055633
GH19F055619 1.1 Ensembl ENCODE 11.7 +21.3 21268 3.6 HDGF PKNOX1 MAX CEBPG TEAD3 POLR2A PAF1 ZNF362 TEAD1 CEBPB ZNF524 SBK3 SBK2 ENSG00000268593 ZNF580 GC19M055621 ENSG00000276488
GH19F055519 1 FANTOM5 Ensembl ENCODE 11.7 -79.5 -79546 1.0 HDGF ATF1 ZNF493 ZNF133 GLI4 YBX1 ZNF416 ZNF548 FOS MCM3 FIZ1 ZNF580 NAT14 U2AF2 SHISA7 ZNF667 ZNF667-AS1 SSC5D SBK3 LOC100506374
GH19F055521 0.6 ENCODE 11.7 -77.9 -77872 0.7 SBK3 ZNF524 FIZ1 SSC5D NAT14 SYT5 RDH13 EPS8L1 TMEM86B SBK2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF524 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF524 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000349039 45 2801 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A YBX1 FEZF1 DMAP1
ENSR00001818972 1745 201 BCOR CBX3 PKNOX1 ZNF792 ZMYM3 HDAC2 ADNP KDM1A ZNF391 ZNF24

Genomic Location for ZNF524 Gene

Chromosome:
19
Start:
55,599,755 bp from pter
End:
55,603,138 bp from pter
Size:
3,384 bases
Orientation:
Plus strand

Genomic View for ZNF524 Gene

Genes around ZNF524 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF524 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF524 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF524 Gene

Proteins for ZNF524 Gene

  • Protein details for ZNF524 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C55-ZN524_HUMAN
    Recommended name:
    Zinc finger protein 524
    Protein Accession:
    Q96C55
    Secondary Accessions:
    • Q6NW31
    • Q96IL7

    Protein attributes for ZNF524 Gene

    Size:
    264 amino acids
    Molecular mass:
    28709 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF524 Gene

Post-translational modifications for ZNF524 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF524 Gene

No data available for DME Specific Peptides for ZNF524 Gene

Domains & Families for ZNF524 Gene

Gene Families for ZNF524 Gene

Protein Domains for ZNF524 Gene

Suggested Antigen Peptide Sequences for ZNF524 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C55

UniProtKB/Swiss-Prot:

ZN524_HUMAN :
  • Contains 1 A.T hook DNA-binding domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 A.T hook DNA-binding domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF524: view

Function for ZNF524 Gene

Molecular function for ZNF524 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF524: view
genes like me logo Genes that share phenotypes with ZNF524: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF524 Gene

Localization for ZNF524 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF524 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF524 Gene COMPARTMENTS Subcellular localization image for ZNF524 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF524: view

Pathways & Interactions for ZNF524 Gene

SuperPathways for ZNF524 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF524: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF524 Gene

Transcripts for ZNF524 Gene

mRNA/cDNA for ZNF524 Gene

Unigene Clusters for ZNF524 Gene

Zinc finger protein 524:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF524 Gene

No ASD Table

Relevant External Links for ZNF524 Gene

GeneLoc Exon Structure for
ZNF524
ECgene alternative splicing isoforms for
ZNF524

Expression for ZNF524 Gene

mRNA expression in normal human tissues for ZNF524 Gene

mRNA expression in normal human tissues for ZNF524 Gene

Protein differential expression in normal tissues from HIPED for ZNF524 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF524 Gene



Protein tissue co-expression partners for ZNF524 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF524 Gene:

ZNF524

SOURCE GeneReport for Unigene cluster for ZNF524 Gene:

Hs.440291
genes like me logo Genes that share expression patterns with ZNF524: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF524 Gene

Orthologs for ZNF524 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF524 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF524 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia ZNF524 34 35
  • 91.06 (n)
cow
(Bos Taurus)
Mammalia ZNF524 34
  • 87.6 (n)
rat
(Rattus norvegicus)
Mammalia Zfp524 34
  • 82.22 (n)
mouse
(Mus musculus)
Mammalia Zfp524 34 16 35
  • 81.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
OneToMany
-- 35
  • 19 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF581 35
  • 13 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Lin29 35
  • 5 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
OneToOne
Species where no ortholog for ZNF524 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF524 Gene

ENSEMBL:
Gene Tree for ZNF524 (if available)
TreeFam:
Gene Tree for ZNF524 (if available)

Paralogs for ZNF524 Gene

Paralogs for ZNF524 Gene

(12) SIMAP similar genes for ZNF524 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF524: view

Variants for ZNF524 Gene

Sequence variations from dbSNP and Humsavar for ZNF524 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403342 -- 55,601,575(+) TTCCT(C/T)ATCCA intron-variant, upstream-variant-2KB
rs1077806 -- 55,602,679(-) ACGCG(A/G)TGGTG reference, synonymous-codon
rs111957536 -- 55,598,877(+) TACAC(C/T)CTTAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112710490 -- 55,599,556(+) CAGCT(C/T)CCTTC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs113093590 -- 55,601,435(+) GAACT(A/G)TGTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF524 Gene

Variant ID Type Subtype PubMed ID
nsv828643 CNV loss 20364138
nsv953624 CNV deletion 24416366

Variation tolerance for ZNF524 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF524 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF524

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF524 Gene

Disorders for ZNF524 Gene

Relevant External Links for ZNF524

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF524

No disorders were found for ZNF524 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF524 Gene

Publications for ZNF524 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF524 Gene

Sources for ZNF524 Gene

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