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ZNF521 Gene

protein-coding   GIFtS: 49
GCID: GC18M022641

Zinc Finger Protein 521

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5211 2     Early Hematopoietic Zinc Finger1
EHZF2 3 5     Evi32
Early Hematopoietic Zinc Finger Protein2 3     LIP33
LYST-Interacting Protein 32 3     EVI35

External Ids:    HGNC: 246051   Entrez Gene: 259252   Ensembl: ENSG000001987957   OMIM: 6109745   UniProtKB: Q96K833   

Export aliases for ZNF521 gene to outside databases

Previous GC identifers: GC18M020894 GC18M020895 GC18M019498


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF521 Gene:
ZNF521 (zinc finger protein 521) is a protein-coding gene. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83
Function: Transcription factor that can both act as an activator or a repressor depending on the context. Involved
in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with
SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional
repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this
interaction preventing EBF1 to bind DNA and activate target genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF521 gene promoter:
         STAT5B   NF-YA   p300   FOXL1   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF521 promoter sequence
   Search Chromatin IP Primers for ZNF521

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF521


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q11.2   HGNC cytogenetic band: 18q11.2

ZNF521 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF521 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M022641:  view genomic region     (about GC identifiers)

Start:
22,641,888 bp from pter      End:
22,932,214 bp from pter
Size:
290,327 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83 (See protein sequence)
Recommended Name: Zinc finger protein 521  
Size: 1311 amino acids; 147866 Da
Subunit: Interacts with EBF1. Interacts with SMAD1 and SMAD4
Sequence caution: Sequence=ABI33104.1; Type=Erroneous initiation; Sequence=BAB13829.1; Type=Erroneous initiation;
Secondary accessions: A3QVP7 B0YJB7 Q8IXI0 Q8TES6 Q9C065 Q9HAL5 Q9UFK4

Explore the universe of human proteins at neXtProt for ZNF521: NX_Q96K83

Explore proteomics data for ZNF521 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF521 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056276.1  
    ENSEMBL proteins: 
     ENSP00000354794   ENSP00000463000   ENSP00000382352   ENSP00000440768   ENSP00000463748  
     ENSP00000462718   ENSP00000462724   ENSP00000464415   ENSP00000462746  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for ZNF521

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    antibodies-online antibodies for ZNF521 (34 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96K83

    ProtoNet protein and cluster: Q96K83

    UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83
    Domain: Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic
    system (By similarity)
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 30 C2H2-type zinc fingers


    Find genes that share domains with ZNF521           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN521_HUMAN, Q96K83
    Function: Transcription factor that can both act as an activator or a repressor depending on the context. Involved
    in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with
    SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional
    repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this
    interaction preventing EBF1 to bind DNA and activate target genes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0019904protein domain specific binding IPI11984006
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF521           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF521:
     Decreased viability with cispl 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zfp521):
     craniofacial  growth/size/body  skeleton 

    Find genes that share phenotypes with ZNF521           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zfp521tm2Ngc for ZNF521

       genOway: Develop your customized and physiologically relevant rodent model for ZNF521

    miRNA
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    miRTarBase miRNAs that target ZNF521:
    hsa-mir-19b-3p (MIRT031286)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF521 (see all 53):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-361-5p hsa-miR-300 hsa-miR-517a hsa-miR-25 hsa-miR-517c hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidZNF521 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF521


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN521_HUMAN, Q96K83: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12393497

    Find genes that share ontologies with ZNF521           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF521
    Interactions:

        Search GeneGlobe Interaction Network for ZNF521

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ZNF521 (Q96K833 ENSP000003547944) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EBF1Q9UH733, ENSP000003228984I2D: score=1 STRING: ENSP00000322898
    GATA1P159763, ENSP000003658584I2D: score=1 STRING: ENSP00000365858
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    SMAD4Q134853, ENSP000003415514I2D: score=1 STRING: ENSP00000341551
    LYSTQ996983, ENSP000003744434I2D: score=1 STRING: ENSP00000374443
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with ZNF521           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF521 (ZN521)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF521 gene: 
    NM_015461.2  

    Unigene Cluster for ZNF521:

    Zinc finger protein 521
    Hs.116935  [show with all ESTs]
    Unigene Representative Sequence: NM_015461
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361524(uc002kvk.2 uc010xbe.1 uc010dly.2 uc002kvl.2)
    ENST00000584787 ENST00000399425 ENST00000538137 ENST00000577775 ENST00000577720
    ENST00000577801 ENST00000581869 ENST00000580488 ENST00000583005 ENST00000579111
    ENST00000583398 ENST00000582584 ENST00000577461
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF521 (see all 53):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-361-5p hsa-miR-300 hsa-miR-517a hsa-miR-25 hsa-miR-517c hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidZNF521 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZNF521
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF521
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF521 (NM_015461)
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF521
      QuantiFast Probe-based Assays in human, mouse, rat ZNF521

    Additional mRNA sequence: 

    AF141339.1 AJ518106.1 AK021452.1 AK027354.1 AK074046.1 AK293067.1 AL117615.1 BC032869.2 
    BC113622.1 BC113648.1 BC143727.1 

    4 DOTS entries:

    DT.92421283  DT.115143  DT.100020429  DT.100758705 

    Selected AceView cDNA sequences (see all 76):

    AA461093 AI810111 BU077823 BI494001 AA460904 AA181862 W40354 AI018812 
    AI216371 BQ005116 CA415157 CK902413 F06765 CD243284 AW299743 AK027354 
    AI308209 AA374181 AA461407 AK074046 AK021452 BE856882 NM_015461 AW196998 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF521 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -           -                 -     -     -     -                                                   
    SP2:        -     -     -                 -     -     -     -                                                   
    SP3:        -     -     -                                                                                       
    SP4:                    -                                                                                       
    SP5:                                                        -                                                   


    ECgene alternative splicing isoforms for ZNF521

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF521 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTATGTCG
    ZNF521 Expression
    About this image


    ZNF521 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
    ZNF521 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF521 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116935

    UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83
    Tissue specificity: Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain
    stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal
    liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral
    blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to
    hemopoietins

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF521

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF521 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5211 , 5 zinc finger protein 5211, 5 88.25(n)1
    97.48(a)1
      18 (7.68 cM)5
    2252071  NM_145492.41  NP_663467.11 
     136870135 
    chicken
    (Gallus gallus)
    Aves ZNF5211 zinc finger protein 521 85.13(n)
    96.41(a)
      421083  XM_004939803.1  XP_004939860.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF5216
    zinc finger protein 521
    91(a)
    1 ↔ 1
    4(37176301-37492311)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146982 Xenopus laevis transcribed sequence with moderate similarity more 85.79(n)    CD253190.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CU861664.16
    Uncharacterized protein
    43(a)
    many ↔ many
    20(18371628-18376404) ENSDARG00000086825
    fruit fly
    (Drosophila melanogaster)
    Insecta Oaz6
    O/E-associated zinc finger protein
    25(a)
    1 → many
    2R(10323404-10353386)


    ENSEMBL Gene Tree for ZNF521 (if available)
    TreeFam Gene Tree for ZNF521 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF521 gene
    ZNF912  PEG32  ZNF8502  ZNF7292  ZNF4232  ZNF2082  
    Selected SIMAP similar genes for ZNF521 using alignment to 9 protein entries:     ZN521_HUMAN (see all proteins) (see all similar genes):
    ZNF423    kr-znf3    ZIC1    ZNF263    ZNF285    ZNF78L1
    ZFP64    DKFZp686N0199    ZNF426    ZNF540    ZNF55    ZNF22
    DKFZp686O1631    HKR1    ZBTB48    ZFX    ZNF253    ZNF565

    Find genes that share paralogs with ZNF521           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF521 (see all 6073)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782393121,2
    C,F--22641428(+) CCCATC/TGGGAG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1178325911,2
    F--22641744(+) GCATTT/CGGCCC 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1422318461,2
    C--22642200(+) ACATCC/TCTTCA 1 -- ut310--------
    rs1511859881,2
    C--22642367(+) ATCTTA/CAGCCA 1 -- ut310--------
    rs454539011,2
    C,F--22642499(+) GGTCTA/GTCCGG 1 -- ut312Minor allele frequency- G:0.03NS NA 158
    rs1403313661,2
    --22642500(+) GTCTAC/TCCGGT 1 -- ut310--------
    rs1469510931,2
    --22642503(+) TATCCA/GGTGCG 1 -- ut310--------
    rs1926003781,2
    --22642554(+) CAAGTC/TTTATG 1 -- ut310--------
    rs2005000271,2
    --22642644(+) CCACAA/CAATCA 1 -- ut310--------
    rs1165228791,2
    C--22642699(+) CATTGT/AATGAT 2 /T /S mis11Minor allele frequency- A:0.01EA 200

    HapMap Linkage Disequilibrium report for ZNF521 (22641888 - 22891888 bp, first 250kb of ZNF521)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF521 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716874CNV Deletion23290073
    esv2908CNV Deletion18987735
    esv2660658CNV Deletion23128226
    esv2663271CNV Deletion23128226
    esv1007123CNV Deletion20482838
    esv2716872CNV Deletion23290073
    esv1137776CNV Deletion17803354
    esv1005517CNV Insertion20482838
    esv8931CNV Loss19470904
    nsv510733CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF521
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF521

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610974    OMIM disorders: --

    UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83
  • Note=A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation
    t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus
    part of PAX5 and the C-terminus part of ZNF521


  • Find genes that share disorders with ZNF521           About GenesLikeMe

    Genetic Association Database (GAD): ZNF521

    Export disorders for ZNF521 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF521 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ZNF521)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. (PubMed id 14630787)1, 2, 3, 9 Bond H.M.... Venuta S. (Blood 2004)
    2. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)1, 2, 3 Tchernev V.T.... Kingsmore S.F. (Mol. Med. 2002)
    3. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)1, 4 McCormack M....Cavalleri G.L. (Pharmacogenomics 2012)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells. (PubMed id 19342626)1, 9 La Rocca R....Carbone E. (J. Immunol. 2009)
    6. Zinc finger protein 521, a new player in bone formation. (PubMed id 20392215)1, 9 Hesse E....Baron R. (Ann. N. Y. Acad. Sci. 2010)
    7. The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation. (PubMed id 19049973)1, 9 Matsubara E....Yasukawa M. (J. Biol. Chem. 2009)
    8. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    9. Zinc finger protein 521 antagonizes early B-cell factor 1 and modulates the B-lymphoid differentiation of primary hematopoietic progenitors. (PubMed id 21593590)1 Mega T....Morrone G. (Cell Cycle 2011)
    10. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PubMed id 19851299)4 Johansson A....Gyllensten U. (Obesity (Silver Spring) 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25925 HGNC: 24605 AceView: ZNF521 Ensembl:ENSG00000198795 euGenes: HUgn25925
    ECgene: ZNF521 H-InvDB: ZNF521

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF521 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF521 gene:
    Search GeneIP for patents involving ZNF521

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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