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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF521 Gene

protein-coding   GIFtS: 48
GCID: GC18M022641

zinc finger protein 521
 Explore 5 diseases affiliated with
ZNF521 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNF521    

Aliases
for ZNF521 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Protein 5211 2     LYST-Interacting Protein 32 3
EHZF1 2 3 5     LIP33
Evi31 2     EVI35
Early Hematopoietic Zinc Finger Protein2 3     

External Ids:    HGNC: 246051   Entrez Gene: 259252   Ensembl: ENSG000001987957   OMIM: 6109745   UniProtKB: Q96K833   

Export aliases for ZNF521 gene to outside databases

Previous GC identifers: GC18M020894 GC18M020895 GC18M019498


Summaries
for ZNF521 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83
Function: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in
BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in
response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its
interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing
EBF1 to bind DNA and activate target genes




Genomic Views
for ZNF521 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF521 gene promoter:
         STAT5B   NF-YA   p300   FOXL1   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF521 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF521

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF521


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q11.2   HGNC cytogenetic band: 18q11.2

ZNF521 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF521 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M022641:  view genomic region     (about GC identifiers)

Start:
 22,641,888 bp from pter      End:
 22,932,214 bp from pter
Size:
 290,327 bases      Orientation:
 minus strand

Proteins
for ZNF521 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83 (See protein sequence)
Recommended Name: Zinc finger protein 521  
Size: 1311 amino acids; 147866 Da
Subunit: Interacts with EBF1. Interacts with SMAD1 and SMAD4
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=ABI33104.1; Type=Erroneous initiation; Sequence=BAB13829.1; Type=Erroneous initiation;
Secondary accessions: A3QVP7 B0YJB7 Q8IXI0 Q8TES6 Q9C065 Q9HAL5 Q9UFK4

Explore the universe of human proteins at neXtProt for ZNF521: NX_Q96K83

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96K83

    • ZNF521 Protein expression data from MOPED and PaxDb:    About this image 
    ZNF521 Protein Expression
    REFSEQ proteins: NP_056276.1  
    ENSEMBL proteins: 
     ENSP00000354794   ENSP00000463000   ENSP00000382352   ENSP00000440768   ENSP00000463748  
     ENSP00000462718   ENSP00000462724   ENSP00000464415   ENSP00000462746  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF521

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12393497

    ZNF521 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZNF521 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNF521 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96K83

    ProtoNet protein and cluster: Q96K83

    UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83
    Domain: Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system
    (By similarity)
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 30 C2H2-type zinc fingers


    Function
    for ZNF521 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN521_HUMAN, Q96K83
    Function: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in
    BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in
    response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its
    interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing
    EBF1 to bind DNA and activate target genes

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0019904protein domain specific binding IPI11984006
         
    ZNF521 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF521:
     Decreased viability with cispl 

         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Zfp521):
     craniofacial  growth/size  skeleton 

    ZNF521 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Zfp521tm2Ngc for ZNF521
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF521 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ZNF521 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ZNF521 

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF521


    Pathways & Interactions
    for ZNF521 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF521

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for ZNF521 (Q96K833 ENSP000003547944) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EBF1Q9UH733, ENSP000003228984I2D: score=1 STRING: ENSP00000322898
    GATA1P159763, ENSP000003658584I2D: score=1 STRING: ENSP00000365858
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    SMAD4Q134853, ENSP000003415514I2D: score=1 STRING: ENSP00000341551
    LYSTQ996983, ENSP000003744434I2D: score=1 STRING: ENSP00000374443
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--

    ZNF521 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF521 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF521
    Search CenterWatch for drugs/clinical trials and news about ZNF521 / ZN521 

    Transcripts
    for ZNF521 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZNF521 gene: 
    NM_015461.2  

    Unigene Cluster for ZNF521:

    Zinc finger protein 521
    Hs.116935  [show with all ESTs]
    Unigene Representative Sequence: NM_015461
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361524(uc002kvk.2 uc010xbe.1 uc010dly.2 uc002kvl.2)
    ENST00000584787 ENST00000399425 ENST00000538137 ENST00000577775 ENST00000577720
    ENST00000577801 ENST00000581869 ENST00000580488 ENST00000583005 ENST00000579111
    ENST00000583398 ENST00000582584 ENST00000577461

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF521
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF521 (see all 53):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-361-5p hsa-miR-300 hsa-miR-517a hsa-miR-25 hsa-miR-517c hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF521 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF521 (see all 7)
    OriGene shRNA RFP: ZNF521
    OriGene siRNA: ZNF521
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF521
    Sirion Biotech Custom design and validation of potent shRNA sequences against ZNF521 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF521
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    GenScript: all cDNA clones in your preferred vector: ZNF521 (NM_015461)
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    Primer
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    Additional cDNA sequence: 

    AF141339.1 AJ518106.1 AK021452.1 AK027354.1 AK074046.1 AK293067.1 AL117615.1 BC032869.2 
    BC113622.1 BC113648.1 BC143727.1 

    4 DOTS entries:

    DT.92421283  DT.115143  DT.100020429  DT.100758705 

    24/76 AceView cDNA sequences (see all 76):

    BE856882 AI810111 AI018812 AA181862 AA460904 W40354 BQ005116 AI216371 
    NM_015461 CA415157 BU077823 BI494001 AA461093 F06765 CD243284 AK027354 
    AW299743 CK902413 AA461407 AA374181 AI308209 AK021452 AK074046 Z39828 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF521 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -           -                 -     -     -     -                                                   
    SP2:        -     -     -                 -     -     -     -                                                   
    SP3:        -     -     -                                                                                       
    SP4:                    -                                                                                       
    SP5:                                                        -                                                   


    ECgene alternative splicing isoforms for ZNF521

    Expression
    for ZNF521 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF521 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTATGTCG
    ZNF521 Expression
    About this image

    ZNF521 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See ZNF521 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF521

    SOURCE GeneReport for Unigene cluster: Hs.116935

    UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83
    Tissue specificity: Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and
    progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within
    the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and
    its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins

        SABiosciences Custom PCR Arrays for ZNF521
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF521

    Orthologs
    for ZNF521 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZNF521 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZNF5211 zinc finger protein 521 84.71(n)
    96(a)    		   421083  XM_419167.3  XP_419167.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ZNF5216
    		 --
    		 94(a)
    		 1 ↔ 1
    		 4(37295920-37321932)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.146982 Xenopus laevis transcribed sequence with moderate similarity more 85.79(n)    CD253190.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii znf4236
    CU861664.16
    		 --
    		 51(a)
    39(a)
    		 possible ortholog
    1 ↔ 1
    		 18(17618849-17654244)
    20(18371628-18376404)
    fruit fly
    (Drosophila melanogaster)    		 Insecta hang6
    Oaz6
    		 O/E-associated zinc finger protein
    		 9(a)
    22(a)
    		 possible ortholog
    1 ↔ many
    		 X(16316877-16331531)
    2R(10323404-10353386)
    worm
    (Caenorhabditis elegans)    		 Secernentea C09F5.36
    		 Putative zinc finger protein C09F5.3
    		 24(a)
    		 1 → many
    		 III(662844-666261)


    ENSEMBL Gene Tree for ZNF521 (if available)
    TreeFam Gene Tree for ZNF521 (if available) 

    Paralogs
    for ZNF521 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF521 gene
    ZNF4232  
    18/87 SIMAP similar genes for ZNF521 using alignment to 9 protein entries:     ZN521_HUMAN (see all proteins) (see all similar genes):
    ZNF423    kr-znf3    ZIC1    ZNF263    ZNF285    ZNF78L1
    ZFP64    DKFZp686N0199    ZEB1    ZNF426    ZNF540    ZNF55
    ZNF22    DKFZp686O1631    HKR1    ZBTB48    ZFX    ZNF253

    ZNF521 for paralogs           About GeneDecksing



    Genomic Variants
    for ZNF521 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5172 NCBI SNPs in ZNF521 are shown (see all 5172)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs782393121,2
    		F--22641428(+) CCCATC/TGGGAG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1178325911,2
    		--22641744(+) GCATTT/CGGCCC 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1422318461,2
    		--22642200(+) ACATCC/TCTTCA 1 -- ut310--------
    rs1511859881,2
    		--22642367(+) ATCTTA/CAGCCA 1 -- ut310--------
    rs454539011,2
    		C,F--22642499(+) GGTCTA/GTCCGG 1 -- ut312Minor allele frequency- G:0.03NS NA 158
    rs1403313661,2
    		--22642500(+) GTCTAC/TCCGGT 1 -- ut310--------
    rs1469510931,2
    		--22642503(+) TATCCA/GGTGCG 1 -- ut310--------
    rs1926003781,2
    		--22642554(+) CAAGTC/TTTATG 1 -- ut310--------
    rs2005000271,2
    		--22642644(+) CCACAA/CAATCA 1 -- ut310--------
    rs1165228791,2
    		C--22642699(+) CATTGT/AATGAT 2 /T /S mis11Minor allele frequency- A:0.01EA 200

    HapMap Linkage Disequilibrium report for ZNF521 (22641888 - 22891888 bp, first 250kb of ZNF521)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for ZNF521
         1 CNV: 5897
         6 Indels: 26010 61604 42968 11932 40216 11933

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    Disorders / Diseases
    for ZNF521 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZNF521 for disorders           About GeneDecksing

    OMIM gene information: 610974    OMIM disorders: --

    UniProtKB/Swiss-Prot: ZN521_HUMAN, Q96K83
  • Note=A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation
    • t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part
    of PAX5 and the C-terminus part of ZNF521

    5 diseases for ZNF521:    About MalaCards
    b-cell lymphomas    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia
    hangover


    Export disorders for ZNF521 gene to outside databases

    Publications
    for ZNF521 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF521 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF521)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. (PubMed id 14630787)1, 2, 3, 9 Bond H.M....Venuta S. (2004)
    2. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)1, 2, 3 Tchernev V.T....Kingsmore S.F. (2002)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells. (PubMed id 19342626)1, 9 La Rocca R....Carbone E. (2009)
    5. Zinc finger protein 521, a new player in bone formati on. (PubMed id 20392215)1, 9 Hesse E....Baron R. (2010)
    6. The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation. (PubMed id 19049973)1, 9 Matsubara E....Yasukawa M. (2009)
    7. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)1 McCormack M....Cavalleri G.L. (2012)
    8. Zinc finger protein 521 antagonizes early B-cell facto r 1 and modulates the B-lymphoid differentiation of primary hematopoietic progen itors. (PubMed id 21593590)1 Mega T....Morrone G. (2011)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for ZNF521 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ZNF521 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25925 HGNC: 24605 AceView: ZNF521 Ensembl:ENSG00000198795 euGenes: HUgn25925
    ECgene: ZNF521 H-InvDB: ZNF521

    Other Databases showing ZNF521 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNF521 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF521 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF521 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNF521 gene:
    Search GeneIP for patents involving ZNF521

    GeneCards and IP:
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