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Aliases for ZNF521 Gene

Aliases for ZNF521 Gene

  • Zinc Finger Protein 521 2 3
  • EHZF 3 4 6
  • Early Hematopoietic Zinc Finger Protein 3 4
  • LYST-Interacting Protein 3 3 4
  • Evi3 3 6
  • Early Hematopoietic Zinc Finger 2
  • LIP3 4

External Ids for ZNF521 Gene

Previous GeneCards Identifiers for ZNF521 Gene

  • GC18M020894
  • GC18M020895
  • GC18M022641
  • GC18M019498

Summaries for ZNF521 Gene

GeneCards Summary for ZNF521 Gene

ZNF521 (Zinc Finger Protein 521) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF521 Gene

  • Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF521 Gene

Genomics for ZNF521 Gene

Regulatory Elements for ZNF521 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF521 Gene

Start:
25,061,924 bp from pter
End:
25,352,250 bp from pter
Size:
290,327 bases
Orientation:
Minus strand

Genomic View for ZNF521 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF521 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF521 Gene

Proteins for ZNF521 Gene

  • Protein details for ZNF521 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K83-ZN521_HUMAN
    Recommended name:
    Zinc finger protein 521
    Protein Accession:
    Q96K83
    Secondary Accessions:
    • A3QVP7
    • B0YJB7
    • Q8IXI0
    • Q8TES6
    • Q9C065
    • Q9HAL5
    • Q9UFK4

    Protein attributes for ZNF521 Gene

    Size:
    1311 amino acids
    Molecular mass:
    147866 Da
    Quaternary structure:
    • Interacts with EBF1. Interacts with SMAD1 and SMAD4.
    SequenceCaution:
    • Sequence=ABI33104.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB13829.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF521 Gene

Proteomics data for ZNF521 Gene at MOPED

Post-translational modifications for ZNF521 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF521 Gene

Domains for ZNF521 Gene

Gene Families for ZNF521 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF521 Gene

Suggested Antigen Peptide Sequences for ZNF521 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96K83

UniProtKB/Swiss-Prot:

ZN521_HUMAN :
  • Q96K83
Domain:
  • Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 30 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF521: view

Function for ZNF521 Gene

Molecular function for ZNF521 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.

Gene Ontology (GO) - Molecular Function for ZNF521 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0019904 protein domain specific binding IPI 11984006
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF521: view

Phenotypes for ZNF521 Gene

genes like me logo Genes that share phenotypes with ZNF521: view

Animal Models for ZNF521 Gene

MGI Knock Outs for ZNF521:

Animal Model Products

CRISPR Products

miRNA for ZNF521 Gene

miRTarBase miRNAs that target ZNF521

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF521

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZNF521 Gene

Localization for ZNF521 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF521 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF521 Gene COMPARTMENTS Subcellular localization image for ZNF521 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF521 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12393497
genes like me logo Genes that share ontologies with ZNF521: view

Pathways for ZNF521 Gene

SuperPathways for ZNF521 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF521 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZNF521: view

No data available for Pathways by source for ZNF521 Gene

Transcripts for ZNF521 Gene

Unigene Clusters for ZNF521 Gene

Zinc finger protein 521:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF521

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF521

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF521 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5: -
SP6:
SP7: - - - -

Relevant External Links for ZNF521 Gene

GeneLoc Exon Structure for
ZNF521
ECgene alternative splicing isoforms for
ZNF521

Expression for ZNF521 Gene

mRNA expression in normal human tissues for ZNF521 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF521 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.6) and Brain - Cerebellum (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF521 Gene

SOURCE GeneReport for Unigene cluster for ZNF521 Gene Hs.116935

mRNA Expression by UniProt/SwissProt for ZNF521 Gene

Q96K83-ZN521_HUMAN
Tissue specificity: Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins.
genes like me logo Genes that share expressions with ZNF521: view

In Situ Assay Products

Orthologs for ZNF521 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF521 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF521 35
  • 99.64 (n)
  • 99.92 (a)
ZNF521 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF521 35
  • 88.94 (n)
  • 97.56 (a)
ZNF521 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF521 35
  • 92.55 (n)
  • 99.08 (a)
ZNF521 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp521 35
  • 88.25 (n)
  • 97.48 (a)
Zfp521 16
Zfp521 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF521 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp521 35
  • 87.81 (n)
  • 97.43 (a)
chicken
(Gallus gallus)
Aves ZNF521 35
  • 85.13 (n)
  • 96.41 (a)
ZNF521 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF521 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14698 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18842 35
znf521 35
  • 78.59 (n)
  • 91.23 (a)
zebrafish
(Danio rerio)
Actinopterygii CU861664.1 36
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Oaz 36
  • 25 (a)
OneToMany
Species with no ortholog for ZNF521:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF521 Gene

ENSEMBL:
Gene Tree for ZNF521 (if available)
TreeFam:
Gene Tree for ZNF521 (if available)

Paralogs for ZNF521 Gene

Paralogs for ZNF521 Gene

genes like me logo Genes that share paralogs with ZNF521: view

Variants for ZNF521 Gene

Sequence variations from dbSNP and Humsavar for ZNF521 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1140026 -- 25,195,221(-) ATCAA(A/G)TGTCA synonymous-codon, reference
rs2235025 -- 25,330,438(-) mcctg(C/T)aatcc intron-variant
rs3934832 -- 25,132,006(+) TTTTA(A/C)AAGTT intron-variant
rs3934903 -- 25,159,965(+) GCCAA(A/C)ATAAA intron-variant
rs3936078 -- 25,112,150(-) aACTC(C/T)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF521 Gene

Variant ID Type Subtype PubMed ID
esv2663271 CNV Deletion 23128226
esv2716872 CNV Deletion 23290073
esv1005517 CNV Insertion 20482838
nsv527984 CNV Loss 19592680
nsv131198 CNV Loss 16902084
nsv510733 CNV Loss 20534489
nsv828193 CNV Gain 20364138
esv2908 CNV Deletion 18987735
esv2716874 CNV Deletion 23290073
esv2660658 CNV Deletion 23128226
dgv56n6 CNV Loss 16902084
esv1007123 CNV Deletion 20482838
esv1137776 CNV Deletion 17803354
esv8931 CNV Loss 19470904
nsv828194 CNV Gain 20364138
nsv521168 CNV Loss 19592680

Relevant External Links for ZNF521 Gene

HapMap Linkage Disequilibrium report
ZNF521

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF521 Gene

Disorders for ZNF521 Gene

UniProtKB/Swiss-Prot

ZN521_HUMAN
  • Note=A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521.

Relevant External Links for ZNF521

Genetic Association Database (GAD)
ZNF521
genes like me logo Genes that share disorders with ZNF521: view

Publications for ZNF521 Gene

  1. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. (PMID: 14630787) Bond H.M. … Venuta S. (Blood 2004) 2 3 4 23
  2. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev V.T. … Kingsmore S.F. (Mol. Med. 2002) 2 3 4
  3. Zinc finger protein 521, a new player in bone formation. (PMID: 20392215) Hesse E. … Baron R. (Ann. N. Y. Acad. Sci. 2010) 3 23
  4. The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation. (PMID: 19049973) Matsubara E. … Yasukawa M. (J. Biol. Chem. 2009) 3 23
  5. Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells. (PMID: 19342626) La Rocca R. … Carbone E. (J. Immunol. 2009) 3 23

Products for ZNF521 Gene

Sources for ZNF521 Gene

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