ZNF519 Gene
protein-coding GIFtS: 49
GCID: GC18M014030
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|
zinc finger protein 519
| |
Aliases
for ZNF519 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5191 2 | | HsT23621 2 | | FLJ368091 |
Export aliases for ZNF519 gene to outside databasesPrevious GC identifer: GC18M014094 |
Summaries
for ZNF519 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN519_HUMAN, Q8TB69Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF519 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF519 gene promoter:
SRF SRF (504 AA) XBP-1 RelA NF-kappaB SREBP-1b C/EBPalpha GATA-1 SREBP-1a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF519
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF519 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.21 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.21ZNF519 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M014030: view genomic region
(about GC identifiers)
Start:
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14,057,456 bp from pter |
End:
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14,132,489 bp from pter |
Size:
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75,034 bases |
Orientation:
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minus strand |
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Proteins
for ZNF519 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN519_HUMAN, Q8TB69 (See
protein sequence)Recommended Name: Zinc finger protein 519 Size: 540 amino acids; 63020 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for ZNF519: NX_Q8TB69
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TB69
ZNF519 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660330.2
ENSEMBL proteins: ENSP00000468250 ENSP00000465159 ENSP00000464872 Reactome Protein details: Q8TB69
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF519 for ontologies About GeneDecksing
ZNF519 Antibody Products:
Assay Products for ZNF519: |
Protein
Domains /
Families
for ZNF519 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF519 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TB69ProtoNet protein and cluster: Q8TB69 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN519_HUMAN, Q8TB69Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF519 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN519_HUMAN, Q8TB69Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF519 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF519
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF519 (NM_145287) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF519 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF519 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF519 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF519 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF519 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF519
ZNF519 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF519
1 Interacting protein for ZNF519 (Q8TB693) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF519 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF519 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF519
Search CenterWatch for drugs/clinical trials and news about ZNF519 / ZN519
|
Transcripts
for ZNF519 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF519 gene: NM_145287.3 Unigene Cluster for ZNF519: Zinc finger protein 519 Hs.352635 [show with all ESTs]Unigene Representative Sequence: NM_14528713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592345 ENST00000589203 ENST00000587419 ENST00000592049 ENST00000592411
ENST00000591393 ENST00000589498 ENST00000309305(uc002ksr.2 uc002ksq.2 uc002kst.2)
ENST00000590202 ENST00000588435 ENST00000587512 ENST00000586507 ENST00000591987
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF519 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF519
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF519 (NM_145287) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF519 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF519 |
Additional cDNA sequence: AB209417.1 AK094128.1 AK096748.1 AK124851.1 BC010705.1 BC024227.1 BC037787.1 NR_033354.1 8 DOTS entries: DT.97794276 DT.40252376 DT.95192253 DT.99930662 DT.91991325 DT.121088234 DT.207648 DT.121088223 24/36 AceView cDNA sequences (see all 36): BC010705 BE673636 AI376961 AI491739 AA287940 AK096748 AA489200 AA288004 AW298781 CD657761 BC024227 AK094128 BM475097 NM_145287 BF701340 BX112003 BX114450 BE780539 BC037787 AK124851 BG778551 M78627 CD385642 BG705921
GeneLoc Exon Structure
|
Expression
for ZNF519 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF519 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTCTAATT
About this image
See ZNF519 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF519
SOURCE GeneReport for Unigene cluster: Hs.352635
SABiosciences Custom PCR Arrays for ZNF519
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF519
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF519 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF519 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF519 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF519 |
Orthologs
for ZNF519 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF519 gene from 2/5 species (see all 5) About this table
ENSEMBL Gene Tree for ZNF519 (if available)
TreeFam Gene Tree for ZNF519 (if available) |
Paralogs
for ZNF519 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF519 gene
18/504 SIMAP similar genes for ZNF519 using alignment to 3 protein entries: ZN519_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 ZNF670 ZNF721 ZNF528 ZNF695 ZNF761
ZNF595 ZNF818P ZNF195 kr-znf3 MGC12518 ZNF813
ZNF283 DKFZp686M04222 ZNF232 ZNF573 ZNF534 ZFS-6
ZNF519 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for ZNF519 (see all 7)
PGOHUM00000238860 PGOHUM00000246629 PGOHUM00000246641 PGOHUM00000245291 PGOHUM00000233213
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Genomic Variants
for ZNF519 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF519 (14057456 - 14132489 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF519
2 CNVs: 4053 73115 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF519 |
|
Disorders
/ Diseases
for ZNF519 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF519 for disorders About GeneDecksing
1  disease for ZNF519: About MalaCardsanonychia congenita
1 disease from the University of Copenhagen DISEASES database for ZNF519:Nail disease Human Genome Epidemiology (HuGE) Navigator: ZNF519 (1 document)
Export disorders for ZNF519 gene to outside databases
|
Publications
for ZNF519 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF519 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF519) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Screening for replication of genome-wide SNP associations in sporadic ALS. (PubMed id 18987618)1 Cronin S....Hardiman O. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for ZNF519 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF519 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF519 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF519 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF519 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF519 gene:
Search GeneIP for patents involving ZNF519
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF519 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF519 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF519 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF519 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF519 | | OriGene 3'-UTR Clone for ZNF519 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF519 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF519 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF519 | | OriGene Custom Protein Services for ZNF519 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF519 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF519 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF519 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF519 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF519 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF519 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF519 |
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 | | | ZNF519 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF519 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF519 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF519 |
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