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Aliases for ZNF519 Gene

Aliases for ZNF519 Gene

  • Zinc Finger Protein 519 2 3 5
  • Similar To Zinc Finger Protein 85 (Zinc Finger Protein HPF4) (HTF1) 2
  • HsT2362 3

External Ids for ZNF519 Gene

Previous GeneCards Identifiers for ZNF519 Gene

  • GC18M014094
  • GC18M014030

Summaries for ZNF519 Gene

GeneCards Summary for ZNF519 Gene

ZNF519 (Zinc Finger Protein 519) is a Protein Coding gene. Diseases associated with ZNF519 include Anonychia Congenita and Nail Disease. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF267.

UniProtKB/Swiss-Prot for ZNF519 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF519 Gene

Genomics for ZNF519 Gene

Regulatory Elements for ZNF519 Gene

Enhancers for ZNF519 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF519 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF519 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF519 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF519 Gene

Chromosome:
18
Start:
14,056,324 bp from pter
End:
14,132,490 bp from pter
Size:
76,167 bases
Orientation:
Minus strand

Genomic View for ZNF519 Gene

Genes around ZNF519 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF519 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF519 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF519 Gene

Proteins for ZNF519 Gene

  • Protein details for ZNF519 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB69-ZN519_HUMAN
    Recommended name:
    Zinc finger protein 519
    Protein Accession:
    Q8TB69

    Protein attributes for ZNF519 Gene

    Size:
    540 amino acids
    Molecular mass:
    63020 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF519 Gene

Post-translational modifications for ZNF519 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF519 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF519 Gene

Domains & Families for ZNF519 Gene

Gene Families for ZNF519 Gene

Protein Domains for ZNF519 Gene

Suggested Antigen Peptide Sequences for ZNF519 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TB69

UniProtKB/Swiss-Prot:

ZN519_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF519: view

Function for ZNF519 Gene

Molecular function for ZNF519 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF519: view
genes like me logo Genes that share phenotypes with ZNF519: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF519 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF519
  • Consensus sequence: GAGSCCGAGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF519 Gene

Localization for ZNF519 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF519 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF519 Gene COMPARTMENTS Subcellular localization image for ZNF519 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF519: view

Pathways & Interactions for ZNF519 Gene

SuperPathways for ZNF519 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF519: view

Pathways by source for ZNF519 Gene

2 Reactome pathways for ZNF519 Gene

Gene Ontology (GO) - Biological Process for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF519: view

No data available for SIGNOR curated interactions for ZNF519 Gene

Drugs & Compounds for ZNF519 Gene

No Compound Related Data Available

Transcripts for ZNF519 Gene

Unigene Clusters for ZNF519 Gene

Zinc finger protein 519:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF519 Gene

No ASD Table

Relevant External Links for ZNF519 Gene

GeneLoc Exon Structure for
ZNF519
ECgene alternative splicing isoforms for
ZNF519

Expression for ZNF519 Gene

mRNA expression in normal human tissues for ZNF519 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF519 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.0) and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for ZNF519 Gene

This gene is overexpressed in Ovary (54.9) and Skin (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF519 Gene



Protein tissue co-expression partners for ZNF519 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF519 Gene:

ZNF519

SOURCE GeneReport for Unigene cluster for ZNF519 Gene:

Hs.352635
genes like me logo Genes that share expression patterns with ZNF519: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF519 Gene

Orthologs for ZNF519 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF519 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Zfp386 34
  • 61.79 (n)
  • 44.68 (a)
Zfp386 16
Zfp493 35
  • 53 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF519 34
  • 99.44 (n)
  • 99.07 (a)
ZNF519 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp386 34
  • 63 (n)
  • 49.91 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 34 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
Species where no ortholog for ZNF519 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF519 Gene

ENSEMBL:
Gene Tree for ZNF519 (if available)
TreeFam:
Gene Tree for ZNF519 (if available)

Paralogs for ZNF519 Gene

Paralogs for ZNF519 Gene

(514) SIMAP similar genes for ZNF519 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF519: view

Variants for ZNF519 Gene

Sequence variations from dbSNP and Humsavar for ZNF519 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs16941623 - 14,124,428(+) TTTCC(A/G)CTCTT intron-variant, reference, missense
rs10221432 - 14,106,275(+) TTCAC(C/G/T)TATAC intron-variant, reference, missense, utr-variant-5-prime
rs2159940 - 14,105,924(-) TTCAA(A/G)AAAAG intron-variant, reference, missense
rs8094412 - 14,105,854(+) AAATT(A/C)TTTGA intron-variant, reference, missense
rs957408 -- 14,091,718(-) TCATT(C/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF519 Gene

Variant ID Type Subtype PubMed ID
dgv3321n100 CNV loss 25217958
dgv3322n100 CNV loss 25217958
dgv602e214 CNV loss 21293372
esv27400 CNV gain 19812545
esv2758715 CNV gain 17122850
esv2760500 CNV loss 21179565
esv3555094 CNV deletion 23714750
esv3641872 CNV loss 21293372
esv994375 CNV loss 20482838
nsv1061483 CNV loss 25217958
nsv1066142 CNV loss 25217958
nsv516839 CNV loss 19592680
nsv520945 CNV loss 19592680
nsv528944 CNV loss 19592680
nsv576529 CNV gain 21841781
nsv576531 CNV gain 21841781
nsv828185 CNV gain 20364138
nsv828187 CNV gain 20364138
nsv962493 CNV duplication 23825009
nsv978608 CNV duplication 23825009
nsv978609 CNV duplication 23825009

Variation tolerance for ZNF519 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF519 Gene

Human Gene Mutation Database (HGMD)
ZNF519
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF519

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF519 Gene

Disorders for ZNF519 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF519 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anonychia congenita
  • nail disorder, nonsyndromic congenital, 4
nail disease
  • nail diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF519

Genetic Association Database (GAD)
ZNF519
Human Genome Epidemiology (HuGE) Navigator
ZNF519
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF519
genes like me logo Genes that share disorders with ZNF519: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF519 Gene

Publications for ZNF519 Gene

  1. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 46 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3 65
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65

Products for ZNF519 Gene

Sources for ZNF519 Gene

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