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Aliases for ZNF519 Gene

Aliases for ZNF519 Gene

  • Zinc Finger Protein 519 2 3
  • Similar To Zinc Finger Protein 85 (Zinc Finger Protein HPF4) (HTF1) 2
  • HsT2362 3

External Ids for ZNF519 Gene

Summaries for ZNF519 Gene

GeneCards Summary for ZNF519 Gene

ZNF519 (Zinc Finger Protein 519) is a Protein Coding gene. Diseases associated with ZNF519 include nail disease. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF519 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF519 Gene

Genomics for ZNF519 Gene

Genomic Location for ZNF519 Gene

Start:
14,057,457 bp from pter
End:
14,132,490 bp from pter
Size:
75,034 bases
Orientation:
Minus strand

Genomic View for ZNF519 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF519 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF519 Gene

Regulatory Elements for ZNF519 Gene

Proteins for ZNF519 Gene

  • Protein details for ZNF519 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB69-ZN519_HUMAN
    Recommended name:
    Zinc finger protein 519
    Protein Accession:
    Q8TB69
    Secondary Accessions:

    Protein attributes for ZNF519 Gene

    Size:
    540 amino acids
    Molecular mass:
    63020 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF519 Gene

Proteomics data for ZNF519 Gene at MOPED

Post-translational modifications for ZNF519 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys355

Other Protein References for ZNF519 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF519 Gene

Domains for ZNF519 Gene

Gene Families for ZNF519 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF519 Gene

UniProtKB/Swiss-Prot:

ZN519_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q8TB69
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8TB69
Similarity:
  • Contains 10 C2H2-type zinc fingers.:
    • Q8TB69
genes like me logo Genes that share domains with ZNF519: view

Function for ZNF519 Gene

Molecular function for ZNF519 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF519: view

miRNA for ZNF519 Gene

miRTarBase miRNAs that target ZNF519

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF519 Gene

Localization for ZNF519 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF519 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF519 Gene COMPARTMENTS Subcellular localization image for ZNF519 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF519: view

Pathways for ZNF519 Gene

SuperPathways for ZNF519 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF519: view

Pathways by source for ZNF519 Gene

2 Reactome pathways for ZNF519 Gene

Gene Ontology (GO) - Biological Process for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF519: view

Transcripts for ZNF519 Gene

Unigene Clusters for ZNF519 Gene

Zinc finger protein 519:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF519 Gene

No ASD Table

Relevant External Links for ZNF519 Gene

GeneLoc Exon Structure for
ZNF519
ECgene alternative splicing isoforms for
ZNF519

Expression for ZNF519 Gene

mRNA expression in normal human tissues for ZNF519 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF519 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.0) and Brain - Cerebellum (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF519 Gene

SOURCE GeneReport for Unigene cluster for ZNF519 Gene Hs.352635

genes like me logo Genes that share expressions with ZNF519: view

Orthologs for ZNF519 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF519 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF519 36
  • 99.44 (n)
  • 99.07 (a)
ZNF519 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 34 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp386 36
  • 61.79 (n)
  • 44.68 (a)
Zfp386 16
Zfp493 37
  • 53 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 37 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp386 36
  • 63 (n)
  • 49.91 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 45 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
Species with no ortholog for ZNF519:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF519 Gene

ENSEMBL:
Gene Tree for ZNF519 (if available)
TreeFam:
Gene Tree for ZNF519 (if available)

Paralogs for ZNF519 Gene

Selected SIMAP similar genes for ZNF519 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF519: view

Variants for ZNF519 Gene

Sequence variations from dbSNP and Humsavar for ZNF519 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs957408 -- 14,091,718(-) TCATT(C/T)TTCTC intron-variant
rs1057498 -- 14,076,200(-) AAAAA(A/G/T)AAAAT nc-transcript-variant
rs1940808 -- 14,078,211(+) CTGTG(C/T)GGCCA nc-transcript-variant
rs1940809 -- 14,096,922(+) ATCCA(A/G)GTTGT intron-variant
rs1940812 -- 14,099,375(+) TAACT(C/G)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF519 Gene

Variant ID Type Subtype PubMed ID
nsv909415 CNV Gain 21882294
dgv1013e1 CNV Complex 17122850
nsv909416 CNV Gain 21882294
nsv520945 CNV Loss 19592680
nsv909417 CNV Gain 21882294
nsv828185 CNV Gain 20364138
essv3388 CNV CNV 17122850
nsv516839 CNV Loss 19592680
nsv528944 CNV Loss 19592680
nsv828187 CNV Gain 20364138
esv994375 CNV Loss 20482838
esv27400 CNV Gain 19812545

Relevant External Links for ZNF519 Gene

HapMap Linkage Disequilibrium report
ZNF519

Disorders for ZNF519 Gene

(1) MalaCards Diseases for ZNF519 Gene

Search for ZNF519 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZNF519 Gene

Relevant External Links for ZNF519

Genetic Association Database (GAD)
ZNF519
Human Genome Epidemiology (HuGE) Navigator
ZNF519
genes like me logo Genes that share disorders with ZNF519: view

No data available for UniProtKB/Swiss-Prot for ZNF519 Gene

Publications for ZNF519 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 49
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF519 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF519
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF519
    • Block miRNA regulation of ZNF519 using miScript Target Protectors

    Sources for ZNF519 Gene

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