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Aliases for ZNF518B Gene

Aliases for ZNF518B Gene

  • Zinc Finger Protein 518B 2 3 5
  • KIAA1729 4

External Ids for ZNF518B Gene

Previous GeneCards Identifiers for ZNF518B Gene

  • GC04M010050
  • GC04M009775

Summaries for ZNF518B Gene

GeneCards Summary for ZNF518B Gene

ZNF518B (Zinc Finger Protein 518B) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF518A.

UniProtKB/Swiss-Prot for ZNF518B Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF518B Gene

Genomics for ZNF518B Gene

Regulatory Elements for ZNF518B Gene

Enhancers for ZNF518B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G010167 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +285.3 285306 8.5 HDGF PKNOX1 ARNT ZNF766 CBX5 REST ZNF592 SREBF1 SMARCA4 HMBOX1 ENSG00000261490 SLC2A9 ZNF518B LOC105374476 ENSG00000251296 LOC100129344
GH04G010203 1.2 ENCODE dbSUPER 13.6 +253.0 253002 1.6 HDGF ATF1 ZNF766 CBX5 GATA2 FOS KLF13 NCOA1 ZNF592 MBD2 SLC2A9 ZNF518B ENSG00000261490 LOC100129344 ENSG00000271544
GH04G010344 1.1 FANTOM5 ENCODE 11.4 +111.5 111453 2.0 HDAC1 PKNOX1 TBL1XR1 TCF12 ZNF766 GATA2 ZBTB11 NCOA1 ZEB2 ZNF592 SLC2A9 ZNF518B LOC100422639 GC04M010387
GH04G010281 0.8 ENCODE 14.6 +173.7 173711 4.2 HDAC1 ESRRA PKNOX1 TBL1XR1 JUN FOSL1 TCF12 GATA2 NCOR1 NR2F6 ZNF518B SLC2A9 ENSG00000261490 LOC100422637 ENSG00000250074
GH04G009979 0.7 FANTOM5 12.2 +478.0 478015 0.3 CTCF HDGF ZIK1 FEZF1 YBX1 PLRG1 ZIC2 OSR2 GLIS2 GLIS1 ENPP7P10 ZNF518B LOC105374476 PIR53482
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF518B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF518B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000165879 310 1001 HDAC1 HDGF ATF1 PKNOX1 NFRKB SIN3A ZBTB40 YY1 EGR1 CBX5

Genomic Location for ZNF518B Gene

Chromosome:
4
Start:
10,439,873 bp from pter
End:
10,457,410 bp from pter
Size:
17,538 bases
Orientation:
Minus strand

Genomic View for ZNF518B Gene

Genes around ZNF518B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF518B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF518B Gene

Proteins for ZNF518B Gene

  • Protein details for ZNF518B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D4-Z518B_HUMAN
    Recommended name:
    Zinc finger protein 518B
    Protein Accession:
    Q9C0D4
    Secondary Accessions:
    • Q96LN8

    Protein attributes for ZNF518B Gene

    Size:
    1074 amino acids
    Molecular mass:
    119531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF518B Gene

Post-translational modifications for ZNF518B Gene

  • Ubiquitination at isoforms=68, isoforms=414, posLast=508508, isoforms=875, posLast=912912, and posLast=10041004
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF518B Gene

No data available for DME Specific Peptides for ZNF518B Gene

Domains & Families for ZNF518B Gene

Gene Families for ZNF518B Gene

Protein Domains for ZNF518B Gene

Suggested Antigen Peptide Sequences for ZNF518B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0D4

UniProtKB/Swiss-Prot:

Z518B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF518B: view

Function for ZNF518B Gene

Molecular function for ZNF518B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF518B: view

Phenotypes for ZNF518B Gene

GenomeRNAi human phenotypes for ZNF518B:
genes like me logo Genes that share phenotypes with ZNF518B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF518B Gene

Localization for ZNF518B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF518B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF518B gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF518B: view

Pathways & Interactions for ZNF518B Gene

SuperPathways for ZNF518B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF518B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF518B Gene

Drugs & Compounds for ZNF518B Gene

No Compound Related Data Available

Transcripts for ZNF518B Gene

Unigene Clusters for ZNF518B Gene

Zinc finger protein 518B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF518B Gene

No ASD Table

Relevant External Links for ZNF518B Gene

GeneLoc Exon Structure for
ZNF518B
ECgene alternative splicing isoforms for
ZNF518B

Expression for ZNF518B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF518B Gene

Protein differential expression in normal tissues from HIPED for ZNF518B Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF518B Gene



Protein tissue co-expression partners for ZNF518B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF518B Gene:

ZNF518B

SOURCE GeneReport for Unigene cluster for ZNF518B Gene:

Hs.455089

Evidence on tissue expression from TISSUES for ZNF518B Gene

  • Adrenal gland(2.1)
  • Lung(2.1)
  • Skin(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ZNF518B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF518B Gene

Orthologs for ZNF518B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF518B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF518B 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia ZNF518B 34 35
  • 84.84 (n)
cow
(Bos Taurus)
Mammalia ZNF518B 34 35
  • 79.2 (n)
rat
(Rattus norvegicus)
Mammalia Zfp518b 34
  • 75.94 (n)
mouse
(Mus musculus)
Mammalia Zfp518b 34 16 35
  • 75.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF518B 35
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF518B 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF518B 34 35
  • 58.49 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF518B 35
  • 14 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16698 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15195 34
zebrafish
(Danio rerio)
Actinopterygii ZNF518B 35
  • 19 (a)
OneToOne
Species where no ortholog for ZNF518B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF518B Gene

ENSEMBL:
Gene Tree for ZNF518B (if available)
TreeFam:
Gene Tree for ZNF518B (if available)

Paralogs for ZNF518B Gene

Paralogs for ZNF518B Gene

genes like me logo Genes that share paralogs with ZNF518B: view

Variants for ZNF518B Gene

Sequence variations from dbSNP and Humsavar for ZNF518B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000056824 -- 10,442,822(+) AAAGA(A/C)AAGTC utr-variant-3-prime
rs1000076579 -- 10,452,221(+) TGTCC(C/G)TCATT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000151484 -- 10,443,468(+) CTTCT(A/G)GCGAG reference, missense
rs1000182371 -- 10,446,201(+) ACAAA(A/T)GGGTT reference, missense
rs1000286419 -- 10,440,645(+) GAAAA(C/T)CCTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF518B Gene

Variant ID Type Subtype PubMed ID
esv2759223 CNV loss 17122850
esv3599589 CNV gain 21293372
esv3599622 CNV gain 21293372
esv3893876 CNV gain 25118596
esv3893877 CNV loss 25118596
nsv1014335 CNV gain 25217958
nsv1122083 CNV deletion 24896259
nsv517971 CNV gain 19592680
nsv593727 CNV gain 21841781
nsv829858 CNV gain+loss 17160897

Variation tolerance for ZNF518B Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF518B Gene

Human Gene Mutation Database (HGMD)
ZNF518B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF518B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF518B Gene

Disorders for ZNF518B Gene

Relevant External Links for ZNF518B

Human Genome Epidemiology (HuGE) Navigator
ZNF518B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF518B

No disorders were found for ZNF518B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF518B Gene

Publications for ZNF518B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. In silico RNA-seq and experimental analyses reveal the differential expression and splicing of EPDR1 and ZNF518B genes in relation to KRAS mutations in colorectal cancer cells. (PMID: 27805251) Riffo-Campos A.8.L. … Franco L. (Oncol. Rep. 2016) 3 64
  4. Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets. (PMID: 25591661) Jin T.B. … Kang L. (Rheumatol. Int. 2015) 3 64
  5. SLC2A9 and ZNF518B polymorphisms correlate with gout-related metabolic indices in Chinese Tibetan populations. (PMID: 26345926) Zhang X.Y. … Chen C. (Genet. Mol. Res. 2015) 3 64

Products for ZNF518B Gene

Sources for ZNF518B Gene

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