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ZNF518B Gene

protein-coding   GIFtS: 42
GCID: GC04M010442

Zinc Finger Protein 518B

  Search for ZNF518B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 518B1 2
KIAA17293

External Ids:    HGNC: 293651   Entrez Gene: 854602   Ensembl: ENSG000001781637   UniProtKB: Q9C0D43   

Export aliases for ZNF518B gene to outside databases

Previous GC identifers: GC04M010050 GC04M009775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF518B Gene:
ZNF518B (zinc finger protein 518B) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity.

UniProtKB/Swiss-Prot: Z518B_HUMAN, Q9C0D4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF518B gene promoter:
         Nkx3-1   STAT1   Nkx3-1 v4   STAT1beta   Nkx3-1 v1   STAT1alpha   Nkx3-1 v2   STAT2   STAT3   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF518B promoter sequence
   Search Chromatin IP Primers for ZNF518B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF518B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

ZNF518B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF518B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M010442:  view genomic region     (about GC identifiers)

Start:
10,441,498 bp from pter      End:
10,459,034 bp from pter
Size:
17,537 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: Z518B_HUMAN, Q9C0D4 (See protein sequence)
Recommended Name: Zinc finger protein 518B  
Size: 1074 amino acids; 119531 Da
Secondary accessions: Q96LN8

Explore the universe of human proteins at neXtProt for ZNF518B: NX_Q9C0D4

Explore proteomics data for ZNF518B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys68, Lys76, Lys414, Lys508, Lys875, Lys912, Lys1004
  • Modification sites at PhosphoSitePlus

  • See ZNF518B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_444270.2  
    ENSEMBL proteins: 
     ENSP00000317614   ENSP00000425298  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam
     IPR028379 Znf_518B
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9C0D4

    ProtoNet protein and cluster: Q9C0D4

    UniProtKB/Swiss-Prot: Z518B_HUMAN, Q9C0D4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with ZNF518B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z518B_HUMAN, Q9C0D4
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF518B           About GenesLikeMe


    Animal Models:
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    hsa-miR-548j hsa-miR-15a hsa-miR-29a hsa-miR-218 hsa-miR-424 hsa-miR-155 hsa-miR-155* hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNF518B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    Z518B_HUMAN, Q9C0D4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    Find genes that share ontologies with ZNF518B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF518B
    Interactions:

        Search GeneGlobe Interaction Network for ZNF518B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF518B (ENSP000003176144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with ZNF518B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF518B (Z518B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF518B gene: 
    NM_053042.2  

    Unigene Cluster for ZNF518B:

    Zinc finger protein 518B
    Hs.455089  [show with all ESTs]
    Unigene Representative Sequence: NM_053042
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326756(uc003gmn.3) ENST00000507515 ENST00000500268 ENST00000515072
    ENST00000503068
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF518B (see all 42):
    hsa-miR-548j hsa-miR-15a hsa-miR-29a hsa-miR-218 hsa-miR-424 hsa-miR-155 hsa-miR-155* hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNF518B 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF518B

    Additional mRNA sequence: 

    AB051516.1 AK058072.2 AK092268.1 AK122755.1 AL833306.1 BC040874.1 BC067880.1 BC111484.1 
    BC146815.1 

    3 DOTS entries:

    DT.445472  DT.40229642  DT.100060805 

    Selected AceView cDNA sequences (see all 98):

    AI871840 AI984645 AA588167 H57246 CR591804 CR605217 CR613517 T16318 
    AW512869 BU194138 AA723833 BX327437 AA905318 BC040874 AL520650 AA907152 
    BM994659 AA653420 CA449522 CD656908 AL833306 AW270138 BQ716939 AA450069 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF518B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTATATA
    ZNF518B Expression
    About this image

    ZNF518B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF518B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.455089
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF518B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp518b1 , 5 zinc finger protein 518B1, 5 75.87(n)1
    72.1(a)1
      5 (20.77 cM)5
    1005151  NM_001081144.21  NP_001074613.21 
     386684845 
    chicken
    (Gallus gallus)
    Aves ZNF518B1 zinc finger protein 518B 58.49(n)
    50.58(a)
      422841  XM_004936164.1  XP_004936221.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF518B6
    zinc finger protein 518B
    14(a)
    1 ↔ 1
    GL343262.1(1394417-1398883)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151952 Xenopus laevis transcribed sequence with weak similarity more 76.82(n)    BU914159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF518B6
    zinc finger protein 518B
    19(a)
    1 ↔ 1
    14(264899-267553) ENSDARG00000090832


    ENSEMBL Gene Tree for ZNF518B (if available)
    TreeFam Gene Tree for ZNF518B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF518B (see all 549)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449853091,2
    C--10441450(+) CTCAGA/TAATGT 1 -- ds50010--------
    rs1490818711,2
    --10441454(+) GAAATA/GTATAA 1 -- ds50010--------
    rs1448227751,2
    --10441456(+) AATGTA/GTAATA 1 -- ds50010--------
    rs1997360621,2
    --10441530(+) TGTTG-/CTTT  
            
    ATTTA
    1 -- ut310--------
    rs353695961,2
    C--10441531(+) GTTGC-/TTTA  
            
    TTTAA
    1 -- ut310--------
    rs1387572701,2
    C--10441551(+) TTATGC/TCAACT 1 -- ut310--------
    rs1440596161,2
    C--10441614(+) TGTTA-/ACACAGG 1 -- ut310--------
    rs1861956241,2
    --10441656(+) AATGTC/TTTGTT 1 -- ut310--------
    rs1404090731,2
    --10441666(+) TTCTGC/TTCATA 1 -- ut310--------
    rs1452014101,2
    C--10441687(+) CAGATC/TTAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF518B (10441498 - 10459034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF518B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517971CNV Gain19592680
    dgv5479n71CNV Gain21882294
    nsv829858CNV Gain+Loss17160897
    dgv1580e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF518B           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: ZNF518B (1 document)

    Export disorders for ZNF518B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF518B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF518B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85460 HGNC: 29365 AceView: KIAA1729 Ensembl:ENSG00000178163 euGenes: HUgn85460
    ECgene: ZNF518B H-InvDB: ZNF518B

    (According to HUGE)
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    HUGE: KIAA1729

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF518B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF518B gene:
    Search GeneIP for patents involving ZNF518B

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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