Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF518B Gene

Aliases for ZNF518B Gene

  • Zinc Finger Protein 518B 2 3 5
  • KIAA1729 4

External Ids for ZNF518B Gene

Previous GeneCards Identifiers for ZNF518B Gene

  • GC04M010050
  • GC04M009775

Summaries for ZNF518B Gene

GeneCards Summary for ZNF518B Gene

ZNF518B (Zinc Finger Protein 518B) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF518A.

UniProtKB/Swiss-Prot for ZNF518B Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF518B Gene

Genomics for ZNF518B Gene

Regulatory Elements for ZNF518B Gene

Promoters for ZNF518B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF518B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF518B Gene

Chromosome:
4
Start:
10,439,873 bp from pter
End:
10,457,410 bp from pter
Size:
17,538 bases
Orientation:
Minus strand

Genomic View for ZNF518B Gene

Genes around ZNF518B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF518B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF518B Gene

Proteins for ZNF518B Gene

  • Protein details for ZNF518B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D4-Z518B_HUMAN
    Recommended name:
    Zinc finger protein 518B
    Protein Accession:
    Q9C0D4
    Secondary Accessions:
    • Q96LN8

    Protein attributes for ZNF518B Gene

    Size:
    1074 amino acids
    Molecular mass:
    119531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF518B Gene

Proteomics data for ZNF518B Gene at MOPED

Post-translational modifications for ZNF518B Gene

  • Ubiquitination at Lys 68, Lys 414, Lys 508, Lys 875, Lys 912, and Lys 1004
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF518B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF518B Gene

Domains & Families for ZNF518B Gene

Gene Families for ZNF518B Gene

Protein Domains for ZNF518B Gene

Suggested Antigen Peptide Sequences for ZNF518B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0D4

UniProtKB/Swiss-Prot:

Z518B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF518B: view

Function for ZNF518B Gene

Molecular function for ZNF518B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF518B Gene

GenomeRNAi human phenotypes for ZNF518B:
genes like me logo Genes that share phenotypes with ZNF518B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF518B Gene

Localization for ZNF518B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF518B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF518B Gene COMPARTMENTS Subcellular localization image for ZNF518B gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF518B Gene

Pathways & Interactions for ZNF518B Gene

SuperPathways for ZNF518B Gene

No Data Available

Interacting Proteins for ZNF518B Gene

Gene Ontology (GO) - Biological Process for ZNF518B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF518B Gene

Drugs & Compounds for ZNF518B Gene

No Compound Related Data Available

Transcripts for ZNF518B Gene

Unigene Clusters for ZNF518B Gene

Zinc finger protein 518B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF518B Gene

No ASD Table

Relevant External Links for ZNF518B Gene

GeneLoc Exon Structure for
ZNF518B
ECgene alternative splicing isoforms for
ZNF518B

Expression for ZNF518B Gene

mRNA expression in normal human tissues for ZNF518B Gene

Protein differential expression in normal tissues from HIPED for ZNF518B Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF518B Gene



SOURCE GeneReport for Unigene cluster for ZNF518B Gene Hs.455089

genes like me logo Genes that share expression patterns with ZNF518B: view

Protein tissue co-expression partners for ZNF518B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF518B Gene

Orthologs for ZNF518B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF518B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF518B 35
  • 99.1 (n)
  • 98.6 (a)
ZNF518B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF518B 36
  • 77 (a)
OneToOne
ZNF518B 35
  • 79.2 (n)
  • 75.28 (a)
dog
(Canis familiaris)
Mammalia ZNF518B 35
  • 84.84 (n)
  • 80.67 (a)
ZNF518B 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp518b 16
Zfp518b 36
  • 70 (a)
OneToOne
Zfp518b 35
  • 75.87 (n)
  • 72.1 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF518B 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF518B 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp518b 35
  • 75.94 (n)
  • 71.44 (a)
chicken
(Gallus gallus)
Aves ZNF518B 36
  • 39 (a)
OneToOne
ZNF518B 35
  • 58.49 (n)
  • 50.58 (a)
lizard
(Anolis carolinensis)
Reptilia ZNF518B 36
  • 14 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15195 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16698 35
zebrafish
(Danio rerio)
Actinopterygii ZNF518B 36
  • 19 (a)
OneToOne
Species with no ortholog for ZNF518B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF518B Gene

ENSEMBL:
Gene Tree for ZNF518B (if available)
TreeFam:
Gene Tree for ZNF518B (if available)

Paralogs for ZNF518B Gene

Paralogs for ZNF518B Gene

genes like me logo Genes that share paralogs with ZNF518B: view

Variants for ZNF518B Gene

Sequence variations from dbSNP and Humsavar for ZNF518B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10016702 - 10,446,016(+) ACTGG(A/G/T)ATTAT reference, missense
rs9291410 - 10,444,761(+) GTGAG(C/G/T)TACTG reference, missense
rs10007352 - 10,446,055(+) TGCAC(C/T)GAGGC reference, missense
rs3217 -- 10,443,026(+) TATTT(C/T)TTCTA utr-variant-3-prime
rs4279200 -- 10,451,327(+) AAAAT(G/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF518B Gene

Variant ID Type Subtype PubMed ID
nsv829858 CNV Gain+Loss 17160897
dgv1580e1 CNV Complex 17122850
nsv517971 CNV Gain 19592680
dgv5479n71 CNV Gain 21882294

Variation tolerance for ZNF518B Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF518B Gene

HapMap Linkage Disequilibrium report
ZNF518B
Human Gene Mutation Database (HGMD)
ZNF518B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF518B Gene

Disorders for ZNF518B Gene

Relevant External Links for ZNF518B

Human Genome Epidemiology (HuGE) Navigator
ZNF518B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF518B

No disorders were found for ZNF518B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF518B Gene

Publications for ZNF518B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF518B Gene

Sources for ZNF518B Gene

Back to Top

Content