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Aliases for ZNF518B Gene

Aliases for ZNF518B Gene

  • Zinc Finger Protein 518B 2 3
  • KIAA1729 4

External Ids for ZNF518B Gene

Previous GeneCards Identifiers for ZNF518B Gene

  • GC04M010050
  • GC04M009775

Summaries for ZNF518B Gene

GeneCards Summary for ZNF518B Gene

ZNF518B (Zinc Finger Protein 518B) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity.

UniProtKB/Swiss-Prot for ZNF518B Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF518B Gene

Genomics for ZNF518B Gene

Regulatory Elements for ZNF518B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF518B Gene

Start:
10,439,873 bp from pter
End:
10,457,410 bp from pter
Size:
17,538 bases
Orientation:
Minus strand

Genomic View for ZNF518B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF518B Gene

Proteins for ZNF518B Gene

  • Protein details for ZNF518B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D4-Z518B_HUMAN
    Recommended name:
    Zinc finger protein 518B
    Protein Accession:
    Q9C0D4
    Secondary Accessions:
    • Q96LN8

    Protein attributes for ZNF518B Gene

    Size:
    1074 amino acids
    Molecular mass:
    119531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF518B Gene

Proteomics data for ZNF518B Gene at MOPED

Post-translational modifications for ZNF518B Gene

  • Ubiquitination at Lys68, Lys76, Lys414, Lys508, Lys875, Lys912, and Lys1004
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF518B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF518B Gene

Domains for ZNF518B Gene

Gene Families for ZNF518B Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF518B Gene

Suggested Antigen Peptide Sequences for ZNF518B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0D4

UniProtKB/Swiss-Prot:

Z518B_HUMAN :
  • Q9C0D4
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF518B: view

Function for ZNF518B Gene

Molecular function for ZNF518B Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF518B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF518B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF518B Gene

Localization for ZNF518B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF518B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF518B Gene COMPARTMENTS Subcellular localization image for ZNF518B gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF518B: view

Pathways for ZNF518B Gene

SuperPathways for ZNF518B Gene

No Data Available

Interacting Proteins for ZNF518B Gene

Gene Ontology (GO) - Biological Process for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF518B: view

No data available for Pathways by source for ZNF518B Gene

Transcripts for ZNF518B Gene

Unigene Clusters for ZNF518B Gene

Zinc finger protein 518B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF518B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF518B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF518B Gene

No ASD Table

Relevant External Links for ZNF518B Gene

GeneLoc Exon Structure for
ZNF518B
ECgene alternative splicing isoforms for
ZNF518B

Expression for ZNF518B Gene

mRNA expression in normal human tissues for ZNF518B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF518B Gene

SOURCE GeneReport for Unigene cluster for ZNF518B Gene Hs.455089

genes like me logo Genes that share expressions with ZNF518B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF518B Gene

Orthologs for ZNF518B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF518B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF518B 35
  • 99.1 (n)
  • 98.6 (a)
ZNF518B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF518B 35
  • 79.2 (n)
  • 75.28 (a)
ZNF518B 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF518B 35
  • 84.84 (n)
  • 80.67 (a)
ZNF518B 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp518b 35
  • 75.87 (n)
  • 72.1 (a)
Zfp518b 16
Zfp518b 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF518B 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF518B 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp518b 35
  • 75.94 (n)
  • 71.44 (a)
chicken
(Gallus gallus)
Aves ZNF518B 35
  • 58.49 (n)
  • 50.58 (a)
ZNF518B 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF518B 36
  • 14 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15195 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16698 35
zebrafish
(Danio rerio)
Actinopterygii ZNF518B 36
  • 19 (a)
OneToOne
Species with no ortholog for ZNF518B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF518B Gene

ENSEMBL:
Gene Tree for ZNF518B (if available)
TreeFam:
Gene Tree for ZNF518B (if available)

Paralogs for ZNF518B Gene

No data available for Paralogs for ZNF518B Gene

Variants for ZNF518B Gene

Sequence variations from dbSNP and Humsavar for ZNF518B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3217 -- 10,443,026(+) TATTT(C/T)TTCTA utr-variant-3-prime
rs9565 -- 10,440,138(+) CTAAA(A/G)AAAAA utr-variant-3-prime
rs4075869 -- 10,458,354(-) CCTTG(C/G)CCCGC upstream-variant-2KB
rs4077362 -- 10,457,345(+) AGGTC(C/T)CGGCG utr-variant-5-prime
rs4077363 -- 10,457,513(+) CGCCC(C/G/T)CGCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF518B Gene

Variant ID Type Subtype PubMed ID
nsv829858 CNV Gain+Loss 17160897
dgv1580e1 CNV Complex 17122850
nsv517971 CNV Gain 19592680
dgv5479n71 CNV Gain 21882294

Relevant External Links for ZNF518B Gene

HapMap Linkage Disequilibrium report
ZNF518B
Human Gene Mutation Database (HGMD)
ZNF518B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF518B Gene

Disorders for ZNF518B Gene

Relevant External Links for ZNF518B

Human Genome Epidemiology (HuGE) Navigator
ZNF518B
genes like me logo Genes that share disorders with ZNF518B: view

No data available for UniProtKB/Swiss-Prot for ZNF518B Gene

Publications for ZNF518B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF518B Gene

Sources for ZNF518B Gene

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