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Aliases for ZNF518A Gene

Aliases for ZNF518A Gene

  • Zinc Finger Protein 518A 2 3 5
  • Zinc Finger Protein 518 2 3
  • ZNF518 3 4
  • KIAA0335 4

External Ids for ZNF518A Gene

Previous HGNC Symbols for ZNF518A Gene

  • ZNF518

Previous GeneCards Identifiers for ZNF518A Gene

  • GC10P097880
  • GC10P091517

Summaries for ZNF518A Gene

Entrez Gene Summary for ZNF518A Gene

  • The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for ZNF518A Gene

ZNF518A (Zinc Finger Protein 518A) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF518B.

UniProtKB/Swiss-Prot for ZNF518A Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF518A Gene

Genomics for ZNF518A Gene

Regulatory Elements for ZNF518A Gene

Promoters for ZNF518A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF518A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF518A Gene

Chromosome:
10
Start:
96,129,200 bp from pter
End:
96,205,288 bp from pter
Size:
76,089 bases
Orientation:
Plus strand

Genomic View for ZNF518A Gene

Genes around ZNF518A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF518A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF518A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF518A Gene

Proteins for ZNF518A Gene

  • Protein details for ZNF518A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AHZ1-Z518A_HUMAN
    Recommended name:
    Zinc finger protein 518A
    Protein Accession:
    Q6AHZ1
    Secondary Accessions:
    • A0PJI5
    • O15044
    • Q32MP4

    Protein attributes for ZNF518A Gene

    Size:
    1483 amino acids
    Molecular mass:
    166782 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30967.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA20793.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF518A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF518A Gene

Proteomics data for ZNF518A Gene at MOPED

Post-translational modifications for ZNF518A Gene

  • Ubiquitination at Lys 433, Lys 1121, and Lys 1438
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF518A Gene

No data available for DME Specific Peptides for ZNF518A Gene

Domains & Families for ZNF518A Gene

Gene Families for ZNF518A Gene

Protein Domains for ZNF518A Gene

Suggested Antigen Peptide Sequences for ZNF518A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6AHZ1

UniProtKB/Swiss-Prot:

Z518A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF518A: view

Function for ZNF518A Gene

Molecular function for ZNF518A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF518A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF518A: view

Phenotypes for ZNF518A Gene

GenomeRNAi human phenotypes for ZNF518A:
genes like me logo Genes that share phenotypes with ZNF518A: view

Animal Model Products

CRISPR Products

miRNA for ZNF518A Gene

miRTarBase miRNAs that target ZNF518A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF518A Gene

Localization for ZNF518A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF518A Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZNF518A Gene

Pathways & Interactions for ZNF518A Gene

SuperPathways for ZNF518A Gene

No Data Available

Interacting Proteins for ZNF518A Gene

Selected Interacting proteins: Q6AHZ1-Z518A_HUMAN for ZNF518A Gene via MINT I2D

Symbol External ID(s) Details
ATF7IP

Gene Ontology (GO) - Biological Process for ZNF518A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF518A: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF518A Gene

Drugs & Compounds for ZNF518A Gene

No Compound Related Data Available

Transcripts for ZNF518A Gene

Unigene Clusters for ZNF518A Gene

Zinc finger protein 518A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF518A Gene

No ASD Table

Relevant External Links for ZNF518A Gene

GeneLoc Exon Structure for
ZNF518A
ECgene alternative splicing isoforms for
ZNF518A

Expression for ZNF518A Gene

mRNA expression in normal human tissues for ZNF518A Gene

Protein differential expression in normal tissues from HIPED for ZNF518A Gene

This gene is overexpressed in Bone (33.5), Plasma (19.5), and Prostate (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZNF518A Gene



SOURCE GeneReport for Unigene cluster for ZNF518A Gene Hs.600823

genes like me logo Genes that share expression patterns with ZNF518A: view

Protein tissue co-expression partners for ZNF518A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF518A Gene

Orthologs for ZNF518A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF518A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF518A 35
  • 87.86 (n)
  • 80.45 (a)
dog
(Canis familiaris)
Mammalia ZNF518A 35
  • 90.1 (n)
  • 85.05 (a)
mouse
(Mus musculus)
Mammalia Zfp518a 35
  • 80.56 (n)
  • 69.61 (a)
Zfp518a 16
chimpanzee
(Pan troglodytes)
Mammalia ZNF518A 35
  • 99.46 (n)
  • 98.85 (a)
rat
(Rattus norvegicus)
Mammalia Zfp518a 35
  • 80.45 (n)
  • 69.79 (a)
chicken
(Gallus gallus)
Aves ZNF518A 35
  • 61.58 (n)
  • 48.75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf518a 35
  • 56.48 (n)
  • 46.39 (a)
Species with no ortholog for ZNF518A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF518A Gene

ENSEMBL:
Gene Tree for ZNF518A (if available)
TreeFam:
Gene Tree for ZNF518A (if available)

Paralogs for ZNF518A Gene

Paralogs for ZNF518A Gene

(2) SIMAP similar genes for ZNF518A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF518A: view

Variants for ZNF518A Gene

Sequence variations from dbSNP and Humsavar for ZNF518A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3814228 - 96,159,158(-) CTTGT(G/T)AGTAA reference, missense
rs3814226 - 96,160,305(-) AAAGC(C/T)GCAAA reference, missense
rs3300 -- 96,144,776(-) GAGGA(C/T)TTGTA intron-variant
rs713070 -- 96,143,590(+) AGAAG(C/G)CTTTG intron-variant
rs1172937 -- 96,140,047(-) aaccc(C/T)gccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF518A Gene

Variant ID Type Subtype PubMed ID
nsv831947 CNV Gain+Loss 17160897

Relevant External Links for ZNF518A Gene

HapMap Linkage Disequilibrium report
ZNF518A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF518A Gene

Disorders for ZNF518A Gene

Relevant External Links for ZNF518A

Genetic Association Database (GAD)
ZNF518A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF518A

No disorders were found for ZNF518A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF518A Gene

Publications for ZNF518A Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for ZNF518A Gene

Sources for ZNF518A Gene

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