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Aliases for ZNF518A Gene

Aliases for ZNF518A Gene

  • Zinc Finger Protein 518A 2 3
  • Zinc Finger Protein 518 2 3
  • ZNF518 3 4
  • KIAA0335 4

External Ids for ZNF518A Gene

Previous Symbols for ZNF518A Gene

  • ZNF518

Summaries for ZNF518A Gene

Entrez Gene Summary for ZNF518A Gene

  • The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for ZNF518A Gene

ZNF518A (Zinc Finger Protein 518A) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity.

UniProtKB/Swiss-Prot for ZNF518A Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF518A Gene

Genomics for ZNF518A Gene

Genomic Location for ZNF518A Gene

Start:
96,129,715 bp from pter
End:
96,205,288 bp from pter
Size:
75,574 bases
Orientation:
Plus strand

Genomic View for ZNF518A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF518A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF518A Gene

Regulatory Elements for ZNF518A Gene

Proteins for ZNF518A Gene

  • Protein details for ZNF518A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AHZ1-Z518A_HUMAN
    Recommended name:
    Zinc finger protein 518A
    Protein Accession:
    Q6AHZ1
    Secondary Accessions:
    • A0PJI5
    • O15044
    • Q32MP4

    Protein attributes for ZNF518A Gene

    Size:
    1483 amino acids
    Molecular mass:
    166782 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30967.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA20793.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF518A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF518A Gene

Proteomics data for ZNF518A Gene at MOPED

Post-translational modifications for ZNF518A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys433, Lys1121, and Lys1438

Other Protein References for ZNF518A Gene

No data available for DME Specific Peptides for ZNF518A Gene

Domains for ZNF518A Gene

Gene Families for ZNF518A Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF518A Gene

UniProtKB/Swiss-Prot:

Z518A_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q6AHZ1
Similarity:
  • Contains 5 C2H2-type zinc fingers.:
    • Q6AHZ1
genes like me logo Genes that share domains with ZNF518A: view

Function for ZNF518A Gene

Molecular function for ZNF518A Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF518A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF518A: view

miRNA for ZNF518A Gene

miRTarBase miRNAs that target ZNF518A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF518A Gene

Localization for ZNF518A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF518A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF518A Gene COMPARTMENTS Subcellular localization image for ZNF518A gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF518A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF518A: view

Pathways for ZNF518A Gene

SuperPathways for ZNF518A Gene

No Data Available

Interacting Proteins for ZNF518A Gene

Selected Interacting proteins: Q6AHZ1-Z518A_HUMAN for ZNF518A Gene via MINT I2D

Symbol External ID(s) Details
ATF7IP

Gene Ontology (GO) - Biological Process for ZNF518A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF518A: view

No data available for Pathways by source for ZNF518A Gene

Transcripts for ZNF518A Gene

Unigene Clusters for ZNF518A Gene

Zinc finger protein 518A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF518A Gene

No ASD Table

Relevant External Links for ZNF518A Gene

GeneLoc Exon Structure for
ZNF518A
ECgene alternative splicing isoforms for
ZNF518A

Expression for ZNF518A Gene

mRNA expression in normal human tissues for ZNF518A Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZNF518A Gene

SOURCE GeneReport for Unigene cluster for ZNF518A Gene Hs.600823

genes like me logo Genes that share expressions with ZNF518A: view

Orthologs for ZNF518A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF518A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF518A 36
  • 99.46 (n)
  • 98.85 (a)
cow
(Bos Taurus)
Mammalia ZNF518A 36
  • 87.86 (n)
  • 80.45 (a)
dog
(Canis familiaris)
Mammalia ZNF518A 36
  • 90.1 (n)
  • 85.05 (a)
mouse
(Mus musculus)
Mammalia Zfp518a 36
  • 80.56 (n)
  • 69.61 (a)
Zfp518a 16
rat
(Rattus norvegicus)
Mammalia Zfp518a 36
  • 80.45 (n)
  • 69.79 (a)
chicken
(Gallus gallus)
Aves ZNF518A 36
  • 61.58 (n)
  • 48.75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf518a 36
  • 56.48 (n)
  • 46.39 (a)
Species with no ortholog for ZNF518A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF518A Gene

ENSEMBL:
Gene Tree for ZNF518A (if available)
TreeFam:
Gene Tree for ZNF518A (if available)

Paralogs for ZNF518A Gene

Selected SIMAP similar genes for ZNF518A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF518A: view

No data available for Paralogs for ZNF518A Gene

Variants for ZNF518A Gene

Sequence variations from dbSNP and Humsavar for ZNF518A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3300 -- 96,144,776(-) GAGGA(C/T)TTGTA intron-variant
rs713070 -- 96,143,590(+) AGAAG(C/G)CTTTG intron-variant
rs1172937 -- 96,140,047(-) aaccc(C/T)gccac intron-variant
rs1172938 -- 96,138,794(-) aatgt(C/T)cttta intron-variant
rs1172939 -- 96,138,045(-) cctga(C/T)atgct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF518A Gene

Variant ID Type Subtype PubMed ID
nsv831947 CNV Gain+Loss 17160897

Relevant External Links for ZNF518A Gene

HapMap Linkage Disequilibrium report
ZNF518A

Disorders for ZNF518A Gene

Relevant External Links for ZNF518A

Genetic Association Database (GAD)
ZNF518A
genes like me logo Genes that share disorders with ZNF518A: view

No data available for UniProtKB/Swiss-Prot for ZNF518A Gene

Publications for ZNF518A Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3

Products for ZNF518A Gene

Sources for ZNF518A Gene

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