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ZNF518A Gene

protein-coding   GIFtS: 44
GCID: GC10P097880

Zinc Finger Protein 518A

(Previous name: zinc finger protein 518)
(Previous symbol: ZNF518)
  Search for ZNF518A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 518A1 2
ZNF5181 2 3
Zinc Finger Protein 5181 2
KIAA03353

External Ids:    HGNC: 290091   Entrez Gene: 98492   Ensembl: ENSG000001778537   UniProtKB: Q6AHZ13   
ORGUL members:         

Export aliases for ZNF518A gene to outside databases

Previous GC identifer: GC10P091517


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF518A Gene:
The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded
protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Several transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Jun 2013)

GeneCards Summary for ZNF518A Gene:
ZNF518A (zinc finger protein 518A) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity.

UniProtKB/Swiss-Prot: Z518A_HUMAN, Q6AHZ1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF518A gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   GATA-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF518A promoter sequence
   Search Chromatin IP Primers for ZNF518A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF518A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23.33

ZNF518A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF518A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P097880:  view genomic region     (about GC identifiers)

Start:
97,889,472 bp from pter      End:
97,965,044 bp from pter
Size:
75,573 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF518A

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: Z518A_HUMAN, Q6AHZ1 (See protein sequence)
Recommended Name: Zinc finger protein 518A  
Size: 1483 amino acids; 166782 Da
Sequence caution: Sequence=AAH30967.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA20793.2; Type=Erroneous initiation;
Secondary accessions: A0PJI5 O15044 Q32MP4
Alternative splicing: 2 isoforms:  Q6AHZ1-1   Q6AHZ1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF518A: NX_Q6AHZ1

Explore proteomics data for ZNF518A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys433, Lys1121, Lys1438
  • Modification sites at PhosphoSitePlus

  • See ZNF518A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265453.1  NP_001265454.1  NP_001265455.1  NP_055618.2  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR027760 ZNF518A
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6AHZ1

    ProtoNet protein and cluster: Q6AHZ1

    UniProtKB/Swiss-Prot: Z518A_HUMAN, Q6AHZ1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    ZNF518A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z518A_HUMAN, Q6AHZ1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF518A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF518A
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    miRNA
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    miRTarBase miRNAs that target ZNF518A:
    hsa-mir-335-5p (MIRT017067)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF518A (see all 79):
    hsa-miR-124* hsa-miR-411* hsa-miR-640 hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-411 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidZNF518A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF518A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    Z518A_HUMAN, Q6AHZ1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF518A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF518A
    Interactions:

        Search GeneGlobe Interaction Network for ZNF518A

    1 Interacting protein for ZNF518A (Q6AHZ12, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61888 I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--

    ZNF518A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF518A (Z518A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF518A gene (4 alternative transcripts): 
    NM_001278524.1  NM_001278525.1  NM_001278526.1  NM_014803.3  

    Unigene Cluster for ZNF518A:

    Zinc finger protein 518A
    Hs.600823  [show with all ESTs]
    Unigene Representative Sequence: NM_014803
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567632(processed_transcript) ENST00000488700(processed_transcript) ENST00000539666(processed_transcript) ENST00000478086(processed_transcript) ENST00000563195(processed_transcript)
    ENST00000484770(processed_transcript) ENST00000371192(processed_transcript) ENST00000442635(processed_transcript) ENST00000534948(processed_transcript) ENST00000316045(processed_transcript)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF518A (see all 79):
    hsa-miR-124* hsa-miR-411* hsa-miR-640 hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-411 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidZNF518A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ZNF518A (NM_014803)
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF518A
      QuantiFast Probe-based Assays in human, mouse, rat ZNF518A

    Additional mRNA sequence: 

    AK095317.1 BC030967.1 BC109045.1 BC109046.1 CR627437.1 

    7 DOTS entries:

    DT.100776754  DT.100652479  DT.114767  DT.95155112  DT.91751016  DT.70102275  DT.91738699 

    Selected AceView cDNA sequences (see all 132):

    BM352112 AA635715 AI473763 CR627437 BM929932 CR600301 AI640190 AW168219 
    BQ004989 CA311955 AA151407 BX109826 CB177955 AI038680 AW664309 AA713943 
    AB002333 BQ773899 N22186 AI191951 AA237019 BM982446 AA410363 BE900217 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF518A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTTAAAG
    ZNF518A Expression
    About this image

    ZNF518A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF518A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.600823
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF518A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF518A gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp518a1 , 5 zinc finger protein 518A1, 5 80.56(n)1
    69.61(a)1
      19 (34.26 cM)5
    726721  NM_028319.11  NP_082595.11 
     408947055 
    chicken
    (Gallus gallus)
    Aves ZNF518A1 zinc finger protein 518A 61.58(n)
    48.75(a)
      428964  XM_004942161.1  XP_004942218.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf518a1 zinc finger protein 518A 56.48(n)
    46.39(a)
      100490499  XM_004915877.1  XP_004915934.1 


    ENSEMBL Gene Tree for ZNF518A (if available)
    TreeFam Gene Tree for ZNF518A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF518A gene
    2 SIMAP similar genes for ZNF518A using alignment to 1 protein entry:     Z518A_HUMAN:
    kr-znf3    ZNF

    ZNF518A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF518A (see all 300)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115958091,2
    C,F,H--97887621(+) TGAATC/TGTACG 1 -- us2k115Minor allele frequency- T:0.25NA NS EA WA 814
    rs753229701,2
    F--97888358(+) GCAAGG/ATTTTG 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs350294981,2
    F--97888895(+) CTGCCC/TTAAGA 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs105097001,2
    C,F,H--97894531(+) TATTAG/CAATGA 1 -- int120Minor allele frequency- C:0.22NS NA EA WA 1030
    rs591453861,2
    C--97897787(+) CTTTC-/TTTC  
            
    AGAGA
    1 -- int10--------
    rs582555211,2
    C--97901067(+) TCAGA-/GAAAGGA 1 -- int10--------
    rs3756021301,2
    C--97902064(+) TAGGG-/TGTGTG 1 -- int10--------
    rs669113871,2
    C--97902066(-) CACAC-/A/    
       ACA
    /C
    CACCC
    2 -- int1 cds11NA 2
    rs606248251,2
    C--97902111(+) TGTGT-/GT    
       
    /GTGT
    TTCTA
    1 -- int12NA 4
    rs344635151,2
    C--97903192(+) CATTGG/TTTCTT 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for ZNF518A (97889472 - 97965044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF518A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831947CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF518A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    ZNF518A for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF518A

    Export disorders for ZNF518A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF518A gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF518A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    8. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9849 HGNC: 29009 AceView: ZNF518 Ensembl:ENSG00000177853 euGenes: HUgn9849
    ECgene: ZNF518A H-InvDB: ZNF518A

    (According to HUGE)
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    HUGE: KIAA0335

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF518A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF518A gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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