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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF518A Gene

protein-coding   GIFtS: 40
GCID: GC10P097880

zinc finger protein 518A

(Previous name: zinc finger protein 518 )
(Previous symbol: ZNF518)
  Search for ZNF518A
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNF518A    

Aliases
for ZNF518A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 518A1 2
ZNF5181 2 3
Zinc Finger Protein 5181 2
KIAA03351 3

External Ids:    HGNC: 290091   Entrez Gene: 98492   Ensembl: ENSG000001778537   UniProtKB: Q6AHZ13   
ORGUL members:         
NONCODE:n340111    

Export aliases for ZNF518A gene to outside databases

Previous GC identifer: GC10P091517


Summaries
for ZNF518A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: Z518A_HUMAN, Q6AHZ1
Function: May be involved in transcriptional regulation




Genomic Views
for ZNF518A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF518A gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   GATA-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF518A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF518A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF518A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23.33

ZNF518A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF518A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P097880:  view genomic region     (about GC identifiers)

Start:
 97,889,472 bp from pter      End:
 97,965,044 bp from pter
Size:
 75,573 bases      Orientation:
 plus strand

Proteins
for ZNF518A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: Z518A_HUMAN, Q6AHZ1 (See protein sequence)
Recommended Name: Zinc finger protein 518A  
Size: 1483 amino acids; 166782 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH30967.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=BAA20793.2; Type=Erroneous initiation;
Secondary accessions: A0PJI5 O15044 Q32MP4
Alternative splicing: 2 isoforms:  Q6AHZ1-1   Q6AHZ1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF518A: NX_Q6AHZ1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6AHZ1

    • ZNF518A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055618.2  
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    Uscn Proteins for ZNF518A

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF518A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZNF518A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNF518A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6AHZ1

    ProtoNet protein and cluster: Q6AHZ1

    UniProtKB/Swiss-Prot: Z518A_HUMAN, Q6AHZ1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    Function
    for ZNF518A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: Z518A_HUMAN, Q6AHZ1
    Function: May be involved in transcriptional regulation

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF518A for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZNF518A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF518A

    1 Interacting protein for ZNF518A (Q6AHZ12, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61888 I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF518A for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF518A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF518A
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    Transcripts
    for ZNF518A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for ZNF518A gene: 
    NM_014803.3  

    Unigene Cluster for ZNF518A:

    Zinc finger protein 518A
    Hs.600823  [show with all ESTs]
    Unigene Representative Sequence: NM_014803
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567632(lincRNA)(uc001klo.1) ENST00000488700(lincRNA) ENST00000539666(lincRNA) ENST00000478086(lincRNA)
    ENST00000563195(lincRNA) ENST00000484770(lincRNA) ENST00000371192(lincRNA) ENST00000442635(lincRNA) ENST00000534948(lincRNA)(uc001klp.3 uc001klq.3 uc001klr.3)
    ENST00000316045(lincRNA)

    miRNA
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    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF518A (see all 79):
    hsa-miR-124* hsa-miR-411* hsa-miR-640 hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-411 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF518A 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK095317.1 BC030967.1 BC109045.1 BC109046.1 CR627437.1 

    7 DOTS entries:

    DT.100776754  DT.100652479  DT.114767  DT.95155112  DT.91751016  DT.70102275  DT.91738699 

    24/132 AceView cDNA sequences (see all 132):

    AI191951 AA151407 BX109826 AI473763 AB002333 BE900217 AA635715 N22186 
    BM352112 BQ773899 BX954912 BQ004989 AW168219 BM982446 CB177955 AA361886 
    CA311955 BC030967 CR627437 AI492759 BX488208 AA713943 CR600301 BM929932 

    GeneLoc Exon Structure


    Expression
    for ZNF518A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF518A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGTTTAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ZNF518A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF518A

    SOURCE GeneReport for Unigene cluster: Hs.600823
        SABiosciences Custom PCR Arrays for ZNF518A
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    In Situ
    Assay Products:     
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    Orthologs
    for ZNF518A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF518A gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp518a1 , 5 zinc finger protein 518A1, 5 80.61(n)1
    69.61(a)1    		   19 (34.26 cM)5
    726721  NM_028319.11  NP_082595.11 
     408947055 
    chicken
    (Gallus gallus)    		 Aves ZNF518A1 zinc finger protein 518A 60.87(n)
    47.8(a)    		   428964  XM_426521.3  XP_426521.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii im:69124471 im:6912447 45.62(n)
    33.67(a)    		   798582  XM_001338990.4  XP_001339026.1 


    ENSEMBL Gene Tree for ZNF518A (if available)
    TreeFam Gene Tree for ZNF518A (if available) 

    Paralogs
    for ZNF518A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ZNF518A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 NCBI SNPs in ZNF518A are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1131782781,2
    		C,--97920099(+) AATGTC/-CTAGG 2 /CP /CP* fra11Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for ZNF518A (97889472 - 97965044 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF518A: --

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    Disorders / Diseases
    for ZNF518A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for ZNF518A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF518A gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF518A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    10. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)

    External Searches for ZNF518A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNF518A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9849 HGNC: 29009 AceView: ZNF518 Ensembl:ENSG00000177853 euGenes: HUgn9849
    ECgene: ZNF518A H-InvDB: ZNF518A

    Other Databases showing ZNF518A gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0335

    Specialized Databases showing ZNF518A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF518A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF518A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNF518A gene:
    Search GeneIP for patents involving ZNF518A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZNF518A gene

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    About This Section

     
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