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Aliases for ZNF517 Gene

Aliases for ZNF517 Gene

  • Zinc Finger Protein 517 2 3 5

External Ids for ZNF517 Gene

Previous GeneCards Identifiers for ZNF517 Gene

  • GC08P146029
  • GC08P145995
  • GC08P146024
  • GC08P141139

Summaries for ZNF517 Gene

GeneCards Summary for ZNF517 Gene

ZNF517 (Zinc Finger Protein 517) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF517 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF517 Gene

Genomics for ZNF517 Gene

Regulatory Elements for ZNF517 Gene

Enhancers for ZNF517 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF517 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF517 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF517 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF517 Gene

Chromosome:
8
Start:
144,798,876 bp from pter
End:
144,811,169 bp from pter
Size:
12,294 bases
Orientation:
Plus strand

Genomic View for ZNF517 Gene

Genes around ZNF517 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF517 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF517 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF517 Gene

Proteins for ZNF517 Gene

  • Protein details for ZNF517 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMY9-ZN517_HUMAN
    Recommended name:
    Zinc finger protein 517
    Protein Accession:
    Q6ZMY9

    Protein attributes for ZNF517 Gene

    Size:
    492 amino acids
    Molecular mass:
    54711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF517 Gene

Proteomics data for ZNF517 Gene at MOPED

Post-translational modifications for ZNF517 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF517 Gene

No data available for DME Specific Peptides for ZNF517 Gene

Domains & Families for ZNF517 Gene

Gene Families for ZNF517 Gene

Protein Domains for ZNF517 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMY9

UniProtKB/Swiss-Prot:

ZN517_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF517: view

Function for ZNF517 Gene

Molecular function for ZNF517 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF517: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF517 Gene

Localization for ZNF517 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF517 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF517 Gene COMPARTMENTS Subcellular localization image for ZNF517 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF517 Gene

Pathways & Interactions for ZNF517 Gene

SuperPathways for ZNF517 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF517: view

Pathways by source for ZNF517 Gene

2 Reactome pathways for ZNF517 Gene

Interacting Proteins for ZNF517 Gene

Gene Ontology (GO) - Biological Process for ZNF517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF517: view

No data available for SIGNOR curated interactions for ZNF517 Gene

Drugs & Compounds for ZNF517 Gene

No Compound Related Data Available

Transcripts for ZNF517 Gene

Unigene Clusters for ZNF517 Gene

Zinc finger protein 517:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF517 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8
SP1: - -
SP2: - - - - - - - -
SP3:
SP4: - -
SP5: -
SP6: - - - - - -

Relevant External Links for ZNF517 Gene

GeneLoc Exon Structure for
ZNF517
ECgene alternative splicing isoforms for
ZNF517

Expression for ZNF517 Gene

mRNA expression in normal human tissues for ZNF517 Gene

Protein differential expression in normal tissues from HIPED for ZNF517 Gene

This gene is overexpressed in Heart (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF517 Gene



SOURCE GeneReport for Unigene cluster for ZNF517 Gene Hs.521942

genes like me logo Genes that share expression patterns with ZNF517: view

Protein tissue co-expression partners for ZNF517 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF517 Gene

Orthologs for ZNF517 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF517 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF517 35
  • 80.59 (n)
  • 78.27 (a)
ZNF517 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF517 35
  • 98.49 (n)
  • 97.95 (a)
ZNF517 36
  • 99 (a)
OneToOne
Species with no ortholog for ZNF517:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF517 Gene

ENSEMBL:
Gene Tree for ZNF517 (if available)
TreeFam:
Gene Tree for ZNF517 (if available)

Paralogs for ZNF517 Gene

(481) SIMAP similar genes for ZNF517 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF517: view

No data available for Paralogs for ZNF517 Gene

Variants for ZNF517 Gene

Sequence variations from dbSNP and Humsavar for ZNF517 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2976649 - 144,802,931(+) ACTCC(C/T)GATGC reference, synonymous-codon, missense
rs7829752 -- 144,800,116(+) TCTGC(A/G)TATGG intron-variant, upstream-variant-2KB
rs7840744 -- 144,798,455(+) gagcg(A/G)gactc upstream-variant-2KB
rs9801844 -- 144,801,564(+) GCTCC(A/G)CCTCC intron-variant
rs10089228 -- 144,804,699(+) CAAGG(C/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF517 Gene

Variant ID Type Subtype PubMed ID
nsv891807 CNV Loss 21882294
nsv891897 CNV Loss 21882294
nsv522459 CNV Loss 19592680
nsv891925 CNV Loss 21882294
dgv7985n71 CNV Loss 21882294
nsv891929 CNV Loss 21882294
nsv523879 CNV Loss 19592680

Variation tolerance for ZNF517 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF517 Gene

HapMap Linkage Disequilibrium report
ZNF517
Human Gene Mutation Database (HGMD)
ZNF517

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF517 Gene

Disorders for ZNF517 Gene

Relevant External Links for ZNF517

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF517

No disorders were found for ZNF517 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF517 Gene

Publications for ZNF517 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF517 Gene

Sources for ZNF517 Gene

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