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ZNF516 Gene

protein-coding   GIFtS: 50
GCID: GC18M074071

Zinc Finger Protein 516

  Search for ZNF516
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5161 2
KIAA02223 5
HsT2872

External Ids:    HGNC: 289901   Entrez Gene: 96582   Ensembl: ENSG000001014937   OMIM: 6151145   UniProtKB: Q926183   

Export aliases for ZNF516 gene to outside databases

Previous GC identifers: GC18M072199 GC18M072209 GC18M072201 GC18M070754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF516 Gene:
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell
proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the
krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. (provided by
RefSeq, Sep 2012)

GeneCards Summary for ZNF516 Gene:
ZNF516 (zinc finger protein 516) is a protein-coding gene. An important paralog of this gene is ZNF217.

UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618
Function: May be involved in transcriptional regulation. May act as suppressor of replication stress and
chromosome missegregation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF516 gene promoter:
         FOXF2   CUTL1   IRF-1   Meis-1b   AREB6   FOXO4   Meis-1a   TGIF   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF516

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF516


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

ZNF516 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF516 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M074071:  view genomic region     (about GC identifiers)

Start:
74,069,637 bp from pter      End:
74,207,146 bp from pter
Size:
137,510 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF516

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618 (See protein sequence)
Recommended Name: Zinc finger protein 516  
Size: 1163 amino acids; 124289 Da
Sequence caution: Sequence=BAA13211.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for ZNF516: NX_Q92618

Explore proteomics data for ZNF516 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF516 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055458.1  
    ENSEMBL proteins: 
     ENSP00000445902   ENSP00000446211   ENSP00000394757  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q92618

    ProtoNet protein and cluster: Q92618

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    Find genes that share domains with ZNF516           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN516_HUMAN, Q92618
    Function: May be involved in transcriptional regulation. May act as suppressor of replication stress and
    chromosome missegregation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF516           About GenesLikeMe


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ZNF516:
    hsa-mir-186-5p (MIRT045309)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF516 (see all 134):
    hsa-miR-194* hsa-miR-579 hsa-miR-361-5p hsa-miR-4275 hsa-miR-208b hsa-miR-298 hsa-miR-200b hsa-miR-374b*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN516_HUMAN, Q92618: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF516           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF516
    Interactions:

        Search GeneGlobe Interaction Network for ZNF516

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF516 (Q926182, 3 ENSP000003947574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KDM1AO603413, ENSP000003490494I2D: score=1 STRING: ENSP00000349049
    HIST3H3Q166953, ENSP000003556574I2D: score=1 STRING: ENSP00000355657
    ZBP1Q9H1713, ENSP000003602154I2D: score=1 STRING: ENSP00000360215
    MAP2K5Q131633I2D: score=1 
    --Q9WVS72MINT-19870
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF516           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF516 (ZN516)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF516 gene: 
    NM_014643.3  

    Unigene Cluster for ZNF516:

    Zinc finger protein 516
    Hs.436973  [show with all ESTs]
    Unigene Representative Sequence: NM_014643
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524431 ENST00000543743 ENST00000529449 ENST00000542818 ENST00000532857
    ENST00000443185(uc002lmd.3 uc021ulp.1)
    miRNA
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    hsa-miR-194* hsa-miR-579 hsa-miR-361-5p hsa-miR-4275 hsa-miR-208b hsa-miR-298 hsa-miR-200b hsa-miR-374b*
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF516

    Additional mRNA sequence: 

    BC108287.1 BC113085.1 BC113086.1 BC128041.1 D16475.1 D86975.1 

    11 DOTS entries:

    DT.116122  DT.116120  DT.100022355  DT.95177465  DT.91765727  DT.95156073  DT.97825443  DT.121087510 
    DT.91765726  DT.91948460  DT.97786452 

    1 AceView cDNA sequence:

    AA706353 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF516    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:                                      -               


    ECgene alternative splicing isoforms for ZNF516

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF516 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF516 Expression
    About this image


    ZNF516 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    ZNF516 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF516 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436973
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF516 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5161 , 5 zinc finger protein 5161, 5 81.74(n)1
    82.59(a)1
      18 (57.39 cM)5
    3290031  NM_001177464.11  NP_001170935.11 
     829108795 
    chicken
    (Gallus gallus)
    Aves ZNF5161 zinc finger protein 516 66.73(n)
    62.08(a)
      421009  XM_419095.4  XP_419095.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF5166
    zinc finger protein 516
    56(a)
    1 ↔ 1
    4(50577706-50699046)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35312 Xenopus laevis transcribed sequence with weak similarity more 75.41(n)    BJ040197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000038661 zinc finger protein 51.69(n)
    44.19(a)
      100003866  NM_001159669.1  NP_001153141.1 


    ENSEMBL Gene Tree for ZNF516 (if available)
    TreeFam Gene Tree for ZNF516 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF516 gene
    ZNF2172  ZNF2192  ZNF5362  
    Selected SIMAP similar genes for ZNF516 using alignment to 4 protein entries:     ZN516_HUMAN (see all proteins) (see all similar genes):
    IKZF2    ZBTB32    KLF1    MYNN    ZNF426    ZNF536
    ZSCAN10    ZNF219    ZNF626    A-328A3.4    DKFZp686N0199    MAZ
    ZFS-3    ZNF213    ZNF566    FIZ1    DKFZp434J0650    ZNF253

    Find genes that share paralogs with ZNF516           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF516 (see all 3381)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808062471,2
    --70754288(+) ATTAAA/GGACTT 1 -- ds50010--------
    rs170592641,2
    C,F,H--70754323(+) GCACGC/TCCGTC 1 -- ds500122Minor allele frequency- T:0.46NA EA NS CSA 2332
    rs1483091741,2
    C--74069230(+) CAGAG-/TTATCA 1 -- ds50010--------
    rs1847400201,2
    --74069277(+) AGAGTA/GGCGCA 1 -- ds50010--------
    rs129584601,2
    C--74069281(+) TGGCGC/TACCca 1 -- ds50010--------
    rs1501286971,2
    --74069307(+) CCCAGC/TGCAGA 1 -- ds50010--------
    rs713544971,2
    C,F--74069320(+) GGCGTC/ACCCAG 1 -- ds50012Minor allele frequency- A:0.05NA 122
    rs1816055481,2
    --74069326(+) CCCAGC/TGCAGA 1 -- ds50010--------
    rs713544981,2
    C,F--74069328(+) CAGCGG/CAGAGT 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs129622341,2
    C,A--74069347(+) cagcgC/Gagagt 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF516 (74069637 - 74207146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF516 (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2282909CNV Deletion18987734
    esv2717397CNV Deletion23290073
    esv1000604CNV Deletion20482838
    dgv510e201CNV Deletion23290073
    esv2717393CNV Deletion23290073
    esv2717403CNV Deletion23290073
    esv2717389CNV Deletion23290073
    esv2508066CNV Deletion19546169
    esv2717388CNV Deletion23290073
    esv2717392CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615114    OMIM disorders: --


    Find genes that share disorders with ZNF516           About GenesLikeMe

    Genetic Association Database (GAD): ZNF516

    Export disorders for ZNF516 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF516 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF516)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    2. Joint influence of small-effect genetic variants on human longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (Aging (Albany NY) 2010)
    3. A genome-wide association study of recipient genotype and medium-term kidney allograft function. (PubMed id 23432519)1 O'Brien R.P....Conlon P.J. (Clin Transplant 2013)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. Replication stress links structural and numerical cancer chromosomal instability. (PubMed id 23446422)2 Burrell R.A.... Swanton C. (Nature 2013)
    6. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    7. GWAS of dental caries patterns in the permanent dentition. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (J. Dent. Res. 2013)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9658 HGNC: 28990 AceView: ZNF516.2 Ensembl:ENSG00000101493 euGenes: HUgn9658
    ECgene: ZNF516 H-InvDB: ZNF516

    (According to HUGE)
    About This Section

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    HUGE: KIAA0222

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF516 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZNF516 gene:
    Search GeneIP for patents involving ZNF516

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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