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Aliases for ZNF516 Gene

Aliases for ZNF516 Gene

  • Zinc Finger Protein 516 2 3
  • KIAA0222 4
  • HsT287 3

External Ids for ZNF516 Gene

Previous GeneCards Identifiers for ZNF516 Gene

  • GC18M072199
  • GC18M072209
  • GC18M072201
  • GC18M074071
  • GC18M070754

Summaries for ZNF516 Gene

Entrez Gene Summary for ZNF516 Gene

  • Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]

GeneCards Summary for ZNF516 Gene

ZNF516 (Zinc Finger Protein 516) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF219.

UniProtKB/Swiss-Prot for ZNF516 Gene

  • Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF516 Gene

Genomics for ZNF516 Gene

Regulatory Elements for ZNF516 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF516 Gene

Chromosome:
18
Start:
76,357,682 bp from pter
End:
76,495,234 bp from pter
Size:
137,553 bases
Orientation:
Minus strand

Genomic View for ZNF516 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF516 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF516 Gene

Proteins for ZNF516 Gene

  • Protein details for ZNF516 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92618-ZN516_HUMAN
    Recommended name:
    Zinc finger protein 516
    Protein Accession:
    Q92618

    Protein attributes for ZNF516 Gene

    Size:
    1163 amino acids
    Molecular mass:
    124289 Da
    Quaternary structure:
    • Interacts with PRDM16; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific genes.
    SequenceCaution:
    • Sequence=BAA13211.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF516 Gene

Proteomics data for ZNF516 Gene at MOPED

Post-translational modifications for ZNF516 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF516 Gene

No data available for DME Specific Peptides for ZNF516 Gene

Domains & Families for ZNF516 Gene

Gene Families for ZNF516 Gene

Protein Domains for ZNF516 Gene

Suggested Antigen Peptide Sequences for ZNF516 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92618

UniProtKB/Swiss-Prot:

ZN516_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF516: view

Function for ZNF516 Gene

Molecular function for ZNF516 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).

Gene Ontology (GO) - Molecular Function for ZNF516 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding ISS --
GO:0003676 nucleic acid binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0033613 activating transcription factor binding IBA --
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF516: view
genes like me logo Genes that share phenotypes with ZNF516: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF516

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF516 Gene

Localization for ZNF516 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF516 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF516 Gene COMPARTMENTS Subcellular localization image for ZNF516 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF516 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with ZNF516: view

Pathways & Interactions for ZNF516 Gene

SuperPathways for ZNF516 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF516 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007165 signal transduction IBA --
GO:0007275 multicellular organismal development IBA --
GO:0009409 response to cold IEA --
genes like me logo Genes that share ontologies with ZNF516: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF516 Gene

Drugs & Compounds for ZNF516 Gene

No Compound Related Data Available

Transcripts for ZNF516 Gene

mRNA/cDNA for ZNF516 Gene

(10) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF516 Gene

Zinc finger protein 516:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF516

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF516 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for ZNF516 Gene

GeneLoc Exon Structure for
ZNF516
ECgene alternative splicing isoforms for
ZNF516

Expression for ZNF516 Gene

mRNA expression in normal human tissues for ZNF516 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF516 Gene

This gene is overexpressed in Brain (33.8) and Pancreatic juice (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF516 Gene



SOURCE GeneReport for Unigene cluster for ZNF516 Gene Hs.436973

genes like me logo Genes that share expression patterns with ZNF516: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF516 Gene

Orthologs for ZNF516 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF516 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF516 35
  • 79.31 (n)
  • 74.66 (a)
ZNF516 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF516 35
  • 81.87 (n)
  • 79.67 (a)
ZNF516 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp516 35
  • 81.74 (n)
  • 82.59 (a)
Zfp516 16
Zfp516 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF516 35
  • 99 (n)
  • 98.62 (a)
ZNF516 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp516 35
  • 81.48 (n)
  • 81.24 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF516 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF516 35
  • 66.73 (n)
  • 62.08 (a)
ZNF516 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF516 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100036701 35
  • 55.75 (n)
  • 52.67 (a)
Str.16781 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3531 35
zebrafish
(Danio rerio)
Actinopterygii LOC100003866 35
  • 51.69 (n)
  • 44.19 (a)
znf516 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 36
  • 22 (a)
OneToMany
Species with no ortholog for ZNF516:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF516 Gene

ENSEMBL:
Gene Tree for ZNF516 (if available)
TreeFam:
Gene Tree for ZNF516 (if available)

Paralogs for ZNF516 Gene

Paralogs for ZNF516 Gene

genes like me logo Genes that share paralogs with ZNF516: view

Variants for ZNF516 Gene

Sequence variations from dbSNP and Humsavar for ZNF516 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs583410 -- 76,403,358(-) GTACC(C/T)GTGTT intron-variant
rs585594 -- 76,368,715(-) TCTTG(A/G)TTCTG intron-variant
rs586692 -- 76,476,812(+) ATTTC(A/G)CATGA intron-variant
rs586769 -- 76,445,758(-) TGTCT(C/T)TGGAG intron-variant
rs588378 -- 76,357,495(+) AGTGG(C/T)GTACC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF516 Gene

Variant ID Type Subtype PubMed ID
esv2717388 CNV Deletion 23290073
dgv3468n71 CNV Loss 21882294
esv2717389 CNV Deletion 23290073
nsv523904 CNV Loss 19592680
nsv909929 CNV Loss 21882294
dgv3469n71 CNV Loss 21882294
nsv828316 CNV Gain 20364138
esv2717391 CNV Deletion 23290073
esv2508066 CNV Deletion 19546169
esv2282909 CNV Deletion 18987734
esv2671026 CNV Deletion 23128226
esv2717392 CNV Deletion 23290073
nsv512546 CNV Loss 21212237
esv2717393 CNV Deletion 23290073
esv28838 CNV Gain 19812545
esv2629775 CNV Insertion 19546169
esv1525447 CNV Insertion 17803354
esv2717394 CNV Deletion 23290073
dgv510e201 CNV Deletion 23290073
nsv131595 CNV Loss 16902084
esv2717397 CNV Deletion 23290073
esv2717399 CNV Deletion 23290073
esv988971 CNV Deletion 20482838
esv2717401 CNV Deletion 23290073
nsv458302 CNV Loss 19166990
esv2661749 CNV Deletion 23128226
esv2717402 CNV Deletion 23290073
nsv131684 CNV Loss 16902084
esv1000604 CNV Deletion 20482838
esv2717403 CNV Deletion 23290073
esv1570708 CNV Deletion 17803354
nsv131705 CNV Loss 16902084
nsv458303 CNV Loss 19166990
dgv3470n71 CNV Loss 21882294
dgv3471n71 CNV Loss 21882294
nsv458305 CNV Loss 19166990

Variation tolerance for ZNF516 Gene

Gene Damage Index Score: 3.61; 56.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF516 Gene

HapMap Linkage Disequilibrium report
ZNF516

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF516 Gene

Disorders for ZNF516 Gene

Relevant External Links for ZNF516

Genetic Association Database (GAD)
ZNF516
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF516
genes like me logo Genes that share disorders with ZNF516: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF516 Gene

Publications for ZNF516 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 67
  2. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. (PMID: 25578880) Dempersmier J. … Sul H.S. (Mol. Cell 2015) 67
  5. Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population. (PMID: 24241165) Brebi P. … Guerrero-Preston R. (Epigenetics 2014) 67

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