Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF516 Gene

Aliases for ZNF516 Gene

  • Zinc Finger Protein 516 2 3 5
  • KIAA0222 4
  • HsT287 3

External Ids for ZNF516 Gene

Previous GeneCards Identifiers for ZNF516 Gene

  • GC18M072199
  • GC18M072209
  • GC18M072201
  • GC18M074071
  • GC18M070754

Summaries for ZNF516 Gene

Entrez Gene Summary for ZNF516 Gene

  • Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]

GeneCards Summary for ZNF516 Gene

ZNF516 (Zinc Finger Protein 516) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF536.

UniProtKB/Swiss-Prot for ZNF516 Gene

  • Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).

Additional gene information for ZNF516 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF516 Gene

Genomics for ZNF516 Gene

GeneHancer (GH) Regulatory Elements for ZNF516 Gene

Promoters and enhancers for ZNF516 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I076489 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 556.6 +2.0 2032 7.6 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 ZNF516 LOC101927989 ZNF236 C18orf65 GC18P076461
GH18I076563 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 26.4 -70.3 -70263 4.2 PKNOX1 SIN3A FEZF1 ZNF48 ZNF335 ZNF366 FOS ZNF202 NFYC CEBPB ZNF516 ZNF236 LINC00908 LINC00683 GC18P076461
GH18I076397 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.9 +96.8 96755 1.4 ELF3 ARID4B IRF4 ZNF48 RAD21 GLIS2 ZNF143 BCLAF1 RUNX3 ZNF654 ZNF516 GC18M075766 ENSG00000280205
GH18I076466 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 20.4 +27.4 27433 2.8 SCRT1 MAX ZIC2 ZBTB48 POLR2A GLIS1 ZNF341 MYC ZBTB20 ZNF516 GC18P076461 LOC101927989
GH18I076444 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +46.4 46354 9.5 FOXA2 FEZF1 RAD21 ETS1 ZNF335 GLIS2 ZNF366 RCOR1 ETV6 FOS ZNF516 GC18M076458 PIR52199 GC18P076431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF516 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF516 gene promoter:

Genomic Locations for ZNF516 Gene

Genomic Locations for ZNF516 Gene
137,553 bases
Minus strand

Genomic View for ZNF516 Gene

Genes around ZNF516 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF516 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF516 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF516 Gene

Proteins for ZNF516 Gene

  • Protein details for ZNF516 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 516
    Protein Accession:

    Protein attributes for ZNF516 Gene

    1163 amino acids
    Molecular mass:
    124289 Da
    Quaternary structure:
    • Interacts with PRDM16; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific genes.
    • Sequence=BAA13211.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF516 Gene

Post-translational modifications for ZNF516 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF516 Gene

Domains & Families for ZNF516 Gene

Gene Families for ZNF516 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF516 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF516: view

Function for ZNF516 Gene

Molecular function for ZNF516 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).

Phenotypes From GWAS Catalog for ZNF516 Gene

Gene Ontology (GO) - Molecular Function for ZNF516 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 proximal promoter sequence-specific DNA binding ISS --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0033613 activating transcription factor binding IEA,IBA --
genes like me logo Genes that share ontologies with ZNF516: view
genes like me logo Genes that share phenotypes with ZNF516: view

Animal Model Products

CRISPR Products

miRNA for ZNF516 Gene

miRTarBase miRNAs that target ZNF516

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF516 Gene

Localization for ZNF516 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF516 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF516 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF516 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
genes like me logo Genes that share ontologies with ZNF516: view

Pathways & Interactions for ZNF516 Gene

SuperPathways for ZNF516 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF516 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IBA --
GO:0007165 signal transduction IBA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with ZNF516: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF516 Gene

Drugs & Compounds for ZNF516 Gene

No Compound Related Data Available

Transcripts for ZNF516 Gene

mRNA/cDNA for ZNF516 Gene

(11) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF516 Gene

Zinc finger protein 516:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF516 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP2: -

Relevant External Links for ZNF516 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF516 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF516 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF516 Gene

This gene is overexpressed in Brain (33.8) and Pancreatic juice (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF516 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF516 Gene:


SOURCE GeneReport for Unigene cluster for ZNF516 Gene:


Evidence on tissue expression from TISSUES for ZNF516 Gene

  • Bone marrow(4.2)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with ZNF516: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF516 Gene

Orthologs for ZNF516 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF516 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF516 33 34
  • 99 (n)
(Canis familiaris)
Mammalia ZNF516 33 34
  • 81.87 (n)
(Mus musculus)
Mammalia Zfp516 33 16 34
  • 81.74 (n)
(Rattus norvegicus)
Mammalia Zfp516 33
  • 81.48 (n)
(Bos Taurus)
Mammalia ZNF516 33 34
  • 79.31 (n)
(Monodelphis domestica)
Mammalia ZNF516 34
  • 67 (a)
(Gallus gallus)
Aves ZNF516 33 34
  • 66.73 (n)
(Anolis carolinensis)
Reptilia ZNF516 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100036701 33
  • 55.75 (n)
Str.16781 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3531 33
(Danio rerio)
Actinopterygii LOC100003866 33
  • 51.69 (n)
znf516 34
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 34
  • 22 (a)
Species where no ortholog for ZNF516 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF516 Gene

Gene Tree for ZNF516 (if available)
Gene Tree for ZNF516 (if available)

Paralogs for ZNF516 Gene

Variants for ZNF516 Gene

Sequence variations from dbSNP and Humsavar for ZNF516 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000006694 -- 76,468,673(-) G/C intron_variant
rs1000033709 -- 76,378,176(-) C/T intron_variant
rs1000033933 -- 76,468,273(-) A/G intron_variant
rs1000062357 -- 76,399,046(-) C/G intron_variant
rs1000104321 -- 76,408,147(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF516 Gene

Variant ID Type Subtype PubMed ID
dgv1640n106 CNV deletion 24896259
dgv1641n106 CNV deletion 24896259
dgv1642n106 CNV deletion 24896259
dgv469e201 CNV deletion 23290073
dgv6070n54 CNV gain 21841781
dgv6071n54 CNV loss 21841781
dgv6072n54 CNV gain+loss 21841781
dgv6073n54 CNV loss 21841781
dgv6074n54 CNV loss 21841781
dgv6075n54 CNV loss 21841781
dgv6076n54 CNV loss 21841781
dgv642e214 CNV loss 21293372
esv1000604 CNV deletion 20482838
esv1525447 CNV insertion 17803354
esv1570708 CNV deletion 17803354
esv2282909 CNV deletion 18987734
esv2508066 CNV deletion 19546169
esv2629775 CNV insertion 19546169
esv2656391 CNV loss 23635498
esv2661749 CNV deletion 23128226
esv2671026 CNV deletion 23128226
esv2717388 CNV deletion 23290073
esv2717389 CNV deletion 23290073
esv2717391 CNV deletion 23290073
esv2717392 CNV deletion 23290073
esv2717393 CNV deletion 23290073
esv2717394 CNV deletion 23290073
esv2717397 CNV deletion 23290073
esv2717399 CNV deletion 23290073
esv2717401 CNV deletion 23290073
esv2717402 CNV deletion 23290073
esv2717403 CNV deletion 23290073
esv28838 CNV gain 19812545
esv3429410 CNV duplication 20981092
esv3449264 CNV duplication 20981092
esv3643163 CNV loss 21293372
esv3643171 CNV loss 21293372
esv3643173 CNV gain 21293372
esv988971 CNV deletion 20482838
nsv1063632 CNV gain 25217958
nsv1064685 CNV gain 25217958
nsv1071864 CNV deletion 25765185
nsv1072278 CNV deletion 25765185
nsv1072814 CNV deletion 25765185
nsv1143884 CNV deletion 24896259
nsv1143885 CNV deletion 24896259
nsv131595 CNV deletion 16902084
nsv131684 CNV deletion 16902084
nsv131705 CNV deletion 16902084
nsv458302 CNV loss 19166990
nsv458303 CNV loss 19166990
nsv458305 CNV loss 19166990
nsv476459 CNV novel sequence insertion 20440878
nsv512546 CNV loss 21212237
nsv523904 CNV loss 19592680
nsv577661 CNV loss 21841781
nsv577662 CNV loss 21841781
nsv577663 CNV gain+loss 21841781
nsv577664 CNV gain 21841781
nsv577667 CNV gain+loss 21841781
nsv577671 CNV gain 21841781
nsv577672 CNV gain+loss 21841781
nsv577677 CNV loss 21841781
nsv577678 CNV loss 21841781
nsv577684 CNV loss 21841781
nsv577685 CNV loss 21841781
nsv828316 CNV gain 20364138
nsv953560 CNV deletion 24416366
nsv953561 CNV deletion 24416366

Variation tolerance for ZNF516 Gene

Gene Damage Index Score: 3.61; 56.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF516 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF516 Gene

Disorders for ZNF516 Gene

Additional Disease Information for ZNF516

No disorders were found for ZNF516 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF516 Gene

Publications for ZNF516 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 58
  2. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin AI … Ukraintseva SV (Aging 2010) 3 44 58
  3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF516 Gene

Sources for ZNF516 Gene

Loading form....