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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF516 Gene

protein-coding   GIFtS: 45
GCID: GC18M074071

zinc finger protein 516

  Search for ZNF516
in our new
 Human Malady Compendium 
Biological research products
for ZNF516
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3.2

Aliases
Zinc Finger Protein 5161 2
HsT2871 2
KIAA02221 3

External Ids:    HGNC: 289901   Entrez Gene: 96582   Ensembl: ENSG000001014937   UniProtKB: Q926183   
ORGUL members:    fRNAdb10:FR263179      
NONCODE:n333547 n339927    
RNAdb:EVF25337    

Export aliases for ZNF516 gene to outside databases

Previous GC identifers: GC18M072199 GC18M072209 GC18M072201 GC18M070754


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF516:
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell
proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel
C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. (provided by RefSeq, Sep 2012)

UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618
Function: May be involved in transcriptional regulation



fRNAdb sequence ontology for ZNF516:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for ZNF516

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF516 gene promoter:
         FOXF2   CUTL1   IRF-1   Meis-1b   AREB6   FOXO4   Meis-1a   TGIF   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF516

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF516


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

ZNF516 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF516 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M074071:  view genomic region     (about GC identifiers)

Start:
74,069,637 bp from pter      End:
74,207,146 bp from pter
Size:
137,510 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF516

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618 (See protein sequence)
Recommended Name: Zinc finger protein 516  
Size: 1163 amino acids; 124289 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA13211.2; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for ZNF516: NX_Q92618

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92618

  • ZNF516 Protein expression data from MOPED and PaxDb:    About this image 
    ZNF516 Protein Expression
    REFSEQ proteins: NP_055458.1  
    ENSEMBL proteins: 
     ENSP00000445902   ENSP00000446211   ENSP00000394757  

    Human Recombinant Protein Products for ZNF516: 
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    Uscn Proteins for ZNF516

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF516 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF516 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q92618

    ProtoNet protein and cluster: Q92618

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN516_HUMAN, Q92618
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZNF516 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    hsa-miR-194* hsa-miR-579 hsa-miR-361-5p hsa-miR-4275 hsa-miR-208b hsa-miR-298 hsa-miR-200b hsa-miR-374b*
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF516

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF516 (Q926182, 3 ENSP000003947574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KDM1AO603413, ENSP000003490494I2D: score=1 STRING: ENSP00000349049
    HIST3H3Q166953, ENSP000003556574I2D: score=1 STRING: ENSP00000355657
    ZBP1Q9H1713, ENSP000003602154I2D: score=1 STRING: ENSP00000360215
    MAP2K5Q131633I2D: score=1 
    --Q9WVS72MINT-19870
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF516 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF516
    Search CenterWatch for drugs/clinical trials and news about ZNF516 / ZN516 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for ZNF516 gene: 
    NM_014643.3  

    Unigene Cluster for ZNF516:

    Zinc finger protein 516
    Hs.436973  [show with all ESTs]
    Unigene Representative Sequence: NM_014643
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524431 ENST00000543743 ENST00000529449 ENST00000542818 ENST00000532857
    ENST00000443185(uc002lmd.3 uc021ulp.1)

    miRNA
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    8/134 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF516 (see all 134):
    hsa-miR-194* hsa-miR-579 hsa-miR-361-5p hsa-miR-4275 hsa-miR-208b hsa-miR-298 hsa-miR-200b hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF516 (see all 4)
    OriGene shRNA RFP: ZNF516
    OriGene siRNA: ZNF516
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    Clone
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    Additional cDNA sequence: 

    BC108287.1 BC113085.1 BC113086.1 BC128041.1 D16475.1 D86975.1 

    11 DOTS entries:

    DT.116120  DT.116122  DT.100022355  DT.95177465  DT.91765727  DT.95156073  DT.97825443  DT.121087510 
    DT.91765726  DT.91948460  DT.97786452 

    1 AceView cDNA sequence:

    AA706353 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF516    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:                                      -               


    ECgene alternative splicing isoforms for ZNF516

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF516 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    ZNF516 Expression
    About this image
    See ZNF516 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF516

    SOURCE GeneReport for Unigene cluster: Hs.436973
        SABiosciences Custom PCR Arrays for ZNF516

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF516

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF516 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZNF5161 zinc finger protein 516 67.05(n)
    62.63(a)
      421009  XM_419095.3  XP_419095.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF5166
    --
    53(a)
    1 ↔ 1
    4(50591221-50639599)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35312 Xenopus laevis transcribed sequence with weak similarity more 75.41(n)    BJ040197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000038661 zinc finger protein 49.11(n)
    40.1(a)
      100003866  NM_001159669.1  NP_001153141.1 


    ENSEMBL Gene Tree for ZNF516 (if available)
    TreeFam Gene Tree for ZNF516 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF516 gene
    ZNF2172  ZNF2192  ZNF5362  
    18/64 SIMAP similar genes for ZNF516 using alignment to 4 protein entries:     ZN516_HUMAN (see all proteins) (see all similar genes):
    IKZF2    ZBTB32    ZNF121    KLF1    ZNF426    ZNF536
    ZSCAN10    ZNF219    ZNF626    A-328A3.4    DKFZp686N0199    MAZ
    ZFS-3    ZNF213    ZNF566    ZNF66P    FIZ1    DKFZp434J0650

    ZNF516 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2750 NCBI SNPs in ZNF516 are shown (see all 2750    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483091741,2
    C--74069230(+) CAGAG-/TTATCA 1 -- ds50010--------
    rs1847400201,2
    --74069277(+) AGAGTA/GGCGCA 1 -- ds50010--------
    rs129584601,2
    C--74069281(+) TGGCGC/TACCCA 1 -- ds50010--------
    rs1501286971,2
    --74069307(+) CCCAGC/TGCAGA 1 -- ds50010--------
    rs713544971,2
    C--74069320(+) GGCGTC/ACCCAG 1 -- ds50012Minor allele frequency- A:0.05NA 122
    rs1816055481,2
    --74069326(+) CCCAGC/TGCAGA 1 -- ds50010--------
    rs713544981,2
    C--74069328(+) CAGCGG/CAGAGT 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs129622341,2
    A--74069347(+) cagcgC/Gagagt 1 -- ds50010--------
    rs1173465171,2
    C,F--74069355(+) AGTGGC/TGTACC 1 -- ds50011Minor allele frequency- T:0.05NA 120
    rs129666111,2
    --74069357(+) tggcgC/Taccca 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF516 (74069637 - 74207146 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 15 variations for ZNF516
         12 CNVs: 102717 77941 88933 88932 73173 77942 88931 88930 77940 77938 77939 77937
         3 Indels: 45690 34305 102718

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF516 for disorders           About MalaCards

    ZNF516 for disorders           About GeneDecksing

    OMIM information: 612461    

    Export disorders for ZNF516 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF516 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF516)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
    2. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    3. Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1 Yashin A.I....Ukraintseva S.V. (2010)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. (PubMed id 16079794)1 Lee M.G.... Shiekhattar R. (2005)
    6. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
    7. Coordinated histone modifications mediated by a CtBP co-repressor complex. (PubMed id 12700765)1 Shi Y.... Shi Y. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. (PubMed id 16628248)10 
    10. (PubMed id 15608161)10 

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9658 HGNC: 28990 AceView: ZNF516.2 Ensembl:ENSG00000101493 euGenes: HUgn9658
    ECgene: ZNF516 H-InvDB: ZNF516

    (According to HUGE)
    About This Section
    HUGE: KIAA0222

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF516 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF516 gene:
    Search GeneIP for patents involving ZNF516

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
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