ZNF516 Gene
protein-coding GIFtS: 45
GCID: GC18M074071
|
|
zinc finger protein 516
| |
Aliases for ZNF516 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
| This gene clusters with an RNA gene Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3.2
| Aliases |
|---|
| Zinc Finger Protein 5161 2 | | HsT2871 2 | | KIAA02221 3 |
| External Ids: | HGNC: 289901 | Entrez Gene: 96582 | Ensembl: ENSG000001014937 | UniProtKB: Q926183 | Export aliases for ZNF516 gene to outside databasesPrevious GC identifers: GC18M072199 GC18M072209 GC18M072201 GC18M070754
Summaries for ZNF516 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ZNF516: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cellproliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppelC2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. (provided by RefSeq, Sep 2012) UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618Function: May be involved in transcriptional regulation
fRNAdb sequence ontology for ZNF516: nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
View fRNAdb secondary structures for ZNF516 |
Genomic Views for ZNF516 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF516 gene promoter: FOXF2 CUTL1 IRF-1 Meis-1b AREB6 FOXO4 Meis-1a TGIF Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF516
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF516 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q23ZNF516 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M074071: view genomic region
(about GC identifiers)
Start:
|
74,069,637 bp from pter |
End:
|
74,207,146 bp from pter |
Size:
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137,510 bases |
Orientation:
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minus strand |
ORGUL member locations: Legend (see complete legend)
 |
Proteins for ZNF516 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618 (See
protein sequence)Recommended Name: Zinc finger protein 516 Size: 1163 amino acids; 124289 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA13211.2; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for ZNF516: NX_Q92618
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92618 ZNF516 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_055458.1 ENSEMBL proteins: ENSP00000445902 ENSP00000446211 ENSP00000394757 Human Recombinant Protein Products for ZNF516:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF516 for ontologies About GeneDecksing
ZNF516 Antibody Products: Assay Products for ZNF516: |
Protein
Domains / Families for ZNF516 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF516 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92618ProtoNet protein and cluster: Q92618 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN516_HUMAN, Q92618Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingers |
Function for ZNF516 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: ZN516_HUMAN, Q92618Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF516 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF516 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF516 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF516 (NM_014643) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF516 |
|
Pathways & Interactions for ZNF516 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF516
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
 5 Interacting proteins for ZNF516 (Q926182, 3 ENSP000003947574) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF516 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF516 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF516 Search CenterWatch for drugs/clinical trials and news about ZNF516 / ZN516 
|
Transcripts for ZNF516 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| 1 fRNAdb Secondary structure:
 REFSEQ mRNAs for ZNF516 gene: NM_014643.3 Unigene Cluster for ZNF516: Zinc finger protein 516 Hs.436973 [show with all ESTs]Unigene Representative Sequence: NM_0146436 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524431 ENST00000543743 ENST00000529449 ENST00000542818 ENST00000532857 ENST00000443185(uc002lmd.3 uc021ulp.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF516 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF516 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF516 (NM_014643) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF516 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF516  |
Additional cDNA sequence: BC108287.1 BC113085.1 BC113086.1 BC128041.1 D16475.1 D86975.1 11 DOTS entries: DT.116120 DT.116122 DT.100022355 DT.95177465 DT.91765727 DT.95156073 DT.97825443 DT.121087510 DT.91765726 DT.91948460 DT.97786452 1 AceView cDNA sequence: AA706353 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF516 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | |   |
ECgene alternative splicing isoforms for ZNF516
|
Expression for ZNF516 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF516 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
 About this image See ZNF516 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF516
SOURCE GeneReport for Unigene cluster: Hs.436973 SABiosciences Custom PCR Arrays for ZNF516
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF516 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF516 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF516 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF516 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF516 |
Orthologs for ZNF516 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF516 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ZNF5161 |
zinc finger protein 516 |
67.05(n) 62.63(a) |
  |
421009 XM_419095.3 XP_419095.3 |
lizard (Anolis carolinensis) |
Reptilia |
ZNF5166 |
-- |
53(a) |
1 ↔ 1 |
4(50591221-50639599) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.35312 |
Xenopus laevis transcribed sequence with weak similarity more |
75.41(n) |
  |
BJ040197.1 |
zebrafish (Danio rerio) |
Actinopterygii |
LOC1000038661 |
zinc finger protein |
49.11(n) 40.1(a) |
  |
100003866 NM_001159669.1 NP_001153141.1 |
ENSEMBL Gene Tree for ZNF516 (if available) TreeFam Gene Tree for ZNF516 (if available)  |
Paralogs for ZNF516 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF516 gene
- ZNF2172 ZNF2192 ZNF5362
18/64 SIMAP similar genes for ZNF516 using alignment to 4 protein entries: ZN516_HUMAN (see all proteins)
(see all similar genes):IKZF2 ZBTB32 ZNF121 KLF1 ZNF426 ZNF536 ZSCAN10 ZNF219 ZNF626 A-328A3.4 DKFZp686N0199 MAZ ZFS-3 ZNF213 ZNF566 ZNF66P FIZ1 DKFZp434J0650
ZNF516 for paralogs About GeneDecksing
|
Genomic Variants for ZNF516 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 18 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF516 (74069637 - 74207146 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 15 variations for ZNF516 12 CNVs: 102717 77941 88933 88932 73173 77942 88931 88930 77940 77938 77939 77937 3 Indels: 45690 34305 102718  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF516 |
|
Disorders
/ Diseases for ZNF516 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF516 for disorders About MalaCards
ZNF516 for disorders About GeneDecksing
OMIM information: 612461 Export disorders for ZNF516 gene to outside databases
|
Publications for ZNF516 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF516 gene integrated from 9 sources: (articles sorted by number of sources associating them with ZNF516) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1 Yashin A.I....Ukraintseva S.V. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. (PubMed id 16079794)1 Lee M.G.... Shiekhattar R. (2005)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
- Coordinated histone modifications mediated by a CtBP co-repressor complex. (PubMed id 12700765)1 Shi Y.... Shi Y. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- (PubMed id 16628248)10
- (PubMed id 15608161)10
|
External Searches for ZNF516 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF516 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF516 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF516 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF516 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF516 gene: Search GeneIP for patents involving ZNF516
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF516 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF516 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF516 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF516 | | OriGene Protein Over-expression Lysate for ZNF516 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ZNF516 | | OriGene 3'-UTR Clone for ZNF516 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF516 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF516 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | Search Tocris compounds for ZNF516 |
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 | | ZNF516 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF516 |
|  |  |  |  | | | Search ThermoFisher Antibodies for ZNF516 |
| | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF516 |
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