External Ids for ZNF516 Gene
Previous GeneCards Identifiers for ZNF516 Gene
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
GeneCards Summary for ZNF516 Gene
ZNF516 (Zinc Finger Protein 516) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF219.
UniProtKB/Swiss-Prot for ZNF516 Gene
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).