ZNF513 Gene
protein-coding GIFtS: 48
GCID: GC02M027600
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zinc finger protein 513
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Aliases for ZNF513 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5131 2 | | RP582 5 | | FLJ322031 | | HMFT06562 |
Export aliases for ZNF513 gene to outside databasesPrevious GC identifers: GC02M027574 GC02M027511 GC02M027455 GC02M027342 |
Summaries for ZNF513 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ZNF513: The protein encoded by this gene is a possible transcriptional regulator involved in retinal development. Defects inthis gene can be a cause of autosomal-recessive retinitis pigmentosa. Two transcript variants encoding differentisoforms have been found for this gene. (provided by RefSeq, Mar 2011) UniProtKB/Swiss-Prot: ZN513_HUMAN, Q8N8E2Function: Transcriptional regulator that plays a role in retinal development and maintenance
|
Genomic Views for ZNF513 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF513 gene promoter: AP-1 Pax-5 Lmo2 Tal-1beta CBF-C E47 CBF-A CBF-B Pax-4a CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF513
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF513 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3ZNF513 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M027600: view genomic region
(about GC identifiers)
Start:
|
27,600,098 bp from pter |
End:
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27,603,657 bp from pter |
Size:
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3,560 bases |
Orientation:
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minus strand |
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Proteins for ZNF513 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN513_HUMAN, Q8N8E2 (See
protein sequence)Recommended Name: Zinc finger protein 513 Size: 541 amino acids; 57882 Da
Subunit: Binds DNA. Can associate with the proximal promoter regions of PAX6 and SP4, and their known targets includingARR3, RHO, OPN1MW2 and OPN1SW
Subcellular location: Nucleus
Sequence caution: Sequence=BAB71274.1; Type=Erroneous initiation;
Secondary accessions: A8K3S5 B7WP71 Q3ZCU1 Q68CJ1 Q86UZ3 Q8NDL8 Q96ML3Alternative splicing: 3 isoforms: Q8N8E2-1 Q8N8E2-2 Q8N8E2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF513: NX_Q8N8E2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N8E2 ZNF513 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_001188388.1 NP_653232.3 ENSEMBL proteins: ENSP00000318373 ENSP00000384874 ENSP00000394226 Human Recombinant Protein Products for ZNF513:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF513 for ontologies About GeneDecksing
ZNF513 Antibody Products: Assay Products for ZNF513: |
Protein
Domains / Families for ZNF513 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF513 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N8E2ProtoNet protein and cluster: Q8N8E2 UniProtKB/Swiss-Prot: ZN513_HUMAN, Q8N8E2Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 8 C2H2-type zinc fingers |
Function for ZNF513 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: ZN513_HUMAN, Q8N8E2Function: Transcriptional regulator that plays a role in retinal development and maintenance Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IDA | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0044212 | transcription regulatory region DNA binding |
IDA | -- |
ZNF513 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for ZNF513: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF513 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF513 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF513 (NM_144631) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF513 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF513  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF513 |
|
Pathways & Interactions for ZNF513 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF513
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 5/8 Interacting proteins for ZNF513 (Q8N8E23 ENSP000003183734) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007601 | visual perception |
IEA | -- | | GO:0050896 | response to stimulus |
IEA | -- | | GO:0060041 | retina development in camera-type eye |
IMP | -- |
ZNF513 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF513 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF513 Search CenterWatch for drugs/clinical trials and news about ZNF513 / ZN513 
|
Transcripts for ZNF513 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF513 gene (2 alternative transcripts): NM_001201459.1 NM_144631.5 Unigene Cluster for ZNF513: Zinc finger protein 513 Hs.515872 [show with all ESTs]Unigene Representative Sequence: NM_1446314 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000323703(uc002rkk.3) ENST00000407879(uc002rkj.3) ENST00000491924 ENST00000436006
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF513 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF513 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF513 (NM_144631) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF513 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF513  |
Additional cDNA sequence: AB075875.1 AK056765.1 AK096933.1 AK290690.1 BC040650.1 BC052282.1 15 DOTS entries: DT.208617 DT.95223874 DT.95223940 DT.92008771 DT.100682843 DT.100031576 DT.437116 DT.85104263 DT.97788854 DT.92463194 DT.95223936 DT.100807245 DT.92463197 DT.92463217 DT.95318645 24/126 AceView cDNA sequences (see all 126): AK056765 BC052282 BG820518 AA648531 AI093552 AB075875 BU733013 AI766724 AL534516 AI140313 CB153131 AA421294 BM692506 NM_144631 AI080715 AI088608 CA312898 AK096933 BQ072985 BU687338 AL833946 AI167835 CR620947 AI420829 GeneLoc Exon Structure
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Expression for ZNF513 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF513 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGCGGGGGGG
 About this image See ZNF513 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF513
SOURCE GeneReport for Unigene cluster: Hs.515872
UniProtKB/Swiss-Prot: ZN513_HUMAN, Q8N8E2Tissue specificity: In the retina, expressed in the outer and inner nuclear layers, and the ganglion cell layer SABiosciences Custom PCR Arrays for ZNF513
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF513 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF513 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF513 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF513 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF513 |
Orthologs for ZNF513 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF513 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ZNF5131 |
zinc finger protein 513 |
66.98(n) 64.2(a) |
  |
421989 XM_419998.3 XP_419998.3 |
lizard (Anolis carolinensis) |
Reptilia |
ZNF5136 |
-- |
66(a) |
1 ↔ 1 |
AAWZ02039497(3222-3500) |
zebrafish (Danio rerio) |
Actinopterygii |
znf5131 |
zinc finger protein 513 |
58.64(n) 56.72(a) |
  |
568216 XM_691532.5 XP_696624.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
hb6 |
hunchback |
6(a) |
1 → many |
3R(4517038-4523540) |
worm (Caenorhabditis elegans) |
Secernentea |
hbl-16 |
Hunchback-like protein |
3(a) |
1 → many |
X(5822242-5826399) |
ENSEMBL Gene Tree for ZNF513 (if available) TreeFam Gene Tree for ZNF513 (if available)  |
Paralogs for ZNF513 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for ZNF513 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF513 (27600098 - 27603657 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF513: -- Human Gene Mutation Database (HGMD): ZNF513
 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for ZNF513 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF513 for disorders About GeneDecksing
OMIM gene information: 613598 OMIM disorders: 613617 UniProtKB/Swiss-Prot: ZN513_HUMAN, Q8N8E2
Defects in ZNF513 are the cause of retinitis pigmentosa type 58 (RP58) [MIM:613617]. A retinal dystrophybelonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment depositsvisible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of conephotoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As theircondition progresses, they lose their far peripheral visual field and eventually central vision as well 8 diseases for ZNF513: About MalaCardsretinitis pigmentosa retinitis pigmentary retinopathy night blindness blindness hepatoblastoma pharyngitis neuronitis 1 disease from the University of Copenhagen DISEASES database for ZNF513:Night blindness Human Genome Epidemiology (HuGE) Navigator: ZNF513 (3 documents) Export disorders for ZNF513 gene to outside databases
|
Publications for ZNF513 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF513 gene, integrated from 9 sources (see all 14): (articles sorted by number of sources associating them with ZNF513) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A mutation in ZNF513, a putative regulator of photore ceptor development, causes autosomal-recessive retinitis pigmentosa. (PubMed id 20797688)1, 2 Li L....Hejtmancik J.F. (2010)
- Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
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External Searches for ZNF513 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF513 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF513 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF513 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF513 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF513 gene: Search GeneIP for patents involving ZNF513
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF513 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF513 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF513 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF513 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF513 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF513 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF513 |
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 | | ZNF513 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF513 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF513 |
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