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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF512 Gene

protein-coding   GIFtS: 43
GCID: GC02P027805

Zinc Finger Protein 512

  Search for ZNF512
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5121 2
KIAA18053

External Ids:    HGNC: 293801   Entrez Gene: 844502   Ensembl: ENSG000002439437   UniProtKB: Q96ME73   

Export aliases for ZNF512 gene to outside databases

Previous GC identifers: GC02P027780 GC02P027717 GC02P027659 GC02P027547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF512 Gene:
This gene encodes a protein containing four putative zinc finger motifs. Zinc finger motifs may bind to proteins
or nucleic acids. Zinc finger-containing proteins are involved in a variety of processes, including regulation of
transcription. Alternative splicing results in multiple transcript variants for this gene. (provided by RefSeq,
Sep 2012)

GeneCards Summary for ZNF512 Gene: 
ZNF512 (zinc finger protein 512) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF512B.

UniProtKB/Swiss-Prot: ZN512_HUMAN, Q96ME7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF512 gene promoter:
         STAT5B   USF1   Sox5   AML1a   FOXD1   XBP-1   LCR-F1   Cdc5   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF512 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF512

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF512


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

ZNF512 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF512 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027805:  view genomic region     (about GC identifiers)

Start:
27,805,893 bp from pter      End:
27,858,041 bp from pter
Size:
52,149 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN512_HUMAN, Q96ME7 (See protein sequence)
Recommended Name: Zinc finger protein 512  
Size: 567 amino acids; 64682 Da
Subcellular location: Nucleus (Potential)
1 PDB 3D structure from and Proteopedia for ZNF512:
2CTD (3D)    
Secondary accessions: B4DSM5 Q53RZ7 Q86XK6 Q96JM0
Alternative splicing: 3 isoforms:  Q96ME7-1   Q96ME7-2   Q96ME7-3   

Explore the universe of human proteins at neXtProt for ZNF512: NX_Q96ME7

Explore proteomics data for ZNF512 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96ME7

  • ZNF512 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF512 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001258215.1  NP_001258216.1  NP_001258217.1  NP_001258218.1  NP_001258247.1  NP_115810.2  

    ENSEMBL proteins: 
     ENSP00000369040   ENSP00000347648   ENSP00000407038   ENSP00000395660   ENSP00000451572  

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    Cloud-Clone Corp. Proteins for ZNF512 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF512 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96ME7

    ProtoNet protein and cluster: Q96ME7

    UniProtKB/Swiss-Prot: ZN512_HUMAN, Q96ME7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    ZNF512 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN512_HUMAN, Q96ME7
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF512 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF512:
     Decreased influenza A/WSN/33 r  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF512 
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    SwitchGear 3'UTR luciferase reporter plasmidZNF512 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF512

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF512 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF512 (ZN512)

    Search CenterWatch for drugs/clinical trials and news about ZNF512 / ZN512

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF512 gene (6 alternative transcripts): 
    NM_001271286.1  NM_001271287.1  NM_001271288.1  NM_001271289.1  NM_001271318.1  NM_032434.3  

    Unigene Cluster for ZNF512:

    Zinc finger protein 512
    Hs.529178  [show with all ESTs]
    Unigene Representative Sequence: NM_001271318
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379717 ENST00000355467(uc010ylw.2 uc002rlb.3 uc010ylx.2 uc002rlc.3 uc002rla.3 uc010ylv.2 uc010ylz.2)
    ENST00000494548 ENST00000461705 ENST00000488055 ENST00000416005 ENST00000413371
    ENST00000556601
    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF512 (see all 31):
    hsa-miR-4317 hsa-miR-320a hsa-miR-1226 hsa-miR-16-2* hsa-miR-137 hsa-miR-765 hsa-miR-583 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidZNF512 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AB058708.1 AK057028.1 AK293771.1 AK294055.1 AK299818.1 AK316011.1 AK316299.1 AL833748.1 
    BC015707.1 BC043221.2 BC093041.1 BX647996.1 

    12 DOTS entries:

    DT.116138  DT.121010758  DT.95173172  DT.121010677  DT.95173176  DT.95206056  DT.95302977  DT.121010770 
    DT.97813177  DT.100025195  DT.443941  DT.95173171 

    24/195 AceView cDNA sequences (see all 195):

    BG057669 AB058708 BE891950 AA987715 NM_032434 AI972990 CD722360 BQ215308 
    CK826128 NM_032266 AI765343 AW189183 CA413244 BU508484 AK057028 BC015707 
    T33419 BC043221 AW769939 CD652891 AA975968 BG570919 AI768018 BI861228 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF512 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATATGCAC
    ZNF512 Expression
    About this image


    See ZNF512 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF512

    SOURCE GeneReport for Unigene cluster: Hs.529178
        SABiosciences Custom PCR Arrays for ZNF512
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF512

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF512 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5121 , 5 zinc finger protein 5121, 5 86.05(n)1
    87.84(a)1
      5 (17.27 cM)5
    2696391  NM_172993.31  NP_766581.21 
     314524365 
    chicken
    (Gallus gallus)
    Aves ZNF5121 zinc finger protein 512 63.58(n)
    61.32(a)
      769868  XM_001232517.1  XP_001232518.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF5126
    Uncharacterized protein
    57(a)
    1 ↔ 1
    GL343953.1(29227-47847)
    zebrafish
    (Danio rerio)
    Actinopterygii znf5126
    zinc finger protein 512
    49(a)
    1 ↔ 1
    20(38554469-38563183)


    ENSEMBL Gene Tree for ZNF512 (if available)
    TreeFam Gene Tree for ZNF512 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF512 gene
    ZNF512B2  
    2 SIMAP similar genes for ZNF512 using alignment to 3 protein entries:     ZN512_HUMAN (see all proteins):
    DKFZp666L156    ZNF512B

    ZNF512 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/781 SNPs in ZNF512 are shown (see all 781)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000500301,2
    --27806561(+) GGAGCA/GCGAGG 8 T A mis1 int1 ut510--------
    rs1459576421,2
    C--27806793(+) TAAGG-/TTTCTT 6 -- int10--------
    rs1469791591,2
    --27806901(+) CTTTTA/GAGCGC 6 -- int10--------
    rs1158892451,2
    F--27806939(+) ATTGAA/GTTTTA 6 -- int11Minor allele frequency- G:0.03WA 118
    rs1871408191,2
    --27807213(+) GTCTGC/TAAGAC 6 -- int10--------
    rs1380269641,2
    C--27807410(+) GGAGAC/TAGGCA 6 -- int10--------
    rs621389611,2
    C--27807414(+) ATAGGC/GAAGTA 6 -- int13Minor allele frequency- G:0.16NA EA 242
    rs609724761,2
    C,F--27807484(+) TGAGGG/AAGGGG 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs1929908231,2
    --27807560(+) GGAATA/CATGCA 6 -- int10--------
    rs130266211,2
    C,F,H--27807624(+) GGAAAA/GAGTTA 6 -- int115Minor allele frequency- G:0.34NS EA NA WA CSA 671

    HapMap Linkage Disequilibrium report for ZNF512 (27805893 - 27858041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF512:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677128CNV Deletion23128226
    nsv817684CNV Gain17921354

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF512 for disorders           About MalaCards

    ZNF512 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF512
    Human Genome Epidemiology (HuGE) Navigator: ZNF512 (1 document)

    Export disorders for ZNF512 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF512 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF512)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (2012)
    3. A bivariate genome-wide approach to metabolic syndrom e: STAMPEED consortium. (PubMed id 21386085)1, 4 Kraja A.T....Borecki I.B. (2011)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genome-wide association study identifies novel loci as sociated with concentrations of four plasma phospholipid fatty acids in the de n ovo lipogenesis pathway: results from the Cohorts for Heart and Aging Research i n Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (2013)
    6. Genomic study in Mexicans identifies a new locus for t riglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (2013)
    7. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Generalist genes analysis of DNA markers associated w ith mathematical ability and disability reveals shared influence across ages an d abilities. (PubMed id 20602751)1 Docherty S.J....Plomin R. (2010)
    10. In vitro nuclear interactome of the HIV-1 Tat protein . (PubMed id 19454010)1 Gautier V.W....Hall W.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84450 HGNC: 29380 AceView: C2orf16andZNF512 Ensembl:ENSG00000243943 euGenes: HUgn84450
    ECgene: ZNF512 H-InvDB: ZNF512

    (According to HUGE)
    About This Section
    HUGE: KIAA1805

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF512 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF512 gene:
    Search GeneIP for patents involving ZNF512

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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