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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF511 Gene

protein-coding   GIFtS: 40
GCID: GC10P135121

Zinc Finger Protein 511

  Search for ZNF511
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5111 2

External Ids:    HGNC: 284451   Entrez Gene: 1184722   Ensembl: ENSG000001985467   UniProtKB: Q8NB153   

Export aliases for ZNF511 gene to outside databases

Previous GC identifers: GC10P134595 GC10P135011 GC10P134973 GC10P128668


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF511 Gene: 
ZNF511 (zinc finger protein 511) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding.

UniProtKB/Swiss-Prot: ZN511_HUMAN, Q8NB15
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008818.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF511 gene promoter:
         USF1   AP-2alpha isoform 3   Pax-2   Pax-2a   AP-2alpha isoform 2   AREB6   USF-1   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF511 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF511

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF511


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

ZNF511 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF511 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P135121:  view genomic region     (about GC identifiers)

Start:
135,121,979 bp from pter      End:
135,166,033 bp from pter
Size:
44,055 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN511_HUMAN, Q8NB15 (See protein sequence)
Recommended Name: Zinc finger protein 511  
Size: 262 amino acids; 29428 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH15139.1; Type=Erroneous initiation;
Secondary accessions: A8K8L5 Q8WUP1 Q96BV2
Alternative splicing: 2 isoforms:  Q8NB15-1   Q8NB15-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF511: NX_Q8NB15

Explore proteomics data for ZNF511 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NB15

  • ZNF511 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF511 Protein Expression
    REFSEQ proteins: NP_665805.2  
    ENSEMBL proteins: 
     ENSP00000355251   ENSP00000351929   ENSP00000357542  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF511 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8NB15

    ProtoNet protein and cluster: Q8NB15

    UniProtKB/Swiss-Prot: ZN511_HUMAN, Q8NB15
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    ZNF511 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN511_HUMAN, Q8NB15
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF511 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF511

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF511 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Search CenterWatch for drugs/clinical trials and news about ZNF511 / ZN511

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for ZNF511 gene: 
    NM_145806.2  

    Unigene Cluster for ZNF511:

    Zinc finger protein 511
    Hs.422113  [show with all ESTs]
    Unigene Representative Sequence: BF242702
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361518(uc001lmj.1) ENST00000359035(uc001lml.1) ENST00000482153
    ENST00000463816 ENST00000368554(uc021qbf.1)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK292380.1 BC015139.1 BC019897.1 

    7 DOTS entries:

    DT.91680333  DT.442363  DT.95255003  DT.121285603  DT.97843668  DT.121285606  DT.92430796 

    24/157 AceView cDNA sequences (see all 157):

    BM545376 CR620153 CR607321 BM725265 BQ011799 CF528617 BE901320 AW673249 
    BE884285 AL583632 BE018297 AW513083 BX332048 AI269185 BE888228 BG575063 
    AK091711 CR611284 CR617311 AI269077 CR590792 AI202178 BM709894 BM677708 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF511 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAAGTAT
    ZNF511 Expression
    About this image


    See ZNF511 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF511

    SOURCE GeneReport for Unigene cluster: Hs.422113
        SABiosciences Custom PCR Arrays for ZNF511
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF511

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZNF511 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5111 , 5 zinc finger protein 5111, 5 77.41(n)1
    75.51(a)1
      7 (85.03 cM)5
    697521  NM_027201.11  NP_081477.11 
     1400363915 
    chicken
    (Gallus gallus)
    Aves ZNF5111 zinc finger protein 511 65.98(n)
    58.2(a)
      428940  XM_426494.3  XP_426494.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    40(a)
    40(a)
    many → 1
    many → 1
    GL344009.1(80622-84889)
    AAWZ02041292(21-5839)
    zebrafish
    (Danio rerio)
    Actinopterygii BI709799.12   -- 73.84(n)    BI709799.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)k102016
    lethal (2) k10201
    24(a)
    1 ↔ 1
    2R(5286594-5287404)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G141401 nucleic acid binding / zinc ion binding protein 47.74(n)
    35.68(a)
      831264  NM_121418.2  NP_196918.2 
    rice
    (Oryza sativa)
    Liliopsida Os11g04984001 hypothetical protein 51.45(n)
    38.41(a)
      4350555  NM_001074470.2  NP_001067938.1 


    ENSEMBL Gene Tree for ZNF511 (if available)
    TreeFam Gene Tree for ZNF511 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF511 gene
    1 SIMAP similar gene for ZNF511 using alignment to 2 protein entries:     ZN511_HUMAN (see all proteins):
    PRAP1

    ZNF511 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF511
    PGOHUM00000249412


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/162 SNPs in ZNF511 are shown (see all 162)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460106471,2
    --128666308(+) GACCGA/GGCCTC 1 -- us2k10--------
    rs1842464311,2
    --128666309(+) ACCGGA/GCCTCC 1 -- us2k10--------
    rs1873080761,2
    --128666435(+) AAGGGC/TGGGGG 1 -- us2k10--------
    rs30083531,2
    C,F,A--128666442(+) GGGGAT/CGCTAA 1 -- us2k1 tfbs313Minor allele frequency- C:0.24NA WA CSA EA 555
    rs1920800841,2
    --128666467(+) GTCCCA/GCCAGA 1 -- us2k10--------
    rs1846842561,2
    C--128666495(+) TGAAAA/TCACAG 1 -- us2k10--------
    rs30083541,2
    C,F,A,H--128666525(+) GTGGCT/CGCTTC 1 -- us2k127Minor allele frequency- C:0.22NS EA NA WA CSA 2714
    rs750632701,2
    --128666550(+) AGCCAC/TGGCCG 1 -- us2k10--------
    rs1902179161,2
    --128666643(+) CTGACA/GTCCTC 1 -- us2k10--------
    rs1433448851,2
    --128666712(+) TCACAC/TTCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF511 (135121979 - 135166033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for ZNF511 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    nsv832036CNV Loss17160897
    dgv879n71CNV Loss21882294
    nsv896310CNV Loss21882294
    nsv896258CNV Loss21882294
    dgv882n71CNV Loss21882294
    dgv880n71CNV Loss21882294
    nsv896182CNV Loss21882294
    dgv856n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF511 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF511)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 118472 HGNC: 28445 AceView: ZNF511 Ensembl:ENSG00000198546 euGenes: HUgn118472
    ECgene: ZNF511 H-InvDB: ZNF511

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF511 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF511 gene:
    Search GeneIP for patents involving ZNF511

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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