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ZNF510 Gene

protein-coding   GIFtS: 52
GCID: GC09M099518

Zinc Finger Protein 510

  Search for ZNF510
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5101 2
KIAA09723

External Ids:    HGNC: 291611   Entrez Gene: 228692   Ensembl: ENSG000000813867   UniProtKB: Q9Y2H83   

Export aliases for ZNF510 gene to outside databases

Previous GC identifers: GC09M094897 GC09M096597 GC09M098557 GC09M069128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF510 Gene:
ZNF510 (zinc finger protein 510) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN510_HUMAN, Q9Y2H8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF510 gene promoter:
         AREB6   CREB   FAC1   FOXO4   deltaCREB   FOXO1a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF510 promoter sequence
   Search Chromatin IP Primers for ZNF510

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF510


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.33

ZNF510 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF510 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099518:  view genomic region     (about GC identifiers)

Start:
99,518,147 bp from pter      End:
99,540,411 bp from pter
Size:
22,265 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN510_HUMAN, Q9Y2H8 (See protein sequence)
Recommended Name: Zinc finger protein 510  
Size: 683 amino acids; 79142 Da
Sequence caution: Sequence=BAA76816.2; Type=Erroneous initiation;
Secondary accessions: Q5SZP5

Explore the universe of human proteins at neXtProt for ZNF510: NX_Q9Y2H8

Explore proteomics data for ZNF510 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF510 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055745.1  
    ENSEMBL proteins: 
     ENSP00000364379   ENSP00000363772   ENSP00000223428  
    Reactome Protein details: Q9Y2H8

    ZNF510 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for ZNF510 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y2H8

    ProtoNet protein and cluster: Q9Y2H8

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN510_HUMAN, Q9Y2H8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF510           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN510_HUMAN, Q9Y2H8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF510           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF510
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF510
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF510

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF510

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF510 (NM_014930)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF510
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF510

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN510_HUMAN, Q9Y2H8: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF510           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF510 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF510           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF510
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF510
    Interactions:

        Search GeneGlobe Interaction Network for ZNF510

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ZNF510 (Q9Y2H82, 3 ENSP000002234284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62022 I2D: score=3 
    GABARAPO951663I2D: score=1 
    MT-ND5ENSP000003548134STRING: ENSP00000354813
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF510           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF510 (ZN510)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF510 gene: 
    NM_014930.1  

    Unigene Cluster for ZNF510:

    Zinc finger protein 510
    Hs.75264  [show with all ESTs]
    Unigene Representative Sequence: AB023189
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375231(uc004awo.1) ENST00000472201 ENST00000374641 ENST00000223428(uc004awn.1)

    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate ZNF510
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    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF510
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF510 (NM_014930)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF510
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF510
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF510
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF510
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF510
      QuantiFast Probe-based Assays in human, mouse, rat ZNF510

    Additional mRNA sequence: 

    AB023189.1 AK292600.1 BC036676.1 BC058022.1 BC068587.1 

    8 DOTS entries:

    DT.441207  DT.101974705  DT.121211213  DT.455586  DT.92026419  DT.95079496  DT.97810782  DT.40279933 

    Selected AceView cDNA sequences (see all 93):

    CR603078 AW440283 BM684345 F01804 F09049 BP377650 BE768697 BM468467 
    BP339782 BE220198 Z44336 BQ958836 AI872156 BM801784 AB023189 BM272137 
    BX493437 F05532 R52368 AA411750 BX093365 BP376000 BI467226 AA912086 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF510    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:                    -                                                               
    SP2:                                                                                    
    SP3:                    -                                                               
    SP4:                    -                 -                                             
    SP5:                                      -     -     -     -     -                     


    ECgene alternative splicing isoforms for ZNF510

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF510 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGTACAA
    ZNF510 Expression
    About this image

    ZNF510 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF510 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75264
        Custom PCR Arrays for ZNF510
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF510

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF510 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL869001.22   -- 75.11(n)    AL869001.2 
            Species with no ortholog for ZNF510

    ENSEMBL Gene Tree for ZNF510 (if available)
    TreeFam Gene Tree for ZNF510 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF510 gene
    ZNF1752  ZNF6742  ZNF4872  ZIM32  ZNF6142  ZNF1572  ZNF262  ZNF6132  
    ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  ENSG000002365752  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF510 using alignment to 3 protein entries:     ZN510_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    kr-znf3    FIK    ZNF78L1    ZFS-5    POM121C
    KRBOX4    ZNF300P1    ZNF    HZF36    ZNF558    DKFZp686M04222
    ZKSCAN1    ZNF487    zf30    ZFP90    ZNF320    DKFZp666C237

    Find genes that share paralogs with ZNF510           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF510
    PGOHUM00000244796


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF510 (see all 691)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109788111,2
    C,F,A,H--99517669(+) CAGGGA/CCTAAC 1 -- ds500118Minor allele frequency- C:0.14NS EA NA WA CSA 1644
    rs109788121,2
    C,F,A,H--99517755(+) TTATGC/TTCTCC 1 -- ds500115Minor allele frequency- T:0.12NS EA NA WA CSA 1554
    rs120062491,2
    C,F,H--99517783(+) CTTGGG/TAAGGC 1 -- ds50011Minor allele frequency- T:0.50NA 4
    rs791694651,2
    C,F--99517828(+) TATGAT/CATTCT 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1499071841,2
    C--99517941(+) TACATA/GCCAGT 1 -- ds50010--------
    rs1438470981,2
    --99518125(+) TATATA/CCAATG 1 -- ds50010--------
    rs771748451,2
    F--99518137(+) CATCAA/GTGGAA 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1486240301,2
    --99518145(+) GAAGCA/GTCAGA 1 -- ds50010--------
    rs1424517291,2
    --99518167(+) TTATTC/TTGTAC 1 -- ut310--------
    rs132962231,2
    H--99518171(+) TTTGTA/CCAGTA 1 -- ut31 ese34Minor allele frequency- C:0.00NS EA 418

    HapMap Linkage Disequilibrium report for ZNF510 (99518147 - 99540411 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF510:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520001CNV Loss19592680
    nsv893605CNV Gain21882294
    nsv831660CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF510
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF510

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF510           About GenesLikeMe

    Genetic Association Database (GAD): ZNF510
    Human Genome Epidemiology (HuGE) Navigator: ZNF510 (1 document)

    Export disorders for ZNF510 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF510 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF510)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. (PubMed id 19030899)1, 4 Lei S.F....Deng H.W. (Hum. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. Salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages. (PubMed id 21497587)1 Jou Y.J....Lin C.W. ( international journal of clinical chemistry 2011)
    6. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22869 HGNC: 29161 AceView: ZNF510 Ensembl:ENSG00000081386 euGenes: HUgn22869
    ECgene: ZNF510 H-InvDB: ZNF510

    (According to HUGE)
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    HUGE: KIAA0972

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF510 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF510 gene:
    Search GeneIP for patents involving ZNF510

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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