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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF506 Gene

protein-coding GIFtS: 45
GCID: GC19M019896

zinc finger protein 506

Explore 1 disease affiliated with
ZNF506 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 506¹ ²
DKFZp761G1812¹

External Ids:	HGNC: 23780¹	Entrez Gene: 440515²	Ensembl: ENSG00000081665⁷	UniProtKB: Q5JVG8³

Export aliases for ZNF506 gene to outside databases

Previous GC identifers: GC19M019757 GC19M019763 GC19U900445 GC19M019466 GC19M019902

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN506_HUMAN, Q5JVG8

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF506 gene promoter:
Sox5 Nkx2-2 Pax-2 Pax-2a Evi-1 Pax-2b FOXO4 FOXO1a FOXO1 En-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZNF506

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF506

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11

ZNF506 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF506 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M019896: view genomic region (about GC identifiers)

Start:	19,896,648 bp from pter	End:	19,932,560 bp from pter
Size:	35,913 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN506_HUMAN, Q5JVG8 (See protein sequence)

Recommended Name: Zinc finger protein 506

Size: 444 amino acids; 51537 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: B3KTH6

Alternative splicing: 2 isoforms: Q5JVG8-1 Q5JVG8-2

Explore the universe of human proteins at neXtProt for ZNF506: NX_Q5JVG8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5JVG8

ZNF506 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001092739.1 NP_001138876.1

ENSEMBL proteins:

ENSP00000468150 ENSP00000468217 ENSP00000464733 ENSP00000467047 ENSP00000440625

ENSP00000408892 ENSP00000468206 ENSP00000464837 ENSP00000445149 ENSP00000393835

Reactome Protein details: Q5JVG8
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	Uscn Proteins for ZNF506

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005730	nucleolus	IDA	--

ZNF506 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF506 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q5JVG8

ProtoNet protein and cluster: Q5JVG8

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN506_HUMAN, Q5JVG8

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 8 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN506_HUMAN, Q5JVG8

Function: May be involved in transcriptional regulation

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZNF506

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF506 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF506:

Decreased Wnt reporter activit

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF506

	Generic Transcription Pathway
	Gene Expression

ZNF506 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF506

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF506 (Q5JVG8³ ENSP00000393835⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PML	P29590³, ENSP00000268058⁴	I2D: score=1 STRING: ENSP00000268058

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF506 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF506
Search CenterWatch for drugs/clinical trials and news about ZNF506 / ZN506

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF506 gene (3 alternative transcripts):

NM_001145405.1 NM_001099269.2 NM_001145404.1

Unigene Cluster for ZNF506:

Zinc finger protein 506

Hs.351906 [show with all ESTs]

Unigene Representative Sequence: NM_001099269

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000591639 ENST00000587461 ENST00000586260 ENST00000590766 ENST00000540806(uc010eci.2)

ENST00000450683(uc002noh.3) ENST00000587822 ENST00000590319 ENST00000587452

ENST00000545006(uc010ecj.2) ENST00000443905(uc021urk.1)

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF506 OriGene shRNA RFP: ZNF506 OriGene siRNA: ZNF506
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF506

Additional cDNA sequence:

AK095575.1 AK122848.1 BC018100.1 BC034920.1

24/25 DOTS entries (see all 25):

DT.40129875 DT.411501 DT.95204354 DT.70105097 DT.40316414 DT.95289159 DT.100035889 DT.100775831

DT.121492927 DT.91937483 DT.95280084 DT.100020145 DT.121492787 DT.121492952 DT.40208205 DT.40301892

DT.92421638 DT.95100464 DT.95178937 DT.101977487 DT.121493003 DT.433029 DT.75154095 DT.91702022

24/99 AceView cDNA sequences (see all 99):

AI497946 CF528721 AW007318 BU176374 BM741043 AI269334 CB215342 R72088

CD676644 AV651901 AI364837 CA441296 CR615667 BE253394 BM837027 R72139

AI332710 BM805432 AK122848 AI703041 BM263738 AW901984 BC018100 BM543351

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF506 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGCAGACC

About this image

ZNF506 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung Bud

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF506 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF506

SOURCE GeneReport for Unigene cluster: Hs.351906

SABiosciences Custom PCR Arrays for ZNF506

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZNF506

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF506 gene from 1/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 7)	--	37(a) 37(a) (see all 7)	many ↔ many many ↔ many (see all 7)	GL343330.1(1093706-1292239) AAWZ02037240(11818-13836)

ENSEMBL Gene Tree for ZNF506 (if available)
TreeFam Gene Tree for ZNF506 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF506 gene

ZNF85² ZNF493² ZNF486² ZNF100² ZNF92² ZNF732² ZNF138² ZNF675²

ZNF273² ZNF66P² ZNF695² ZNF626² ZNF680² ZNF253² ZNF479² ZNF93²

ZNF492² ZNF682² ZNF676² ZNF141² ZNF681² ZNF679² ZNF257² ZNF254²

ZNF737² ZNF724P² ZNF98² ZNF849P² ZNF716² ZNF714² ZNF429² ZNF430²

ZNF730² ZNF678² ZNF117² ZNF708² ZNF107² ZNF431² ZNF90²

18/521 SIMAP similar genes for ZNF506 using alignment to 8 protein entries: ZN506_HUMAN (see all proteins) (see all similar genes):

ZNF90 A4GALT MGC12518 ZNF66 C8orf44 ZNF273

ZNF737 ZNF93 ZNF66P ZNF492 ZNF98 ZNF724P

ZNF430 ZNF708 ZNF254 ZNF429 ZNF85 ZNF486

ZNF506 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for ZNF506
PGOHUM00000259308 PGOHUM00000259309 PGOHUM00000234224

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191025954^1,2		--	19903027(+)	`GGTGCA/GGTGGC`	2	--	int¹		0	--	--	--	--
rs183290153^1,2		--	19903081(+)	`ATCACA/GAGGTC`	2	--	int¹		0	--	--	--	--
rs199940184^1,2		--	19903087(+)	`AGGTC-/AGGAGATT`	2	--	int¹		0	--	--	--	--
rs147228540^1,2		--	19903166(+)	`GTGGCA/GGGTGC`	2	--	int¹		0	--	--	--	--
rs4808987^1,2	C,A,H,	--	19903262(+)	`ACAGCG/ACTCCA`	2	--	int¹		10		NA WA CSA	17
rs35881648^1,2	C,F,	--	19903296(+)	`ATCTC-/AAAAAA`	2	--	int¹		2		NA CSA	4
rs71172538^1,2	C	--	19903297(+)	`AAAAAA/-GAAAA`	2	--	int¹		1		NA	2
rs186531034^1,2		--	19903342(+)	`TTAAAC/TGCAGA`	2	--	int¹		0	--	--	--	--
rs4808988^1,2	C,A,H,	--	19903438(+)	`GTACAA/GTTAGT`	2	--	int¹		10		NA WA CSA EA	371
rs77479727^1,2	F,	--	19903497(+)	`AATGTA/CGAAAA`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for ZNF506 (19896648 - 19932560 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF506: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF506

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF506

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF506 for disorders About GeneDecksing

1 disease for ZNF506: About MalaCards

parotitis

Export disorders for ZNF506 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF506 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF506)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies. (PubMed id 16412420)¹ Fleischer S....Hofmann T.G. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)² Wiemann S.... Poustka A. (2001)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 440515	HGNC: 23780	AceView: LOC439924	Ensembl:ENSG00000081665	euGenes: HUgn440515
ECgene: ZNF506	H-InvDB: ZNF506

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF506	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF506 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF506 gene:
Search GeneIP for patents involving ZNF506

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF506
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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ZNF506 Gene

zinc finger protein 506

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ZNF506 Gene

zinc finger protein 506

Aliasesfor ZNF506 gene

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Protein Domains /Familiesfor ZNF506 gene

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