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Aliases for ZNF506 Gene

Aliases for ZNF506 Gene

  • Zinc Finger Protein 506 2 3 5

External Ids for ZNF506 Gene

Previous GeneCards Identifiers for ZNF506 Gene

  • GC19M019757
  • GC19M019763
  • GC19U900445
  • GC19M019896
  • GC19M019466
  • GC19M019902

Summaries for ZNF506 Gene

GeneCards Summary for ZNF506 Gene

ZNF506 (Zinc Finger Protein 506) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF506 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF506 Gene

Genomics for ZNF506 Gene

Regulatory Elements for ZNF506 Gene

Enhancers for ZNF506 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF506 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF506 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF506 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF506 Gene

19,785,839 bp from pter
19,821,751 bp from pter
35,913 bases
Minus strand

Genomic View for ZNF506 Gene

Genes around ZNF506 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF506 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF506 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF506 Gene

Proteins for ZNF506 Gene

  • Protein details for ZNF506 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 506
    Protein Accession:
    Secondary Accessions:
    • B3KTH6

    Protein attributes for ZNF506 Gene

    444 amino acids
    Molecular mass:
    51537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF506 Gene


neXtProt entry for ZNF506 Gene

Proteomics data for ZNF506 Gene at MOPED

Post-translational modifications for ZNF506 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF506 Gene

Domains & Families for ZNF506 Gene

Gene Families for ZNF506 Gene

Protein Domains for ZNF506 Gene

Suggested Antigen Peptide Sequences for ZNF506 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF506: view

Function for ZNF506 Gene

Molecular function for ZNF506 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF506 Gene

genes like me logo Genes that share phenotypes with ZNF506: view

Animal Model Products

CRISPR Products

miRNA for ZNF506 Gene

miRTarBase miRNAs that target ZNF506

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF506 Gene

Localization for ZNF506 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF506 Gene

Subcellular locations from

Jensen Localization Image for ZNF506 Gene COMPARTMENTS Subcellular localization image for ZNF506 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF506 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ZNF506: view

Pathways & Interactions for ZNF506 Gene

SuperPathways for ZNF506 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF506: view

Pathways by source for ZNF506 Gene

2 Reactome pathways for ZNF506 Gene

Gene Ontology (GO) - Biological Process for ZNF506 Gene


No data available for SIGNOR curated interactions for ZNF506 Gene

Drugs & Compounds for ZNF506 Gene

No Compound Related Data Available

Transcripts for ZNF506 Gene

Unigene Clusters for ZNF506 Gene

Zinc finger protein 506:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF506 Gene

No ASD Table

Relevant External Links for ZNF506 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF506 Gene

mRNA expression in normal human tissues for ZNF506 Gene

Protein differential expression in normal tissues from HIPED for ZNF506 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF506 Gene

SOURCE GeneReport for Unigene cluster for ZNF506 Gene Hs.351906

genes like me logo Genes that share expression patterns with ZNF506: view

Protein tissue co-expression partners for ZNF506 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF506 Gene

Orthologs for ZNF506 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF506 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF506 35
  • 99.17 (n)
  • 98.42 (a)
ZNF506 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
(Canis familiaris)
Mammalia -- 36
  • 29 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
-- 36
  • 43 (a)
(Mus musculus)
Mammalia Zfp386 36
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
-- 36
  • 25 (a)
-- 36
  • 30 (a)
-- 36
  • 30 (a)
-- 36
  • 23 (a)
-- 36
  • 22 (a)
-- 36
  • 22 (a)
-- 36
  • 22 (a)
Species with no ortholog for ZNF506:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF506 Gene

Gene Tree for ZNF506 (if available)
Gene Tree for ZNF506 (if available)

Paralogs for ZNF506 Gene

(534) SIMAP similar genes for ZNF506 Gene using alignment to 8 proteins: Pseudogenes for ZNF506 Gene

genes like me logo Genes that share paralogs with ZNF506: view

Variants for ZNF506 Gene

Sequence variations from dbSNP and Humsavar for ZNF506 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs16996376 - 19,795,322(+) TGTAG(C/G/T)ACGGG reference, missense
rs7256535 -- 19,797,812(+) AAAAA(A/C)ATTTT intron-variant
rs12980375 -- 19,808,438(+) catta(A/T)ctgca intron-variant
rs12980383 -- 19,808,443(+) actgc(A/G)ctagg intron-variant
rs12983878 -- 19,818,171(+) tatat(C/G/T)tactt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF506 Gene

Variant ID Type Subtype PubMed ID
dgv3790n71 CNV Gain 21882294
nsv458375 CNV Gain 19166990
dgv3791n71 CNV Loss 21882294
nsv519535 CNV Gain 19592680
esv2669979 CNV Deletion 23128226
esv2718296 CNV Deletion 23290073
esv2665024 CNV Deletion 23128226

Variation tolerance for ZNF506 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF506 Gene

Disorders for ZNF506 Gene

Relevant External Links for ZNF506

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF506 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF506 Gene

Publications for ZNF506 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies. (PMID: 16412420) Fleischer S. … Hofmann T.G. (Exp. Cell Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3

Products for ZNF506 Gene

Sources for ZNF506 Gene