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Aliases for ZNF503 Gene

Aliases for ZNF503 Gene

  • Zinc Finger Protein 503 2 3 5
  • NOLZ1 3 4
  • NOLZ-1 3
  • Nlz2 3

External Ids for ZNF503 Gene

Previous GeneCards Identifiers for ZNF503 Gene

  • GC10M076502
  • GC10M076827
  • GC10M077157
  • GC10M071156
  • GC10M077040
  • GC10M075397

Summaries for ZNF503 Gene

GeneCards Summary for ZNF503 Gene

ZNF503 (Zinc Finger Protein 503) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF703.

UniProtKB/Swiss-Prot for ZNF503 Gene

  • May function as a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF503 Gene

Genomics for ZNF503 Gene

Regulatory Elements for ZNF503 Gene

Enhancers for ZNF503 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF503 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF503 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF503 Gene

Chromosome:
10
Start:
75,279,726 bp from pter
End:
75,401,906 bp from pter
Size:
122,181 bases
Orientation:
Minus strand

Genomic View for ZNF503 Gene

Genes around ZNF503 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF503 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF503 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF503 Gene

Proteins for ZNF503 Gene

  • Protein details for ZNF503 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F45-ZN503_HUMAN
    Recommended name:
    Zinc finger protein 503
    Protein Accession:
    Q96F45
    Secondary Accessions:
    • Q8NAC5
    • Q96E25
    • Q96IJ0

    Protein attributes for ZNF503 Gene

    Size:
    646 amino acids
    Molecular mass:
    62555 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03999.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF503 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF503 Gene

Post-translational modifications for ZNF503 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF503 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF503 Gene

Domains & Families for ZNF503 Gene

Gene Families for ZNF503 Gene

Protein Domains for ZNF503 Gene

Suggested Antigen Peptide Sequences for ZNF503 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F45

UniProtKB/Swiss-Prot:

ZN503_HUMAN :
  • Belongs to the Elbow/Noc family.
  • Contains 1 C2H2-type zinc finger.
Family:
  • Belongs to the Elbow/Noc family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF503: view

Function for ZNF503 Gene

Molecular function for ZNF503 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF503: view
genes like me logo Genes that share phenotypes with ZNF503: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF503 Gene

Localization for ZNF503 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF503 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF503 Gene COMPARTMENTS Subcellular localization image for ZNF503 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF503: view

Pathways & Interactions for ZNF503 Gene

SuperPathways for ZNF503 Gene

No Data Available

Interacting Proteins for ZNF503 Gene

Gene Ontology (GO) - Biological Process for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008285 negative regulation of cell proliferation IDA 20735826
GO:0010629 negative regulation of gene expression IDA 20735826
GO:0061351 neural precursor cell proliferation IEA --
genes like me logo Genes that share ontologies with ZNF503: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF503 Gene

Drugs & Compounds for ZNF503 Gene

No Compound Related Data Available

Transcripts for ZNF503 Gene

mRNA/cDNA for ZNF503 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF503 Gene

Zinc finger protein 503:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF503 Gene

No ASD Table

Relevant External Links for ZNF503 Gene

GeneLoc Exon Structure for
ZNF503
ECgene alternative splicing isoforms for
ZNF503

Expression for ZNF503 Gene

mRNA expression in normal human tissues for ZNF503 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF503 Gene

This gene is overexpressed in Brain (59.0) and Cerebrospinal fluid (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF503 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF503 Gene:

ZNF503

SOURCE GeneReport for Unigene cluster for ZNF503 Gene:

Hs.195710
genes like me logo Genes that share expression patterns with ZNF503: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF503 Gene

Orthologs for ZNF503 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF503 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF503 34
  • 92.06 (n)
  • 95.83 (a)
ZNF503 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF503 34
  • 92.26 (n)
  • 96.75 (a)
ZNF503 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp503 34
  • 89.35 (n)
  • 96.12 (a)
Zfp503 16
Zfp503 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF503 34
  • 99.33 (n)
  • 99.53 (a)
ZNF503 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp503 34
  • 89.22 (n)
  • 95.8 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF503 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF503 34
  • 78.42 (n)
  • 78.8 (a)
ZNF503 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF503 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18810 34
znf503 34
  • 68.11 (n)
  • 75.15 (a)
zebrafish
(Danio rerio)
Actinopterygii noz2 34
znf503 34
  • 69.87 (n)
  • 80.75 (a)
znf503 35
  • 77 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for ZNF503 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF503 Gene

ENSEMBL:
Gene Tree for ZNF503 (if available)
TreeFam:
Gene Tree for ZNF503 (if available)

Paralogs for ZNF503 Gene

Paralogs for ZNF503 Gene

(1) SIMAP similar genes for ZNF503 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF503: view

Variants for ZNF503 Gene

Sequence variations from dbSNP and Humsavar for ZNF503 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs35764982 - 75,399,163(+) GGGTC(G/T)TTAGG intron-variant, reference, missense
rs2004523 -- 75,291,336(-) ccaca(C/G)ccagc intron-variant
rs2013448 -- 75,291,515(-) TCCCC(A/C/G)TCAGC intron-variant
rs3814638 -- 75,398,953(-) TCGGG(C/T)GCACC intron-variant, reference, synonymous-codon
rs748207 -- 75,282,475(-) gatga(C/T)ttcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF503 Gene

Variant ID Type Subtype PubMed ID
dgv163n67 CNV gain 20364138
dgv927n100 CNV gain 25217958
dgv928n100 CNV gain 25217958
esv1490079 CNV insertion 17803354
esv2858569 CNV duplication 24192839
esv3379237 CNV insertion 20981092
esv3623849 CNV loss 21293372
esv991439 CNV insertion 20482838
nsv1042547 CNV gain 25217958
nsv1069060 CNV deletion 25765185
nsv1126260 CNV deletion 24896259
nsv7221 CNV insertion 18451855
nsv950978 CNV deletion 24416366

Variation tolerance for ZNF503 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF503 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF503

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF503 Gene

Disorders for ZNF503 Gene

Relevant External Links for ZNF503

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF503

No disorders were found for ZNF503 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF503 Gene

Publications for ZNF503 Gene

  1. Nlz1/Znf703 acts as a repressor of transcription. (PMID: 19014486) Nakamura M. … SagerstrAPm C.G. (BMC Dev. Biol. 2008) 2 3 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for ZNF503 Gene

Sources for ZNF503 Gene

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