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Aliases for ZNF503 Gene

Aliases for ZNF503 Gene

  • Zinc Finger Protein 503 2 3
  • NOLZ1 3 4 6
  • NOLZ-1 3
  • Nlz2 3

External Ids for ZNF503 Gene

Summaries for ZNF503 Gene

GeneCards Summary for ZNF503 Gene

ZNF503 (Zinc Finger Protein 503) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF703.

UniProtKB/Swiss-Prot for ZNF503 Gene

  • May function as a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF503 Gene

Genomics for ZNF503 Gene

Genomic Location for ZNF503 Gene

Start:
75,397,830 bp from pter
End:
75,401,906 bp from pter
Size:
4,077 bases
Orientation:
Minus strand

Genomic View for ZNF503 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF503 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF503 Gene

Regulatory Elements for ZNF503 Gene

Proteins for ZNF503 Gene

  • Protein details for ZNF503 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F45-ZN503_HUMAN
    Recommended name:
    Zinc finger protein 503
    Protein Accession:
    Q96F45
    Secondary Accessions:
    • Q8NAC5
    • Q96E25
    • Q96IJ0

    Protein attributes for ZNF503 Gene

    Size:
    646 amino acids
    Molecular mass:
    62555 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03999.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF503 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF503 Gene

Proteomics data for ZNF503 Gene at MOPED

Post-translational modifications for ZNF503 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF503 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF503 Gene

Domains for ZNF503 Gene

Gene Families for ZNF503 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF503 Gene

UniProtKB/Swiss-Prot:

ZN503_HUMAN
Family:
  • Belongs to the Elbow/Noc family.:
    • Q96F45
Similarity:
  • Contains 1 C2H2-type zinc finger.:
    • Q96F45
genes like me logo Genes that share domains with ZNF503: view

Function for ZNF503 Gene

Molecular function for ZNF503 Gene

UniProtKB/Swiss-Prot Function: May function as a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF503: view

Phenotypes for ZNF503 Gene

GenomeRNAi human phenotypes for ZNF503:
genes like me logo Genes that share phenotypes with ZNF503: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF503 Gene

Localization for ZNF503 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF503 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF503 Gene COMPARTMENTS Subcellular localization image for ZNF503 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF503: view

Pathways for ZNF503 Gene

SuperPathways for ZNF503 Gene

No Data Available

Interacting Proteins for ZNF503 Gene

Gene Ontology (GO) - Biological Process for ZNF503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008285 negative regulation of cell proliferation IDA 20735826
GO:0010629 negative regulation of gene expression IDA 20735826
GO:0061351 neural precursor cell proliferation IEA --
genes like me logo Genes that share ontologies with ZNF503: view

No data available for Pathways by source for ZNF503 Gene

Transcripts for ZNF503 Gene

mRNA/cDNA for ZNF503 Gene

Unigene Clusters for ZNF503 Gene

Zinc finger protein 503:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF503 Gene

No ASD Table

Relevant External Links for ZNF503 Gene

GeneLoc Exon Structure for
ZNF503
ECgene alternative splicing isoforms for
ZNF503

Expression for ZNF503 Gene

mRNA expression in normal human tissues for ZNF503 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF503 Gene

SOURCE GeneReport for Unigene cluster for ZNF503 Gene Hs.195710

genes like me logo Genes that share expressions with ZNF503: view

Orthologs for ZNF503 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF503 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF503 36
  • 99.33 (n)
  • 99.53 (a)
ZNF503 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF503 36
  • 92.06 (n)
  • 95.83 (a)
ZNF503 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF503 36
  • 92.26 (n)
  • 96.75 (a)
ZNF503 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp503 36
  • 89.35 (n)
  • 96.12 (a)
Zfp503 16
Zfp503 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF503 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp503 36
  • 89.22 (n)
  • 95.8 (a)
chicken
(Gallus gallus)
Aves ZNF503 36
  • 78.42 (n)
  • 78.8 (a)
ZNF503 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF503 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18810 36
znf503 36
  • 68.11 (n)
  • 75.15 (a)
zebrafish
(Danio rerio)
Actinopterygii noz2 36
znf503 36
  • 69.87 (n)
  • 80.75 (a)
znf503 37
  • 77 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToMany
Species with no ortholog for ZNF503:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF503 Gene

ENSEMBL:
Gene Tree for ZNF503 (if available)
TreeFam:
Gene Tree for ZNF503 (if available)

Paralogs for ZNF503 Gene

Paralogs for ZNF503 Gene

Selected SIMAP similar genes for ZNF503 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF503: view

Variants for ZNF503 Gene

Sequence variations from dbSNP and Humsavar for ZNF503 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs748207 -- 75,282,475(-) gatga(C/T)ttcaa intron-variant
rs931819 -- 75,286,812(+) GGGGC(C/T)GCGTC intron-variant
rs1053323 -- 75,398,483(+) TTTTC(C/T)TTTTT utr-variant-3-prime, intron-variant
rs1053391 -- 75,398,830(+) GCGGC(A/G)GGCAC reference, synonymous-codon, intron-variant
rs1064659 -- 75,398,482(+) TTTTT(C/T)CTTTT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF503 Gene

Variant ID Type Subtype PubMed ID
dgv163n67 CNV Gain 20364138
nsv895730 CNV Loss 21882294

Relevant External Links for ZNF503 Gene

HapMap Linkage Disequilibrium report
ZNF503

Disorders for ZNF503 Gene

No disorders were found for ZNF503 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF503 Gene

Publications for ZNF503 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Nlz1/Znf703 acts as a repressor of transcription. (PMID: 19014486) Nakamura M. … SagerstrAPm C.G. (BMC Dev. Biol. 2008) 2 3
  3. Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling. (PMID: 20735826) UrbA!n N. … Canals J.M. (Neural Dev 2010) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for ZNF503 Gene

  • antibodies-online peptides for ZNF503
  • antibodies-online antibodies for ZNF503
  • antibodies-online kits for ZNF503

Sources for ZNF503 Gene

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