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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF501 Gene

protein-coding GIFtS: 41
GCID: GC03P044771

zinc finger protein 501

(Previous name: zinc finger protein 52 )
(Previous symbol: ZNF52)

Explore 1 disease affiliated with
ZNF501 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 501¹ ²
Zinc Finger Protein 52¹ ² ³
ZNF52¹ ² ³
MGC21738¹
ZNF²

External Ids:	HGNC: 23717¹	Entrez Gene: 115560²	Ensembl: ENSG00000186446⁷	UniProtKB: Q96CX3³

Export aliases for ZNF501 gene to outside databases

Previous GC identifers: GC03P044731 GC03P044746

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN501_HUMAN, Q96CX3

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF501 gene promoter:
TBP RFX1 Pax-6 CUTL1 Ik-3 Gfi-1 HNF-4alpha1 TFIID ARP-1 Sox9
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF501 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF501

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF501

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.32

ZNF501 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF501 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P044771: view genomic region (about GC identifiers)

Start:	44,771,088 bp from pter	End:	44,778,575 bp from pter
Size:	7,488 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN501_HUMAN, Q96CX3 (See protein sequence)

Recommended Name: Zinc finger protein 501

Size: 271 amino acids; 31179 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: B4DLY7 Q96NU9

Alternative splicing: 2 isoforms: Q96CX3-1 Q96CX3-2 (May be due to exon skipping)

Explore the universe of human proteins at neXtProt for ZNF501: NX_Q96CX3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96CX3

ZNF501 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001245209.1 NP_659481.2

ENSEMBL proteins:

ENSP00000379363

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	Uscn Proteins for ZNF501

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF501 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF501 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96CX3

ProtoNet protein and cluster: Q96CX3

UniProtKB/Swiss-Prot: ZN501_HUMAN, Q96CX3

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 9 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN501_HUMAN, Q96CX3

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF501 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for ZNF501:

Downregulation of NF-kappaB pa

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF501

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF501 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF501
Search CenterWatch for drugs/clinical trials and news about ZNF501 / ZN501

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF501 gene (2 alternative transcripts):

NM_001258280.1 NM_145044.3

Unigene Cluster for ZNF501:

Zinc finger protein 501

Hs.401045 [show with all ESTs]

Unigene Representative Sequence: NM_001258280

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000396048(uc003cnu.1) ENST00000486486 ENST00000491543 ENST00000484233

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Additional cDNA sequence:

AK054613.1 AK297216.1 AK316574.1 BC013762.1

3 DOTS entries:

DT.103239 DT.91796010 DT.120882062

23 AceView cDNA sequences:

H68118 BP368765 AL535140 H67036 NM_145044 CR596464 BC013762 BU679812

AA351812 BF439979 AW444544 BG621468 AK054613 BX430977 BI962794 BP370352

AU252876 BX430976 AI571332 H16097 AL535139 H16098 H83164

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF501 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b
SP1:							-				-
SP2:											-
SP3:							-

ECgene alternative splicing isoforms for ZNF501

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF501 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAGCAAA

About this image
See ZNF501 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF501

SOURCE GeneReport for Unigene cluster: Hs.401045

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF501 gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZNF629⁶ --	Uncharacterized protein	49(a) 42(a)	many ↔ many many ↔ many	14(13134237-13135043) 16(414281-415279)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	54(a) 47(a) (see all 4)	possible ortholog 1 ↔ many (see all 4)	GL343733.1(146697-147482) 2(189268029-189269119)
worm (Caenorhabditis elegans)	Secernentea	Y5F2A.4⁶	Protein Y5F2A.4	10(a)	1 → many	IV(11076063-11078563)

ENSEMBL Gene Tree for ZNF501 (if available)
TreeFam Gene Tree for ZNF501 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF501 gene

ZNF71² ZNF586² ZNF16² ZNF623² ZFP2² ZNF345² ZNF23² ZNF852²

ZFP3² ZNF502² ZNF35² ZNF660² ZKSCAN7²

18/572 SIMAP similar genes for ZNF501 using alignment to 1 protein entry: ZN501_HUMAN(see all similar genes):

ZNF78L1 DKFZp761O1618 ZFP41 ZNF ZNF211 ZNF418

ZNF619 ZNF135 ZNF599 ZKSCAN1 ZNF271 ZNF483

ZNF554 ZNF583 DKFZp571N1833 DKFZp666C237 DKFZp686H20223 DKFZp686N14223

ZNF501 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182154869^1,2		--	44769118(+)	`TTTCCA/CCCTCA`	2	--	us2k¹		0	--	--	--	--
rs116146938^1,2		--	44769133(+)	`AAGAAG/TCTCAG`	2	--	us2k¹		1		WA	118
rs140105114^1,2		--	44769248(+)	`TTTGAA/TGCCTA`	2	--	us2k¹		0	--	--	--	--
rs150364441^1,2		--	44769284(+)	`CTAGGC/GTCTCT`	2	--	us2k¹		0	--	--	--	--
rs186773378^1,2		--	44769302(+)	`GAGATA/GTTAGG`	2	--	us2k¹		0	--	--	--	--
rs116788782^1,2	F,	--	44769308(+)	`TTAGGG/ACTGGA`	2	--	us2k¹		1		NA	120
rs145090160^1,2		--	44769355(+)	`AGAATC/GTGACA`	2	--	us2k¹		0	--	--	--	--
rs77524610^1,2	C,F,	--	44769410(+)	`TGACAA/GTTTTA`	2	--	us2k¹		1		WA	118
rs148132196^1,2	C,	--	44769510(+)	`GAAAA-/CCAGCC`	2	--	us2k¹		0	--	--	--	--
rs34621629^1,2	C	--	44769538(+)	`GGATA-/TTTTTT`	2	--	us2k¹		2		NA CSA	4

HapMap Linkage Disequilibrium report for ZNF501 (44771088 - 44778575 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF501: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF501 for disorders About GeneDecksing

1 disease for ZNF501: About MalaCards

enamel erosion

Export disorders for ZNF501 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF501 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF501)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)^{1, 3} Lichter P....Ward D.C. (1992)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)¹ Bray P.L.... Dawid I.B. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 115560	HGNC: 23717	AceView: ZNF501	Ensembl:ENSG00000186446	euGenes: HUgn115560
ECgene: ZNF501	H-InvDB: ZNF501

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF501	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF501 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF501 gene:
Search GeneIP for patents involving ZNF501

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF501 gene at Home site.

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ZNF501 Gene

zinc finger protein 501

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ZNF501 Gene

zinc finger protein 501

Aliasesfor ZNF501 gene

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Protein Domains /Familiesfor ZNF501 gene

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Specialized Databases showing ZNF501 gene

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for ZNF501 gene

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for ZNF501 gene

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for ZNF501 gene

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for ZNF501 gene

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for ZNF501 gene

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