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Aliases for ZNF500 Gene

Aliases for ZNF500 Gene

  • Zinc Finger Protein 500 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 18 3 4
  • ZKSCAN18 3 4
  • KIAA0557 4
  • ZSCAN50 3

External Ids for ZNF500 Gene

Previous GeneCards Identifiers for ZNF500 Gene

  • GC16M004801
  • GC16M004798
  • GC16M004738

Summaries for ZNF500 Gene

GeneCards Summary for ZNF500 Gene

ZNF500 (Zinc Finger Protein 500) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF213.

UniProtKB/Swiss-Prot for ZNF500 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF500 Gene

Genomics for ZNF500 Gene

Regulatory Elements for ZNF500 Gene

Enhancers for ZNF500 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G004536 1.8 FANTOM5 ENCODE dbSUPER 47.3 +229.4 229433 2.6 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF500 CDIP1 NMRAL1 CREBBP HMOX2 GLIS2 MGRN1 PPL C16orf96 ENSG00000278434
GH16G004611 1.7 Ensembl ENCODE dbSUPER 39.4 +152.1 152053 9.1 CREB3L1 MLX AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 ZNF500 CREBBP MGRN1 ENSG00000263235 ALG1 SEC14L5 GLIS2 HMOX2 GC16M004615
GH16G004368 2 FANTOM5 Ensembl ENCODE dbSUPER 27.3 +393.3 393316 11.0 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 CREBBP ZNF500 NMRAL1 ZNF597 ZNF174 HMOX2 CLUAP1 LOC102724927 MGRN1 UBN1
GH16G004942 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.5 -176.7 -176749 4.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF500 SEPT12 SEC14L5 MGRN1 PPL GC16M004952 GC16P004899
GH16G004473 1.4 ENCODE dbSUPER 36.4 +291.5 291456 5.4 MLX CREB3L1 AGO1 DMAP1 ZNF143 ZNF548 ZNF263 SP3 NFYC GLIS1 NMRAL1 ZNF500 CREBBP CDIP1 HMOX2 NUDT16L1 MGRN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF500 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF500 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000279523 118 1401 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143
ENSR00000279523 524 1401 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143
ENSR00000082864 -1176 1200 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF143
ENSR00000082864 -1582 1200 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF143

Genomic Location for ZNF500 Gene

Chromosome:
16
Start:
4,745,987 bp from pter
End:
4,767,624 bp from pter
Size:
21,638 bases
Orientation:
Minus strand

Genomic View for ZNF500 Gene

Genes around ZNF500 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF500 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF500 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF500 Gene

Proteins for ZNF500 Gene

  • Protein details for ZNF500 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60304-ZN500_HUMAN
    Recommended name:
    Zinc finger protein 500
    Protein Accession:
    O60304
    Secondary Accessions:
    • A8K6X7
    • B4DNN9
    • Q0VAL2
    • Q96CQ8
    • Q9BTG0

    Protein attributes for ZNF500 Gene

    Size:
    480 amino acids
    Molecular mass:
    53674 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF500 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF500 Gene

Post-translational modifications for ZNF500 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ZNF500

No data available for DME Specific Peptides for ZNF500 Gene

Domains & Families for ZNF500 Gene

Gene Families for ZNF500 Gene

Graphical View of Domain Structure for InterPro Entry

O60304

UniProtKB/Swiss-Prot:

ZN500_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF500: view

Function for ZNF500 Gene

Molecular function for ZNF500 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF500: view

Phenotypes for ZNF500 Gene

genes like me logo Genes that share phenotypes with ZNF500: view

Animal Model Products

CRISPR Products

miRNA for ZNF500 Gene

miRTarBase miRNAs that target ZNF500

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF500 Gene

Localization for ZNF500 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF500 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF500 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF500: view

Pathways & Interactions for ZNF500 Gene

SuperPathways for ZNF500 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF500: view

Pathways by source for ZNF500 Gene

2 Reactome pathways for ZNF500 Gene

Gene Ontology (GO) - Biological Process for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF500: view

No data available for SIGNOR curated interactions for ZNF500 Gene

Transcripts for ZNF500 Gene

Unigene Clusters for ZNF500 Gene

Zinc finger protein 500:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF500 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3:

Relevant External Links for ZNF500 Gene

GeneLoc Exon Structure for
ZNF500
ECgene alternative splicing isoforms for
ZNF500

Expression for ZNF500 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF500 Gene

Protein differential expression in normal tissues from HIPED for ZNF500 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF500 Gene



Protein tissue co-expression partners for ZNF500 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF500 Gene:

ZNF500

SOURCE GeneReport for Unigene cluster for ZNF500 Gene:

Hs.513316

Evidence on tissue expression from TISSUES for ZNF500 Gene

  • Nervous system(4.8)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF500: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF500 Gene

Orthologs for ZNF500 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF500 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF500 34 35
  • 98.72 (n)
dog
(Canis familiaris)
Mammalia ZNF500 34 35
  • 82.33 (n)
cow
(Bos Taurus)
Mammalia ZNF500 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF500 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF500 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFP92 35
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
Species where no ortholog for ZNF500 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF500 Gene

ENSEMBL:
Gene Tree for ZNF500 (if available)
TreeFam:
Gene Tree for ZNF500 (if available)

Paralogs for ZNF500 Gene

Paralogs for ZNF500 Gene

(392) SIMAP similar genes for ZNF500 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF500: view

Variants for ZNF500 Gene

Sequence variations from dbSNP and Humsavar for ZNF500 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000187045 -- 4,755,800(+) GGAAA(C/T)CACCC intron-variant
rs1000218095 -- 4,756,054(+) GGAAA(C/T)GGGGA intron-variant
rs1000259365 -- 4,761,950(+) GGGAG(A/G)AAGCT intron-variant
rs1000328107 -- 4,751,474(+) CCGCC(C/G)TGCAG intron-variant, utr-variant-3-prime
rs1000401287 -- 4,757,988(+) TCTCC(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF500 Gene

Variant ID Type Subtype PubMed ID
esv2678305 CNV deletion 23128226
esv3637704 CNV gain 21293372
esv3637705 CNV loss 21293372
nsv1046986 CNV gain 25217958
nsv571302 CNV gain 21841781

Variation tolerance for ZNF500 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF500 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF500

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF500 Gene

Disorders for ZNF500 Gene

Relevant External Links for ZNF500

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF500

No disorders were found for ZNF500 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF500 Gene

Publications for ZNF500 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for ZNF500 Gene

Sources for ZNF500 Gene