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ZNF500 Gene

protein-coding   GIFtS: 47
GCID: GC16M004798

Zinc Finger Protein 500

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5001 2
Zinc Finger Protein With KRAB And SCAN Domains 182 3
ZKSCAN182 3
ZSCAN502
KIAA05573

External Ids:    HGNC: 237161   Entrez Gene: 260482   Ensembl: ENSG000001031997   UniProtKB: O603043   

Export aliases for ZNF500 gene to outside databases

Previous GC identifers: GC16M004801 GC16M004738


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF500 Gene:
ZNF500 (zinc finger protein 500) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF446.

UniProtKB/Swiss-Prot: ZN500_HUMAN, O60304
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF500 gene promoter:
         SRF   AML1a   SREBP-1c   NF-kappaB   SREBP-1b   HEN1   PPAR-gamma1   SREBP-1a   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF500 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF500


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ZNF500 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF500 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004798:  view genomic region     (about GC identifiers)

Start:
4,798,240 bp from pter      End:
4,817,625 bp from pter
Size:
19,386 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN500_HUMAN, O60304 (See protein sequence)
Recommended Name: Zinc finger protein 500  
Size: 480 amino acids; 53674 Da
Sequence caution: Sequence=BAA25483.1; Type=Erroneous initiation;
Secondary accessions: A8K6X7 Q0VAL2 Q96CQ8 Q9BTG0

Explore the universe of human proteins at neXtProt for ZNF500: NX_O60304

Explore proteomics data for ZNF500 at MOPED


See ZNF500 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_067678.1  
ENSEMBL proteins: 
 ENSP00000219478   ENSP00000465073   ENSP00000445714   ENSP00000466375   ENSP00000464747  
 ENSP00000467598   ENSP00000468393  
Reactome Protein details: O60304

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antibodies-online peptides for ZNF500

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

Selected InterPro protein domains (see all 6):
 IPR001909 Krueppel-associated_box
 IPR008916 Retrov_capsid_C
 IPR003309 Tscrpt_reg_SCAN
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd

Graphical View of Domain Structure for InterPro Entry O60304

ProtoNet protein and cluster: O60304

2 Blocks protein domains:
IPB001909 KRAB box
IPB003309 Transcriptional regulator SCAN


UniProtKB/Swiss-Prot: ZN500_HUMAN, O60304
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 5 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain
Similarity: Contains 1 SCAN box domain


Find genes that share domains with ZNF500           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN500_HUMAN, O60304
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF500           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for ZNF500:
 Proliferating cells 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ZNF500

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN500_HUMAN, O60304: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

Find genes that share ontologies with ZNF500           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF500 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40


Find genes that share SuperPaths with ZNF500           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF500
    Generic Transcription Pathway


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Interactions:

    Search GeneGlobe Interaction Network for ZNF500

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----

Find genes that share ontologies with ZNF500           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZNF500 (ZN500)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF500 gene: 
NM_021646.1  

Unigene Cluster for ZNF500:

Zinc finger protein 500
Hs.513316  [show with all ESTs]
Unigene Representative Sequence: AB011129
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000219478(uc002cxo.1 uc002cxp.1) ENST00000588942 ENST00000591026
ENST00000545009(uc010uxt.1) ENST00000589422 ENST00000592425 ENST00000588602
ENST00000585977
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Primer
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Additional mRNA sequence: 

AB011129.1 AF007129.1 AK291792.1 AK297993.1 BC004125.2 BC014054.2 BC033151.1 BC107065.2 
BC121013.1 BC121014.1 

11 DOTS entries:

DT.314094  DT.95160684  DT.100810225  DT.102842667  DT.75184592  DT.92423504  DT.75185753  DT.92016980 
DT.100745771  DT.40251135  DT.97826365 

Selected AceView cDNA sequences (see all 71):

BU501881 F11625 AI369375 BM678198 BU165913 BQ940042 F09279 AA324963 
BQ787723 BE885628 AI570643 BC004125 BC014054 AA984516 BM803730 AI680906 
AW467959 AI333753 AA706789 F12574 AB011129 AA312482 CB240686 AA928845 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF500    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:                          -                     
SP2:                                                
SP3:                                                


ECgene alternative splicing isoforms for ZNF500

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF500 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZNF500 Expression
About this image

ZNF500 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF500 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.513316
    Custom PCR Arrays for ZNF500
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF500 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF5001 zinc finger protein 500 82.33(n)
78.94(a)
  490023  XM_547143.4  XP_547143.3 
chicken
(Gallus gallus)
Aves ZFP926
Gallus gallus zinc finger protein 92 homolog (mous...
30(a)
1 → many
1(91248215-91253003)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 29)
Uncharacterized protein
(see all 29)
38(a)
36(a)
(see all 29)
many ↔ many
many ↔ many
(see all 29)
GL343330.1(962392-968070)
GL343434.1(315086-319035)


ENSEMBL Gene Tree for ZNF500 (if available)
TreeFam Gene Tree for ZNF500 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF500 gene
ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF2132  ZNF2322  ZSCAN302  ZNF1742  
ZNF32  ZKSCAN42  ZNF3962  ZSCAN122  ZNF3942  ZSCAN212  ZSCAN232  ZNF1652  
ZSCAN162  ZKSCAN82  ZSCAN222  ZSCAN312  ZNF242  ZKSCAN32  ZNF182  
Selected SIMAP similar genes for ZNF500 using alignment to 8 protein entries:     ZN500_HUMAN (see all proteins) (see all similar genes):
ZSCAN32    ZSCAN10    SCAND1    ZNF211    ZNF84    LOC100128510
ZFP2    ZNF197    ZNF329    ZNF78L1    ZNF391    ZNF420
kr-znf3    PRDM9    PRMD9    DKFZp666M039    ZFP112    ZFS-1

Find genes that share paralogs with ZNF500           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF500 (see all 599)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1449172471,2
--4800441(+) CTCCAG/TCCTCA 1 -- ds50010--------
rs1467192201,2
--4800484(+) CCATCA/GTGCCT 1 -- ds50010--------
rs2021730411,2
--4800509(+) TTTTT-/TGTGTGG 1 -- ds50010--------
rs779086931,2
C--4800510(+) TTTTTG/TTGTGG 1 -- ds50010--------
rs1118235091,2
C--4800510(+) TTTTTG/-TGTGG 1 -- ds50011Minor allele frequency- -:0.50CSA 2
rs1147265191,2
F--4800544(+) GAGTAC/AAACGG 1 -- ds50011Minor allele frequency- A:0.01WA 118
rs1403662321,2
--4800547(+) TACAAC/TGGTGC 1 -- ds50010--------
rs1929810411,2
--4800553(+) GGTGCA/GACCTC 1 -- ds50010--------
rs1453363591,2
C--4800632(+) CTACAA/GGCACG 1 -- ds50010--------
rs1379137051,2
--4800773(+) CAAGCA/GTGAGC 1 -- ds50010--------

HapMap Linkage Disequilibrium report for ZNF500 (4798240 - 4817625 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for ZNF500:    About this table    
Variant IDTypeSubtypePubMed ID
esv2678305CNV Deletion23128226
nsv905248CNV Loss21882294
nsv905250CNV Loss21882294
dgv2590n71CNV Loss21882294
dgv2589n71CNV Loss21882294
dgv2588n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF500 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF500)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)
  7. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
  8. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26048 HGNC: 23716 AceView: ZNF500 Ensembl:ENSG00000103199 euGenes: HUgn26048
ECgene: ZNF500 H-InvDB: ZNF500

(According to HUGE)
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HUGE: KIAA0557

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF500 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF500 gene:
Search GeneIP for patents involving ZNF500

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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