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Aliases for ZNF500 Gene

Aliases for ZNF500 Gene

  • Zinc Finger Protein 500 2 3
  • Zinc Finger Protein With KRAB And SCAN Domains 18 3 4
  • ZKSCAN18 3 4
  • KIAA0557 4
  • ZSCAN50 3

External Ids for ZNF500 Gene

Previous GeneCards Identifiers for ZNF500 Gene

  • GC16M004801
  • GC16M004798
  • GC16M004738

Summaries for ZNF500 Gene

GeneCards Summary for ZNF500 Gene

ZNF500 (Zinc Finger Protein 500) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZNF500 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF500 Gene

Genomics for ZNF500 Gene

Regulatory Elements for ZNF500 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF500 Gene

Start:
4,748,239 bp from pter
End:
4,767,624 bp from pter
Size:
19,386 bases
Orientation:
Minus strand

Genomic View for ZNF500 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF500 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF500 Gene

Proteins for ZNF500 Gene

  • Protein details for ZNF500 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60304-ZN500_HUMAN
    Recommended name:
    Zinc finger protein 500
    Protein Accession:
    O60304
    Secondary Accessions:
    • A8K6X7
    • B4DNN9
    • Q0VAL2
    • Q96CQ8
    • Q9BTG0

    Protein attributes for ZNF500 Gene

    Size:
    480 amino acids
    Molecular mass:
    53674 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF500 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF500 Gene

Proteomics data for ZNF500 Gene at MOPED

Post-translational modifications for ZNF500 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF500 Gene

No data available for DME Specific Peptides for ZNF500 Gene

Domains for ZNF500 Gene

Gene Families for ZNF500 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Graphical View of Domain Structure for InterPro Entry

O60304

UniProtKB/Swiss-Prot:

ZN500_HUMAN :
  • O60304
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF500: view

Function for ZNF500 Gene

Molecular function for ZNF500 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF500: view

Phenotypes for ZNF500 Gene

GenomeRNAi human phenotypes for ZNF500:
genes like me logo Genes that share phenotypes with ZNF500: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF500

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF500 Gene

Localization for ZNF500 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF500 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF500 Gene COMPARTMENTS Subcellular localization image for ZNF500 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF500: view

Pathways for ZNF500 Gene

SuperPathways for ZNF500 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF500: view

Pathways by source for ZNF500 Gene

2 Reactome pathways for ZNF500 Gene

Interacting Proteins for ZNF500 Gene

Gene Ontology (GO) - Biological Process for ZNF500 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF500: view

Transcripts for ZNF500 Gene

Unigene Clusters for ZNF500 Gene

Zinc finger protein 500:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF500

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF500
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF500 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3:

Relevant External Links for ZNF500 Gene

GeneLoc Exon Structure for
ZNF500
ECgene alternative splicing isoforms for
ZNF500

Expression for ZNF500 Gene

mRNA expression in normal human tissues for ZNF500 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF500 Gene

SOURCE GeneReport for Unigene cluster for ZNF500 Gene Hs.513316

genes like me logo Genes that share expressions with ZNF500: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF500 Gene

Orthologs for ZNF500 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF500 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF500 35
  • 98.72 (n)
  • 99.04 (a)
ZNF500 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF500 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF500 35
  • 82.33 (n)
  • 78.94 (a)
ZNF500 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF500 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF500 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFP92 36
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
Species with no ortholog for ZNF500:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF500 Gene

ENSEMBL:
Gene Tree for ZNF500 (if available)
TreeFam:
Gene Tree for ZNF500 (if available)

Paralogs for ZNF500 Gene

Selected SIMAP similar genes for ZNF500 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF500: view

Variants for ZNF500 Gene

Sequence variations from dbSNP and Humsavar for ZNF500 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs759990 -- 4,763,690(+) CAGAG(A/G)TGTCG intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs921863 -- 4,751,722(+) TGGGG(A/G)ACCCT utr-variant-3-prime, downstream-variant-500B
rs921864 -- 4,751,841(+) GATTC(A/G)AGGCT utr-variant-3-prime, downstream-variant-500B
rs963712 -- 4,753,326(+) GCATG(C/G)TGGCG intron-variant
rs1869909 -- 4,751,583(+) GAAGG(A/C)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF500 Gene

Variant ID Type Subtype PubMed ID
dgv2588n71 CNV Loss 21882294
dgv2589n71 CNV Loss 21882294
dgv2590n71 CNV Loss 21882294
nsv905248 CNV Loss 21882294
nsv905250 CNV Loss 21882294
esv2678305 CNV Deletion 23128226

Relevant External Links for ZNF500 Gene

HapMap Linkage Disequilibrium report
ZNF500

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF500 Gene

Disorders for ZNF500 Gene

No disorders were found for ZNF500 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF500 Gene

Publications for ZNF500 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF500 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF500
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF500
    • Block miRNA regulation of ZNF500 using miScript Target Protectors

    Sources for ZNF500 Gene

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