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ZNF497 Gene

protein-coding   GIFtS: 40
GCID: GC19M058865

Zinc Finger Protein 497

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4971 2
Zinc Finger-Like Protein2

External Ids:    HGNC: 237141   Entrez Gene: 1629682   Ensembl: ENSG000001745867   UniProtKB: Q6ZNH53   

Export aliases for ZNF497 gene to outside databases

Previous GC identifers: GC19M063559 GC19M063557 GC19M055174


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF497 Gene:
ZNF497 (zinc finger protein 497) is a protein-coding gene. An important paralog of this gene is ZNF837.

UniProtKB/Swiss-Prot: ZN497_HUMAN, Q6ZNH5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF497 gene promoter:
         TBP   Pbx1a   Nkx5-1   C/EBPalpha   Meis-1b   RORalpha1   STAT3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF497 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF497


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF497 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF497 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M058865:  view genomic region     (about GC identifiers)

Start:
58,865,723 bp from pter      End:
58,874,214 bp from pter
Size:
8,492 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN497_HUMAN, Q6ZNH5 (See protein sequence)
Recommended Name: Zinc finger protein 497  
Size: 498 amino acids; 54721 Da
Secondary accessions: Q05AG8 Q0VF48 Q6ZTD2 Q9UIA8

Explore the universe of human proteins at neXtProt for ZNF497: NX_Q6ZNH5

Explore proteomics data for ZNF497 at MOPED


See ZNF497 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001193938.1  NP_940860.2  

ENSEMBL proteins: 
 ENSP00000311183   ENSP00000402815   ENSP00000471650  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

3 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6ZNH5

ProtoNet protein and cluster: Q6ZNH5

UniProtKB/Swiss-Prot: ZN497_HUMAN, Q6ZNH5
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 14 C2H2-type zinc fingers


Find genes that share domains with ZNF497           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN497_HUMAN, Q6ZNH5
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF497           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for ZNF497:
 Cell cycle / mitosis defect 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN497_HUMAN, Q6ZNH5: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with ZNF497           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for ZNF497

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with ZNF497           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZNF497 (ZN497)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF497 gene (2 alternative transcripts): 
NM_001207009.1  NM_198458.2  

Unigene Cluster for ZNF497:

Zinc finger protein 497
Hs.447840  [show with all ESTs]
Unigene Representative Sequence: NM_198458
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000311044(uc002qsh.2 uc002qsi.2) ENST00000425453 ENST00000595763

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Additional mRNA sequence: 

AF085829.1 AK125350.1 AK126727.1 AK131209.1 AK172804.1 AY927604.1 BC118983.1 BC125273.1 

3 DOTS entries:

DT.435008  DT.75107587  DT.95204464 

Selected AceView cDNA sequences (see all 152):

CB144216 CB141199 CB163893 CB138231 CR604603 CB130118 BM722278 CB156790 
BM153273 AL118991 CB115657 BX410165 AB073611 CB121414 CB163551 CR603363 
CB130078 CB162205 CB138248 CB134894 CB135246 BF196450 BX282528 CR614062 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF497    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1:                          -                                             
SP2:                                                                        
SP3:                                      -     -                           
SP4:                          -           -     -                           
SP5:                          -     -     -     -                           


ECgene alternative splicing isoforms for ZNF497

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF497 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTGCACTGG
ZNF497 Expression
About this image

ZNF497 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF497 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.447840
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF497 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
Uncharacterized protein
23(a)
many ↔ many
1(99585206-99588111)


ENSEMBL Gene Tree for ZNF497 (if available)
TreeFam Gene Tree for ZNF497 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF497 gene
ZNF8372  
Selected SIMAP similar genes for ZNF497 using alignment to 2 protein entries:     ZN497_HUMAN (see all proteins) (see all similar genes):
ZNF818P    ZNF78L1    ZNF232    kr-znf3    PRDM9    PRMD9
DKFZp547L155    DKFZp666C237    HZF36    ZFS-5    ZNF16    ZNF814
ZNF    ZKSCAN7    ZNF132    ZNF229    ZNF268    ZNF304

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF497 (see all 248)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1441902581,2
--58867077(+) AGCGAA/GCACCT 2 -- ut310--------
rs789889571,2
C--58867114(+) AGCAGC/GTGGTA 2 -- ut310--------
rs3762497601,2
C--58867453(+) CGCCCA/GAGACC 2 -- ut310--------
rs1402660671,2
C,F--58867526(+) CCCCCG/TTGCCG 4 Q H mis11Minor allele frequency- T:0.00NA 4024
rs1380642541,2
C--58867567(+) GCTGAA/GAGGCT 4 L F mis11Minor allele frequency- G:0.00NA 4208
rs1403762251,2
C--58867597(+) GTAGGA/GCCTCT 4 P S mis10--------
rs1471528941,2
C,F--58867643(+) GACTTG/ACGCAC 4 /R syn11Minor allele frequency- A:0.00NA 3274
rs1386384621,2
C,F--58867644(+) ACTTGC/AGCACG 4 /R /L mis11Minor allele frequency- A:0.00NA 3246
rs2001718181,2
--58867730(+) CTGCCA/GCGGAA 4 R syn10--------
rs2003913591,2
C--58867794(+) GGTGGC/TGCGCC 4 H R mis10--------

HapMap Linkage Disequilibrium report for ZNF497 (58865723 - 58874214 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for ZNF497:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833887CNV Loss17160897
nsv817878CNV Loss17921354
dgv4031n71CNV Loss21882294
nsv833888CNV Loss17160897
dgv4030n71CNV Loss21882294
nsv515731CNV Gain+Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF497 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF497)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 162968 HGNC: 23714 AceView: A1BGandZNF497 Ensembl:ENSG00000174586 euGenes: HUgn162968
ECgene: ZNF497 H-InvDB: ZNF497

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF497 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF497 gene:
Search GeneIP for patents involving ZNF497

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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