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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF497 Gene

protein-coding GIFtS: 41
GCID: GC19M058865

zinc finger protein 497

Search for ZNF497
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 497¹ ²
FLJ44773¹
Zinc Finger-Like Protein²

External Ids:	HGNC: 23714¹	Entrez Gene: 162968²	Ensembl: ENSG00000174586⁷	UniProtKB: Q6ZNH5³

Export aliases for ZNF497 gene to outside databases

Previous GC identifers: GC19M063559 GC19M063557 GC19M055174

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN497_HUMAN, Q6ZNH5

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF497 gene promoter:
TBP Pbx1a Nkx5-1 C/EBPalpha Meis-1b RORalpha1 STAT3 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF497 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF497

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF497

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

ZNF497 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF497 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M058865: view genomic region (about GC identifiers)

Start:	58,865,725 bp from pter	End:	58,874,120 bp from pter
Size:	8,396 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN497_HUMAN, Q6ZNH5 (See protein sequence)

Recommended Name: Zinc finger protein 497

Size: 498 amino acids; 54721 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q05AG8 Q0VF48 Q6ZTD2 Q9UIA8

Explore the universe of human proteins at neXtProt for ZNF497: NX_Q6ZNH5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZNH5

ZNF497 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001193938.1 NP_940860.2

ENSEMBL proteins:

ENSP00000311183 ENSP00000402815

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF497 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF497 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6ZNH5

ProtoNet protein and cluster: Q6ZNH5

UniProtKB/Swiss-Prot: ZN497_HUMAN, Q6ZNH5

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 14 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN497_HUMAN, Q6ZNH5

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF497 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF497:

Cell cycle / mitosis defect

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF497

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF497 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for ZNF497
Search CenterWatch for drugs/clinical trials and news about ZNF497 / ZN497

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZNF497 gene (2 alternative transcripts):

NM_001207009.1 NM_198458.2

Unigene Cluster for ZNF497:

Zinc finger protein 497

Hs.743423 [show with all ESTs]

Unigene Representative Sequence: NM_198458

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311044(uc002qsh.2 uc002qsi.2) ENST00000425453

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Additional cDNA sequence:

AF085829.1 AK125350.1 AK126727.1 AK131209.1 AK172804.1 AY927604.1 BC118983.1 BC125273.1

3 DOTS entries:

DT.435008 DT.75107587 DT.95204464

24/152 AceView cDNA sequences (see all 152):

CB156790 CB144216 AB073611 CB130088 CB121414 CB130078 CB138231 CR614062

CR612720 CB141199 CR603363 CR609084 CB148792 AW470952 CB130068 CR604603

BM153273 BF196450 BX410165 BU740127 CB163893 CB138248 CB137690 BM722278

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF497 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d
SP1:									-
SP2:
SP3:													-		-
SP4:									-				-		-
SP5:									-		-		-		-

ECgene alternative splicing isoforms for ZNF497

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF497 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGCACTGG

About this image
See ZNF497 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF497

SOURCE GeneReport for Unigene cluster: Hs.743423

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF497 gene from 3/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	48(a) 39(a) (see all 3)	possible ortholog many ↔ many (see all 3)	GL343238.1(343210-344564) 2(192616857-192618623)
zebrafish (Danio rerio)	Actinopterygii	CU138542.4⁶ BX640584.4⁶ (see all 3)	--	40(a) 38(a) (see all 3)	many ↔ many many ↔ many (see all 3)	Zv9_scaffold3506(145973-169531) 4(43137441-43153959)
honey bee (Apis mellifera)	Insecta	--	--	15(a)	1 → many	Group5.2(736589-739565)

Species with no ortholog for ZNF497

ENSEMBL Gene Tree for ZNF497 (if available)
TreeFam Gene Tree for ZNF497 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF497 gene

ZNF467² ZNF835²

18/492 SIMAP similar genes for ZNF497 using alignment to 2 protein entries: ZN497_HUMAN (see all proteins) (see all similar genes):

ZNF818P ZNF78L1 ZNF232 kr-znf3 PRDM9 PRMD9

DKFZp547L155 DKFZp666C237 HZF36 ZFS-5 ZNF16 ZNF814

ZNF ZNF132 ZNF229 ZNF268 ZNF304 ZNF418

ZNF497 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80194396^1,2	C,F,	--	55176094(+)	`TTGATC/TTGGTT`	1	--	int¹		1		WA	118
rs139278803^1,2		--	58866883(+)	`TCCCCA/CAAAAA`	2	--	ut3¹		0	--	--	--	--
rs144190258^1,2		--	58867077(+)	`AGCGAA/GCACCT`	2	--	ut3¹		0	--	--	--	--
rs78988957^1,2		--	58867114(+)	`AGCAGC/GTGGTA`	2	--	ut3¹		0	--	--	--	--
rs140266067^1,2	C,F	--	58867526(+)	`CCCCCG/TTGCCG`	4	Q H	mis¹		1		NA	4024
rs138064254^1,2	C,	--	58867567(+)	`GCTGAA/GAGGCT`	4	L F	mis¹		1		NA	4208
rs140376225^1,2	C,	--	58867597(+)	`GTAGGA/GCCTCT`	4	P S	mis¹		0	--	--	--	--
rs147152894^1,2	C,F,	--	58867643(+)	`GACTTG/ACGCAC`	4	/R	syn¹		1		NA	3274
rs138638462^1,2	C,F,	--	58867644(+)	`ACTTGC/AGCACG`	4	/R /L	mis¹		1		NA	3246
rs200171818^1,2		--	58867730(+)	`CTGCCA/GCGGAA`	4	R	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF497 (58865725 - 58874120 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZNF497
6 CNVs: 50240 50238 50237 10572 50239 5119

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF497 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF497)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 162968	HGNC: 23714	AceView: A1BGandZNF497	Ensembl:ENSG00000174586	euGenes: HUgn162968
ECgene: ZNF497	H-InvDB: ZNF497

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF497	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF497 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF497 gene:
Search GeneIP for patents involving ZNF497

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF497 gene at Home site.

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ZNF497 Gene

zinc finger protein 497

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ZNF497 Gene

zinc finger protein 497

Aliasesfor ZNF497 gene

Summariesfor ZNF497 gene

Genomic Viewsfor ZNF497 gene

Proteinsfor ZNF497 gene

Protein Domains /Familiesfor ZNF497 gene

Functionfor ZNF497 gene

Pathways & Interactionsfor ZNF497 gene

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Disorders / Diseasesfor ZNF497 gene

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Genome Databases showing ZNF497 gene

Other Databases showing ZNF497 gene

Specialized Databases showing ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene

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for ZNF497 gene