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Aliases for ZNF497 Gene

Aliases for ZNF497 Gene

  • Zinc Finger Protein 497 2 3 5

External Ids for ZNF497 Gene

Previous GeneCards Identifiers for ZNF497 Gene

  • GC19M063559
  • GC19M063557
  • GC19M058865
  • GC19M055174

Summaries for ZNF497 Gene

GeneCards Summary for ZNF497 Gene

ZNF497 (Zinc Finger Protein 497) is a Protein Coding gene. An important paralog of this gene is ZNF575.

UniProtKB/Swiss-Prot for ZNF497 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF497 Gene

Genomics for ZNF497 Gene

Regulatory Elements for ZNF497 Gene

Enhancers for ZNF497 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF497 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF497 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF497 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF497 Gene

58,354,357 bp from pter
58,362,848 bp from pter
8,492 bases
Minus strand

Genomic View for ZNF497 Gene

Genes around ZNF497 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF497 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF497 Gene

Proteins for ZNF497 Gene

  • Protein details for ZNF497 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 497
    Protein Accession:
    Secondary Accessions:
    • Q05AG8
    • Q0VF48
    • Q6ZTD2
    • Q9UIA8

    Protein attributes for ZNF497 Gene

    498 amino acids
    Molecular mass:
    54721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF497 Gene

Proteomics data for ZNF497 Gene at MOPED

Post-translational modifications for ZNF497 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF497 Gene

No data available for DME Specific Peptides for ZNF497 Gene

Domains & Families for ZNF497 Gene

Gene Families for ZNF497 Gene

Protein Domains for ZNF497 Gene

Suggested Antigen Peptide Sequences for ZNF497 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF497: view

Function for ZNF497 Gene

Molecular function for ZNF497 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF497: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF497 Gene

Localization for ZNF497 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF497 Gene

Subcellular locations from

Jensen Localization Image for ZNF497 Gene COMPARTMENTS Subcellular localization image for ZNF497 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF497 Gene

Pathways & Interactions for ZNF497 Gene

SuperPathways for ZNF497 Gene

No Data Available

Interacting Proteins for ZNF497 Gene

Gene Ontology (GO) - Biological Process for ZNF497 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF497: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF497 Gene

Drugs & Compounds for ZNF497 Gene

No Compound Related Data Available

Transcripts for ZNF497 Gene

Unigene Clusters for ZNF497 Gene

Zinc finger protein 497:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF497 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP3: - -
SP4: - - -
SP5: - - - -

Relevant External Links for ZNF497 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF497 Gene

mRNA expression in normal human tissues for ZNF497 Gene

SOURCE GeneReport for Unigene cluster for ZNF497 Gene Hs.447840

genes like me logo Genes that share expression patterns with ZNF497: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF497 Gene

Orthologs for ZNF497 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF497 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF497 35
  • 99.46 (n)
  • 98.59 (a)
ZNF497 36
  • 92 (a)
(Canis familiaris)
Mammalia -- 36
  • 23 (a)
(Monodelphis domestica)
Mammalia ZNF497 36
  • 56 (a)
Species with no ortholog for ZNF497:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF497 Gene

Gene Tree for ZNF497 (if available)
Gene Tree for ZNF497 (if available)

Paralogs for ZNF497 Gene

Paralogs for ZNF497 Gene

(500) SIMAP similar genes for ZNF497 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF497: view

Variants for ZNF497 Gene

Sequence variations from dbSNP and Humsavar for ZNF497 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12609654 - 58,357,114(+) TGCGA(G/T)TGCGC reference, missense
rs71663584 -- 58,358,638(+) ATCTG(-/GAG)AGAAA intron-variant
rs140266067 -- 58,356,160(+) CCCCC(A/C/G/T)TGCCG reference, synonymous-codon, missense
rs140376225 -- 58,356,231(+) GTAGG(A/C/G/T)CCTCT reference, missense
rs141164315 -- 58,359,525(+) CCCCC(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF497 Gene

Variant ID Type Subtype PubMed ID
nsv833887 CNV Loss 17160897
nsv515731 CNV Gain+Loss 19592680
dgv4030n71 CNV Loss 21882294
nsv833888 CNV Loss 17160897
dgv4031n71 CNV Loss 21882294
nsv817878 CNV Loss 17921354

Variation tolerance for ZNF497 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF497 Gene

Disorders for ZNF497 Gene

Relevant External Links for ZNF497

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF497 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF497 Gene

Publications for ZNF497 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF497 Gene

Sources for ZNF497 Gene