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Aliases for ZNF496 Gene

Aliases for ZNF496 Gene

  • Zinc Finger Protein 496 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 17 3 4
  • ZKSCAN17 3 4
  • NSD1 (Nuclear Receptor Binding SET-Domain Containing 1)-Interacting Zinc Finger Protein 1 3
  • ZSCAN49 3
  • ZFP496 3
  • NIZP1 3

External Ids for ZNF496 Gene

Previous GeneCards Identifiers for ZNF496 Gene

  • GC01M244408
  • GC01M243787
  • GC01M245527
  • GC01M247460
  • GC01M217858

Summaries for ZNF496 Gene

GeneCards Summary for ZNF496 Gene

ZNF496 (Zinc Finger Protein 496) is a Protein Coding gene. Diseases associated with ZNF496 include Sotos Syndrome 1. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF500.

UniProtKB/Swiss-Prot for ZNF496 Gene

  • DNA-binding transcription factor that can both act as an activator and a repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF496 Gene

Genomics for ZNF496 Gene

Regulatory Elements for ZNF496 Gene

Enhancers for ZNF496 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF496 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF496 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF496 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF496 Gene

Chromosome:
1
Start:
247,297,412 bp from pter
End:
247,333,376 bp from pter
Size:
35,965 bases
Orientation:
Minus strand

Genomic View for ZNF496 Gene

Genes around ZNF496 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF496 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF496 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF496 Gene

Proteins for ZNF496 Gene

  • Protein details for ZNF496 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IT1-ZN496_HUMAN
    Recommended name:
    Zinc finger protein 496
    Protein Accession:
    Q96IT1
    Secondary Accessions:
    • Q8TBS2

    Protein attributes for ZNF496 Gene

    Size:
    587 amino acids
    Molecular mass:
    66908 Da
    Quaternary structure:
    • Interacts (via zinc-fingers) with JARID2. Interacts with NSD1 (By similarity).

    Alternative splice isoforms for ZNF496 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF496 Gene

Proteomics data for ZNF496 Gene at MOPED

Post-translational modifications for ZNF496 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF496 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF496 Gene

Domains & Families for ZNF496 Gene

Gene Families for ZNF496 Gene

Suggested Antigen Peptide Sequences for ZNF496 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IT1

UniProtKB/Swiss-Prot:

ZN496_HUMAN :
  • The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1.
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF496: view

Function for ZNF496 Gene

Molecular function for ZNF496 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding transcription factor that can both act as an activator and a repressor.

Gene Ontology (GO) - Molecular Function for ZNF496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with ZNF496: view
genes like me logo Genes that share phenotypes with ZNF496: view

Animal Models for ZNF496 Gene

MGI Knock Outs for ZNF496:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF496 Gene

Localization for ZNF496 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF496 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF496 Gene COMPARTMENTS Subcellular localization image for ZNF496 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF496 Gene

Pathways & Interactions for ZNF496 Gene

SuperPathways for ZNF496 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF496: view

Pathways by source for ZNF496 Gene

2 Reactome pathways for ZNF496 Gene

Gene Ontology (GO) - Biological Process for ZNF496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA,ISS --
genes like me logo Genes that share ontologies with ZNF496: view

No data available for SIGNOR curated interactions for ZNF496 Gene

Drugs & Compounds for ZNF496 Gene

No Compound Related Data Available

Transcripts for ZNF496 Gene

Unigene Clusters for ZNF496 Gene

Zinc finger protein 496:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF496 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:

ExUns: 13 ^ 14 ^ 15a · 15b · 15c
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: - -

Relevant External Links for ZNF496 Gene

GeneLoc Exon Structure for
ZNF496
ECgene alternative splicing isoforms for
ZNF496

Expression for ZNF496 Gene

mRNA expression in normal human tissues for ZNF496 Gene

Protein differential expression in normal tissues from HIPED for ZNF496 Gene

This gene is overexpressed in Tlymphocyte (50.5), Ovary (9.6), and Frontal cortex (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF496 Gene



SOURCE GeneReport for Unigene cluster for ZNF496 Gene Hs.654803

genes like me logo Genes that share expression patterns with ZNF496: view

Protein tissue co-expression partners for ZNF496 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF496 Gene

Orthologs for ZNF496 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF496 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF496 35
  • 86.52 (n)
  • 84.13 (a)
ZNF496 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF496 35
  • 81.99 (n)
  • 79.66 (a)
ZNF496 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zkscan17 35
  • 81.18 (n)
  • 79 (a)
Zkscan17 16
Zkscan17 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF496 35
  • 99.43 (n)
  • 99.49 (a)
ZNF496 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp496 35
  • 80.24 (n)
  • 78.34 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF496 36
  • 47 (a)
OneToOne
Species with no ortholog for ZNF496:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF496 Gene

ENSEMBL:
Gene Tree for ZNF496 (if available)
TreeFam:
Gene Tree for ZNF496 (if available)

Paralogs for ZNF496 Gene

Paralogs for ZNF496 Gene

(1) SIMAP similar genes for ZNF496 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF496: view

Variants for ZNF496 Gene

Sequence variations from dbSNP and Humsavar for ZNF496 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs875883 -- 247,297,054(-) AAAAT(A/G)TGAAG downstream-variant-500B
rs872685 -- 247,334,564(-) AGAAT(C/T)GCTGA upstream-variant-2KB
rs947174 -- 247,333,917(+) GTACA(C/T)TCATG upstream-variant-2KB
rs1616299 -- 247,299,399(+) GAAGC(C/T)GCTTC utr-variant-3-prime
rs1631695 -- 247,311,738(-) GGGGC(A/G)GGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF496 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv833126 CNV Loss 17160897
nsv833137 CNV Gain 17160897
nsv509790 CNV Insertion 20534489
nsv873439 CNV Loss 21882294
dgv73e201 CNV Deletion 23290073
esv2335854 CNV Deletion 18987734
esv4468 CNV Deletion 18987735
esv992675 CNV Deletion 20482838
esv21506 CNV Loss 19812545

Variation tolerance for ZNF496 Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF496 Gene

Disorders for ZNF496 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF496 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sotos syndrome 1
  • sotos syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF496

Genetic Association Database (GAD)
ZNF496
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF496
genes like me logo Genes that share disorders with ZNF496: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF496 Gene

Publications for ZNF496 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3

Products for ZNF496 Gene

Sources for ZNF496 Gene

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