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Aliases for ZNF496 Gene

Aliases for ZNF496 Gene

  • Zinc Finger Protein 496 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 17 3 4
  • ZKSCAN17 3 4
  • NSD1 (Nuclear Receptor Binding SET-Domain Containing 1)-Interacting Zinc Finger Protein 1 3
  • ZSCAN49 3
  • ZFP496 3
  • NIZP1 3

External Ids for ZNF496 Gene

Previous GeneCards Identifiers for ZNF496 Gene

  • GC01M244408
  • GC01M243787
  • GC01M245527
  • GC01M247460
  • GC01M217858

Summaries for ZNF496 Gene

GeneCards Summary for ZNF496 Gene

ZNF496 (Zinc Finger Protein 496) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF202.

UniProtKB/Swiss-Prot for ZNF496 Gene

  • DNA-binding transcription factor that can both act as an activator and a repressor.

Additional gene information for ZNF496 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF496 Gene

Genomics for ZNF496 Gene

Regulatory Elements for ZNF496 Gene

Enhancers for ZNF496 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H247330 1.3 ENCODE dbSUPER 37.6 +1.4 1425 3 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 YY1 ETS1 ZNF766 ZNF496 ZNF669 AHCTF1 ZNF670-ZNF695 ZNF124 ENSG00000202079
GH01H247294 0.9 ENCODE dbSUPER 38.4 +37.1 37098 3 PKNOX1 L3MBTL2 TAL1 BHLHE40 MAFG ZNF316 POLR2A MYNN POU5F1 FOS ZNF496 ZNF669 ENSG00000259865 OR1C1 ENSG00000202079
GH01H247322 0.9 Ensembl ENCODE dbSUPER 28.6 +10.3 10304 1 BATF ZNF496 ENSG00000259865 OR1C1 ENSG00000202079
GH01H246564 1.7 FANTOM5 ENCODE dbSUPER 14.7 +763.8 763814 9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF670-ZNF695 ZNF669 AHCTF1 CNST ZNF496 ZNF124 ENSG00000227671 SMYD3 LINC01341 ENSG00000225300
GH01H247356 1.1 Ensembl ENCODE 20.4 -24.1 -24100 1 HDAC1 PKNOX1 ATF1 KLF17 BMI1 BATF ELK1 FOS ATF7 ETV6 ZNF496 ZNF669 NLRP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF496 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF496 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023196 1476 2201 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ETS1 ZNF766 GLIS2 ELK1

Genomic Location for ZNF496 Gene

Chromosome:
1
Start:
247,297,412 bp from pter
End:
247,333,376 bp from pter
Size:
35,965 bases
Orientation:
Minus strand

Genomic View for ZNF496 Gene

Genes around ZNF496 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF496 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF496 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF496 Gene

Proteins for ZNF496 Gene

  • Protein details for ZNF496 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IT1-ZN496_HUMAN
    Recommended name:
    Zinc finger protein 496
    Protein Accession:
    Q96IT1
    Secondary Accessions:
    • Q8TBS2

    Protein attributes for ZNF496 Gene

    Size:
    587 amino acids
    Molecular mass:
    66908 Da
    Quaternary structure:
    • Interacts (via zinc-fingers) with JARID2. Interacts with NSD1 (By similarity).

    Alternative splice isoforms for ZNF496 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF496 Gene

Post-translational modifications for ZNF496 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF496 Gene

Domains & Families for ZNF496 Gene

Gene Families for ZNF496 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF496 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IT1

UniProtKB/Swiss-Prot:

ZN496_HUMAN :
  • The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF496: view

Function for ZNF496 Gene

Molecular function for ZNF496 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding transcription factor that can both act as an activator and a repressor.

Gene Ontology (GO) - Molecular Function for ZNF496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding ISS --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZNF496: view
genes like me logo Genes that share phenotypes with ZNF496: view

Animal Models for ZNF496 Gene

MGI Knock Outs for ZNF496:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF496
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF496 Gene

Localization for ZNF496 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF496 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF496 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,ISS --
GO:0016604 nuclear body IEA --
genes like me logo Genes that share ontologies with ZNF496: view

Pathways & Interactions for ZNF496 Gene

SuperPathways for ZNF496 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF496: view

Pathways by source for ZNF496 Gene

2 Reactome pathways for ZNF496 Gene

Gene Ontology (GO) - Biological Process for ZNF496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZNF496: view

No data available for SIGNOR curated interactions for ZNF496 Gene

Drugs & Compounds for ZNF496 Gene

No Compound Related Data Available

Transcripts for ZNF496 Gene

Unigene Clusters for ZNF496 Gene

Zinc finger protein 496:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF496
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF496 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:

ExUns: 13 ^ 14 ^ 15a · 15b · 15c
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: - -

Relevant External Links for ZNF496 Gene

GeneLoc Exon Structure for
ZNF496
ECgene alternative splicing isoforms for
ZNF496

Expression for ZNF496 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF496 Gene

Protein differential expression in normal tissues from HIPED for ZNF496 Gene

This gene is overexpressed in Tlymphocyte (50.5), Ovary (9.6), and Frontal cortex (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF496 Gene



Protein tissue co-expression partners for ZNF496 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF496 Gene:

ZNF496

SOURCE GeneReport for Unigene cluster for ZNF496 Gene:

Hs.654803

Evidence on tissue expression from TISSUES for ZNF496 Gene

  • Lung(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF496: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF496 Gene

Orthologs for ZNF496 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF496 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF496 33 34
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia ZNF496 33 34
  • 86.52 (n)
dog
(Canis familiaris)
Mammalia ZNF496 33 34
  • 81.99 (n)
mouse
(Mus musculus)
Mammalia Zkscan17 34 16 33
  • 81.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp496 33
  • 80.24 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF496 34
  • 47 (a)
OneToOne
Species where no ortholog for ZNF496 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF496 Gene

ENSEMBL:
Gene Tree for ZNF496 (if available)
TreeFam:
Gene Tree for ZNF496 (if available)

Paralogs for ZNF496 Gene

(1) SIMAP similar genes for ZNF496 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF496: view

Variants for ZNF496 Gene

Sequence variations from dbSNP and Humsavar for ZNF496 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000066348 -- 247,329,795(+) AAGAT(C/G)CCCTC intron-variant
rs1000069200 -- 247,327,912(+) AAGGG(C/T)GCTGG intron-variant, upstream-variant-2KB
rs1000087149 -- 247,330,431(+) TTCCT(C/T)GGCCA intron-variant
rs1000145828 -- 247,311,263(+) GGCGT(A/G)GTGGT intron-variant, upstream-variant-2KB
rs1000325762 -- 247,318,466(+) GCAAA(-/G)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF496 Gene

Variant ID Type Subtype PubMed ID
dgv23e215 CNV deletion 23714750
dgv61e201 CNV deletion 23290073
dgv897n54 CNV gain+loss 21841781
dgv898n54 CNV loss 21841781
dgv899n54 CNV gain 21841781
esv21506 CNV loss 19812545
esv2335854 CNV deletion 18987734
esv33129 CNV gain+loss 17666407
esv3360419 CNV insertion 20981092
esv3589514 CNV gain 21293372
esv4468 CNV loss 18987735
esv992675 CNV deletion 20482838
nsv1145418 CNV deletion 24896259
nsv509790 CNV insertion 20534489
nsv833126 CNV loss 17160897
nsv833137 CNV gain 17160897

Variation tolerance for ZNF496 Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF496 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF496

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF496 Gene

Disorders for ZNF496 Gene

Relevant External Links for ZNF496

Genetic Association Database (GAD)
ZNF496
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF496

No disorders were found for ZNF496 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF496 Gene

Publications for ZNF496 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 60

Products for ZNF496 Gene

Sources for ZNF496 Gene

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