Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF496 Gene

protein-coding GIFtS: 52
GCID: GC01M247460

Zinc Finger Protein 496

Microbiology & Infectious Diseases Congress

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Zinc Finger Protein 496¹ ²		ZFP496²
Zinc Finger Protein With KRAB And SCAN Domains 17² ³		ZSCAN49²
ZKSCAN17² ³		NSD1 (Nuclear Receptor Binding SET-Domain Containing 1)-Interacting Zinc Finger Protein 1²
NIZP1²

External Ids:	HGNC: 23713¹	Entrez Gene: 84838²	Ensembl: ENSG00000162714⁷	OMIM: 613911⁵	UniProtKB: Q96IT1³

Export aliases for ZNF496 gene to outside databases

Previous GC identifers: GC01M244408 GC01M243787 GC01M245527 GC01M217858

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF496 Gene:

ZNF496 (zinc finger protein 496) is a protein-coding gene. Diseases associated with ZNF496 include sotos syndrome, and among its related super-pathways are Gene Expression. GO annotations related to this gene include protein self-association and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF263.

UniProtKB/Swiss-Prot: ZN496_HUMAN, Q96IT1

Function: DNA-binding transcription factor that can both act as an activator and a repressor (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_167186.1 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF496 gene promoter:
Sp1 p300 MyoD AP-2gamma GATA-2 Ik-2 NRF-2 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF496 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF496

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF496

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44

ZNF496 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF496 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M247460: view genomic region (about GC identifiers)

Start:	247,460,714 bp from pter	End:	247,495,148 bp from pter
Size:	34,435 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN496_HUMAN, Q96IT1 (See protein sequence)

Recommended Name: Zinc finger protein 496

Size: 587 amino acids; 66908 Da

Subunit: Interacts (via zinc-fingers) with JARID2. Interacts with NSD1 (By similarity)

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q8TBS2

Alternative splicing: 2 isoforms: Q96IT1-1 Q96IT1-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF496: NX_Q96IT1

Explore proteomics data for ZNF496 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96IT1

ZNF496 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_116141.1

ENSEMBL proteins:

ENSP00000294753 ENSP00000473324 ENSP00000355454

Reactome Protein details: Q96IT1
Human Recombinant Protein Products for ZNF496:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for ZNF496 OriGene Protein Over-expression Lysate for ZNF496 OriGene MassSpec for ZNF496 OriGene Custom Protein Services for ZNF496
	GenScript Custom Purified and Recombinant Proteins Services for ZNF496
	Novus Biologicals ZNF496 Proteins Novus Biologicals ZNF496 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for ZNF496

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	ISS	--
GO:0016604	nuclear body	IEA	--

ZNF496 for ontologies About GeneDecksing

ZNF496 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ZNF496
	GenScript Custom Superior Antibodies Services for ZNF496
	Novus Biologicals ZNF496 Antibodies
	Abcam antibodies for ZNF496
	Cloud-Clone Corp. Antibodies for ZNF496
	Search ThermoFisher Antibodies for ZNF496
	LSBio Antibodies in human, mouse, rat for ZNF496

Assay Products for ZNF496:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for ZNF496
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZNF496
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ZNF496 Cloud-Clone Corp. CLIAs for ZNF496

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

5/6 InterPro protein domains (see all 6):

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR008916 Retrov_capsid_C

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96IT1

ProtoNet protein and cluster: Q96IT1

2 Blocks protein domains:

IPB001909 KRAB box

IPB003309 Transcriptional regulator SCAN

UniProtKB/Swiss-Prot: ZN496_HUMAN, Q96IT1

Domain: The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1 (By similarity)

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 5 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

Similarity: Contains 1 SCAN box domain

ZNF496 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN496_HUMAN, Q96IT1

Function: DNA-binding transcription factor that can both act as an activator and a repressor (By similarity)

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	IBA	--
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	ISS	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0005515	protein binding	IPI	16189514

ZNF496 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF496

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF496

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF496

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF496

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF496
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF496:
		hsa-miR-4324
		SwitchGear 3'UTR luciferase reporter plasmid: ZNF496 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ZNF496
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF496

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ZNF496
			Sirion Biotech Customized adenovirus for overexpression of ZNF496

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for ZNF496 (see all 7) OriGene ORF clones in mouse, rat for ZNF496 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZNF496 (NM_032752)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF496
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF496
		Sirion Biotech Customized lentivirus for stable overexpression of ZNF496 Customized lentivirus expression plasmids for stable overexpression of ZNF496

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZNF496
		Search LifeMap BioReagents cell lines for ZNF496

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF496

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ZNF496 About

See pathways by source

SuperPath

Contained pathways About

Generic Transcription Pathway

Generic Transcription Pathway

0.47

Gene Expression

0.47

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for ZNF496

	Generic Transcription Pathway
	Gene Expression

ZNF496 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ZNF496

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/22 Interacting proteins for ZNF496 (Q96IT1^{1, 2, 3} ENSP00000294753⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARR3	P36575¹^,²^,³, ENSP00000311538⁴	EBI-743906,EBI-718116 MINT-67526 I2D: score=6 STRING: ENSP00000311538
ZNF446	Q9NWS9³, ENSP00000336565⁴	I2D: score=3 STRING: ENSP00000336565
CBX3	Q13185³, ENSP00000336687⁴	I2D: score=1 STRING: ENSP00000336687
JARID2	Q92833³, ENSP00000341280⁴	I2D: score=1 STRING: ENSP00000341280
NR3C1	P04150³, ENSP00000231509⁴	I2D: score=1 STRING: ENSP00000231509

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	IBA	--
GO:0016032	viral process	--	--
GO:0045893	positive regulation of transcription, DNA-dependent	ISS	--

ZNF496 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF496 (ZN496)

Search CenterWatch for drugs/clinical trials and news about ZNF496 / ZN496

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF496 gene:

NM_032752.1

Unigene Cluster for ZNF496:

Zinc finger protein 496

Hs.654803 [show with all ESTs]

Unigene Representative Sequence: BX647480

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000462139 ENST00000294753(uc001ico.3) ENST00000461277 ENST00000478225

ENST00000477903 ENST00000366498(uc001icq.1 uc009xgv.3 uc010pyv.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF496
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF496:
		hsa-miR-4324
		SwitchGear 3'UTR luciferase reporter plasmid: ZNF496 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ZNF496
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF496

Clone Products:		OriGene clones in human, mouse for ZNF496 (see all 7) OriGene ORF clones in mouse, rat for ZNF496 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZNF496 (NM_032752)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF496
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF496
		Sirion Biotech Customized lentivirus for stable overexpression of ZNF496 Customized lentivirus expression plasmids for stable overexpression of ZNF496

Primer Products:		OriGene qPCR primer pairs and template standards for ZNF496 OriGene qSTAR qPCR primer pairs in human, mouse for ZNF496
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ZNF496
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF496
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF496

Additional mRNA sequence:

AK024643.1 AK097397.1 AK098030.1 AK303258.1 AK310669.1 AK311639.1 AL133592.1 BC007263.1

BC025794.1 BX647480.1

10 DOTS entries:

DT.211427 DT.110353 DT.100779158 DT.100779155 DT.92419783 DT.40261834 DT.100743891 DT.100769825

DT.121443942 DT.91843192

24/180 AceView cDNA sequences (see all 180):

AA912492 BM787059 BE297289 AI570527 BU739127 AA059423 Z40566 AI630852

AK024643 AA911660 NM_032752 BF475676 AI038263 BX392012 BC025794 BU183723

Z44743 BI256755 BG256610 AI057460 BU615766 CR610381 AI560693 AI267894

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF496 (see all 11) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^
SP1:																					-		-		-				-								-		-				-		-		-
SP2:																					-		-		-												-		-				-		-		-
SP3:													-								-		-		-				-
SP4:																													-								-		-								-		-
SP5:																													-								-		-				-		-		-

ExUns:	13	^	14	^	15a	·	15b	·	15c
SP1:	-		-
SP2:	-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ZNF496

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF496 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See ZNF496 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF496

SOURCE GeneReport for Unigene cluster: Hs.654803

SABiosciences Custom PCR Arrays for ZNF496

Primer Products:		OriGene qPCR primer pairs and template standards for ZNF496 OriGene qSTAR qPCR primer pairs in human, mouse for ZNF496
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ZNF496
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF496
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF496

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF496

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF496 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zkscan17^{1 , 5}	zinc finger with KRAB and SCAN domains 17^{1, 5}	81.24(n)¹ 79(a)¹		11 (37.72 cM)⁵ 268417¹ NM_172941.3¹ NP_766529.3¹ 59485520⁵
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 10)	--	36(a) 36(a) (see all 10)	possible ortholog possible ortholog (see all 10)	GL344256.1(48097-50057) GL343312.1(281945-282496)

ENSEMBL Gene Tree for ZNF496 (if available)
TreeFam Gene Tree for ZNF496 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF496 gene

ZNF263² ZNF202² ZSCAN25² ZKSCAN5² ZNF641²

1 SIMAP similar gene for ZNF496 using alignment to 1 protein entry: ZN496_HUMAN:

ZNF501

ZNF496 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141238505^1,2		--	247463230(+)	`CTGCGA/GGGTGC`	1	--	int¹		0	--	--	--	--
rs144950034^1,2	C	--	247463306(+)	`CCCTGA/CTCCCC`	1	--	int¹		0	--	--	--	--
rs139020840^1,2		--	247463555(+)	`CAGAAC/TACCTG`	1	--	int¹		0	--	--	--	--
rs185044571^1,2		--	247463667(+)	`CTCCCA/CTGGCA`	1	--	ut3¹		0	--	--	--	--
rs188982025^1,2		--	247463724(+)	`GCTCTC/TTATCC`	1	--	ut3¹		0	--	--	--	--
rs140578935^1,2	C	--	247463792(+)	`CCAGCA/CAGGGT`	1	--	ut3¹		0	--	--	--	--
rs200730880^1,2	C	--	247463816(+)	`GCGGAA/GAGGCT`	1	--	ut3¹		0	--	--	--	--
rs114499203^1,2	C,F	--	247463835(+)	`GTTCAG/AAGCCT`	2	/L	syn¹		2		WA NA	4648
rs140961822^1,2	F	--	247463884(+)	`AGGAGG/ATCATA`	2	/D	syn¹		1		NA	4548
rs181901316^1,2	C	--	247464002(+)	`CCTTCC/TCACAC`	2	E G	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF496 (247460714 - 247495148 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for ZNF496: About this table

Variant ID	Type	Subtype	PubMed ID
esv992675	CNV	Deletion	20482838
dgv73e201	CNV	Deletion	23290073
esv4468	CNV	Deletion	18987735
esv2335854	CNV	Deletion	18987734
nsv509790	CNV	Insertion	20534489
nsv833126	CNV	Loss	17160897
esv21506	CNV	Loss	19812545
nsv873439	CNV	Loss	21882294
nsv833137	CNV	Gain	17160897
esv33129	CNV	Gain+Loss	17666407

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF496

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF496

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 613911 OMIM disorders: --

2 diseases for ZNF496: About MalaCards

sotos syndrome

1 disease from the University of Copenhagen DISEASES database for ZNF496:

Sotos syndrome

ZNF496 for disorders About GeneDecksing

Genetic Association Database (GAD): ZNF496

Export disorders for ZNF496 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF496 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with ZNF496)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
NSD1 PHD domains bind methylated H3K4 and H3K9 using i nteractions disrupted by point mutations in human sotos syndrome. (PubMed id 21972110)¹ Pasillas M.P....Kamps M.P. (2011)
Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (2011)
The NIZP1 KRAB and C2HR domains cross-talk for transc riptional regulation. (PubMed id 20176155)¹ Losson R. and Nielsen A.L. (2010)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)¹ Ouyang J....Gill G. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)² Cantin G.T....Yates J.R. III (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84838	HGNC: 23713	AceView: ZNF496	Ensembl:ENSG00000162714	euGenes: HUgn84838
ECgene: ZNF496	H-InvDB: ZNF496

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF496	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF496 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF496 gene:
Search GeneIP for patents involving ZNF496

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for ZNF496
	OriGene qPCR primer pairs and template standards for ZNF496		OriGene Protein Over-expression Lysate for ZNF496
	OriGene MassSpec something-or-other for ZNF496		OriGene clones in human, mouse for ZNF496
	OriGene qSTAR qPCR primer pairs in human, mouse for ZNF496		OriGene Purified Protein for ZNF496
	OriGene ORF clones in mouse, rat for ZNF496		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ZNF496		OriGene Custom Protein Services for ZNF496

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF496
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF496
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF496
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF496
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF496
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF496

	GenScript Custom Purified and Recombinant Proteins Services for ZNF496		GenScript cDNA clones with any tag delivered in your preferred vector for ZNF496
	GenScript Custom Assay Services for ZNF496		GenScript Custom Superior Antibodies Services for ZNF496
	GenScript Custom overexpressing Cell Line Services for ZNF496		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ZNF496 promoter
	Search Chromatin IP Primers for ZNF496
	RT² qPCR Primer Assay in human, mouse, rat ZNF496
	GNC Network for ZNF496
	SABiosciences Custom PCR Arrays for ZNF496

Search Tocris compounds for ZNF496 (ZN496)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ZNF496 antibodies
	ZNF496 proteins
	ZNF496 lysates

	Antibodies for ZNF496
	See all of Abcam's Antibodies, Kits and Proteins for ZNF496
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for ZNF496
	Antibodies for ZNF496
	ELISAs for ZNF496
	CLIAs for ZNF496

Search LifeMap BioReagents cell lines for ZNF496

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF496

	SwitchGear 3'UTR luciferase reporter plasmids for ZNF496
	SwitchGear Promoter luciferase reporter plasmids for ZNF496

Search ThermoFisher Antibodies for ZNF496

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF496

	inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF496
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF496

Customized:

	lentivirus for stable overexpression of ZNF496
	lentivirus expression plasmids for stable overexpression of ZNF496
	adenovirus for overexpression of ZNF496

LSBio Antibodies in human, mouse, rat for ZNF496

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF496 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ZNF496 Gene

Zinc Finger Protein 496

Aliases
for ZNF496 gene

Summaries
for ZNF496 gene

Genomic Views
for ZNF496 gene

Proteins
for ZNF496 gene

Protein Domains /
Families
for ZNF496 gene

Function
for ZNF496 gene

Pathways & Interactions
for ZNF496 gene

Drugs & Compounds
for ZNF496 gene

Transcripts
for ZNF496 gene

Expression
for ZNF496 gene

Orthologs
for ZNF496 gene

Paralogs
for ZNF496 gene

Genomic Variants
for ZNF496 gene

Disorders / Diseases
for ZNF496 gene

Publications
for ZNF496 gene

External Searches for ZNF496 gene

Genome Databases showing ZNF496 gene

Other Databases showing ZNF496 gene

Specialized Databases showing ZNF496 gene

Intellectual Property
for ZNF496 gene

Products
for ZNF496 gene

View Random Gene

Advanced Search

Export list of displayed genes

ZNF496 Gene

Zinc Finger Protein 496

Aliasesfor ZNF496 gene

Summariesfor ZNF496 gene

Genomic Viewsfor ZNF496 gene

Proteinsfor ZNF496 gene

Protein Domains /Familiesfor ZNF496 gene

Functionfor ZNF496 gene

Pathways & Interactionsfor ZNF496 gene

Drugs & Compoundsfor ZNF496 gene

Transcriptsfor ZNF496 gene

Expression for ZNF496 gene

Orthologsfor ZNF496 gene

Paralogsfor ZNF496 gene

Genomic Variantsfor ZNF496 gene

Disorders / Diseasesfor ZNF496 gene

Publicationsfor ZNF496 gene

External Searches for ZNF496 gene

Genome Databases showing ZNF496 gene

Other Databases showing ZNF496 gene

Specialized Databases showing ZNF496 gene

Intellectual Propertyfor ZNF496 gene

Productsfor ZNF496 gene

View Random Gene

Aliases
for ZNF496 gene

Summaries
for ZNF496 gene

Genomic Views
for ZNF496 gene

Proteins
for ZNF496 gene

Protein Domains /
Families
for ZNF496 gene

Function
for ZNF496 gene

Pathways & Interactions
for ZNF496 gene

Drugs & Compounds
for ZNF496 gene

Transcripts
for ZNF496 gene

Expression
for ZNF496 gene

Orthologs
for ZNF496 gene

Paralogs
for ZNF496 gene

Genomic Variants
for ZNF496 gene

Disorders / Diseases
for ZNF496 gene

Publications
for ZNF496 gene

Intellectual Property
for ZNF496 gene

Products
for ZNF496 gene