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Aliases for ZNF496 Gene

Aliases for ZNF496 Gene

  • Zinc Finger Protein 496 2 3
  • Zinc Finger Protein With KRAB And SCAN Domains 17 3 4
  • ZKSCAN17 3 4
  • ZFP496 3 6
  • NIZP1 3 6
  • NSD1 (Nuclear Receptor Binding SET-Domain Containing 1)-Interacting Zinc Finger Protein 1 3
  • ZSCAN49 3

External Ids for ZNF496 Gene

Previous GeneCards Identifiers for ZNF496 Gene

  • GC01M244408
  • GC01M243787
  • GC01M245527
  • GC01M247460
  • GC01M217858

Summaries for ZNF496 Gene

GeneCards Summary for ZNF496 Gene

ZNF496 (Zinc Finger Protein 496) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and protein self-association. An important paralog of this gene is ZNF202.

UniProtKB/Swiss-Prot for ZNF496 Gene

  • DNA-binding transcription factor that can both act as an activator and a repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF496 Gene

Genomics for ZNF496 Gene

Regulatory Elements for ZNF496 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF496 Gene

247,297,412 bp from pter
247,331,977 bp from pter
34,566 bases
Minus strand

Genomic View for ZNF496 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF496 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF496 Gene

Proteins for ZNF496 Gene

  • Protein details for ZNF496 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 496
    Protein Accession:
    Secondary Accessions:
    • Q8TBS2

    Protein attributes for ZNF496 Gene

    587 amino acids
    Molecular mass:
    66908 Da
    Quaternary structure:
    • Interacts (via zinc-fingers) with JARID2. Interacts with NSD1 (By similarity).

    Alternative splice isoforms for ZNF496 Gene


neXtProt entry for ZNF496 Gene

Proteomics data for ZNF496 Gene at MOPED

Post-translational modifications for ZNF496 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF496 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF496 Gene

Domains for ZNF496 Gene

Gene Families for ZNF496 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF496 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96IT1
  • The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1.
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF496: view

Function for ZNF496 Gene

Molecular function for ZNF496 Gene

UniProtKB/Swiss-Prot Function: DNA-binding transcription factor that can both act as an activator and a repressor.

Gene Ontology (GO) - Molecular Function for ZNF496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZNF496: view

Animal Model Products

CRISPR Products

miRNA for ZNF496 Gene

miRTarBase miRNAs that target ZNF496

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF496 Gene

Localization for ZNF496 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF496 Gene

Subcellular locations from

Jensen Localization Image for ZNF496 Gene COMPARTMENTS Subcellular localization image for ZNF496 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
GO:0016604 nuclear body IEA --
genes like me logo Genes that share ontologies with ZNF496: view

Pathways for ZNF496 Gene

SuperPathways for ZNF496 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF496: view

Pathways by source for ZNF496 Gene

2 Reactome pathways for ZNF496 Gene

Gene Ontology (GO) - Biological Process for ZNF496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZNF496: view

Transcripts for ZNF496 Gene

Unigene Clusters for ZNF496 Gene

Zinc finger protein 496:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF496

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF496 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: -
SP8: - -
SP9: -

ExUns: 13 ^ 14 ^ 15a · 15b · 15c
SP1: - -
SP2: - -
SP6: -
SP11: - -

Relevant External Links for ZNF496 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF496 Gene

mRNA expression in normal human tissues for ZNF496 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF496 Gene

SOURCE GeneReport for Unigene cluster for ZNF496 Gene Hs.654803

genes like me logo Genes that share expressions with ZNF496: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF496 Gene

Orthologs for ZNF496 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF496 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF496 35
  • 99.43 (n)
  • 99.49 (a)
ZNF496 36
  • 88 (a)
(Bos Taurus)
Mammalia ZNF496 35
  • 86.52 (n)
  • 84.13 (a)
ZNF496 36
  • 49 (a)
(Canis familiaris)
Mammalia ZNF496 35
  • 81.99 (n)
  • 79.66 (a)
ZNF496 36
  • 75 (a)
(Mus musculus)
Mammalia Zkscan17 35
  • 81.18 (n)
  • 79 (a)
Zkscan17 16
Zkscan17 36
  • 74 (a)
(Monodelphis domestica)
Mammalia ZNF496 36
  • 47 (a)
(Rattus norvegicus)
Mammalia Zfp496 35
  • 80.24 (n)
  • 78.34 (a)
Species with no ortholog for ZNF496:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF496 Gene

Gene Tree for ZNF496 (if available)
Gene Tree for ZNF496 (if available)

Paralogs for ZNF496 Gene

Paralogs for ZNF496 Gene

Selected SIMAP similar genes for ZNF496 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF496: view

Variants for ZNF496 Gene

Sequence variations from dbSNP and Humsavar for ZNF496 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs875883 -- 247,297,054(-) AAAAT(A/G)TGAAG downstream-variant-500B
rs947174 -- 247,333,917(+) GTACA(C/T)TCATG upstream-variant-2KB
rs1616299 -- 247,299,399(+) GAAGC(C/T)GCTTC utr-variant-3-prime
rs1631695 -- 247,311,738(-) GGGGC(A/G)GGACC intron-variant, upstream-variant-2KB
rs1631697 -- 247,311,735(-) GCGGG(A/G)CCACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF496 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv833126 CNV Loss 17160897
nsv833137 CNV Gain 17160897
nsv509790 CNV Insertion 20534489
nsv873439 CNV Loss 21882294
dgv73e201 CNV Deletion 23290073
esv2335854 CNV Deletion 18987734
esv4468 CNV Deletion 18987735
esv992675 CNV Deletion 20482838
esv21506 CNV Loss 19812545

Relevant External Links for ZNF496 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF496 Gene

Disorders for ZNF496 Gene

(1) University of Copenhagen DISEASES for ZNF496 Gene

Relevant External Links for ZNF496

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZNF496: view

No data available for UniProtKB/Swiss-Prot for ZNF496 Gene

Publications for ZNF496 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif. (PMID: 15169884) Nielsen A.L. … Losson R. (Mol. Cell. Biol. 2004) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ZNF496 Gene

Sources for ZNF496 Gene

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