Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF493 Gene

Aliases for ZNF493 Gene

  • Zinc Finger Protein 493 2 3 5

External Ids for ZNF493 Gene

Previous GeneCards Identifiers for ZNF493 Gene

  • GC19P021398
  • GC19P021372
  • GC19P021373
  • GC19P021579
  • GC19P021070

Summaries for ZNF493 Gene

GeneCards Summary for ZNF493 Gene

ZNF493 (Zinc Finger Protein 493) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot for ZNF493 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF493 Gene

Genomics for ZNF493 Gene

Regulatory Elements for ZNF493 Gene

Enhancers for ZNF493 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F021504 1.4 FANTOM5 ENCODE 4.6 +108.9 108917 2.6 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 SP3 ENSG00000268555 ZNF429 ZNF708 ZNF493 ZNF100 ZNF430 PIR57057 PIR58149
GH19F021322 1.6 FANTOM5 Ensembl ENCODE 3.3 -74.4 -74446 1.1 ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A GLI4 DMAP1 ZNF2 ZNF48 ZNF708 LOC105372321 ZNF429 ZNF493 BNIP3P25 GC19P021323
GH19F021126 1.1 Ensembl ENCODE 4.2 -268.4 -268411 4.2 YBX3 HDAC1 PKNOX1 CHAMP1 CBX5 GATA2 SMARCA4 PBX2 IKZF1 HMBOX1 ZNF714 ZNF431 LOC105372321 BNIP3P17 ZNF493 VN1R81P
GH19F021314 1 FANTOM5 Ensembl ENCODE 3.2 -82.2 -82152 1.3 JUND CUX1 ZNF708 ZNF429 ENSG00000213976 ZNF493 ZNF100 ZNF430 BNIP3P25 GC19M021717
GH19F021585 0.8 FANTOM5 Ensembl 4 +188.4 188373 0.6 ZNF335 PKNOX1 GTF2E2 SCRT2 ZNF429 ZNF493 ZNF100 ZNF708 ENSG00000268555 GC19M021742
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF493 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF493 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000641309 681 2000 ATF1 PKNOX1 SIN3A ARID4B DMAP1 ZNF48 ETS1 YY1 ELK1 FOS

Genomic Location for ZNF493 Gene

Chromosome:
19
Start:
21,397,119 bp from pter
End:
21,427,573 bp from pter
Size:
30,455 bases
Orientation:
Plus strand

Genomic View for ZNF493 Gene

Genes around ZNF493 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF493 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF493 Gene

Proteins for ZNF493 Gene

  • Protein details for ZNF493 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZR52-ZN493_HUMAN
    Recommended name:
    Zinc finger protein 493
    Protein Accession:
    Q6ZR52
    Secondary Accessions:
    • G5E974
    • Q59GM3
    • Q6ZSF6
    • Q8N1Z6
    • Q8N965
    • Q9BR99

    Protein attributes for ZNF493 Gene

    Size:
    646 amino acids
    Molecular mass:
    75342 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04591.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86997.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92323.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF493 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF493 Gene

Post-translational modifications for ZNF493 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF493 Gene

Domains & Families for ZNF493 Gene

Gene Families for ZNF493 Gene

Protein Domains for ZNF493 Gene

Suggested Antigen Peptide Sequences for ZNF493 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZR52

UniProtKB/Swiss-Prot:

ZN493_HUMAN :
  • Contains 22 C2H2-type zinc fingers.
Similarity:
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF493: view

Function for ZNF493 Gene

Molecular function for ZNF493 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF493: view
genes like me logo Genes that share phenotypes with ZNF493: view

Animal Model Products

miRNA for ZNF493 Gene

miRTarBase miRNAs that target ZNF493

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF493 Gene

Localization for ZNF493 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF493 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF493 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF493: view

Pathways & Interactions for ZNF493 Gene

SuperPathways for ZNF493 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF493: view

Pathways by source for ZNF493 Gene

2 Reactome pathways for ZNF493 Gene

Interacting Proteins for ZNF493 Gene

Gene Ontology (GO) - Biological Process for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF493: view

No data available for SIGNOR curated interactions for ZNF493 Gene

Transcripts for ZNF493 Gene

Unigene Clusters for ZNF493 Gene

Zinc finger protein 493:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF493 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: -
SP8:
SP9: -
SP10: - - - - - - - - - -

Relevant External Links for ZNF493 Gene

GeneLoc Exon Structure for
ZNF493
ECgene alternative splicing isoforms for
ZNF493

Expression for ZNF493 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF493 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF493 Gene

This gene is overexpressed in Brain - Cerebellum (x4.7).

Protein differential expression in normal tissues from HIPED for ZNF493 Gene

This gene is overexpressed in Islet of Langerhans (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF493 Gene



Protein tissue co-expression partners for ZNF493 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF493 Gene:

ZNF493

SOURCE GeneReport for Unigene cluster for ZNF493 Gene:

Hs.656558
genes like me logo Genes that share expression patterns with ZNF493: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF493 Gene

Orthologs for ZNF493 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF493 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF493 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp457 35
  • 51 (a)
ManyToMany
Zfp458 35
  • 47 (a)
ManyToMany
Zfp738 35
  • 47 (a)
ManyToMany
Zfp759 35
  • 46 (a)
ManyToMany
A530054K11Rik 35
  • 39 (a)
ManyToMany
Zfp748 35
  • 37 (a)
ManyToMany
AA987161 35
  • 35 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 36 (a)
ManyToMany
Species where no ortholog for ZNF493 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF493 Gene

ENSEMBL:
Gene Tree for ZNF493 (if available)
TreeFam:
Gene Tree for ZNF493 (if available)

Paralogs for ZNF493 Gene

(526) SIMAP similar genes for ZNF493 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF493 Gene

genes like me logo Genes that share paralogs with ZNF493: view

Variants for ZNF493 Gene

Sequence variations from dbSNP and Humsavar for ZNF493 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10405716 -- 21,401,562(+) attca(A/G)ctgta intron-variant
rs10410243 -- 21,426,723(+) AATAT(A/G)TTTTC utr-variant-3-prime
rs10410762 -- 21,404,459(+) CTTTA(C/T)GTAGC intron-variant
rs10414834 -- 21,423,917(+) CACAC(C/G)TTACT reference, missense
rs10424079 -- 21,406,377(+) ACATA(A/G)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF493 Gene

Variant ID Type Subtype PubMed ID
nsv978789 CNV duplication 23825009
nsv578952 CNV gain 21841781
nsv578809 CNV gain 21841781
nsv458377 CNV gain 19166990
nsv1151573 OTHER inversion 26484159
nsv1140249 OTHER inversion 24896259
nsv1061327 CNV gain 25217958
esv4924 OTHER complex 18987735
esv3556174 CNV deletion 23714750
esv2751783 CNV loss 17911159
esv2718330 CNV deletion 23290073
esv2718325 CNV deletion 23290073
esv2665276 CNV deletion 23128226
esv2663001 CNV deletion 23128226
dgv6320n54 CNV loss 21841781

Variation tolerance for ZNF493 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF493 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF493

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF493 Gene

Disorders for ZNF493 Gene

Relevant External Links for ZNF493

Genetic Association Database (GAD)
ZNF493
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF493

No disorders were found for ZNF493 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF493 Gene

Publications for ZNF493 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Genome-wide association study of acute post-surgical pain in humans. (PMID: 19207018) Kim H. … Dionne R.A. (Pharmacogenomics 2009) 46 64
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF493 Gene

Sources for ZNF493 Gene

Content
Loading form....