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ZNF493 Gene

protein-coding   GIFtS: 47
GCID: GC19P021579

Zinc Finger Protein 493

  Search for ZNF493
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4931 2

External Ids:    HGNC: 237081   Entrez Gene: 2844432   Ensembl: ENSG000001962687   UniProtKB: Q6ZR523   

Export aliases for ZNF493 gene to outside databases

Previous GC identifers: GC19P021398 GC19P021372 GC19P021373 GC19P021070


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF493 Gene:
ZNF493 (zinc finger protein 493) is a protein-coding gene. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZN493_HUMAN, Q6ZR52
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF493 gene promoter:
         SRF   Sox5   SRF (504 AA)   Nkx2-2   Pax-2   Pax-2a   AREB6   Pax-2b   POU2F1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF493 promoter sequence
   Search Chromatin IP Primers for ZNF493

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF493


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF493 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF493 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P021579:  view genomic region     (about GC identifiers)

Start:
21,579,921 bp from pter      End:
21,610,375 bp from pter
Size:
30,455 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN493_HUMAN, Q6ZR52 (See protein sequence)
Recommended Name: Zinc finger protein 493  
Size: 646 amino acids; 75342 Da
Sequence caution: Sequence=BAC04591.1; Type=Erroneous initiation; Sequence=BAC86997.1; Type=Erroneous initiation;
Sequence=BAD92323.1; Type=Erroneous initiation;
Secondary accessions: G5E974 Q59GM3 Q6ZSF6 Q8N1Z6 Q8N965 Q9BR99
Alternative splicing: 3 isoforms:  Q6ZR52-1   Q6ZR52-2   Q6ZR52-3   (Ref.6 (AAH06408) sequence is in conflict in position: 94:S->G)

Explore the universe of human proteins at neXtProt for ZNF493: NX_Q6ZR52

Explore proteomics data for ZNF493 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys390
  • Modification sites at PhosphoSitePlus

  • See ZNF493 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070146.1  NP_663299.2  NP_787106.4  

    ENSEMBL proteins: 
     ENSP00000469368   ENSP00000376110   ENSP00000469170   ENSP00000469680   ENSP00000347691  
     ENSP00000340651   ENSP00000472110  
    Reactome Protein details: Q6ZR52

    ZNF493 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF493

     
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    Abcam antibodies for ZNF493 (Q9BR99, Q6ZR52)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZR52

    ProtoNet protein and cluster: Q6ZR52

    UniProtKB/Swiss-Prot: ZN493_HUMAN, Q6ZR52
    Similarity: Contains 22 C2H2-type zinc fingers


    Find genes that share domains with ZNF493           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN493_HUMAN, Q6ZR52
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF493           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF493
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    miRNA
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    miRTarBase miRNAs that target ZNF493:
    hsa-mir-155-5p (MIRT020784)

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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF493

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF493


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN493_HUMAN, Q6ZR52: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF493           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF493 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF493           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF493
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF493
    Interactions:

        Search GeneGlobe Interaction Network for ZNF493

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF493           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF493 (ZN493)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF493 gene (3 alternative transcripts): 
    NM_001076678.2  NM_145326.2  NM_175910.6  

    Unigene Cluster for ZNF493:

    Zinc finger protein 493
    Hs.656558  [show with all ESTs]
    Unigene Representative Sequence: NM_001076678
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596302 ENST00000392288(uc002npw.3 uc002npx.3 uc002npy.3)
    ENST00000596815 ENST00000594390 ENST00000355504 ENST00000339914(uc002npu.3)
    ENST00000599461 ENST00000598152 ENST00000599517
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF493
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    GenScript: all cDNA clones in your preferred vector (see all 3): ZNF493 (NM_175910)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF493
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF493
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF493
      QuantiFast Probe-based Assays in human, mouse, rat ZNF493

    Additional mRNA sequence: 

    AB209086.1 AK092178.1 AK093823.1 AK095616.1 AK127476.1 AK128494.1 BC006408.1 BC112346.1 
    BX648842.1 

    12 DOTS entries:

    DT.100655529  DT.101978422  DT.92063411  DT.91857359  DT.100025515  DT.40120431  DT.121496587  DT.95114454 
    DT.97858275  DT.121496522  DT.121496658  DT.207182 

    Selected AceView cDNA sequences (see all 66):

    BC022394 BG110628 BM473806 CB069353 AI805962 AV727695 AW468427 BX648842 
    AL699600 BC006408 AA974841 BU570095 BG426514 AI742351 N27156 AI538553 
    AI880381 BX106757 CD642557 AK095616 AK122810 AI091022 BF515263 BE551157 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF493 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                    -                             -     -           -     -                                       
    SP2:                    -                             -     -     -     -     -                                       
    SP3:                    -                             -     -                                                         
    SP4:                    -                             -     -     -     -     -                                       
    SP5:                    -                             -     -                                                         


    ECgene alternative splicing isoforms for ZNF493

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF493 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTGCGCT
    ZNF493 Expression
    About this image

    ZNF493 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF493 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656558
        Custom PCR Arrays for ZNF493
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF493

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF493 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp4575 zinc finger protein 457   --   13 (34.54 cM) 67292450 


    ENSEMBL Gene Tree for ZNF493 (if available)
    TreeFam Gene Tree for ZNF493 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF493 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF5462  ZNF992  ZNF8362  ZNF7212  ZNF5942  
    ZFP622  ZNF8412  ZNF432  ZNF780B2  ZNF1972  ZNF1072  ZNF585A2  ZNF8082  
    ZNF3472  ZNF8452  ZNF585B2  ZNF6582  ZNF6292  ZNF6242  ZNF2682  ZNF8142  
    Selected SIMAP similar genes for ZNF493 using alignment to 5 protein entries:     ZN493_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF724P    ZNF98    ZNF738    ZNF430    ZNF273
    ZNF43    ZFS-6    ZNF90    DKFZp762K012    ZFS-4    ZNF78L1
    ZNF431    ZNF257    ZNF85    ZNF91    ZNF254    ZNF429

    Find genes that share paralogs with ZNF493           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF493
    PGOHUM00000234601


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF493 (see all 789)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420392641,2
    --21578044(+) TCTGCA/CTCCCA 3 -- us2k10--------
    rs1456607891,2
    --21578082(+) TCCTGA/TGTAGC 3 -- us2k10--------
    rs1858134431,2
    --21578182(+) AACTCC/TTGACC 3 -- us2k10--------
    rs118789421,2
    H--21578254(+) cctggG/TGGCCC 3 -- us2k10--------
    rs1881519221,2
    --21578344(+) TTATTC/TTTGAT 3 -- us2k10--------
    rs1381988711,2
    C--21578755(+) TGCTCA/TGTTTC 3 -- us2k10--------
    rs621103771,2
    C,F--21578829(+) ATTCTC/TCTGCC 3 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1810081691,2
    --21578848(+) TCTATC/TAGCTG 3 -- us2k10--------
    rs1507906271,2
    --21578961(+) TGATCA/CGCCTG 3 -- us2k10--------
    rs1391554411,2
    --21579012(+) CTACAA/CCCGGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF493 (21579921 - 21610375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF493:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663001CNV Deletion23128226
    esv2718330CNV Deletion23290073
    esv2665276CNV Deletion23128226
    esv2718325CNV Deletion23290073
    nsv911420CNV Loss21882294
    esv2751783CNV Loss17911159
    nsv911421CNV Loss21882294
    nsv458377CNV Gain19166990
    esv4924CNV Complex18987735

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF493           About GenesLikeMe

    Genetic Association Database (GAD): ZNF493

    Export disorders for ZNF493 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF493 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF493)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    4. Genome-wide association study of acute post-surgical pain in humans. (PubMed id 19207018)4 Kim H....Dionne R.A. (Pharmacogenomics 2009)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284443 HGNC: 23708 AceView: LOC115648 Ensembl:ENSG00000196268 euGenes: HUgn284443
    ECgene: ZNF493 H-InvDB: ZNF493

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF493 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF493 gene:
    Search GeneIP for patents involving ZNF493

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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