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Aliases for ZNF493 Gene

Aliases for ZNF493 Gene

  • Zinc Finger Protein 493 2 3 5

External Ids for ZNF493 Gene

Previous GeneCards Identifiers for ZNF493 Gene

  • GC19P021398
  • GC19P021372
  • GC19P021373
  • GC19P021579
  • GC19P021070

Summaries for ZNF493 Gene

GeneCards Summary for ZNF493 Gene

ZNF493 (Zinc Finger Protein 493) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF493 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF493 Gene

Genomics for ZNF493 Gene

Regulatory Elements for ZNF493 Gene

Enhancers for ZNF493 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF493 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF493 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF493 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF493 Gene

Chromosome:
19
Start:
21,397,119 bp from pter
End:
21,427,573 bp from pter
Size:
30,455 bases
Orientation:
Plus strand

Genomic View for ZNF493 Gene

Genes around ZNF493 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF493 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF493 Gene

Proteins for ZNF493 Gene

  • Protein details for ZNF493 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZR52-ZN493_HUMAN
    Recommended name:
    Zinc finger protein 493
    Protein Accession:
    Q6ZR52
    Secondary Accessions:
    • G5E974
    • Q59GM3
    • Q6ZSF6
    • Q8N1Z6
    • Q8N965
    • Q9BR99

    Protein attributes for ZNF493 Gene

    Size:
    646 amino acids
    Molecular mass:
    75342 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04591.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86997.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92323.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF493 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF493 Gene

Proteomics data for ZNF493 Gene at MOPED

Post-translational modifications for ZNF493 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF493 Gene

Domains & Families for ZNF493 Gene

Gene Families for ZNF493 Gene

Protein Domains for ZNF493 Gene

Suggested Antigen Peptide Sequences for ZNF493 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZR52

UniProtKB/Swiss-Prot:

ZN493_HUMAN :
  • Contains 22 C2H2-type zinc fingers.
Similarity:
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF493: view

Function for ZNF493 Gene

Molecular function for ZNF493 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF493: view

Animal Model Products

CRISPR Products

miRNA for ZNF493 Gene

miRTarBase miRNAs that target ZNF493

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF493 Gene

Localization for ZNF493 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF493 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF493 Gene COMPARTMENTS Subcellular localization image for ZNF493 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF493 Gene

Pathways & Interactions for ZNF493 Gene

SuperPathways for ZNF493 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF493: view

Pathways by source for ZNF493 Gene

2 Reactome pathways for ZNF493 Gene

Interacting Proteins for ZNF493 Gene

Gene Ontology (GO) - Biological Process for ZNF493 Gene

None

No data available for SIGNOR curated interactions for ZNF493 Gene

Drugs & Compounds for ZNF493 Gene

No Compound Related Data Available

Transcripts for ZNF493 Gene

Unigene Clusters for ZNF493 Gene

Zinc finger protein 493:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF493 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: -
SP8:
SP9: -
SP10: - - - - - - - - - -

Relevant External Links for ZNF493 Gene

GeneLoc Exon Structure for
ZNF493
ECgene alternative splicing isoforms for
ZNF493

Expression for ZNF493 Gene

mRNA expression in normal human tissues for ZNF493 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF493 Gene

This gene is overexpressed in Brain - Cerebellum (x4.7).

Protein differential expression in normal tissues from HIPED for ZNF493 Gene

This gene is overexpressed in Islet of Langerhans (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF493 Gene



SOURCE GeneReport for Unigene cluster for ZNF493 Gene Hs.656558

genes like me logo Genes that share expression patterns with ZNF493: view

Protein tissue co-expression partners for ZNF493 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF493 Gene

Orthologs for ZNF493 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF493 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia A530054K11Rik 36
  • 39 (a)
ManyToMany
AA987161 36
  • 35 (a)
ManyToMany
Zfp457 36
  • 51 (a)
ManyToMany
Zfp458 36
  • 47 (a)
ManyToMany
Zfp738 36
  • 47 (a)
ManyToMany
Zfp748 36
  • 37 (a)
ManyToMany
Zfp759 36
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF493 36
  • 76 (a)
OneToOne
Species with no ortholog for ZNF493:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF493 Gene

ENSEMBL:
Gene Tree for ZNF493 (if available)
TreeFam:
Gene Tree for ZNF493 (if available)

Paralogs for ZNF493 Gene

(526) SIMAP similar genes for ZNF493 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF493 Gene

genes like me logo Genes that share paralogs with ZNF493: view

Variants for ZNF493 Gene

Sequence variations from dbSNP and Humsavar for ZNF493 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs4621113 - 21,423,627(+) TAAAT(G/T)TGAAG reference, missense
rs10414834 - 21,423,917(+) CACAC(A/C/G)TTACT reference, missense
rs7257857 -- 21,396,736(+) tttcA(C/T)AAGAT upstream-variant-2KB
rs7259311 -- 21,415,360(+) gaatg(C/T)ctaga intron-variant
rs12975981 -- 21,408,556(+) TTACA(A/G)TCAAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF493 Gene

Variant ID Type Subtype PubMed ID
nsv458377 CNV Gain 19166990
esv2665276 CNV Deletion 23128226
esv4924 CNV Complex 18987735
esv2718325 CNV Deletion 23290073
nsv911420 CNV Loss 21882294
esv2751783 CNV Loss 17911159
esv2663001 CNV Deletion 23128226
esv2718330 CNV Deletion 23290073
nsv911421 CNV Loss 21882294

Variation tolerance for ZNF493 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF493 Gene

HapMap Linkage Disequilibrium report
ZNF493

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF493 Gene

Disorders for ZNF493 Gene

Relevant External Links for ZNF493

Genetic Association Database (GAD)
ZNF493
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF493

No disorders were found for ZNF493 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF493 Gene

Publications for ZNF493 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF493 Gene

Sources for ZNF493 Gene

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