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Aliases for ZNF493 Gene

Aliases for ZNF493 Gene

  • Zinc Finger Protein 493 2 3

External Ids for ZNF493 Gene

Previous GeneCards Identifiers for ZNF493 Gene

  • GC19P021398
  • GC19P021372
  • GC19P021373
  • GC19P021579
  • GC19P021070

Summaries for ZNF493 Gene

GeneCards Summary for ZNF493 Gene

ZNF493 (Zinc Finger Protein 493) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF493 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF493 Gene

Genomics for ZNF493 Gene

Regulatory Elements for ZNF493 Gene

Genomic Location for ZNF493 Gene

21,397,119 bp from pter
21,427,573 bp from pter
30,455 bases
Plus strand

Genomic View for ZNF493 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF493 Gene

Proteins for ZNF493 Gene

  • Protein details for ZNF493 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 493
    Protein Accession:
    Secondary Accessions:
    • G5E974
    • Q59GM3
    • Q6ZSF6
    • Q8N1Z6
    • Q8N965
    • Q9BR99

    Protein attributes for ZNF493 Gene

    646 amino acids
    Molecular mass:
    75342 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04591.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86997.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92323.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF493 Gene


neXtProt entry for ZNF493 Gene

Proteomics data for ZNF493 Gene at MOPED

Post-translational modifications for ZNF493 Gene

  • Ubiquitination at Lys390 and Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF493 Gene

No data available for DME Specific Peptides for ZNF493 Gene

Domains for ZNF493 Gene

Gene Families for ZNF493 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF493 Gene

Suggested Antigen Peptide Sequences for ZNF493 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6ZR52
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF493: view

Function for ZNF493 Gene

Molecular function for ZNF493 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF493: view

Animal Model Products

CRISPR Products

miRNA for ZNF493 Gene

miRTarBase miRNAs that target ZNF493

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF493

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF493 Gene

Localization for ZNF493 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF493 Gene

Subcellular locations from

Jensen Localization Image for ZNF493 Gene COMPARTMENTS Subcellular localization image for ZNF493 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF493: view

Pathways for ZNF493 Gene

SuperPathways for ZNF493 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF493: view

Pathways by source for ZNF493 Gene

2 Reactome pathways for ZNF493 Gene

Interacting Proteins for ZNF493 Gene

Gene Ontology (GO) - Biological Process for ZNF493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF493: view

Transcripts for ZNF493 Gene

Unigene Clusters for ZNF493 Gene

Zinc finger protein 493:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF493

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF493 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: -
SP9: -
SP10: - - - - - - - - - -

Relevant External Links for ZNF493 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF493 Gene

mRNA expression in normal human tissues for ZNF493 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF493 Gene

This gene is overexpressed in Brain - Cerebellum (4.7).

Protein differential expression in normal tissues for ZNF493 Gene

This gene is overexpressed in Islet of Langerhans (65.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF493 Gene

SOURCE GeneReport for Unigene cluster for ZNF493 Gene Hs.656558

genes like me logo Genes that share expressions with ZNF493: view

Expression partners for ZNF493 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF493 Gene

Orthologs for ZNF493 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF493 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Zfp457 16
A530054K11Rik 36
  • 39 (a)
AA987161 36
  • 35 (a)
Zfp457 36
  • 51 (a)
Zfp458 36
  • 47 (a)
Zfp738 36
  • 47 (a)
Zfp748 36
  • 37 (a)
Zfp759 36
  • 46 (a)
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Pan troglodytes)
Mammalia ZNF493 36
  • 76 (a)
Species with no ortholog for ZNF493:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF493 Gene

Gene Tree for ZNF493 (if available)
Gene Tree for ZNF493 (if available)

Paralogs for ZNF493 Gene

Selected SIMAP similar genes for ZNF493 Gene using alignment to 5 proteins: Pseudogenes for ZNF493 Gene

genes like me logo Genes that share paralogs with ZNF493: view

Variants for ZNF493 Gene

Sequence variations from dbSNP and Humsavar for ZNF493 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1055750 -- 21,405,856(+) CCCCA(A/G)GTAGG missense, reference, intron-variant, utr-variant-5-prime
rs1055753 -- 21,405,890(+) ATAGA(C/T)GAAAG intron-variant
rs1114305 -- 21,401,467(-) attat(A/G)taaaa intron-variant
rs1909771 -- 21,424,892(+) GTGAA(A/G)CATGT missense, reference, intron-variant
rs1967182 -- 21,420,337(-) ATATA(C/G)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF493 Gene

Variant ID Type Subtype PubMed ID
nsv458377 CNV Gain 19166990
esv2665276 CNV Deletion 23128226
esv4924 CNV Complex 18987735
esv2718325 CNV Deletion 23290073
nsv911420 CNV Loss 21882294
esv2751783 CNV Loss 17911159
esv2663001 CNV Deletion 23128226
esv2718330 CNV Deletion 23290073
nsv911421 CNV Loss 21882294

Relevant External Links for ZNF493 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF493 Gene

Disorders for ZNF493 Gene

Relevant External Links for ZNF493

Genetic Association Database (GAD)

No disorders were found for ZNF493 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF493 Gene

Publications for ZNF493 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. (PMID: 25391492) Lamoliatte F. … Thibault P. (Nat Commun 2014) 3

Products for ZNF493 Gene

Sources for ZNF493 Gene

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